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NU7441 (KU-57788) DNA-PK 억제제

Name: NU7441 (KU-57788)
Brand: Selleck Chemicals
SKU: S2638
Rating: 5 (303 reviews)

제품 번호S2638

NU7441 (KU-57788)은 IC50 14 nM의 매우 강력하고 선택적인 DNA-PK 억제제입니다. 또한 무세포 분석에서 IC50 1.7 μM 및 5 μM로 mTOR 및 PI3K를 억제하고, Cas9 매개 DNA 절단 후 NHEJ 빈도를 줄이는 동시에 HDR 속도를 증가시킵니다.

NU7441 (KU-57788) DNA-PK 억제제 Chemical Structure

화학 구조

분자량: 413.49

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품질 관리

배치: 순도: 99.94%

99.94

함께 자주 사용되는 제품 NU7441 (KU-57788)

KU-0060648

It and KU-0060648 reduce the frequency of the non-homologous end joining (NHEJ) pathway while increasing the rate of homology-directed recombination (HDR).

KU-55933

It and KU-55933 combination treatment significantly increase X-ray cytotoxicity in MDCK cells.

NU7026

It and NU7026 are potent DNA-PK inhibitors that inhibit the DSBs repair pathway and enhance the sensitivity of cancer cells to ionizing radiation or chemo-potentiation.

관련 타겟	HDAC PARP ATM/ATR WRN DNA/RNA Synthesis Topoisomerase PPAR Sirtuin Casein Kinase eIF
기타 DNA-PK 억제제	Nedisertib (M3814) AZD7648 VX-984 CC-115 YU238259 LTURM34 Compound 401

