Home Neuronal Signaling -GPCR & G Protein 5-HT Receptor 5-HT3-선택적 Agonists | Antagonists

5-HT3-선택적 Agonists | Antagonists

  • 5-HT1
  • 5-HT2
  • 5-HT3
  • 5-HT4
  • 5-HT6
  • 5-HT7
  • 5-HT5
Cat.No. 제품명 정보 선택적 / 팬 IC50 / Ki
S2865 VUF 10166 VUF10166 is a novel, potent and competitive antagonist for 5-HT3A receptor with Ki of 0.04 nM, its affinity at 5-HT3AB receptor is significantly lower. Selective 5-HT3A, Ki: 0.04 nM; 5-HT3AB, Ki: 22 nM
S2106 Azasetron HCl Azasetron HCl is a selective 5-HT3 receptor antagonist with IC50 of 0.33 nM used in the management of nausea and vomiting induced by cancer chemotherapy. Selective 5-HT3, IC50: 0.33 nM
S1345 Granisetron HCl Granisetron HCl is a serotonin 5-HT3 receptor antagonist. Selective
S1898 Tropisetron HCl Tropisetron HCl is a selective 5-HT3 receptor antagonist and α7-nicotinic receptor agonist with an IC50 of 70.1 ± 0.9 nM for 5-HT3 receptor. Selective
S3050 Palonosetron HCl Palonosetron HCl is a 5-HT3 antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting. Selective
S1390 Ondansetron HCl Ondansetron HCl is a serotonin 5-HT3 receptor antagonist. Selective
S1996 Ondansetron Ondansetron is a serotonin 5-HT3 receptor antagonist used mainly as an antiemetic. Selective
S2875 Prucalopride Prucalopride is a selective, high affinity 5-HT receptor agonist for 5-HT4A and 5-HT4B receptor with Ki of 2.5 nM and 8 nM, respectively, exhibits >290-fold selectivity against other 5-HT receptor subtypes. Pan 5-HT3, Ki: 3.822 μM
S2691 BMY 7378 BMY 7378 is a multi-targeted inhibitor of α2C-adrenoceptor and α1D-adrenoceptor with pKi of 6.54 and 8.2, respectively, and acts as a mixed agonist and antagonist for 5-HT1A receptor with pKi of 8.3. Pan 5-HT3, pIC50: <5.0