연구용
A-769662 AMPK activator
제품 번호: S2697
화학 구조
분자량: 360.39
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품질 관리 (Quality Control)
배치:
순도:
99.67%
99.67
세포 배양, 처리 및 작업 농도
(Cell Culture, Treatment & Working Concentration)
| 세포주 | 분석 유형 | 농도 | 배양 시간 | 제형 | 활성 설명 | PMID |
|---|---|---|---|---|---|---|
| mouse hepatocytes | Function assay | 1 mM | DMSO | inhibits fatty acid synthesis with IC50 of 3.6 μM | 16753576 | |
| rat hepatocytes | Function assay | 1 mM | DMSO | inhibits fatty acid synthesis with IC50 of 3.6 μM | 16753576 | |
| HEK293 | Kinase assay | 200 μM | DMSO | activates endogenous AMPK | 17728241 | |
| CCL13 | Kinase assay | 200 μM | DMSO | activates endogenous AMPK | 17728241 | |
| MEFs | Function assay | 300 μM | DMSO | inhibits proteasomal function by an AMPK-independent mechanism | 18593584 | |
| epididymal clear cells | Function assay | 200 μM | DMSO | inhibits the pH-mediated V-ATPase accumulation at the apical membrane | 19211918 | |
| 3T3-L1 | Function assay | 1.2 mM | DMSO | inhibits 3T3-L1 Adipogenesis | 19483304 | |
| 3T3-L1 | Function assay | 1.2 mM | DMSO | inhibits the Expression of AdipogenesisRelated Transcription Factors and Markers | 19483304 | |
| 3T3-L1 | Function assay | 1.2 mM | DMSO | inhibits Mitotic Clonal Expansion | 19483304 | |
| 3T3-L1 | cytotoxicity assay | 1.2 mM | DMSO | decreases Cell Viability | 19483304 | |
| 3T3-L1 | Kinase assay | 1.2 mM | DMSO | activates AMPK | 19483304 | |
| L6 skeletal muscle cells | Function assay | 250 μM | DMSO | activates AMPK signaling pathways | 19828836 | |
| L6 skeletal muscle cells | Function assay | 250 μM | DMSO | inhibits the Na+-K+-ATPase transport activity and cell surface abundance | 19828836 | |
| MDA-MB231 | Apoptosis assay | 400 μM | DMSO | sensitizes human breast cancer cell lines to TRAIL-induced apoptosis | 19896469 | |
| BT474 | Apoptosis assay | 400 μM | DMSO | sensitizes human breast cancer cell lines to TRAIL-induced apoptosis | 19896469 | |
| MCF7 | Apoptosis assay | 400 μM | DMSO | sensitizes human breast cancer cell lines to TRAIL-induced apoptosis | 19896469 | |
| Mesenchymal stem cells | Kinase assay | 10 µM | DMSO | induces a robust and sustained AMPK activation | 24104879 | |
| Mesenchymal stem cells | cytotoxicity assay | 100 µM | DMSO | decreases the MSC proliferation | 24104879 | |
| MG-63 | cytotoxicity assay | 10 µM | DMSO | inhibits H2O2-Induced Osteoblast Cell Death | 24960362 | |
| MC3T3-E1 | cytotoxicity assay | 10 µM | DMSO | inhibits H2O2-Induced Osteoblast Cell Death | 24960362 | |
| MG-63 | Apoptosis assay | 10 µM | DMSO | suppresses H2O2-Induced Osteoblast Cell Apoptosis | 24960362 | |
| MC3T3-E1 | Apoptosis assay | 10 µM | DMSO | suppresses H2O2-Induced Osteoblast Cell Apoptosis | 24960362 | |
| MG-63 | Function assay | 10 µM | DMSO | alleviates ROS accumulation and ATP depletion caused by H2O2 | 24960362 | |
| MC3T3-E1 | Function assay | 10 µM | DMSO | alleviates ROS accumulation and ATP depletion caused by H2O2 | 24960362 | |
| MG-63 | Function assay | 10 µM | DMSO | facilitates H2O2-induced autophagy activation | 24960362 | |
| MC3T3-E1 | Function assay | 10 µM | DMSO | facilitates H2O2-induced autophagy activation | 24960362 | |
| PC3 | Kinase assay | 100 µM | DMSO | upregulates the levels of AMPK and ACC phosphorylation | 25594043 | |
| PC3M | Kinase assay | 100 µM | DMSO | upregulates the levels of AMPK and ACC phosphorylation | 25594043 | |
| PC3 | Function assay | 100 µM | DMSO | induces PI3K/mTOR pathways | 25594043 | |
| PC3M | Function assay | 100 µM | DMSO | induces PI3K/mTOR pathways | 25594043 | |
| PC3 | Growth inhibitory assay | 100 µM | DMSO | suppresses proliferation | 25594043 | |
| PC3M | Growth inhibitory assay | 100 µM | DMSO | suppresses proliferation | 25594043 | |
| MC3T3-E1 | Kinase assay | 10 μM | DMSO | induces significant AMPK activation | 26891866 | |
| MC3T3-E1 | Growth inhibitory assay | 10 μM | DMSO | inhibits Dex-induced osteoblast cell death | 26891866 | |
| MC3T3-E1 | Function assay | 10 μM | DMSO | inhibits Dex-induced oxidative stress | 26891866 | |
| BL21 | Function assay | 1 to 10 mins | Binding affinity to human recombinant N-terminal AVI-tagged phosphorylated AMPK alpha1beta1gamma1 expressed in Escherichia coli BL21 cells after 1 to 10 mins by biolayer interferometry, Kd = 0.51 μM. | 26510622 | ||
| BL21 | Function assay | 1 to 10 mins | Binding affinity to human recombinant N-terminal AVI-tagged phosphorylated AMPK alpha1beta2gamma1 expressed in Escherichia coli BL21 cells after 1 to 10 mins by biolayer interferometry, Kd = 14.5 μM. | 26510622 | ||
| HeLa | Function assay | 100 uM | 1 hr | Effect on AMPK activation in HeLa cells at 100 uM after 1 hr by immunoprecipitate kinase assay | 17855357 | |
| HeLa | Function assay | 100 uM | 1 hr | Effect on AMPK phosphorylation in HeLa cells at 100 uM after 1 hr by immunoprecipitate kinase assay | 17855357 | |
| HeLa | Function assay | 100 uM | 5 mins | Effect on AMPK phosphorylation in HeLa cells at 100 uM after 5 mins by immunoprecipitate kinase assay | 17855357 | |
| HeLa | Function assay | 100 uM | 1 hr | Effect on acetyl-CoA carboxylase phosphorylation in HeLa cells at 100 uM after 1 hr by densitometry | 17855357 | |
| HeLa | Function assay | 100 uM | 1 hr | Reduction of AMPK phosphorylation in HeLa cells at 100 uM after 1 hr in presence of STO-609 by immunoprecipitate kinase assay | 17855357 | |
| HeLa | Function assay | 100 uM | 1 hr | Reduction of AMPK activation in HeLa cells at 100 uM after 1 hr in presence of STO-609 by immunoprecipitate kinase assay | 17855357 | |
| HeLa | Function assay | 100 uM | 1 hr | Reduction of acetyl-CoA carboxylase phosphorylation in HeLa cells at 100 uM after 1 hr in presence of STO-609 by densitometry | 17855357 | |
| CMK | Growth Inhibition Assay | Inhibition of human CMK cell growth in a cell viability assay, IC50 = 0.002202 μM. | SANGER | |||
| SIG-M5 | Growth Inhibition Assay | Inhibition of human SIG-M5 cell growth in a cell viability assay, IC50 = 0.007856 μM. | SANGER | |||
| MV-4-11 | Growth Inhibition Assay | Inhibition of human MV-4-11 cell growth in a cell viability assay, IC50 = 0.02274 μM. | SANGER | |||
| GDM-1 | Growth Inhibition Assay | Inhibition of human GDM-1 cell growth in a cell viability assay, IC50 = 0.02553 μM. | SANGER | |||
| A431 | Growth Inhibition Assay | Inhibition of human A431 cell growth in a cell viability assay, IC50 = 0.02919 μM. | SANGER | |||
| NALM-6 | Growth Inhibition Assay | Inhibition of human NALM-6 cell growth in a cell viability assay, IC50 = 0.03166 μM. | SANGER | |||
| KM12 | Growth Inhibition Assay | Inhibition of human KM12 cell growth in a cell viability assay, IC50 = 0.03213 μM. | SANGER | |||
| QIMR-WIL | Growth Inhibition Assay | Inhibition of human QIMR-WIL cell growth in a cell viability assay, IC50 = 0.03642 μM. | SANGER | |||
| NH-12 | Growth Inhibition Assay | Inhibition of human NH-12 cell growth in a cell viability assay, IC50 = 0.03689 μM. | SANGER | |||