세포 배양, 처리 및 작업 농도

세포주	분석 유형	농도	배양 시간	활성 설명	PMID
NCI-H1770	Growth Inhibition Assay			IC50=0.02143 μM	SANGER
A172	Growth Inhibition Assay			IC50=0.15316 μM	SANGER
NCI-H526	Growth Inhibition Assay			IC50=0.28407 μM	SANGER
HDLM-2	Growth Inhibition Assay			IC50=0.32345 μM	SANGER
HuO-3N1	Growth Inhibition Assay			IC50=0.46636 μM	SANGER
NCI-SNU-1	Growth Inhibition Assay			IC50=0.60994 μM	SANGER
SK-N-AS	Growth Inhibition Assay			IC50=0.62216 μM	SANGER
LoVo	Growth Inhibition Assay			IC50=0.86749 μM	SANGER
LAMA-84	Growth Inhibition Assay			IC50=0.98833 μM	SANGER
CTB-1	Growth Inhibition Assay			IC50=1.11546 μM	SANGER
KP-N-YS	Growth Inhibition Assay			IC50=1.14231 μM	SANGER
HH	Growth Inhibition Assay			IC50=1.18093 μM	SANGER
CHL-1	Growth Inhibition Assay			IC50=1.21368 μM	SANGER
NB7	Growth Inhibition Assay			IC50=1.24745 μM	SANGER
HL-60	Growth Inhibition Assay			IC50=1.3819 μM	SANGER
639-V	Growth Inhibition Assay			IC50=1.44128 μM	SANGER
NCI-H1793	Growth Inhibition Assay			IC50=1.4584 μM	SANGER
NEC8	Growth Inhibition Assay			IC50=1.5535 μM	SANGER
PA-1	Growth Inhibition Assay			IC50=1.58294 μM	SANGER
D-423MG	Growth Inhibition Assay			IC50=1.69361 μM	SANGER
NCI-H292	Growth Inhibition Assay			IC50=1.74013 μM	SANGER
SK-MEL-1	Growth Inhibition Assay			IC50=1.79479 μM	SANGER
LB2241-RCC	Growth Inhibition Assay			IC50=2.14146 μM	SANGER
SK-MEL-3	Growth Inhibition Assay			IC50=2.1649 μM	SANGER
MHH-PREB-1	Growth Inhibition Assay			IC50=2.16609 μM	SANGER
BFTC-905	Growth Inhibition Assay			IC50=2.16687 μM	SANGER
Ramos-2G6-4C10	Growth Inhibition Assay			IC50=2.19909 μM	SANGER
G-361	Growth Inhibition Assay			IC50=2.2168 μM	SANGER
MOLT-4	Growth Inhibition Assay			IC50=2.21888 μM	SANGER
DEL	Growth Inhibition Assay			IC50=2.35564 μM	SANGER
MV-4-11	Growth Inhibition Assay			IC50=2.3739 μM	SANGER
SK-NEP-1	Growth Inhibition Assay			IC50=2.38783 μM	SANGER
RS4-11	Growth Inhibition Assay			IC50=2.56023 μM	SANGER
HuH-7	Growth Inhibition Assay			IC50=2.56702 μM	SANGER
A101D	Growth Inhibition Assay			IC50=2.61338 μM	SANGER
KG-1	Growth Inhibition Assay			IC50=2.67924 μM	SANGER
KALS-1	Growth Inhibition Assay			IC50=2.69633 μM	SANGER
VMRC-RCZ	Growth Inhibition Assay			IC50=2.77328 μM	SANGER
SK-UT-1	Growth Inhibition Assay			IC50=3.1531 μM	SANGER
SW962	Growth Inhibition Assay			IC50=3.20352 μM	SANGER
DBTRG-05MG	Growth Inhibition Assay			IC50=3.28085 μM	SANGER
PANC-08-13	Growth Inhibition Assay			IC50=3.41278 μM	SANGER
QIMR-WIL	Growth Inhibition Assay			IC50=3.41341 μM	SANGER
SK-MEL-30	Growth Inhibition Assay			IC50=3.42598 μM	SANGER
697	Growth Inhibition Assay			IC50=3.44993 μM	SANGER
NY	Growth Inhibition Assay			IC50=3.45022 μM	SANGER
ES7	Growth Inhibition Assay			IC50=3.46729 μM	SANGER
JVM-3	Growth Inhibition Assay			IC50=3.48077 μM	SANGER
U031	Growth Inhibition Assay			IC50=3.59368 μM	SANGER
