Home NF-κB NF-κB 억제제 BAY 11-7082 (BAY 11-7821)

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BAY 11-7082 (BAY 11-7821) NF-κB 억제제

제품 번호S2913

BAY 11-7082 (BAY 11-7821)는 NF-κB 억제제로, 종양 세포에서 TNFα 유도 IκBα 인산화를 IC50 10 μM로 억제합니다. BAY 11-7082는 유비퀴틴 특이적 프로테아제 USP7 및 USP21을 각각 IC50 0.19 μM 및 0.96 μM로 억제합니다. BAY 11-7082는 위암 세포에서 아폽토시스 및 S기 정지를 유도합니다.
BAY 11-7082 (BAY 11-7821) NF-κB 억제제 Chemical Structure

화학 구조

분자량: 207.25

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품질 관리

배치: 순도: 99.98%
99.98

세포 배양, 처리 및 작업 농도

세포주 분석 유형 농도 배양 시간 제형 활성 설명 PMID
HeLa Function Assay 10 μM 1.5 h abolishes BPA induced up regulation of FN and MMP-9  25797437
SiHa  Function Assay 10 μM 1.5 h abolishes BPA induced up regulation of FN and MMP-9  25797437
ARPE-19 Function Assay 1 μM 0.5 h suppresses TG-induced IL-8 promoter activation 25593029
HCT116 Function Assay 5 μM 2 h DMSO attenuates silymarin-induced downregulation of cyclin D1 25479723
HMECs Function Assay 5 μM 2 h abolishes TNF-α-induced VCAM-1 expression  25193116
A549  Function Assay 10 µM 12 h suppresses Dvl-3 induced activation of p65 25156800
RAW 264.7 Function Assay 5 μM 1 h inhibits TNF-α and IL-12 p40 production 25019567
macrophages Function Assay 5 µM 3 h partially blocks YPFS-induced expression of iNOS and COX-2  24967898
HUVECs Function Assay 3-30 μM 1 h reduces the expression of miR-146a in a dose-dependent manner 24863965
HeLa  Function Assay 5 μM 24 h DMSO reduces the activity of TNF-α promoter  24657783
A549 Function Assay 10 μM 1 h inhibits the increase of phospho-IκBα in PA103-infected cultures  24612488
HUVEC Function Assay 20 µM 0.5 h DMSO prevents the induction of EAM expression 24551209
A549RT-eto Apoptosis Assay 10 μM 24 h DMSO accelerates FERO-mediated apoptosis 24535083
THP-1  Function Assay 0.1/1 μM 0.5 h abrogates TNF-α secretion as well as the increased secretion of IL-6 and IL-1β 24378536
SKCXCR2  Growth Inhibition Assay 2 µM 48 h decreases cell proliferation significantly 24376747
SKCXCR2  Function Assay 2 µM 48 h blocks the CXCL1-induced cell invasion 24376747
OVCXCR2 Function Assay 2 µM 48 h blocks the CXCL1-induced cell invasion 24376747
DSCs  Function Assay 2.5 μM 0.5 h reverses the enhancement of CCL2/CCR2 expression of DSCs induced by IL-33 24344240
WPs Function Assay 25 μM 5 min suppresses ATP and vWF secretion 24331207
A549RT-eto Apoptosis Assay 10 μM 24 h accelerates F14 extract-mediated apoptosis combined treatment with F14 24220725
A549RT-eto Function Assay 10 μM 24 h decreases the expression levels of NF-κB and P-gp  24220725
FaDu Function Assay 2 h inhibits p65 expression and blocks TNFα-induced TWIST expression 24220622
IVD  Function Assay 10 μM 3 d reverses TNF-α–mediated suppression of the disc matrix macromolecules aggrecan and collagen II 24176808
IVD  Function Assay 10 μM 3 d abrogates TNF-α–induced up-regulation of ADAMTS-4 and ADAMTS-5  24176808
iNKT Function Assay 10/100 μM 0.5 h inhibits the induction of A2AR mRNA and other factor 24124453
PC-3 Function Assay 2.5/5/10 μM 0.5 h blocks IGF-II-induced STS mRNA expression  24055520
THP-1  Function Assay 10 μM 1 h abolishes the effect of rHSP27 on SR-A mRNA 23939398
A549 Function Assay 1 μM 48 h enhances the up-regulation of IκB and subsequent decrease in Bax expression induced by combined stimulation 23900080
A549 Apoptosis Assay 1 μM 48 h reduces the cell death induced by combined stimulation 23900080
NCI-N87 Growth Inhibition Assay 10/20/30 μM 6/24 h suppresses cell viability significantly 23846545
AGS Growth Inhibition Assay 10/20/30 μM 6/24 h suppresses cell viability significantly 23846545
MGC80-3 Growth Inhibition Assay 10/20/30 μM 6/24 h suppresses cell viability significantly 23846545
HGC-27  Function Assay 7.5/15/30 μM 6 h induces the dephosphorylation and up-regulation of IκBα 23846545
MGC80-3 Function Assay 7.5/15/30 μM 6 h induces the dephosphorylation and up-regulation of IκBα 23846545
