Home NF-κB IκB/IKK IKK-선택적 Inhibitors | Modulators

IKK-선택적 Inhibitors | Modulators

  • IκB
  • IKK
Cat.No. 제품명 정보 선택적 / 팬 IC50 / Ki
S2824 TPCA-1 TPCA-1 is an inhibitor of IKK-2 with IC50 of 17.9 nM, inhibits NF-κB pathway, exhibits 22-fold selectivity over IKK-1. Selective IKK2, IC50: 17.9 nM
S2882 IKK-16 (IKK Inhibitor VII) IKK-16 (IKK Inhibitor VII) is a selective IκB kinase (IKK) inhibitor for IKK-2, IKK complex and IKK-1 with IC50 of 40 nM, 70 nM and 200 nM, respectively. Selective IKK complex, IC50: 70 nM; IKK2, IC50: 40 nM; IKK1, IC50: 200 nM
S8044 BMS-345541 BMS-345541 is a highly selective inhibitor of the catalytic subunits of IKK-2 and IKK-1 with IC50 of 0.3 μM and 4 μM, respectively. Selective IKK1, IC50: 4 μM; IKK2, IC50: 0.3 μM; IKK1, IC50: 4 μM; IKK2, IC50: 0.3 μM; IKK1, IC50: 4 μM; IKK2, IC50: 0.3 μM
S4907 SC-514 SC-514 is an orally active, ATP-competitive IKK-2 inhibitor with IC50 of 3-12 μM, blocks NF-κB-dependent gene expression, does not inhibit other IKK isoforms or other serine-threonine and tyrosine kinases. Selective IKK2, IC50: 3 μM-12 μM
S7441 WS3 WS3 is a β cell proliferation inducer via modulation of Erb3 binding protein-1 (EBP1) and the IκB kinase pathway. Selective
S7442 WS6 WS6 is a β cell proliferation inducer via modulation of Erb3 binding protein-1 (EBP1) and the IκB kinase pathway. Selective
S2864 IMD 0354 IMD-0354 is an IKKβ inhibitor and blocks IκBα phosphorylation in NF-κB pathway. Selective
S8078 Bardoxolone Methyl Bardoxolone Methyl is an IKK inhibitor, showing potent proapoptotic and anti-inflammatory activities. Phase 3. Selective
S1274 BX-795 BX795 is a potent and specific PDK1 inhibitor with IC50 of 6 nM, 140- and 1600-fold more selective for PDK1 than PKA and PKC, respectively. Meanwhile, in comparison to GSK3β more than 100-fold selectivity observed for PDK1. Selective