BHT-101	Growth Inhibition Assay			IC50=3.59985 μM	SANGER
8305C	Growth Inhibition Assay			IC50=3.61736 μM	SANGER
MG-63	Growth Inhibition Assay			IC50=3.62676 μM	SANGER
NOS-1	Growth Inhibition Assay			IC50=3.65312 μM	SANGER
YH-13	Growth Inhibition Assay			IC50=3.87189 μM	SANGER
LXF-289	Growth Inhibition Assay			IC50=3.91041 μM	SANGER
GOTO	Growth Inhibition Assay			IC50=3.9149 μM	SANGER
EKVX	Growth Inhibition Assay			IC50=4.22524 μM	SANGER
CAL-51	Growth Inhibition Assay			IC50=4.24854 μM	SANGER
AN3-CA	Growth Inhibition Assay			IC50=4.25813 μM	SANGER
IA-LM	Growth Inhibition Assay			IC50=4.27935 μM	SANGER
KU-19-19	Growth Inhibition Assay			IC50=4.32921 μM	SANGER
A704	Growth Inhibition Assay			IC50=4.40888 μM	SANGER
RH-18	Growth Inhibition Assay			IC50=4.44953 μM	SANGER
IST-MEL1	Growth Inhibition Assay			IC50=4.58263 μM	SANGER
LU-134-A	Growth Inhibition Assay			IC50=4.59685 μM	SANGER
SF126	Growth Inhibition Assay			IC50=4.60715 μM	SANGER
EFO-27	Growth Inhibition Assay			IC50=4.66525 μM	SANGER
SN12C	Growth Inhibition Assay			IC50=4.71898 μM	SANGER
L-363	Growth Inhibition Assay			IC50=4.77116 μM	SANGER
MEL-HO	Growth Inhibition Assay			IC50=4.77989 μM	SANGER
TYK-nu	Growth Inhibition Assay			IC50=4.80128 μM	SANGER
MDA-MB-415	Growth Inhibition Assay			IC50=5.00314 μM	SANGER
HCC70	Growth Inhibition Assay			IC50=5.03939 μM	SANGER
IGROV-1	Growth Inhibition Assay			IC50=5.25292 μM	SANGER
NCI-H1355	Growth Inhibition Assay			IC50=5.296 μM	SANGER
23132-87	Growth Inhibition Assay			IC50=5.32024 μM	SANGER
NB69	Growth Inhibition Assay			IC50=5.3242 μM	SANGER
HSC-2	Growth Inhibition Assay			IC50=5.41773 μM	SANGER
KYSE-410	Growth Inhibition Assay			IC50=5.47636 μM	SANGER
GCIY	Growth Inhibition Assay			IC50=5.51378 μM	SANGER
A427	Growth Inhibition Assay			IC50=5.53661 μM	SANGER
ChaGo-K-1	Growth Inhibition Assay			IC50=5.56599 μM	SANGER
PFSK-1	Growth Inhibition Assay			IC50=5.62194 μM	SANGER
MLMA	Growth Inhibition Assay			IC50=5.83606 μM	SANGER
RVH-421	Growth Inhibition Assay			IC50=6.07338 μM	SANGER
LB1047-RCC	Growth Inhibition Assay			IC50=6.17522 μM	SANGER
MHH-NB-11	Growth Inhibition Assay			IC50=6.32721 μM	SANGER
J-RT3-T3-5	Growth Inhibition Assay			IC50=6.63291 μM	SANGER
UM-UC-3	Growth Inhibition Assay			IC50=6.64334 μM	SANGER
IST-SL1	Growth Inhibition Assay			IC50=6.69369 μM	SANGER
NB14	Growth Inhibition Assay			IC50=6.79761 μM	SANGER
NBsusSR	Growth Inhibition Assay			IC50=6.82502 μM	SANGER
D-263MG	Growth Inhibition Assay			IC50=6.91068 μM	SANGER
NCI-H2347	Growth Inhibition Assay			IC50=6.93213 μM	SANGER
ES8	Growth Inhibition Assay			IC50=6.97588 μM	SANGER
786-0	Growth Inhibition Assay			IC50=7.09786 μM	SANGER
EPLC-272H	Growth Inhibition Assay			IC50=7.16246 μM	SANGER
CAPAN-1	Growth Inhibition Assay			IC50=7.24359 μM	SANGER
NCI-H82	Growth Inhibition Assay			IC50=7.26659 μM	SANGER
G-402	Growth Inhibition Assay			IC50=7.30051 μM	SANGER
