Home DNA Damage/DNA Repair Topoisomerase Topo I-선택적 Inhibitors

Topo I-선택적 Inhibitors

  • Topo I
  • Topo II
  • Topo IV
Cat.No. 제품명 정보 선택적 / 팬 IC50 / Ki
S1231 Topotecan HCl Topotecan (NSC 609699) is a topoisomerase I inhibitor for MCF-7 Luc cells and DU-145 Luc cells with IC50 of 13 nM and 2 nM, respectively. Selective Topo I (DU-145 Luc cells), IC50: 2 nM; Topo I (MCF-7 Luc cells), IC50: 13 nM
S1288 Camptothecin Camptothecin is a specific inhibitor of DNA topoisomerase I (Topo I) with IC50 of 0.68 μM. Phase 2. Selective Topo I, IC50: 0.68 μM
S3603 Betulinic acid Betulinic acid, a pentacyclic triterpenoid from Syzigium claviflorum, is a inhibitor of HIV-1 with EC50 of 1.4 μ M. Phase 1/2. Selective Eukaryotic topoisomerase I, IC50: 5 μM
S2423 (S)-10-Hydroxycamptothecin 10-Hydroxycamptothecin is a DNA topoisomerase I inhibitor with potent anti-tumor activity. Selective
S2217 Irinotecan HCl Trihydrate Irinotecan prevents DNA from unwinding by inhibition of topoisomerase 1. Selective
S4908 SN-38 SN-38 is an active metabolite of CPT-11, inhibits DNA topoisomerase I, DNA synthesis and causes frequent DNA single-strand breaks. Selective
S7261 Beta-Lapachone Beta-Lapachone is a selective DNA topoisomerase I inhibitor, exhibiting no inhibitory activities against DNA topoisomerase II or ligase. Phase 2. Selective
S1198 Irinotecan Irinotecan is a topoisomerase I inhibitor for LoVo cells and HT-29 cells with IC50 of 15.8 μM and 5.17 μM, respectively. Selective
S1327 Ellagic acid Ellagic acid has antiproliferative and antioxidant property. Pan