Home Metabolism P450 (e.g. CYP17) P450-선택적 Inhibitors | Chemicals

P450-선택적 Inhibitors | Chemicals

  • P450
  • CYP2
  • CYP3
  • CYP1
  • CYP17
Cat.No. 제품명 정보 선택적 / 팬 IC50 / Ki
S2067 Ozagrel HCl Ozagrel HCl is a selective thromboxane A(2) (TXA(2)) synthetase inhibitor with IC50 of 11 nM for rabbit platelet, used for the improvement of postoperative cerebrovascular contraction and accompanying cerebral ischaemia. Selective thromboxane A2 synthetase, IC50: 11 nM
S2496 Ozagrel Ozagrel is a potent and selective thromboxane A2 synthetase inhibitor with an IC50 of 4 nM. Selective Thromboxane A2 synthetase , IC50: 11 nM
S1195 TAK-700 (Orteronel) TAK-700 (Orteronel) is a potent and highly selective human 17,20-lyase inhibitor with IC50 of 38 nM, exhibits >1000-fold selectivity over other CYPs (e.g. 11-hydroxylase and CYP3A4). Phase 3. Selective 17,20-lyase (Human), IC50: 38 nM; 17,20-lyase (Rat), IC50: 54 nM
S1353 Ketoconazole Ketoconazole inhibits cyclosporine oxidase and testosterone 6 beta-hydroxylase with IC50 of 0.19 mM and 0.22 mM, respectively. Selective Cyclosporine oxidase, IC50: 0.19 mM
S1442 Voriconazole Voriconazole is a new triazole derivative similar to fluconazole and itraconazole that acts by inhibiting fungal cytochrome P-450-dependent, 14-alpha-sterol demethylase-mediated synthesis of ergosterol. Selective
S2401 Sodium Danshensu Sodium Danshensu is a mono sodium of danshensu, which is a natural phenolic acid of caffeic acid derivatives isolated from Salvia miltiorrhiza. Selective
S2329 Naringin Naringin is a flavanone glycoside, which exerts a variety of pharmacological effects such as antioxidant activity, blood lipid lowering, anticancer activity, and inhibition of cytochrome P450 enzymes. Selective
S1331 Fluconazole Fluconazole is a fungal lanosterol 14 alpha-demethylase inhibitor, which thereby prevents the formation of ergosterol,used in the treatment and prevention of superficial and systemic fungal infections. Selective