| KASUMI-1 | Growth Inhibition Assay | Inhibition of human KASUMI-1 cell growth in a cell viability assay, IC50 = 0.0418 μM. | SANGER | |||
| ML-2 | Growth Inhibition Assay | Inhibition of human ML-2 cell growth in a cell viability assay, IC50 = 0.04344 μM. | SANGER | |||
| YT | Growth Inhibition Assay | Inhibition of human YT cell growth in a cell viability assay, IC50 = 0.0467 μM. | SANGER | |||
| Daudi | Growth Inhibition Assay | Inhibition of human Daudi cell growth in a cell viability assay, IC50 = 0.04979 μM. | SANGER | |||
| OCI-AML2 | Growth Inhibition Assay | Inhibition of human OCI-AML2 cell growth in a cell viability assay, IC50 = 0.0572 μM. | SANGER | |||
| ALL-PO | Growth Inhibition Assay | Inhibition of human ALL-PO cell growth in a cell viability assay, IC50 = 0.05793 μM. | SANGER | |||
| MOLT-16 | Growth Inhibition Assay | Inhibition of human MOLT-16 cell growth in a cell viability assay, IC50 = 0.06191 μM. | SANGER | |||
| EHEB | Growth Inhibition Assay | Inhibition of human EHEB cell growth in a cell viability assay, IC50 = 0.06325 μM. | SANGER | |||
| AM-38 | Growth Inhibition Assay | Inhibition of human AM-38 cell growth in a cell viability assay, IC50 = 0.0644 μM. | SANGER | |||
| C8166 | Growth Inhibition Assay | Inhibition of human C8166 cell growth in a cell viability assay, IC50 = 0.06619 μM. | SANGER | |||
| RPMI-6666 | Growth Inhibition Assay | Inhibition of human RPMI-6666 cell growth in a cell viability assay, IC50 = 0.06798 μM. | SANGER | |||
| BC-1 | Growth Inhibition Assay | Inhibition of human BC-1 cell growth in a cell viability assay, IC50 = 0.06973 μM. | SANGER | |||
| CTV-1 | Growth Inhibition Assay | Inhibition of human CTV-1 cell growth in a cell viability assay, IC50 = 0.07303 μM. | SANGER | |||
| HC-1 | Growth Inhibition Assay | Inhibition of human HC-1 cell growth in a cell viability assay, IC50 = 0.08314 μM. | SANGER | |||
| JiyoyeP-2003 | Growth Inhibition Assay | Inhibition of human JiyoyeP-2003 cell growth in a cell viability assay, IC50 = 0.08371 μM. | SANGER | |||
| RS4-11 | Growth Inhibition Assay | Inhibition of human RS4-11 cell growth in a cell viability assay, IC50 = 0.08572 μM. | SANGER | |||
| PF-382 | Growth Inhibition Assay | Inhibition of human PF-382 cell growth in a cell viability assay, IC50 = 0.0859 μM. | SANGER | |||
| G-361 | Growth Inhibition Assay | Inhibition of human G-361 cell growth in a cell viability assay, IC50 = 0.08815 μM. | SANGER | |||
| LOXIMVI | Growth Inhibition Assay | Inhibition of human LOXIMVI cell growth in a cell viability assay, IC50 = 0.08833 μM. | SANGER | |||
| A3-KAW | Growth Inhibition Assay | Inhibition of human A3-KAW cell growth in a cell viability assay, IC50 = 0.09169 μM. | SANGER | |||
| EoL-1-cell | Growth Inhibition Assay | Inhibition of human EoL-1-cell cell growth in a cell viability assay, IC50 = 0.09558 μM. | SANGER | |||
| LOUCY | Growth Inhibition Assay | Inhibition of human LOUCY cell growth in a cell viability assay, IC50 = 0.09641 μM. | SANGER | |||
| HL-60 | Growth Inhibition Assay | Inhibition of human HL-60 cell growth in a cell viability assay, IC50 = 0.09739 μM. | SANGER | |||
| MC116 | Growth Inhibition Assay | Inhibition of human MC116 cell growth in a cell viability assay, IC50 = 0.10014 μM. | SANGER | |||
| CESS | Growth Inhibition Assay | Inhibition of human CESS cell growth in a cell viability assay, IC50 = 0.1011 μM. | SANGER | |||
| REH | Growth Inhibition Assay | Inhibition of human REH cell growth in a cell viability assay, IC50 = 0.10382 μM. | SANGER | |||
| HCC2157 | Growth Inhibition Assay | Inhibition of human HCC2157 cell growth in a cell viability assay, IC50 = 0.10455 μM. | SANGER | |||
| HEL | Growth Inhibition Assay | Inhibition of human HEL cell growth in a cell viability assay, IC50 = 0.10728 μM. | SANGER | |||
| BL-70 | Growth Inhibition Assay | Inhibition of human BL-70 cell growth in a cell viability assay, IC50 = 0.10805 μM. | SANGER | |||
| NCI-H1770 | Growth Inhibition Assay | Inhibition of human NCI-H1770 cell growth in a cell viability assay, IC50 = 0.10865 μM. | SANGER | |||
| SK-MM-2 | Growth Inhibition Assay | Inhibition of human SK-MM-2 cell growth in a cell viability assay, IC50 = 0.10944 μM. | SANGER | |||
| MONO-MAC-6 | Growth Inhibition Assay | Inhibition of human MONO-MAC-6 cell growth in a cell viability assay, IC50 = 0.11372 μM. | SANGER | |||
| SR | Growth Inhibition Assay | Inhibition of human SR cell growth in a cell viability assay, IC50 = 0.11387 μM. | SANGER | |||
| MOLT-4 | Growth Inhibition Assay | Inhibition of human MOLT-4 cell growth in a cell viability assay, IC50 = 0.11446 μM. | SANGER | |||
| KE-37 | Growth Inhibition Assay | Inhibition of human KE-37 cell growth in a cell viability assay, IC50 = 0.12924 μM. | SANGER | |||
| ST486 | Growth Inhibition Assay | Inhibition of human ST486 cell growth in a cell viability assay, IC50 = 0.13527 μM. | SANGER | |||
| HDLM-2 | Growth Inhibition Assay | Inhibition of human HDLM-2 cell growth in a cell viability assay, IC50 = 0.13616 μM. | SANGER | |||
| ARH-77 | Growth Inhibition Assay | Inhibition of human ARH-77 cell growth in a cell viability assay, IC50 = 0.1406 μM. | SANGER | |||
| EB2 | Growth Inhibition Assay | Inhibition of human EB2 cell growth in a cell viability assay, IC50 = 0.14234 μM. | SANGER | |||
| CCRF-CEM | Growth Inhibition Assay | Inhibition of human CCRF-CEM cell growth in a cell viability assay, IC50 = 0.14576 μM. | SANGER | |||
| HD-MY-Z | Growth Inhibition Assay | Inhibition of human HD-MY-Z cell growth in a cell viability assay, IC50 = 0.14791 μM. | SANGER | |||
| BT-474 | Growth Inhibition Assay | Inhibition of human BT-474 cell growth in a cell viability assay, IC50 = 0.15074 μM. | SANGER | |||
| KARPAS-45 | Growth Inhibition Assay | Inhibition of human KARPAS-45 cell growth in a cell viability assay, IC50 = 0.16984 μM. | SANGER | |||
| Ramos-2G6-4C10 | Growth Inhibition Assay | Inhibition of human Ramos-2G6-4C10 cell growth in a cell viability assay, IC50 = 0.1715 μM. | SANGER | |||
| MC-CAR | Growth Inhibition Assay | Inhibition of human MC-CAR cell growth in a cell viability assay, IC50 = 0.17153 μM. | SANGER | |||
| MRK-nu-1 | Growth Inhibition Assay | Inhibition of human MRK-nu-1 cell growth in a cell viability assay, IC50 = 0.17751 μM. | SANGER | |||
| MHH-PREB-1 | Growth Inhibition Assay | Inhibition of human MHH-PREB-1 cell growth in a cell viability assay, IC50 = 0.18242 μM. | SANGER | |||
| SK-NEP-1 | Growth Inhibition Assay | Inhibition of human SK-NEP-1 cell growth in a cell viability assay, IC50 = 0.18514 μM. | SANGER | |||
| BL-41 | Growth Inhibition Assay | Inhibition of human BL-41 cell growth in a cell viability assay, IC50 = 0.18943 μM. | SANGER | |||
| CAS-1 | Growth Inhibition Assay | Inhibition of human CAS-1 cell growth in a cell viability assay, IC50 = 0.19307 μM. | SANGER | |||
| NCI-H1522 | Growth Inhibition Assay | Inhibition of human NCI-H1522 cell growth in a cell viability assay, IC50 = 0.19355 μM. | SANGER | |||