SW982	Growth Inhibition Assay			IC50=7.30203 μM	SANGER
OVCAR-4	Growth Inhibition Assay			IC50=7.31328 μM	SANGER
KARPAS-299	Growth Inhibition Assay			IC50=7.32622 μM	SANGER
MIA-PaCa-2	Growth Inhibition Assay			IC50=7.36823 μM	SANGER
AU565	Growth Inhibition Assay			IC50=7.59833 μM	SANGER
GAMG	Growth Inhibition Assay			IC50=7.64131 μM	SANGER
HuO9	Growth Inhibition Assay			IC50=7.71743 μM	SANGER
ACN	Growth Inhibition Assay			IC50=7.7433 μM	SANGER
RO82-W-1	Growth Inhibition Assay			IC50=7.74533 μM	SANGER
NKM-1	Growth Inhibition Assay			IC50=7.74955 μM	SANGER
CAL-12T	Growth Inhibition Assay			IC50=7.94352 μM	SANGER
FADU	Growth Inhibition Assay			IC50=8.03654 μM	SANGER
NCI-H28	Growth Inhibition Assay			IC50=8.16962 μM	SANGER
LCLC-97TM1	Growth Inhibition Assay			IC50=8.21122 μM	SANGER
CHP-134	Growth Inhibition Assay			IC50=8.24185 μM	SANGER
HT-1080	Growth Inhibition Assay			IC50=8.25093 μM	SANGER
PC-3	Growth Inhibition Assay			IC50=8.27392 μM	SANGER
SNU-449	Growth Inhibition Assay			IC50=8.2793 μM	SANGER
VA-ES-BJ	Growth Inhibition Assay			IC50=8.34686 μM	SANGER
HT	Growth Inhibition Assay			IC50=8.3649 μM	SANGER
HOS	Growth Inhibition Assay			IC50=8.37589 μM	SANGER
KNS-62	Growth Inhibition Assay			IC50=8.37762 μM	SANGER
OAW-42	Growth Inhibition Assay			IC50=8.95964 μM	SANGER
A549	Growth Inhibition Assay			IC50=9.09612 μM	SANGER
CAKI-1	Growth Inhibition Assay			IC50=9.1661 μM	SANGER
HCC1937	Growth Inhibition Assay			IC50=9.69865 μM	SANGER
GI-ME-N	Growth Inhibition Assay			IC50=9.70137 μM	SANGER
DU-4475	Growth Inhibition Assay			IC50=9.96939 μM	SANGER
EM-2	Growth Inhibition Assay			IC50=10.2426 μM	SANGER
NCI-H1755	Growth Inhibition Assay			IC50=10.2428 μM	SANGER
NCI-H1437	Growth Inhibition Assay			IC50=10.5725 μM	SANGER
VM-CUB-1	Growth Inhibition Assay			IC50=10.6164 μM	SANGER
A2058	Growth Inhibition Assay			IC50=10.6404 μM	SANGER
BPH-1	Growth Inhibition Assay			IC50=10.7145 μM	SANGER
NB5	Growth Inhibition Assay			IC50=10.7559 μM	SANGER
G-401	Growth Inhibition Assay			IC50=10.7626 μM	SANGER
CAL-72	Growth Inhibition Assay			IC50=10.8094 μM	SANGER
SK-MEL-28	Growth Inhibition Assay			IC50=10.8202 μM	SANGER
C32	Growth Inhibition Assay			IC50=10.8347 μM	SANGER
NCI-H1155	Growth Inhibition Assay			IC50=10.8376 μM	SANGER
BB49-HNC	Growth Inhibition Assay			IC50=10.8586 μM	SANGER
GMS-10	Growth Inhibition Assay			IC50=10.8971 μM	SANGER
K5	Growth Inhibition Assay			IC50=10.9071 μM	SANGER
OS-RC-2	Growth Inhibition Assay			IC50=11.0559 μM	SANGER
HTC-C3	Growth Inhibition Assay			IC50=11.0714 μM	SANGER
LB996-RCC	Growth Inhibition Assay			IC50=11.0723 μM	SANGER
NCI-H1563	Growth Inhibition Assay			IC50=11.1011 μM	SANGER
CAL-54	Growth Inhibition Assay			IC50=11.4811 μM	SANGER
WM-115	Growth Inhibition Assay			IC50=11.6824 μM	SANGER
COLO-684	Growth Inhibition Assay			IC50=11.7267 μM	SANGER