HGC-27  Apoptosis Assay 7.5/15/30 μM 6 h induces apoptosis in a time- and dose-dependent manner 23846545
HBE  Function Assay 10μM 3h abolishes the increases of IL-6 expression induced by CSE 23824089
HepG2 Function Assay 0.3/1/3 μM 48 h reduces IL6-induced PON1 expression 23791833
THP-1 Function Assay 5 µM 1 h DMSO inhibits MTB-induced NFκB activation 23634218
THP-1  Growth Inhibition Assay 5 µM 4/8 d DMSO reduces the viability of intracellular MTB 23634218
MDM Growth Inhibition Assay 5 µM 4/8 d DMSO reduces the viability of intracellular MTB 23634218
AM Growth Inhibition Assay 5 µM 4/8 d DMSO reduces the viability of intracellular MTB 23634218
RAW 264  Function Assay 0.2-5 µM 30/60/90 min inhibits the phosphatase activity of PTP1B  23578302
HUVEC Function Assay 10 μM 0.5 h DMSO counteractes the loss of Tie2 mRNA 23563632
HT29 Function Assay 10/30/100 μM 1 h inhibites both TWEAK-induced p100 processing 23527154
HT29 Function Assay 10/30/100 μM 1 h inhibits TNF-induced phosphorylation and degradation of IκBα 23527154
MM.1S Apoptosis Assay 30 µM 3 h induces MM cell death involves necrosis 23527154
KMS-12-BM Apoptosis Assay 30 µM 3 h induces MM cell death involves necrosis 23527154
BAFs Function Assay 0.5/1 μM 24 h inhibits TNFα/DEX induced CYP19A1 transcripts 23485457
SP6.5 Function Assay 5 μM 2 h decreases translocation of p65 in the nucleus  23443086
VUP Function Assay 5 μM 2 h decreases translocation of p65 in the nucleus  23443086
OCM1 Function Assay 5 μM 2 h decreases translocation of p65 in the nucleus  23443086
OM431 Function Assay 5 μM 2 h decreases translocation of p65 in the nucleus  23443086
SP6.5 Growth Inhibition Assay 2.5-20 μM 24 h  IC50=5 μM, exhibits strong anti-proliferative effects in a dose-dependent manner 23443086
VUP Growth Inhibition Assay 2.5-20 μM 24 h  IC50=5 μM, exhibits strong anti-proliferative effects in a dose-dependent manner 23443086
OCM1 Growth Inhibition Assay 2.5-20 μM 24 h  IC50=5 μM, exhibits strong anti-proliferative effects in a dose-dependent manner 23443086
OM431 Growth Inhibition Assay 2.5-20 μM 24 h  IC50=5 μM, exhibits strong anti-proliferative effects in a dose-dependent manner 23443086
SP6.5 Apoptosis Assay 5 μM 24 h  induces apoptosis  23443086
VUP Apoptosis Assay 5 μM 24 h  induces apoptosis  23443086
OCM1 Apoptosis Assay 5 μM 24 h  induces apoptosis  23443086
OM431 Apoptosis Assay 5 μM 24 h  induces apoptosis  23443086
SP6.5 Function Assay 5 μM 12 h reduces the migration  23443086
VUP Function Assay 5 μM 12 h reduces the migration  23443086
OCM1 Function Assay 5 μM 12 h reduces the migration  23443086
OM431 Function Assay 5 μM 12 h reduces the migration  23443086
HBL-1  Growth Inhibition Assay 3 μM 24/48/72 h DMSO slows cell growth modestly 23441730
RAW 264.7 Function Assay 2-15 μM 1 h DMSO suppresses the activation of IKK family members 23441730
IL-1R  Function Assay 2-15 μM 1 h DMSO suppresses the activation of IKK family members 23441730
RAW 264.7 Function Assay 15 μM 1 h DMSO suppresses the activation of and JNK 23441730
IL-1R  Function Assay 15 μM 1 h DMSO suppresses the activation of and JNK 23441730
U2OS Function Assay 15 μM 1 h DMSO prevents the LPS- or IL-1-stimulated formation of K63-pUb chains  23441730
MT‐1  Function Assay 8 µm 3 h decreases the levels of p‐STAT3 and p‐4EBP1 23278479
MT‐2  Function Assay 8 µm 3 h decreases the levels of p‐STAT3 and p‐4EBP1 23278479
MT‐1  Function Assay 8 µm 3 h decreases the levels of the p65 subunit of NF‐κB  23278479
MT‐2  Function Assay 8 µm 3 h decreases the levels of the p65 subunit of NF‐κB  23278479
MCF-7  Function Assay 2.5-15 μM 0.5 h DMSO causes the gradual loss of cell adhesion 23093227
HaCaT  Function Assay 5.0 μM 1 h  attenuates the TCOH-induced production of IL-6  23041168
A549  Function Assay 1 h inhibits LTA-induced SP-A mRNA production significantly 23031213
OA chondrocytes  Function Assay 10 μM 1 h blocks the AGE-BSA-induced gene/protein expression of GRP78 or COX-2 (p<0.05) 22982228