| CA46 | Growth Inhibition Assay | Inhibition of human CA46 cell growth in a cell viability assay, IC50 = 0.19556 μM. | SANGER | |||
| L-363 | Growth Inhibition Assay | Inhibition of human L-363 cell growth in a cell viability assay, IC50 = 0.21121 μM. | SANGER | |||
| NCI-H2087 | Growth Inhibition Assay | Inhibition of human NCI-H2087 cell growth in a cell viability assay, IC50 = 0.21446 μM. | SANGER | |||
| GR-ST | Growth Inhibition Assay | Inhibition of human GR-ST cell growth in a cell viability assay, IC50 = 0.21764 μM. | SANGER | |||
| OPM-2 | Growth Inhibition Assay | Inhibition of human OPM-2 cell growth in a cell viability assay, IC50 = 0.21791 μM. | SANGER | |||
| U-698-M | Growth Inhibition Assay | Inhibition of human U-698-M cell growth in a cell viability assay, IC50 = 0.21915 μM. | SANGER | |||
| CAL-148 | Growth Inhibition Assay | Inhibition of human CAL-148 cell growth in a cell viability assay, IC50 = 0.22342 μM. | SANGER | |||
| L-428 | Growth Inhibition Assay | Inhibition of human L-428 cell growth in a cell viability assay, IC50 = 0.22499 μM. | SANGER | |||
| DEL | Growth Inhibition Assay | Inhibition of human DEL cell growth in a cell viability assay, IC50 = 0.22825 μM. | SANGER | |||
| LU-134-A | Growth Inhibition Assay | Inhibition of human LU-134-A cell growth in a cell viability assay, IC50 = 0.23116 μM. | SANGER | |||
| MLMA | Growth Inhibition Assay | Inhibition of human MLMA cell growth in a cell viability assay, IC50 = 0.23399 μM. | SANGER | |||
| DOHH-2 | Growth Inhibition Assay | Inhibition of human DOHH-2 cell growth in a cell viability assay, IC50 = 0.24513 μM. | SANGER | |||
| RPMI-8226 | Growth Inhibition Assay | Inhibition of human RPMI-8226 cell growth in a cell viability assay, IC50 = 0.24596 μM. | SANGER | |||
| NCI-H2196 | Growth Inhibition Assay | Inhibition of human NCI-H2196 cell growth in a cell viability assay, IC50 = 0.24776 μM. | SANGER | |||
| COR-L279 | Growth Inhibition Assay | Inhibition of human COR-L279 cell growth in a cell viability assay, IC50 = 0.25293 μM. | SANGER | |||
| CAPAN-1 | Growth Inhibition Assay | Inhibition of human CAPAN-1 cell growth in a cell viability assay, IC50 = 0.25589 μM. | SANGER | |||
| NOMO-1 | Growth Inhibition Assay | Inhibition of human NOMO-1 cell growth in a cell viability assay, IC50 = 0.26322 μM. | SANGER | |||
| SUP-T1 | Growth Inhibition Assay | Inhibition of human SUP-T1 cell growth in a cell viability assay, IC50 = 0.26516 μM. | SANGER | |||
| MEG-01 | Growth Inhibition Assay | Inhibition of human MEG-01 cell growth in a cell viability assay, IC50 = 0.2687 μM. | SANGER | |||
| CHP-126 | Growth Inhibition Assay | Inhibition of human CHP-126 cell growth in a cell viability assay, IC50 = 0.26909 μM. | SANGER | |||
| HCC1599 | Growth Inhibition Assay | Inhibition of human HCC1599 cell growth in a cell viability assay, IC50 = 0.27841 μM. | SANGER | |||
| EB-3 | Growth Inhibition Assay | Inhibition of human EB-3 cell growth in a cell viability assay, IC50 = 0.29293 μM. | SANGER | |||
| WSU-NHL | Growth Inhibition Assay | Inhibition of human WSU-NHL cell growth in a cell viability assay, IC50 = 0.29672 μM. | SANGER | |||
| COLO-684 | Growth Inhibition Assay | Inhibition of human COLO-684 cell growth in a cell viability assay, IC50 = 0.3025 μM. | SANGER | |||
| LAMA-84 | Growth Inhibition Assay | Inhibition of human LAMA-84 cell growth in a cell viability assay, IC50 = 0.30816 μM. | SANGER | |||
| TGW | Growth Inhibition Assay | Inhibition of human TGW cell growth in a cell viability assay, IC50 = 0.31095 μM. | SANGER | |||
| NCI-SNU-1 | Growth Inhibition Assay | Inhibition of human NCI-SNU-1 cell growth in a cell viability assay, IC50 = 0.31106 μM. | SANGER | |||
| MHH-NB-11 | Growth Inhibition Assay | Inhibition of human MHH-NB-11 cell growth in a cell viability assay, IC50 = 0.32291 μM. | SANGER | |||
| COLO-824 | Growth Inhibition Assay | Inhibition of human COLO-824 cell growth in a cell viability assay, IC50 = 0.32838 μM. | SANGER | |||
| U-87-MG | Growth Inhibition Assay | Inhibition of human U-87-MG cell growth in a cell viability assay, IC50 = 0.33314 μM. | SANGER | |||
| HT | Growth Inhibition Assay | Inhibition of human HT cell growth in a cell viability assay, IC50 = 0.33482 μM. | SANGER | |||
| THP-1 | Growth Inhibition Assay | Inhibition of human THP-1 cell growth in a cell viability assay, IC50 = 0.34164 μM. | SANGER | |||
| HCC2218 | Growth Inhibition Assay | Inhibition of human HCC2218 cell growth in a cell viability assay, IC50 = 0.3418 μM. | SANGER | |||
| KARPAS-422 | Growth Inhibition Assay | Inhibition of human KARPAS-422 cell growth in a cell viability assay, IC50 = 0.34433 μM. | SANGER | |||
| EM-2 | Growth Inhibition Assay | Inhibition of human EM-2 cell growth in a cell viability assay, IC50 = 0.34443 μM. | SANGER | |||
| TUR | Growth Inhibition Assay | Inhibition of human TUR cell growth in a cell viability assay, IC50 = 0.34453 μM. | SANGER | |||
| MN-60 | Growth Inhibition Assay | Inhibition of human MN-60 cell growth in a cell viability assay, IC50 = 0.34596 μM. | SANGER | |||
| DMS-153 | Growth Inhibition Assay | Inhibition of human DMS-153 cell growth in a cell viability assay, IC50 = 0.37276 μM. | SANGER | |||
| J-RT3-T3-5 | Growth Inhibition Assay | Inhibition of human J-RT3-T3-5 cell growth in a cell viability assay, IC50 = 0.37831 μM. | SANGER | |||
| EVSA-T | Growth Inhibition Assay | Inhibition of human EVSA-T cell growth in a cell viability assay, IC50 = 0.38095 μM. | SANGER | |||
| SHP-77 | Growth Inhibition Assay | Inhibition of human SHP-77 cell growth in a cell viability assay, IC50 = 0.38298 μM. | SANGER | |||
| D-283MED | Growth Inhibition Assay | Inhibition of human D-283MED cell growth in a cell viability assay, IC50 = 0.38569 μM. | SANGER | |||
| GOTO | Growth Inhibition Assay | Inhibition of human GOTO cell growth in a cell viability assay, IC50 = 0.39536 μM. | SANGER | |||
| KMOE-2 | Growth Inhibition Assay | Inhibition of human KMOE-2 cell growth in a cell viability assay, IC50 = 0.39664 μM. | SANGER | |||
| U-266 | Growth Inhibition Assay | Inhibition of human U-266 cell growth in a cell viability assay, IC50 = 0.40452 μM. | SANGER | |||
| NCI-H226 | Growth Inhibition Assay | Inhibition of human NCI-H226 cell growth in a cell viability assay, IC50 = 0.40703 μM. | SANGER | |||
| KG-1 | Growth Inhibition Assay | Inhibition of human KG-1 cell growth in a cell viability assay, IC50 = 0.40876 μM. | SANGER | |||
| NCI-H1882 | Growth Inhibition Assay | Inhibition of human NCI-H1882 cell growth in a cell viability assay, IC50 = 0.40912 μM. | SANGER | |||
| KMS-12-PE | Growth Inhibition Assay | Inhibition of human KMS-12-PE cell growth in a cell viability assay, IC50 = 0.41877 μM. | SANGER | |||
| KM-H2 | Growth Inhibition Assay | Inhibition of human KM-H2 cell growth in a cell viability assay, IC50 = 0.42374 μM. | SANGER | |||