HOP-62	Growth Inhibition Assay			IC50=11.7508 μM	SANGER
NCI-H650	Growth Inhibition Assay			IC50=11.8961 μM	SANGER
TE-11	Growth Inhibition Assay			IC50=11.9315 μM	SANGER
COLO-679	Growth Inhibition Assay			IC50=11.946 μM	SANGER
FTC-133	Growth Inhibition Assay			IC50=12.0076 μM	SANGER
D-283MED	Growth Inhibition Assay			IC50=12.0569 μM	SANGER
SK-PN-DW	Growth Inhibition Assay			IC50=12.1902 μM	SANGER
BALL-1	Growth Inhibition Assay			IC50=12.2662 μM	SANGER
GT3TKB	Growth Inhibition Assay			IC50=12.3074 μM	SANGER
HOP-92	Growth Inhibition Assay			IC50=12.5233 μM	SANGER
M14	Growth Inhibition Assay			IC50=13.0335 μM	SANGER
SKG-IIIa	Growth Inhibition Assay			IC50=13.0554 μM	SANGER
Becker	Growth Inhibition Assay			IC50=13.058 μM	SANGER
ES5	Growth Inhibition Assay			IC50=13.1356 μM	SANGER
NCI-H2030	Growth Inhibition Assay			IC50=13.2062 μM	SANGER
SNU-423	Growth Inhibition Assay			IC50=13.381 μM	SANGER
CP50-MEL-B	Growth Inhibition Assay			IC50=13.6232 μM	SANGER
NCI-H1092	Growth Inhibition Assay			IC50=13.7475 μM	SANGER
8-MG-BA	Growth Inhibition Assay			IC50=13.7513 μM	SANGER
CAL-27	Growth Inhibition Assay			IC50=14.0727 μM	SANGER
AGS	Growth Inhibition Assay			IC50=14.1319 μM	SANGER
MZ2-MEL	Growth Inhibition Assay			IC50=14.1488 μM	SANGER
BFTC-909	Growth Inhibition Assay			IC50=14.5055 μM	SANGER
D-566MG	Growth Inhibition Assay			IC50=14.7706 μM	SANGER
MZ7-mel	Growth Inhibition Assay			IC50=15.1067 μM	SANGER
TE-5	Growth Inhibition Assay			IC50=15.2333 μM	SANGER
647-V	Growth Inhibition Assay			IC50=15.2705 μM	SANGER
DMS-114	Growth Inhibition Assay			IC50=15.3291 μM	SANGER
ME-180	Growth Inhibition Assay			IC50=15.4783 μM	SANGER
MS-1	Growth Inhibition Assay			IC50=15.5623 μM	SANGER
NUGC-3	Growth Inhibition Assay			IC50=15.6245 μM	SANGER
GB-1	Growth Inhibition Assay			IC50=15.6437 μM	SANGER
LOXIMVI	Growth Inhibition Assay			IC50=15.8919 μM	SANGER
NCI-H1304	Growth Inhibition Assay			IC50=15.8928 μM	SANGER
KURAMOCHI	Growth Inhibition Assay			IC50=15.971 μM	SANGER
SW1783	Growth Inhibition Assay			IC50=16.0993 μM	SANGER
EGI-1	Growth Inhibition Assay			IC50=16.5365 μM	SANGER
KGN	Growth Inhibition Assay			IC50=16.5586 μM	SANGER
PANC-03-27	Growth Inhibition Assay			IC50=16.7662 μM	SANGER
RH-1	Growth Inhibition Assay			IC50=16.825 μM	SANGER
HT-1376	Growth Inhibition Assay			IC50=16.8446 μM	SANGER
ZR-75-30	Growth Inhibition Assay			IC50=16.9361 μM	SANGER
TI-73	Growth Inhibition Assay			IC50=16.9408 μM	SANGER
TK10	Growth Inhibition Assay			IC50=17.0079 μM	SANGER
SW684	Growth Inhibition Assay			IC50=17.0154 μM	SANGER
RPMI-8866	Growth Inhibition Assay			IC50=17.0699 μM	SANGER
LNCaP-Clone-FGC	Growth Inhibition Assay			IC50=17.5201 μM	SANGER
NCI-H2291	Growth Inhibition Assay			IC50=18.4345 μM	SANGER
T47D	Growth Inhibition Assay			IC50=18.488 μM	SANGER
A204	Growth Inhibition Assay			IC50=18.5452 μM	SANGER