RAW264.7 Function Assay 15 μM 15-120 min blocks the production of NO, PGE2, and TNF-α 22745523
RAW264.7 Growth Inhibition Assay 5-30 μM 24 h inhibits cell growth in a dose-dependent manner 22745523
HBL6 Apoptosis Assay 0.5/5/25 μM 6/24 h decreases cell viability and leeads to apoptosis in a dose-dependent manner  22074820
HT29  Function Assay 1-10 μM 10 h increases HO-1 mRNA and protein expression 21620964
Ca9–22 Apoptosis Assay 10 μM  1 h completely inhibits ALA-PDT-induced apoptosis 21138480
Ca9–22 Function Assay 10 μM  1 h completely abrogates the ALA-PDT-induced JNK activation 21138480
A-549 Growth Inhibition Assay 10 μM  24/48 h inhibits cell growth in a time-dependent manner 20866043
AP Function Assay 5/10 μM 48 h downregulates the BAD protein level a dose-dependent manner 20596645
AQ1 Function Assay 5/10 μM 48 h downregulates the BAD protein level a dose-dependent manner 20596645
AP Function Assay 20 μM 4/8 h downregulates the BAD protein level a time-dependent manner 20596645
AQ1 Function Assay 20 μM 4/8 h downregulates the BAD protein level a time-dependent manner 20596645
THP-1 Function Assay 5 μM  0.5 h attenuates the LPS-induced p-IκBα protein by 72% 20309718
K562 Growth Inhibition Assay 2-30 μM 24 h IC50=8 μM,inhibits cell growth in a dose-dependent manner 19646807
Jurket Growth Inhibition Assay 2-30 μM 24 h IC50=7.1 μM, inhibits cell growth in a dose-dependent manner 19646807
U937 Growth Inhibition Assay 2-30 μM 24 h IC50=10.5 μM, inhibits cell growth in a dose-dependent manner 19646807
PBMC Growth Inhibition Assay 2-30 μM 24 h IC50=40.2 μM, inhibits cell growth in a dose-dependent manner 19646807
K562 Apoptosis Assay 2-20 μM  24 h induces a dose-dependent apoptosis 19646807
THP1 Cytotoxicity assay 72 hrs Cytotoxicity against human THP1 cells assessed as reduction in cell viability after 72 hrs by MTT assay, TC50 = 1.5 μM. 28410442
RAW264.7 Function assay 6 hrs Inhibition of LPS-induced NF-kappaB activation in mouse RAW264.7 cells treated 30 mins before LPS challenge measured after 6 hrs by luciferase reporter gene assay, IC50 = 1.72 μM. 24315191
HEK293 Function assay 6 hrs Inhibition of TNF-alpha-induced NF-kappaB activity in HEK293 cells after 6 hrs by luciferase reporter gene assay, IC50 = 2 μM. 24533857
HEK293 Function assay 6 hrs Inhibition of TNF-alpha-induced NF-kappaB activity in HEK293 cells after 6 hrs by luciferase reporter gene assay, IC50 = 2 μM. 24992702
HEK293 Function assay 6 hrs Inhibition of TNFalpha-induced NF-kappaB activity (unknown origin) transfected in HEK293 cells after 6 hrs by luciferase reporter gene assay, IC50 = 2 μM. 26343828
HEK293 Function assay 6 hrs Inhibition of TNFalpha-induced NF-kappaB activity expressed in human HEK 293 cells after 6 hrs by luciferase reporter gene assay, IC50 = 2 μM. 22850207
HEK293 Function assay 6 hrs Inhibition of TNFalpha-induced human NFkappaB activity in HEK293 cells incubated for 6 hrs followed by compound wash out measured after 5 mins by by luciferase assay, IC50 = 2.01 μM. 22712432
HEK293 Cytotoxicity assay Cytotoxicity against HEK293 cells, IC50 = 3.8 μM. 24533857
HEK293 Function assay 6 hrs Inhibition of TNFalpha-induced NFkappaB (unknown origin) activation expressed in HEK293 cells after 6 hrs by luciferase reporter gene assay, IC50 = 5 μM. 23316950
HEK293 Function assay Effect on Cdc2 expressed in HEK293 cells assessed as effect on Cdc2:Cdc25C interaction complexes in presence of camptothecin by EYFP and/or YFP Venus fragment based reporter gene assay 16680159
HEK293 Function assay 20 uM 24 hrs Inhibition of TNF-alpha stimulated NFkappaB transactivation in HEK293 cells at 20 uM measured after 24 hrs by dual luciferase reporter gene assay 27736063
RAW264.7 Function assay 20 uM 1 hr Inhibition of LPS-induced NFkB activation in mouse RAW264.7 cells assessed as reduction in nuclear translocation of p65 at 20 uM preincubated for 1 hr followed by LPS stimulation measured after 3 hrs by Western blot method 28667873