| NCI-H1417 | Growth Inhibition Assay | Inhibition of human NCI-H1417 cell growth in a cell viability assay, IC50 = 0.43916 μM. | SANGER | |||
| RPMI-8402 | Growth Inhibition Assay | Inhibition of human RPMI-8402 cell growth in a cell viability assay, IC50 = 0.44161 μM. | SANGER | |||
| EW-18 | Growth Inhibition Assay | Inhibition of human EW-18 cell growth in a cell viability assay, IC50 = 0.45104 μM. | SANGER | |||
| HH | Growth Inhibition Assay | Inhibition of human HH cell growth in a cell viability assay, IC50 = 0.45751 μM. | SANGER | |||
| NCI-H526 | Growth Inhibition Assay | Inhibition of human NCI-H526 cell growth in a cell viability assay, IC50 = 0.46847 μM. | SANGER | |||
| NEC8 | Growth Inhibition Assay | Inhibition of human NEC8 cell growth in a cell viability assay, IC50 = 0.48029 μM. | SANGER | |||
| P12-ICHIKAWA | Growth Inhibition Assay | Inhibition of human P12-ICHIKAWA cell growth in a cell viability assay, IC50 = 0.48862 μM. | SANGER | |||
| DB | Growth Inhibition Assay | Inhibition of human DB cell growth in a cell viability assay, IC50 = 0.48893 μM. | SANGER | |||
| SJRH30 | Growth Inhibition Assay | Inhibition of human SJRH30 cell growth in a cell viability assay, IC50 = 0.49478 μM. | SANGER | |||
| ATN-1 | Growth Inhibition Assay | Inhibition of human ATN-1 cell growth in a cell viability assay, IC50 = 0.49906 μM. | SANGER | |||
| ECC4 | Growth Inhibition Assay | Inhibition of human ECC4 cell growth in a cell viability assay, IC50 = 0.50901 μM. | SANGER | |||
| LU-65 | Growth Inhibition Assay | Inhibition of human LU-65 cell growth in a cell viability assay, IC50 = 0.52007 μM. | SANGER | |||
| NCI-H1092 | Growth Inhibition Assay | Inhibition of human NCI-H1092 cell growth in a cell viability assay, IC50 = 0.54078 μM. | SANGER | |||
| NCI-H187 | Growth Inhibition Assay | Inhibition of human NCI-H187 cell growth in a cell viability assay, IC50 = 0.54464 μM. | SANGER | |||
| LNCaP-Clone-FGC | Growth Inhibition Assay | Inhibition of human LNCaP-Clone-FGC cell growth in a cell viability assay, IC50 = 0.5472 μM. | SANGER | |||
| LC4-1 | Growth Inhibition Assay | Inhibition of human LC4-1 cell growth in a cell viability assay, IC50 = 0.56308 μM. | SANGER | |||
| NCI-H1436 | Growth Inhibition Assay | Inhibition of human NCI-H1436 cell growth in a cell viability assay, IC50 = 0.59043 μM. | SANGER | |||
| NCI-H2171 | Growth Inhibition Assay | Inhibition of human NCI-H2171 cell growth in a cell viability assay, IC50 = 0.62179 μM. | SANGER | |||
| LB647-SCLC | Growth Inhibition Assay | Inhibition of human LB647-SCLC cell growth in a cell viability assay, IC50 = 0.62241 μM. | SANGER | |||
| NCI-H2141 | Growth Inhibition Assay | Inhibition of human NCI-H2141 cell growth in a cell viability assay, IC50 = 0.63266 μM. | SANGER | |||
| NCI-H1304 | Growth Inhibition Assay | Inhibition of human NCI-H1304 cell growth in a cell viability assay, IC50 = 0.63388 μM. | SANGER | |||
| Raji | Growth Inhibition Assay | Inhibition of human Raji cell growth in a cell viability assay, IC50 = 0.66976 μM. | SANGER | |||
| NB69 | Growth Inhibition Assay | Inhibition of human NB69 cell growth in a cell viability assay, IC50 = 0.68575 μM. | SANGER | |||
| NCI-H510A | Growth Inhibition Assay | Inhibition of human NCI-H510A cell growth in a cell viability assay, IC50 = 0.69172 μM. | SANGER | |||
| COR-L88 | Growth Inhibition Assay | Inhibition of human COR-L88 cell growth in a cell viability assay, IC50 = 0.72456 μM. | SANGER | |||
| K052 | Growth Inhibition Assay | Inhibition of human K052 cell growth in a cell viability assay, IC50 = 0.79127 μM. | SANGER | |||
| SK-N-DZ | Growth Inhibition Assay | Inhibition of human SK-N-DZ cell growth in a cell viability assay, IC50 = 0.80231 μM. | SANGER | |||
| KY821 | Growth Inhibition Assay | Inhibition of human KY821 cell growth in a cell viability assay, IC50 = 0.81743 μM. | SANGER | |||
| MDA-MB-157 | Growth Inhibition Assay | Inhibition of human MDA-MB-157 cell growth in a cell viability assay, IC50 = 0.82406 μM. | SANGER | |||
| MS-1 | Growth Inhibition Assay | Inhibition of human MS-1 cell growth in a cell viability assay, IC50 = 0.82745 μM. | SANGER | |||
| L-540 | Growth Inhibition Assay | Inhibition of human L-540 cell growth in a cell viability assay, IC50 = 0.84843 μM. | SANGER | |||
| MDA-MB-361 | Growth Inhibition Assay | Inhibition of human MDA-MB-361 cell growth in a cell viability assay, IC50 = 0.86048 μM. | SANGER | |||
| NCI-SNU-5 | Growth Inhibition Assay | Inhibition of human NCI-SNU-5 cell growth in a cell viability assay, IC50 = 0.94375 μM. | SANGER | |||
| KARPAS-299 | Growth Inhibition Assay | Inhibition of human KARPAS-299 cell growth in a cell viability assay, IC50 = 0.94828 μM. | SANGER | |||
| NCI-H1694 | Growth Inhibition Assay | Inhibition of human NCI-H1694 cell growth in a cell viability assay, IC50 = 0.9773 μM. | SANGER | |||
| P30-OHK | Growth Inhibition Assay | Inhibition of human P30-OHK cell growth in a cell viability assay, IC50 = 0.99292 μM. | SANGER | |||
| LU-165 | Growth Inhibition Assay | Inhibition of human LU-165 cell growth in a cell viability assay, IC50 = 1.05606 μM. | SANGER | |||
| NB1 | Growth Inhibition Assay | Inhibition of human NB1 cell growth in a cell viability assay, IC50 = 1.11241 μM. | SANGER | |||
| UACC-812 | Growth Inhibition Assay | Inhibition of human UACC-812 cell growth in a cell viability assay, IC50 = 1.1488 μM. | SANGER | |||
| RL | Growth Inhibition Assay | Inhibition of human RL cell growth in a cell viability assay, IC50 = 1.16282 μM. | SANGER | |||
| NCI-H69 | Growth Inhibition Assay | Inhibition of human NCI-H69 cell growth in a cell viability assay, IC50 = 1.19391 μM. | SANGER | |||
| SW1417 | Growth Inhibition Assay | Inhibition of human SW1417 cell growth in a cell viability assay, IC50 = 1.23671 μM. | SANGER | |||
| NCI-H1155 | Growth Inhibition Assay | Inhibition of human NCI-H1155 cell growth in a cell viability assay, IC50 = 1.27588 μM. | SANGER | |||
| NCI-H1581 | Growth Inhibition Assay | Inhibition of human NCI-H1581 cell growth in a cell viability assay, IC50 = 1.44028 μM. | SANGER | |||
| MHH-CALL-2 | Growth Inhibition Assay | Inhibition of human MHH-CALL-2 cell growth in a cell viability assay, IC50 = 1.48514 μM. | SANGER | |||
| SCLC-21H | Growth Inhibition Assay | Inhibition of human SCLC-21H cell growth in a cell viability assay, IC50 = 1.67837 μM. | SANGER | |||
| LK-2 | Growth Inhibition Assay | Inhibition of human LK-2 cell growth in a cell viability assay, IC50 = 1.71089 μM. | SANGER | |||
| CPC-N | Growth Inhibition Assay | Inhibition of human CPC-N cell growth in a cell viability assay, IC50 = 1.76764 μM. | SANGER | |||
| SCC-3 | Growth Inhibition Assay | Inhibition of human SCC-3 cell growth in a cell viability assay, IC50 = 2.04311 μM. | SANGER | |||
| NCI-H446 | Growth Inhibition Assay | Inhibition of human NCI-H446 cell growth in a cell viability assay, IC50 = 2.05293 μM. | SANGER | |||
| RH-1 | Growth Inhibition Assay | Inhibition of human RH-1 cell growth in a cell viability assay, IC50 = 2.13933 μM. | SANGER | |||