HT-144	Growth Inhibition Assay			IC50=18.7427 μM	SANGER
MDA-MB-361	Growth Inhibition Assay			IC50=19.0714 μM	SANGER
HCC1806	Growth Inhibition Assay			IC50=19.1591 μM	SANGER
NCI-H596	Growth Inhibition Assay			IC50=19.6391 μM	SANGER
K-562	Growth Inhibition Assay			IC50=19.8926 μM	SANGER
D-336MG	Growth Inhibition Assay			IC50=19.9322 μM	SANGER
SK-MEL-2	Growth Inhibition Assay			IC50=20.1559 μM	SANGER
HEC-1	Growth Inhibition Assay			IC50=20.4978 μM	SANGER
EW-13	Growth Inhibition Assay			IC50=20.5443 μM	SANGER
Hs-578-T	Growth Inhibition Assay			IC50=20.5583 μM	SANGER
SJSA-1	Growth Inhibition Assay			IC50=20.5688 μM	SANGER
RCC10RGB	Growth Inhibition Assay			IC50=20.6719 μM	SANGER
LAN-6	Growth Inhibition Assay			IC50=21.0396 μM	SANGER
NCI-H1048	Growth Inhibition Assay			IC50=21.2258 μM	SANGER
CW-2	Growth Inhibition Assay			IC50=21.2705 μM	SANGER
HCC2157	Growth Inhibition Assay			IC50=21.36 μM	SANGER
EW-22	Growth Inhibition Assay			IC50=21.376 μM	SANGER
A253	Growth Inhibition Assay			IC50=21.4481 μM	SANGER
BE-13	Growth Inhibition Assay			IC50=21.6113 μM	SANGER
KINGS-1	Growth Inhibition Assay			IC50=21.6316 μM	SANGER
ETK-1	Growth Inhibition Assay			IC50=21.8152 μM	SANGER
NCI-H2452	Growth Inhibition Assay			IC50=21.8647 μM	SANGER
HPAF-II	Growth Inhibition Assay			IC50=21.8923 μM	SANGER
D-542MG	Growth Inhibition Assay			IC50=21.9069 μM	SANGER
NCI-H630	Growth Inhibition Assay			IC50=22.0296 μM	SANGER
TGBC11TKB	Growth Inhibition Assay			IC50=22.049 μM	SANGER
BCPAP	Growth Inhibition Assay			IC50=22.611 μM	SANGER
HLE	Growth Inhibition Assay			IC50=22.697 μM	SANGER
NCI-H727	Growth Inhibition Assay			IC50=22.735 μM	SANGER
RD	Growth Inhibition Assay			IC50=22.7518 μM	SANGER
NCI-H522	Growth Inhibition Assay			IC50=22.8431 μM	SANGER
CGTH-W-1	Growth Inhibition Assay			IC50=23.0641 μM	SANGER
SK-LU-1	Growth Inhibition Assay			IC50=23.4683 μM	SANGER
BB65-RCC	Growth Inhibition Assay			IC50=23.7863 μM	SANGER
HSC-3	Growth Inhibition Assay			IC50=23.8527 μM	SANGER
SK-MES-1	Growth Inhibition Assay			IC50=24.0161 μM	SANGER
DB	Growth Inhibition Assay			IC50=24.1028 μM	SANGER
HO-1-N-1	Growth Inhibition Assay			IC50=24.3093 μM	SANGER
MKN1	Growth Inhibition Assay			IC50=24.68 μM	SANGER
MN-60	Growth Inhibition Assay			IC50=24.8519 μM	SANGER
8505C	Growth Inhibition Assay			IC50=25.1845 μM	SANGER
COLO-320-HSR	Growth Inhibition Assay			IC50=25.2208 μM	SANGER
BB30-HNC	Growth Inhibition Assay			IC50=25.2483 μM	SANGER
KM12	Growth Inhibition Assay			IC50=25.5807 μM	SANGER
NB13	Growth Inhibition Assay			IC50=25.5898 μM	SANGER
HCC2998	Growth Inhibition Assay			IC50=26.0283 μM	SANGER
U-118-MG	Growth Inhibition Assay			IC50=26.0808 μM	SANGER
NB10	Growth Inhibition Assay			IC50=26.234 μM	SANGER
SK-LMS-1	Growth Inhibition Assay			IC50=27.0704 μM	SANGER
SW1573	Growth Inhibition Assay			IC50=27.11 μM	SANGER
LB373-MEL-D	Growth Inhibition Assay			IC50=27.1294 μM	SANGER