RAW264.7 Function assay 20 uM 6 hrs Inhibition of LPS-induced NF-kappaB activation in mouse RAW264.7 cells at 20 uM treated 30 mins before LPS challenge measured after 6 hrs by luciferase reporter gene assay 24315191
RAW264.7 Antinflammatory assay 20 uM 18 hrs Antinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production at 20 uM treated 30 mins before LPS challenge measured after 18 hrs by Griess assay 24315191
THP1 Antinflammatory assay 5 uM 24 hrs Antiinflammatory activity in human THP1 cells assessed as inhibition of TPA/ionomycin-induced extracellular IL-1beta level at 5 uM incubated 1 hr prior to TPA/ionomycin challenge measured after 24 hrs by ELISA 24400858
THP1 Antinflammatory assay 5 uM 24 hrs Antiinflammatory activity in human THP1 cells assessed as inhibition of TPA/ionomycin-induced extracellular TNF-alpha production at 5 uM incubated 1 hr prior to TPA/ionomycin challenge measured after 24 hrs by ELISA 24400858
THP1 Antinflammatory assay 5 uM 24 hrs Antiinflammatory activity in human THP1 cells assessed as inhibition of TPA/ionomycin-induced intracellular proIL-1beta level at 5 uM incubated 1 hr prior to TPA/ionomycin challenge measured after 24 hrs by ELISA 24400858
THP1 Antinflammatory assay 5 uM 24 hrs Antiinflammatory activity in human THP1 cells assessed as inhibition of TPA/ionomycin-induced intracellular IL-1beta level at 5 uM incubated 1 hr prior to TPA/ionomycin challenge measured after 24 hrs by ELISA 24400858
RAW264.7 Function assay 0.3 ug/ml 12 hrs Inhibition of LPS-induced NF-kB p65 phosphorylation in mouse RAW264.7 cells at 0.3 ug/ml preincubated for 12 hrs followed by LPS stimulation for 3 hrs by Western blot method 28284806
RAW264.7 Function assay 0.3 ug/ml 12 hrs Inhibition of LPS-induced NF-kB p65 activation in mouse RAW264.7 cells at 0.3 ug/ml preincubated for 12 hrs followed by LPS stimulation for 3 hrs by DAPI staining based inverted fluorescence microscopic method 28284806
RAW264.7 Function assay 0.3 ug/ml 12 hrs Inhibition of NF-kB p65 in mouse RAW264.7 cells assessed as reduction in LPS-induced iNOS expression at 0.3 ug/ml preincubated for 12 hrs followed by LPS stimulation for 3 hrs by Western blot method 28284806
RAW264.7 Function assay 0.3 ug/ml 12 hrs Inhibition of NF-kB p65 in mouse RAW264.7 cells assessed as reduction in LPS-induced COX2 expression at 0.3 ug/ml preincubated for 12 hrs followed by LPS stimulation for 3 hrs by Western blot method 28284806
HEK293 Function assay 20 uM 24 hrs Inhibition of TNFalpha-induced NFkappaB activation in HEK293 cells at 20 uM after 24 hrs by dual luciferase reporter gene assay 28873303
RAW264.7 Function assay 20 uM 2 hrs Inhibition of NFkappaB nuclear translocation in LPS-stimulated mouse RAW264.7 cells at 20 uM pretreated for 2 hrs followed by LPS-induction by DAPI-staining based immunofluorescence microscopic method 29759725
BGC823 Function assay 5 uM 12 hrs Inhibition of colony formation in human BGC823 cells at 5 uM treated for 12 hrs followed by incubation in drug free medium for 14 days by crystal violet staining based assay 28881286
SGC7901 Function assay 5 uM 12 hrs Inhibition of colony formation in human SGC7901 cells at 5 uM treated for 12 hrs followed by incubation in drug free medium for 14 days by crystal violet staining based assay 28881286
RAW264.7 Function assay 10 uM 2 hrs Inhibition of LPS-induced IL-6 mRNA expression in mouse RAW264.7 cells at 10 uM pre-incubated for 2 hrs before LPS stimulation for 24 hrs by qRT-PCR method 27038497
RAW264.7 Function assay 10 uM 2 hrs Inhibition of LPS-induced IL-1beta mRNA expression in mouse RAW264.7 cells at 10 uM pre-incubated for 2 hrs before LPS stimulation for 24 hrs by qRT-PCR method 27038497
RAW264.7 Function assay 10 uM 2 hrs Inhibition of LPS-induced iNOS mRNA expression in mouse RAW264.7 cells at 10 uM pre-incubated for 2 hrs before LPS stimulation for 24 hrs by qRT-PCR method 27038497
클릭하여 더 많은 세포주 실험 데이터 보기