| NCI-H345 | Growth Inhibition Assay | Inhibition of human NCI-H345 cell growth in a cell viability assay, IC50 = 2.14996 μM. | SANGER | |||
| A253 | Growth Inhibition Assay | Inhibition of human A253 cell growth in a cell viability assay, IC50 = 2.25377 μM. | SANGER | |||
| DMS-79 | Growth Inhibition Assay | Inhibition of human DMS-79 cell growth in a cell viability assay, IC50 = 2.36386 μM. | SANGER | |||
| SK-N-FI | Growth Inhibition Assay | Inhibition of human SK-N-FI cell growth in a cell viability assay, IC50 = 2.50034 μM. | SANGER | |||
| SK-MEL-1 | Growth Inhibition Assay | Inhibition of human SK-MEL-1 cell growth in a cell viability assay, IC50 = 2.61066 μM. | SANGER | |||
| HuO-3N1 | Growth Inhibition Assay | Inhibition of human HuO-3N1 cell growth in a cell viability assay, IC50 = 2.69128 μM. | SANGER | |||
| SIMA | Growth Inhibition Assay | Inhibition of human SIMA cell growth in a cell viability assay, IC50 = 2.72143 μM. | SANGER | |||
| SU-DHL-1 | Growth Inhibition Assay | Inhibition of human SU-DHL-1 cell growth in a cell viability assay, IC50 = 2.90246 μM. | SANGER | |||
| P31-FUJ | Growth Inhibition Assay | Inhibition of human P31-FUJ cell growth in a cell viability assay, IC50 = 3.01209 μM. | SANGER | |||
| A101D | Growth Inhibition Assay | Inhibition of human A101D cell growth in a cell viability assay, IC50 = 3.23245 μM. | SANGER | |||
| RPMI-8866 | Growth Inhibition Assay | Inhibition of human RPMI-8866 cell growth in a cell viability assay, IC50 = 3.58797 μM. | SANGER | |||
| NCI-H209 | Growth Inhibition Assay | Inhibition of human NCI-H209 cell growth in a cell viability assay, IC50 = 3.59247 μM. | SANGER | |||
| JVM-2 | Growth Inhibition Assay | Inhibition of human JVM-2 cell growth in a cell viability assay, IC50 = 3.62244 μM. | SANGER | |||
| LP-1 | Growth Inhibition Assay | Inhibition of human LP-1 cell growth in a cell viability assay, IC50 = 3.79042 μM. | SANGER | |||
| IST-SL1 | Growth Inhibition Assay | Inhibition of human IST-SL1 cell growth in a cell viability assay, IC50 = 3.91611 μM. | SANGER | |||
| TE-9 | Growth Inhibition Assay | Inhibition of human TE-9 cell growth in a cell viability assay, IC50 = 3.99619 μM. | SANGER | |||
| NCI-H1618 | Growth Inhibition Assay | Inhibition of human NCI-H1618 cell growth in a cell viability assay, IC50 = 4.17788 μM. | SANGER | |||
| COR-L105 | Growth Inhibition Assay | Inhibition of human COR-L105 cell growth in a cell viability assay, IC50 = 4.51462 μM. | SANGER | |||
| KU-19-19 | Growth Inhibition Assay | Inhibition of human KU-19-19 cell growth in a cell viability assay, IC50 = 4.56729 μM. | SANGER | |||
| HCC70 | Growth Inhibition Assay | Inhibition of human HCC70 cell growth in a cell viability assay, IC50 = 5.75167 μM. | SANGER | |||
| DG-75 | Growth Inhibition Assay | Inhibition of human DG-75 cell growth in a cell viability assay, IC50 = 6.18885 μM. | SANGER | |||
| CCF-STTG1 | Growth Inhibition Assay | Inhibition of human CCF-STTG1 cell growth in a cell viability assay, IC50 = 6.74902 μM. | SANGER | |||
| SBC-1 | Growth Inhibition Assay | Inhibition of human SBC-1 cell growth in a cell viability assay, IC50 = 6.88808 μM. | SANGER | |||
| CAL-85-1 | Growth Inhibition Assay | Inhibition of human CAL-85-1 cell growth in a cell viability assay, IC50 = 7.45587 μM. | SANGER | |||
| BxPC-3 | Growth Inhibition Assay | Inhibition of human BxPC-3 cell growth in a cell viability assay, IC50 = 7.56085 μM. | SANGER | |||
| YAPC | Growth Inhibition Assay | Inhibition of human YAPC cell growth in a cell viability assay, IC50 = 7.74286 μM. | SANGER | |||
| HCC1806 | Growth Inhibition Assay | Inhibition of human HCC1806 cell growth in a cell viability assay, IC50 = 8.04507 μM. | SANGER | |||
| SK-MEL-28 | Growth Inhibition Assay | Inhibition of human SK-MEL-28 cell growth in a cell viability assay, IC50 = 8.42441 μM. | SANGER | |||
| Ca9-22 | Growth Inhibition Assay | Inhibition of human Ca9-22 cell growth in a cell viability assay, IC50 = 8.62748 μM. | SANGER | |||
| NCI-H889 | Growth Inhibition Assay | Inhibition of human NCI-H889 cell growth in a cell viability assay, IC50 = 9.42457 μM. | SANGER | |||
| HT-3 | Growth Inhibition Assay | Inhibition of human HT-3 cell growth in a cell viability assay, IC50 = 9.4754 μM. | SANGER | |||
| H4 | Growth Inhibition Assay | Inhibition of human H4 cell growth in a cell viability assay, IC50 = 9.59864 μM. | SANGER | |||
| NCI-H2228 | Growth Inhibition Assay | Inhibition of human NCI-H2228 cell growth in a cell viability assay, IC50 = 9.87581 μM. | SANGER | |||
| M14 | Growth Inhibition Assay | Inhibition of human M14 cell growth in a cell viability assay, IC50 = 10.5224 μM. | SANGER | |||
| OVCAR-3 | Growth Inhibition Assay | Inhibition of human OVCAR-3 cell growth in a cell viability assay, IC50 = 11.4748 μM. | SANGER | |||
| HCC1187 | Growth Inhibition Assay | Inhibition of human HCC1187 cell growth in a cell viability assay, IC50 = 11.4776 μM. | SANGER | |||
| RT4 | Growth Inhibition Assay | Inhibition of human RT4 cell growth in a cell viability assay, IC50 = 11.6532 μM. | SANGER | |||
| SW962 | Growth Inhibition Assay | Inhibition of human SW962 cell growth in a cell viability assay, IC50 = 12.004 μM. | SANGER | |||
| BB49-HNC | Growth Inhibition Assay | Inhibition of human BB49-HNC cell growth in a cell viability assay, IC50 = 12.0436 μM. | SANGER | |||
| HCE-4 | Growth Inhibition Assay | Inhibition of human HCE-4 cell growth in a cell viability assay, IC50 = 12.7585 μM. | SANGER | |||
| KU812 | Growth Inhibition Assay | Inhibition of human KU812 cell growth in a cell viability assay, IC50 = 13.9562 μM. | SANGER | |||
| JAR | Growth Inhibition Assay | Inhibition of human JAR cell growth in a cell viability assay, IC50 = 14.113 μM. | SANGER | |||
| NCI-H2009 | Growth Inhibition Assay | Inhibition of human NCI-H2009 cell growth in a cell viability assay, IC50 = 14.287 μM. | SANGER | |||
| HuO9 | Growth Inhibition Assay | Inhibition of human HuO9 cell growth in a cell viability assay, IC50 = 14.4446 μM. | SANGER | |||
| U-118-MG | Growth Inhibition Assay | Inhibition of human U-118-MG cell growth in a cell viability assay, IC50 = 14.5013 μM. | SANGER | |||
| SH-4 | Growth Inhibition Assay | Inhibition of human SH-4 cell growth in a cell viability assay, IC50 = 14.942 μM. | SANGER | |||
| ES5 | Growth Inhibition Assay | Inhibition of human ES5 cell growth in a cell viability assay, IC50 = 15.3528 μM. | SANGER | |||
| NB6 | Growth Inhibition Assay | Inhibition of human NB6 cell growth in a cell viability assay, IC50 = 15.4452 μM. | SANGER | |||
| COLO-829 | Growth Inhibition Assay | Inhibition of human COLO-829 cell growth in a cell viability assay, IC50 = 15.6978 μM. | SANGER | |||
| NCI-H524 | Growth Inhibition Assay | Inhibition of human NCI-H524 cell growth in a cell viability assay, IC50 = 15.751 μM. | SANGER | |||
