GPCR Compound Library

Cat.Nr.L2200

Een unieke collectie van 1417 kleine moleculen gericht op G-proteïne gekoppelde receptoren voor high-throughput screening (HTS) en high-content screening (HCS).

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Specifieke verbindingen
Hoeveelheden
96- of 384-wells plaatlay-out
Droge/vaste stof of DMSO-oplossing

Geciteerd door 332 Publicaties

GPCR Compound Library Inhoud

Beschrijving & Voordelen

•A unique collection of 1417 small molecules targeting G protein coupled receptors for high throughput screening (HTS) and high content screening (HCS)
• All of the small molecules in the GPCR library are well characterized with biological and pharmaceutical activity
• A powerful tool for discovering GPCR-based drugs that are the richest signal receptor targets for drug discovery
• It is estimated about 200 so-called orphan GPCRs are functionally unknown, as a result, use of our GPCR Small Molecule Compound Library for screening the functionally unknown GPCRs may yield potentially new GPCR-based drug candidates
• The GPCR compound library contains small molecules associated with receptors including 5-HT Receptor, Dopamine Receptor, Opioid Receptor, Adrenergic Receptors, Cannabinoid Receptor, mGluR, and ETA-receptor etc.
• Structurally diverse, medicinally active, and cell permeable
• Rich documentation with structure and customer reviews
• NMR and HPLC validated to ensure the highest purity

Productdetails

Formulering	1299 compounds pre-dissolved in 10mM DMSO, 76 compounds pre-dissolved in 10mM water, 37 compounds pre-dissolved in 2mM DMSO and 5 compounds pre-dissolved in 2mM water
Container	96 Deep Well Plate verzegeld met aluminiumfolie
Stabiliteit	12 months	-20°C	in DMSO
Stabiliteit	24 months	-80°C	in DMSO
Verzending	Blauw ijs of droog ijs

Casestudies met Selleck Compound Libraries

Toepassing van GPCR Compound Library bij leverkanker (Dit artikel is gepubliceerd in Nature (IF

Nature.2019;574(7777):268-272
Toepassing van Kinase Inhibitor Library bij colorectale kanker (Dit artikel is gepubliceerd in Nature Communications (IF

Nat Commun. 2019 16;10(1):2197
Toepassing van FDA-approved Drug Library bij antivirus (Dit artikel is gepubliceerd in Cell Research (IF

Cell Res. 2019;29(9):739-753
Toepassing van FDA-approved Drug Library bij metabolisme (Dit artikel is gepubliceerd in Movement Disorders (IF

Mov Disord. 2019;34(3):323-334
Toepassing van Epigenetics Compound Library bij acute lymfatische leukemie (Dit artikel is gepubliceerd in Blood (IF

Blood. 2019 17;134(16):1323-1336
Toepassing van Inhibitor Library bij tumorimmunologie (Dit artikel is gepubliceerd in Cancer Immunol Res (IF

Cancer Immunol Res.2017;5(9):790-803