화학 정보, 보관 및 안정성

분자량 207.25 화학식

C10H9NO2S

 보관 (수령일로부터)
CAS 번호 19542-67-7 SDF 다운로드 원액 보관

동의어 BAY 11-7821 Smiles CC1=CC=C(C=C1)S(=O)(=O)C=CC#N

용해도

In vitro
배치:

DMSO : 41 mg/mL (197.82 mM)
(수분으로 오염된 DMSO는 용해도를 감소시킬 수 있습니다. 신선하고 무수 DMSO를 사용하십시오.)

Ethanol : 10 mg/mL

Water : Insoluble

몰농도 계산기

질량 농도 부피 분자량
희석 계산기 분자량 계산기

In vivo
배치:

생체 내 제형 계산기 (투명한 용액)

1단계: 아래 정보 입력 (권장: 실험 중 손실을 고려하여 추가 동물 포함)

mg/kg g μL

2단계: 생체 내 제형 입력 (이것은 계산기일 뿐 제형이 아닙니다. 용해도 섹션에 생체 내 제형이 없는 경우 먼저 당사에 문의하십시오.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

계산 결과:

작업 농도: mg/ml;

DMSO 원액 준비 방법: mg 약물 사전 용해 μL DMSO ( 원액 농도 mg/mL, 농도가 해당 약물 배치의 DMSO 용해도를 초과하는 경우 먼저 당사에 문의하십시오. )

생체 내 제형 준비 방법: 취하다 μL DMSO 원액, 다음 추가μL PEG300, 혼합하고 투명하게 한 다음 추가μL Tween 80, 혼합하고 투명하게 한 다음 추가 μL ddH2O, 혼합하고 투명하게 합니다.

생체 내 제형 준비 방법: 취하다 μL DMSO 원액, 다음 추가 μL 옥수수 기름, 혼합하고 투명하게 합니다.