| HPAF-II | Growth Inhibition Assay | Inhibition of human HPAF-II cell growth in a cell viability assay, IC50 = 16.1017 μM. | SANGER | |||
| GB-1 | Growth Inhibition Assay | Inhibition of human GB-1 cell growth in a cell viability assay, IC50 = 16.5577 μM. | SANGER | |||
| LB771-HNC | Growth Inhibition Assay | Inhibition of human LB771-HNC cell growth in a cell viability assay, IC50 = 16.8228 μM. | SANGER | |||
| HuCCT1 | Growth Inhibition Assay | Inhibition of human HuCCT1 cell growth in a cell viability assay, IC50 = 17.176 μM. | SANGER | |||
| SW837 | Growth Inhibition Assay | Inhibition of human SW837 cell growth in a cell viability assay, IC50 = 17.3011 μM. | SANGER | |||
| NCI-N87 | Growth Inhibition Assay | Inhibition of human NCI-N87 cell growth in a cell viability assay, IC50 = 17.5302 μM. | SANGER | |||
| BEN | Growth Inhibition Assay | Inhibition of human BEN cell growth in a cell viability assay, IC50 = 17.7386 μM. | SANGER | |||
| Mewo | Growth Inhibition Assay | Inhibition of human Mewo cell growth in a cell viability assay, IC50 = 17.8382 μM. | SANGER | |||
| MPP-89 | Growth Inhibition Assay | Inhibition of human MPP-89 cell growth in a cell viability assay, IC50 = 18.2784 μM. | SANGER | |||
| NOS-1 | Growth Inhibition Assay | Inhibition of human NOS-1 cell growth in a cell viability assay, IC50 = 18.3793 μM. | SANGER | |||
| Ca-Ski | Growth Inhibition Assay | Inhibition of human Ca-Ski cell growth in a cell viability assay, IC50 = 19.7889 μM. | SANGER | |||
| SW1088 | Growth Inhibition Assay | Inhibition of human SW1088 cell growth in a cell viability assay, IC50 = 19.9447 μM. | SANGER | |||
| Capan-2 | Growth Inhibition Assay | Inhibition of human Capan-2 cell growth in a cell viability assay, IC50 = 20.3327 μM. | SANGER | |||
| A498 | Growth Inhibition Assay | Inhibition of human A498 cell growth in a cell viability assay, IC50 = 20.4092 μM. | SANGER | |||
| COLO-800 | Growth Inhibition Assay | Inhibition of human COLO-800 cell growth in a cell viability assay, IC50 = 20.9232 μM. | SANGER | |||
| OVCAR-4 | Growth Inhibition Assay | Inhibition of human OVCAR-4 cell growth in a cell viability assay, IC50 = 21.2508 μM. | SANGER | |||
| K-562 | Growth Inhibition Assay | Inhibition of human K-562 cell growth in a cell viability assay, IC50 = 21.9049 μM. | SANGER | |||
| IA-LM | Growth Inhibition Assay | Inhibition of human IA-LM cell growth in a cell viability assay, IC50 = 22.3771 μM. | SANGER | |||
| SK-LMS-1 | Growth Inhibition Assay | Inhibition of human SK-LMS-1 cell growth in a cell viability assay, IC50 = 22.4057 μM. | SANGER | |||
| CAL-51 | Growth Inhibition Assay | Inhibition of human CAL-51 cell growth in a cell viability assay, IC50 = 23.0872 μM. | SANGER | |||
| NCI-H1651 | Growth Inhibition Assay | Inhibition of human NCI-H1651 cell growth in a cell viability assay, IC50 = 24.1303 μM. | SANGER | |||
| GMS-10 | Growth Inhibition Assay | Inhibition of human GMS-10 cell growth in a cell viability assay, IC50 = 24.4376 μM. | SANGER | |||
| NCI-H2347 | Growth Inhibition Assay | Inhibition of human NCI-H2347 cell growth in a cell viability assay, IC50 = 24.6005 μM. | SANGER | |||
| MEL-JUSO | Growth Inhibition Assay | Inhibition of human MEL-JUSO cell growth in a cell viability assay, IC50 = 24.6906 μM. | SANGER | |||
| SW948 | Growth Inhibition Assay | Inhibition of human SW948 cell growth in a cell viability assay, IC50 = 24.9296 μM. | SANGER | |||
| MKN45 | Growth Inhibition Assay | Inhibition of human MKN45 cell growth in a cell viability assay, IC50 = 26.4465 μM. | SANGER | |||
| HCC1954 | Growth Inhibition Assay | Inhibition of human HCC1954 cell growth in a cell viability assay, IC50 = 26.4502 μM. | SANGER | |||
| SAS | Growth Inhibition Assay | Inhibition of human SAS cell growth in a cell viability assay, IC50 = 26.4732 μM. | SANGER | |||
| SCC-25 | Growth Inhibition Assay | Inhibition of human SCC-25 cell growth in a cell viability assay, IC50 = 26.5693 μM. | SANGER | |||
| MKN28 | Growth Inhibition Assay | Inhibition of human MKN28 cell growth in a cell viability assay, IC50 = 26.7093 μM. | SANGER | |||
| T84 | Growth Inhibition Assay | Inhibition of human T84 cell growth in a cell viability assay, IC50 = 26.7743 μM. | SANGER | |||
| HCT-15 | Growth Inhibition Assay | Inhibition of human HCT-15 cell growth in a cell viability assay, IC50 = 26.9389 μM. | SANGER | |||
| DOK | Growth Inhibition Assay | Inhibition of human DOK cell growth in a cell viability assay, IC50 = 27.0723 μM. | SANGER | |||
| SK-MEL-24 | Growth Inhibition Assay | Inhibition of human SK-MEL-24 cell growth in a cell viability assay, IC50 = 28.0766 μM. | SANGER | |||
| HCC1143 | Growth Inhibition Assay | Inhibition of human HCC1143 cell growth in a cell viability assay, IC50 = 28.2552 μM. | SANGER | |||
| JEG-3 | Growth Inhibition Assay | Inhibition of human JEG-3 cell growth in a cell viability assay, IC50 = 28.4578 μM. | SANGER | |||
| SF539 | Growth Inhibition Assay | Inhibition of human SF539 cell growth in a cell viability assay, IC50 = 28.6049 μM. | SANGER | |||
| NB12 | Growth Inhibition Assay | Inhibition of human NB12 cell growth in a cell viability assay, IC50 = 28.8033 μM. | SANGER | |||
| Hs-578-T | Growth Inhibition Assay | Inhibition of human Hs-578-T cell growth in a cell viability assay, IC50 = 29.1197 μM. | SANGER | |||
| HCT-116 | Growth Inhibition Assay | Inhibition of human HCT-116 cell growth in a cell viability assay, IC50 = 29.4423 μM. | SANGER | |||
| EW-3 | Growth Inhibition Assay | Inhibition of human EW-3 cell growth in a cell viability assay, IC50 = 29.5269 μM. | SANGER | |||
| 639-V | Growth Inhibition Assay | Inhibition of human 639-V cell growth in a cell viability assay, IC50 = 29.8546 μM. | SANGER | |||
| IGR-1 | Growth Inhibition Assay | Inhibition of human IGR-1 cell growth in a cell viability assay, IC50 = 30.0191 μM. | SANGER | |||
| LS-411N | Growth Inhibition Assay | Inhibition of human LS-411N cell growth in a cell viability assay, IC50 = 30.351 μM. | SANGER | |||
| D-502MG | Growth Inhibition Assay | Inhibition of human D-502MG cell growth in a cell viability assay, IC50 = 30.3725 μM. | SANGER | |||
| AN3-CA | Growth Inhibition Assay | Inhibition of human AN3-CA cell growth in a cell viability assay, IC50 = 31.4329 μM. | SANGER | |||
| RCC10RGB | Growth Inhibition Assay | Inhibition of human RCC10RGB cell growth in a cell viability assay, IC50 = 31.4464 μM. | SANGER | |||
| GT3TKB | Growth Inhibition Assay | Inhibition of human GT3TKB cell growth in a cell viability assay, IC50 = 31.7096 μM. | SANGER | |||
| BB30-HNC | Growth Inhibition Assay | Inhibition of human BB30-HNC cell growth in a cell viability assay, IC50 = 32.5217 μM. | SANGER | |||
| HT-144 | Growth Inhibition Assay | Inhibition of human HT-144 cell growth in a cell viability assay, IC50 = 32.7065 μM. | SANGER | |||
| NCI-H1355 | Growth Inhibition Assay | Inhibition of human NCI-H1355 cell growth in a cell viability assay, IC50 = 33.3495 μM. | SANGER | |||
| D-542MG | Growth Inhibition Assay | Inhibition of human D-542MG cell growth in a cell viability assay, IC50 = 33.3722 μM. | SANGER | |||
| NCI-H727 | Growth Inhibition Assay | Inhibition of human NCI-H727 cell growth in a cell viability assay, IC50 = 33.4114 μM. | SANGER | |||
| NCI-H1755 | Growth Inhibition Assay | Inhibition of human NCI-H1755 cell growth in a cell viability assay, IC50 = 33.5236 μM. | SANGER | |||
| KS-1 | Growth Inhibition Assay | Inhibition of human KS-1 cell growth in a cell viability assay, IC50 = 33.6298 μM. | SANGER | |||
| SW626 | Growth Inhibition Assay | Inhibition of human SW626 cell growth in a cell viability assay, IC50 = 33.7643 μM. | SANGER | |||
| MZ1-PC | Growth Inhibition Assay | Inhibition of human MZ1-PC cell growth in a cell viability assay, IC50 = 33.8103 μM. | SANGER | |||
| NCI-H1650 | Growth Inhibition Assay | Inhibition of human NCI-H1650 cell growth in a cell viability assay, IC50 = 34.326 μM. | SANGER | |||
| LCLC-97TM1 | Growth Inhibition Assay | Inhibition of human LCLC-97TM1 cell growth in a cell viability assay, IC50 = 34.8526 μM. | SANGER | |||
| HTC-C3 | Growth Inhibition Assay | Inhibition of human HTC-C3 cell growth in a cell viability assay, IC50 = 35.022 μM. | SANGER | |||
| SNU-387 | Growth Inhibition Assay | Inhibition of human SNU-387 cell growth in a cell viability assay, IC50 = 35.2684 μM. | SANGER | |||
| IM-9 | Growth Inhibition Assay | Inhibition of human IM-9 cell growth in a cell viability assay, IC50 = 35.5165 μM. | SANGER | |||
| KYSE-180 | Growth Inhibition Assay | Inhibition of human KYSE-180 cell growth in a cell viability assay, IC50 = 35.6521 μM. | SANGER | |||
| HuH-7 | Growth Inhibition Assay | Inhibition of human HuH-7 cell growth in a cell viability assay, IC50 = 35.6756 μM. | SANGER | |||
| CP66-MEL | Growth Inhibition Assay | Inhibition of human CP66-MEL cell growth in a cell viability assay, IC50 = 35.7968 μM. | SANGER | |||
| 22RV1 | Growth Inhibition Assay | Inhibition of human 22RV1 cell growth in a cell viability assay, IC50 = 35.8423 μM. | SANGER | |||
| SW48 | Growth Inhibition Assay | Inhibition of human SW48 cell growth in a cell viability assay, IC50 = 36.2464 μM. | SANGER | |||
| COLO-205 | Growth Inhibition Assay | Inhibition of human COLO-205 cell growth in a cell viability assay, IC50 = 37.2589 μM. | SANGER | |||
| MFH-ino | Growth Inhibition Assay | Inhibition of human MFH-ino cell growth in a cell viability assay, IC50 = 37.3918 μM. | SANGER | |||
| ECC12 | Growth Inhibition Assay | Inhibition of human ECC12 cell growth in a cell viability assay, IC50 = 37.7142 μM. | SANGER | |||
| CAL-72 | Growth Inhibition Assay | Inhibition of human CAL-72 cell growth in a cell viability assay, IC50 = 37.7221 μM. | SANGER | |||
| KNS-42 | Growth Inhibition Assay | Inhibition of human KNS-42 cell growth in a cell viability assay, IC50 = 37.8215 μM. | SANGER | |||
| U031 | Growth Inhibition Assay | Inhibition of human U031 cell growth in a cell viability assay, IC50 = 37.827 μM. | SANGER | |||
| EFE-184 | Growth Inhibition Assay | Inhibition of human EFE-184 cell growth in a cell viability assay, IC50 = 37.8863 μM. | SANGER | |||
| TCCSUP | Growth Inhibition Assay | Inhibition of human TCCSUP cell growth in a cell viability assay, IC50 = 38.3341 μM. | SANGER | |||
| TE-11 | Growth Inhibition Assay | Inhibition of human TE-11 cell growth in a cell viability assay, IC50 = 39.2614 μM. | SANGER | |||
| SK-MEL-3 | Growth Inhibition Assay | Inhibition of human SK-MEL-3 cell growth in a cell viability assay, IC50 = 39.5577 μM. | SANGER | |||
| NCI-H1703 | Growth Inhibition Assay | Inhibition of human NCI-H1703 cell growth in a cell viability assay, IC50 = 39.5618 μM. | SANGER | |||
| NCI-H748 | Growth Inhibition Assay | Inhibition of human NCI-H748 cell growth in a cell viability assay, IC50 = 39.6102 μM. | SANGER | |||
| HuP-T3 | Growth Inhibition Assay | Inhibition of human HuP-T3 cell growth in a cell viability assay, IC50 = 39.8492 μM. | SANGER | |||
| GCT | Growth Inhibition Assay | Inhibition of human GCT cell growth in a cell viability assay, IC50 = 40.2935 μM. | SANGER | |||
| LU-99A | Growth Inhibition Assay | Inhibition of human LU-99A cell growth in a cell viability assay, IC50 = 40.6473 μM. | SANGER | |||
| TGBC24TKB | Growth Inhibition Assay | Inhibition of human TGBC24TKB cell growth in a cell viability assay, IC50 = 40.7998 μM. | SANGER | |||
| NCI-H1993 | Growth Inhibition Assay | Inhibition of human NCI-H1993 cell growth in a cell viability assay, IC50 = 41.1086 μM. | SANGER | |||
| 769-P | Growth Inhibition Assay | Inhibition of human 769-P cell growth in a cell viability assay, IC50 = 41.226 μM. | SANGER | |||
| NCI-H2126 | Growth Inhibition Assay | Inhibition of human NCI-H2126 cell growth in a cell viability assay, IC50 = 41.3099 μM. | SANGER | |||
| NCI-H1563 | Growth Inhibition Assay | Inhibition of human NCI-H1563 cell growth in a cell viability assay, IC50 = 41.353 μM. | SANGER | |||
| NCI-H82 | Growth Inhibition Assay | Inhibition of human NCI-H82 cell growth in a cell viability assay, IC50 = 41.4039 μM. | SANGER | |||
| SW1783 | Growth Inhibition Assay | Inhibition of human SW1783 cell growth in a cell viability assay, IC50 = 41.6769 μM. | SANGER | |||
| NCI-H1648 | Growth Inhibition Assay | Inhibition of human NCI-H1648 cell growth in a cell viability assay, IC50 = 41.9392 μM. | SANGER | |||
| A388 | Growth Inhibition Assay | Inhibition of human A388 cell growth in a cell viability assay, IC50 = 42.1236 μM. | SANGER | |||
| SK-MEL-30 | Growth Inhibition Assay | Inhibition of human SK-MEL-30 cell growth in a cell viability assay, IC50 = 42.3151 μM. | SANGER | |||
| EKVX | Growth Inhibition Assay | Inhibition of human EKVX cell growth in a cell viability assay, IC50 = 42.3726 μM. | SANGER | |||
| A172 | Growth Inhibition Assay | Inhibition of human A172 cell growth in a cell viability assay, IC50 = 42.8624 μM. | SANGER | |||
| OMC-1 | Growth Inhibition Assay | Inhibition of human OMC-1 cell growth in a cell viability assay, IC50 = 42.9399 μM. | SANGER | |||
| PANC-03-27 | Growth Inhibition Assay | Inhibition of human PANC-03-27 cell growth in a cell viability assay, IC50 = 43.157 μM. | SANGER | |||
| NCI-H747 | Growth Inhibition Assay | Inhibition of human NCI-H747 cell growth in a cell viability assay, IC50 = 43.3223 μM. | SANGER | |||
| HT55 | Growth Inhibition Assay | Inhibition of human HT55 cell growth in a cell viability assay, IC50 = 43.7863 μM. | SANGER | |||
| BV-173 | Growth Inhibition Assay | Inhibition of human BV-173 cell growth in a cell viability assay, IC50 = 43.7946 μM. | SANGER | |||
| LS-1034 | Growth Inhibition Assay | Inhibition of human LS-1034 cell growth in a cell viability assay, IC50 = 43.9899 μM. | SANGER | |||
| NUGC-3 | Growth Inhibition Assay | Inhibition of human NUGC-3 cell growth in a cell viability assay, IC50 = 44.0773 μM. | SANGER | |||
| IST-MEL1 | Growth Inhibition Assay | Inhibition of human IST-MEL1 cell growth in a cell viability assay, IC50 = 44.2633 μM. | SANGER | |||