참고: 1. 다음 용매를 추가하기 전에 액체가 투명한지 확인하십시오.
2. 용매를 순서대로 추가해야 합니다. 다음 용매를 추가하기 전에 이전 추가에서 얻은 용액이 투명한 용액인지 확인해야 합니다. 와동, 초음파 또는 뜨거운 물 중탕과 같은 물리적 방법을 사용하여 용해를 도울 수 있습니다.

작용 메커니즘

Targets/IC50/Ki
E2-conjugating enzymes
(Cell-free assay)
USP7
(Cell-free assay)
0.19 μM
USP21
(Cell-free assay)
0.96 μM
USP6
(Cell-free assay)
1.7 μM
IκBα phosphorylation
(Tumor cells)
10 μM
시험관 내(In vitro)

BAY 11-7082는 NF-κB DNA 결합을 완전하고 특이적으로 저해하여 NF-κB 유도성 사이토카인 IL-6을 하향 조절하고 아폽토시스를 유도합니다.

이 화합물(< 8 μM)은 기저 및 TNFα 자극 NFκB 루시페라제 활성을 용량 의존적으로 효과적으로 억제할 수 있습니다. 이는 (8 μM) NCI-H1703 세포의 증식 속도를 강력하게 억제합니다.

이 화합물(5 μM)은 HTLV-I 감염 T-세포주에서 NF-kappaB의 DNA 결합을 빠르고 효율적으로 감소시키고 항아폽토시스 유전자 Bcl-x(L)의 발현을 하향 조절하는 반면, 다른 전사 인자인 AP-1의 DNA 결합에는 거의 영향을 미치지 않습니다. 이 화학 물질 유도성 원발성 ATL 세포의 아폽토시스는 정상 말초 혈액 단핵 세포보다 더 두드러지며, 이러한 세포의 아폽토시스는 NF-kappaB 활성의 하향 조절과도 관련이 있습니다. 이는 (5 μM) 시클린 D1, 시클린 D2 및 Bcl-xL 발현의 하향 조절과 관련된 HTLV-I 감염 T-세포주의 아폽토시스를 선택적으로 유도합니다.

이 화합물(100 μM)은 NMDA에 의해 유발되는 p65의 핵 전위 및 마우스 해마 절편에서 NMDA 유도성 NF-κB 결합 증가를 방지합니다. 이는 20 μM에서 40%, 100 μM에서 70%의 신경 보호 효과를 통해 해마 절편의 CA1 영역에서 발생하는 NMDA 독성을 방지합니다.

이 화학 물질은 모든 시험 농도에서 지방 조직에서 NF-κB p65 DNA 결합 활성을 유의하게 억제하는 반면, 골격근에서는 50 μM 및 100 μM에서 NF-κB p65 DNA 결합 활성을 유의하게 억제합니다. 이는 (100 μM) 인체 지방 조직 및 골격근에서 IKK-β 단백질을 감소시킵니다. 이 화합물(100 μM)은 지방 조직에서 TNF-α 방출을 유의하게 감소시키는 반면, IL-6 및 IL-8 방출은 이 화학 물질의 모든 시험 농도에서 유의하게 억제됩니다. 이는 (50 μM) 골격근에서 TNF-α, IL-6 및 IL-8 방출을 유의하게 감소시킵니다.

이 화합물은 또한 E2-결합 효소 Ubc (유비퀴틴 결합) 13 및 UbcH7과 E3 리가제 LUBAC (선형 유비퀴틴 조립 복합체)를 비활성화시켜 B-세포 림프종 및 백혈병 T-세포 사멸을 유도하는 것으로 밝혀졌습니다.

생체 내(In vivo)

NF-κB 억제제인 BAY 11-7082는 위암 세포에서 아폽토시스와 S기 정지를 유도합니다.
참조
  • [4] https://pubmed.ncbi.nlm.nih.gov/12176906/
  • [5] https://pubmed.ncbi.nlm.nih.gov/15755516/
  • [6] https://pubmed.ncbi.nlm.nih.gov/23441730/
  • [7] https://pubmed.ncbi.nlm.nih.gov/25159004/
  • [8] https://pubmed.ncbi.nlm.nih.gov/23846545/

적용 분야

방법 바이오마커 이미지 PMID
Western blot NF-κB p-IKKβ/ IκBα p-IRAK4 / IRAK4 NF-κB p-IKKβ/ IκBα p-IRAK4 / IRAK4
S2913-WB1
31332209
Growth inhibition assay Cell viability Cell viability
S2913-viability1
31332209

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