| 8305C | Growth Inhibition Assay | Inhibition of human 8305C cell growth in a cell viability assay, IC50 = 44.31 μM. | SANGER | |||
| IMR-5 | Growth Inhibition Assay | Inhibition of human IMR-5 cell growth in a cell viability assay, IC50 = 44.5743 μM. | SANGER | |||
| TE-6 | Growth Inhibition Assay | Inhibition of human TE-6 cell growth in a cell viability assay, IC50 = 44.8539 μM. | SANGER | |||
| MZ2-MEL | Growth Inhibition Assay | Inhibition of human MZ2-MEL cell growth in a cell viability assay, IC50 = 45.0112 μM. | SANGER | |||
| RT-112 | Growth Inhibition Assay | Inhibition of human RT-112 cell growth in a cell viability assay, IC50 = 45.4472 μM. | SANGER | |||
| SCC-9 | Growth Inhibition Assay | Inhibition of human SCC-9 cell growth in a cell viability assay, IC50 = 45.5616 μM. | SANGER | |||
| SCC-4 | Growth Inhibition Assay | Inhibition of human SCC-4 cell growth in a cell viability assay, IC50 = 45.5626 μM. | SANGER | |||
| CAL-54 | Growth Inhibition Assay | Inhibition of human CAL-54 cell growth in a cell viability assay, IC50 = 45.6635 μM. | SANGER | |||
| LoVo | Growth Inhibition Assay | Inhibition of human LoVo cell growth in a cell viability assay, IC50 = 45.6839 μM. | SANGER | |||
| NCI-H358 | Growth Inhibition Assay | Inhibition of human NCI-H358 cell growth in a cell viability assay, IC50 = 45.7286 μM. | SANGER | |||
| K5 | Growth Inhibition Assay | Inhibition of human K5 cell growth in a cell viability assay, IC50 = 46.029 μM. | SANGER | |||
| LB1047-RCC | Growth Inhibition Assay | Inhibition of human LB1047-RCC cell growth in a cell viability assay, IC50 = 46.4256 μM. | SANGER | |||
| MES-SA | Growth Inhibition Assay | Inhibition of human MES-SA cell growth in a cell viability assay, IC50 = 46.5121 μM. | SANGER | |||
| UACC-257 | Growth Inhibition Assay | Inhibition of human UACC-257 cell growth in a cell viability assay, IC50 = 46.5175 μM. | SANGER | |||
| NCI-H2342 | Growth Inhibition Assay | Inhibition of human NCI-H2342 cell growth in a cell viability assay, IC50 = 46.8809 μM. | SANGER | |||
| TE-15 | Growth Inhibition Assay | Inhibition of human TE-15 cell growth in a cell viability assay, IC50 = 46.8909 μM. | SANGER | |||
| SK-MES-1 | Growth Inhibition Assay | Inhibition of human SK-MES-1 cell growth in a cell viability assay, IC50 = 47.3821 μM. | SANGER | |||
| NCI-H322M | Growth Inhibition Assay | Inhibition of human NCI-H322M cell growth in a cell viability assay, IC50 = 47.6561 μM. | SANGER | |||
| SK-OV-3 | Growth Inhibition Assay | Inhibition of human SK-OV-3 cell growth in a cell viability assay, IC50 = 47.7452 μM. | SANGER | |||
| PANC-08-13 | Growth Inhibition Assay | Inhibition of human PANC-08-13 cell growth in a cell viability assay, IC50 = 47.9641 μM. | SANGER | |||
| 786-0 | Growth Inhibition Assay | Inhibition of human 786-0 cell growth in a cell viability assay, IC50 = 48.073 μM. | SANGER | |||
| NCI-H460 | Growth Inhibition Assay | Inhibition of human NCI-H460 cell growth in a cell viability assay, IC50 = 48.1255 μM. | SANGER | |||
| D-336MG | Growth Inhibition Assay | Inhibition of human D-336MG cell growth in a cell viability assay, IC50 = 48.4845 μM. | SANGER | |||
| SNG-M | Growth Inhibition Assay | Inhibition of human SNG-M cell growth in a cell viability assay, IC50 = 48.6701 μM. | SANGER | |||
| SK-CO-1 | Growth Inhibition Assay | Inhibition of human SK-CO-1 cell growth in a cell viability assay, IC50 = 49.0025 μM. | SANGER | |||
| CAL-27 | Growth Inhibition Assay | Inhibition of human CAL-27 cell growth in a cell viability assay, IC50 = 49.5334 μM. | SANGER | |||
| 8505C | Growth Inhibition Assay | Inhibition of human 8505C cell growth in a cell viability assay, IC50 = 49.5364 μM. | SANGER | |||
| MCF7 | Growth Inhibition Assay | Inhibition of human MCF7 cell growth in a cell viability assay, IC50 = 49.5865 μM. | SANGER | |||
| T47D | Growth Inhibition Assay | Inhibition of human T47D cell growth in a cell viability assay, IC50 = 49.7007 μM. | SANGER | |||
| YKG-1 | Growth Inhibition Assay | Inhibition of human YKG-1 cell growth in a cell viability assay, IC50 = 49.9412 μM. | SANGER | |||
| 클릭하여 더 많은 세포주 실험 데이터 보기 | ||||||
화학 정보, 보관 및 안정성 (Chemical Information, Storage & Stability)
| 분자량 | 360.39 | 화학식 | C20H12N2O3S |
보관 (수령일로부터) | |
|---|---|---|---|---|---|
| CAS 번호 | 844499-71-4 | SDF 다운로드 | 원액 보관 |
|
|
| 동의어 | N/A | Smiles | C1=CC=C(C(=C1)C2=CC=C(C=C2)C3=CSC4=C3C(=C(C(=O)N4)C#N)O)O | ||
용해도 (Solubility)
|
In vitro |
DMSO
: 100 mg/mL
(277.47 mM)
60°C 수조에서 가온;
초음파 처리;
Water : Insoluble Ethanol : Insoluble |
몰농도 계산기
희석 계산기
분자량 계산기
|
In vivo |
|||||
생체 내 제형 계산기 (투명한 용액)
1단계: 아래 정보 입력 (권장: 실험 중 손실을 고려하여 추가 동물 포함)
mg/kg
g
μL
2단계: 생체 내 제형 입력 (이것은 계산기일 뿐 제형이 아닙니다. 용해도 섹션에 생체 내 제형이 없는 경우 먼저 당사에 문의하십시오.)
% DMSO
%
% Tween 80
% ddH2O
%DMSO
%
계산 결과:
작업 농도: mg/ml;
DMSO 원액 준비 방법: mg 약물 사전 용해 μL DMSO ( 원액 농도 mg/mL, 농도가 해당 약물 배치의 DMSO 용해도를 초과하는 경우 먼저 당사에 문의하십시오. )
생체 내 제형 준비 방법: 취하다 μL DMSO 원액, 다음 추가μL PEG300, 혼합하고 투명하게 한 다음 추가μL Tween 80, 혼합하고 투명하게 한 다음 추가 μL ddH2O, 혼합하고 투명하게 합니다.
생체 내 제형 준비 방법: 취하다 μL DMSO 원액, 다음 추가 μL 옥수수 기름, 혼합하고 투명하게 합니다.
참고: 1. 다음 용매를 추가하기 전에 액체가 투명한지 확인하십시오.
2. 용매를 순서대로 추가해야 합니다. 다음 용매를 추가하기 전에 이전 추가에서 얻은 용액이 투명한 용액인지 확인해야 합니다. 와동, 초음파 또는 뜨거운 물 중탕과 같은 물리적 방법을 사용하여 용해를 도울 수 있습니다.
작용 메커니즘 (Mechanism of Action)
| Targets/IC50/Ki |
AMPK
(Cell-free assay) 0.8 μM(EC50)
Fatty acid synthesis
(in primary rat hepatocytes) 3.2 μM
|
|---|---|
| 시험관 내(In vitro) |
A-769662는 0.8 μM의 EC50으로 부분 정제된 쥐 간 AMPK를 자극합니다. 이 화합물은 여러 조직 및 종에서 정제된 AMPK를 용량 반응 방식으로 활성화하며 관찰된 EC50 값에서 약간의 차이를 보입니다. 쥐 심장, 쥐 근육 또는 인간 배아 신장 세포(HEKs)에서 부분 정제된 AMPK 추출물을 사용하여 이 화학 물질에 대해 결정된 EC50 값은 각각 2.2 mM, 1.9 mM 및 1.1 mM입니다. 일차 쥐 간세포를 이 화합물로 4시간 동안 처리하면 용량 의존적으로 ACC 인산화가 증가하며, 이는 3.2 μM의 IC50으로 Fatty Acid Synthase 억제와 상관관계가 있습니다. 또한 3.6 μM의 IC50으로 마우스 간세포에서 Fatty Acid Synthase를 억제합니다 이 화합물은 AMP의 효과와 유사하게 알로스테릭하게 그리고 Thr-172에서 AMPK의 탈인산화를 억제함으로써 AMPK를 활성화합니다. 이것은 AMPK 비의존적 메커니즘을 통해 프로테아좀 기능을 억제합니다. 이 화학 물질은 정제된 26S 프로테아좀의 체외 활성에는 영향을 미치지만 정제된 20S 프로테아좀의 체외 활성에는 영향을 미치지 않습니다. 이는 MEF 세포에 독성 효과를 나타냅니다. 최근 연구에 따르면 이 화합물은 세포 증식과 DNA 합성을 억제하는 것으로 나타났습니다. |
| 키나아제 분석 |
96-well AMPK 분석
|
|
AMPK 활성은 이전에 설명된 프로토콜(Anderson et al., 2004)에 따라 SAMS 펩타이드 기질(표준 분석에서는 20 μM, 가산성 분석에서는 100 μM)의 인산화를 모니터링하여 측정합니다. A-769662에 의해 유도된 AMPK 활성화가 가역적인 방식으로 발생하는지 확인하기 위해, AMPK 활성을 희석하고 측정하기 전에 AMP 또는 이 화합물을 표준 분석 농도의 20배로 랫트 간 AMPK와 함께 10분 동안 전배양합니다.
|
|
| 생체 내(In vivo) |
정상 Sprague Dawley 쥐에게 A-769662를 단기 투여하면 간의 Malonyl CoA 수치와 호흡 교환율인 VCO2/VO2가 감소하며, 이는 전신 지방산 산화율이 증가했음을 나타냅니다. ob/ob 마우스에 이 화합물을 30 mg/kg b.i.d.로 처리하면 PEPCK, G6Pase 및 FAS의 간 발현이 감소하고, 혈장 포도당 수치가 40% 낮아지며, 체중 증가가 억제되고, 혈장 및 간의 트리글리세리드 수치가 유의하게 감소합니다. |
참조 |
|
적용 분야 (Applications)
| 방법 | 바이오마커 | 이미지 | PMID |
|---|---|---|---|
| Western blot | pCofilin / Cofilin / detyrosinated alpha tubulin / acetylated alpha tubulin p-AMPK / AMPK / p-S6K / S6K / p-ACC |
|
26431377 |
제품은 연구용으로만 사용됩니다. 인체에는 사용하지 마십시오. 환자에게 판매하지 않습니다.
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