DK-MG	Growth Inhibition Assay			IC50=27.1817 μM	SANGER
RMG-I	Growth Inhibition Assay			IC50=27.2029 μM	SANGER
SW1088	Growth Inhibition Assay			IC50=27.5042 μM	SANGER
SK-OV-3	Growth Inhibition Assay			IC50=27.7593 μM	SANGER
KP-N-YN	Growth Inhibition Assay			IC50=27.8043 μM	SANGER
RPMI-7951	Growth Inhibition Assay			IC50=28.2456 μM	SANGER
CaR-1	Growth Inhibition Assay			IC50=28.5582 μM	SANGER
MKN7	Growth Inhibition Assay			IC50=28.5964 μM	SANGER
CHP-212	Growth Inhibition Assay			IC50=28.7401 μM	SANGER
KYSE-450	Growth Inhibition Assay			IC50=28.8091 μM	SANGER
RXF393	Growth Inhibition Assay			IC50=29.2906 μM	SANGER
P30-OHK	Growth Inhibition Assay			IC50=29.3048 μM	SANGER
Ca9-22	Growth Inhibition Assay			IC50=29.4299 μM	SANGER
RT-112	Growth Inhibition Assay			IC50=29.4611 μM	SANGER
ES1	Growth Inhibition Assay			IC50=29.8544 μM	SANGER
HCE-4	Growth Inhibition Assay			IC50=29.8786 μM	SANGER
AM-38	Growth Inhibition Assay			IC50=30.0606 μM	SANGER
AsPC-1	Growth Inhibition Assay			IC50=30.8053 μM	SANGER
TE-9	Growth Inhibition Assay			IC50=30.8737 μM	SANGER
HuP-T4	Growth Inhibition Assay			IC50=30.9638 μM	SANGER
LB2518-MEL	Growth Inhibition Assay			IC50=31.0744 μM	SANGER
NCI-H1703	Growth Inhibition Assay			IC50=31.0905 μM	SANGER
NCI-H2228	Growth Inhibition Assay			IC50=31.4651 μM	SANGER
SCC-4	Growth Inhibition Assay			IC50=31.9181 μM	SANGER
KNS-81-FD	Growth Inhibition Assay			IC50=32.0128 μM	SANGER
NTERA-S-cl-D1	Growth Inhibition Assay			IC50=32.0739 μM	SANGER
Daoy	Growth Inhibition Assay			IC50=32.0838 μM	SANGER
ES4	Growth Inhibition Assay			IC50=32.3922 μM	SANGER
MHH-ES-1	Growth Inhibition Assay			IC50=32.4872 μM	SANGER
C-33-A	Growth Inhibition Assay			IC50=32.7728 μM	SANGER
BHY	Growth Inhibition Assay			IC50=32.9495 μM	SANGER
Detroit562	Growth Inhibition Assay			IC50=33.6657 μM	SANGER
EW-1	Growth Inhibition Assay			IC50=33.9322 μM	SANGER
NCI-H1395	Growth Inhibition Assay			IC50=34.0799 μM	SANGER
KM-H2	Growth Inhibition Assay			IC50=36.4743 μM	SANGER
NCI-H520	Growth Inhibition Assay			IC50=36.7541 μM	SANGER
D-392MG	Growth Inhibition Assay			IC50=37.3344 μM	SANGER
NOMO-1	Growth Inhibition Assay			IC50=37.8089 μM	SANGER
TE-6	Growth Inhibition Assay			IC50=38.124 μM	SANGER
HT-3	Growth Inhibition Assay			IC50=38.4436 μM	SANGER
RPMI-8226	Growth Inhibition Assay			IC50=38.9519 μM	SANGER
U251	Growth Inhibition Assay			IC50=39.0124 μM	SANGER
GCT	Growth Inhibition Assay			IC50=39.1852 μM	SANGER
A431	Growth Inhibition Assay			IC50=39.1894 μM	SANGER
TE-12	Growth Inhibition Assay			IC50=39.2448 μM	SANGER
HMV-II	Growth Inhibition Assay			IC50=39.5047 μM	SANGER
IST-MES1	Growth Inhibition Assay			IC50=40.1502 μM	SANGER
SW13	Growth Inhibition Assay			IC50=40.519 μM	SANGER
SF295	Growth Inhibition Assay			IC50=40.8066 μM	SANGER
MDA-MB-157	Growth Inhibition Assay			IC50=40.9462 μM	SANGER
TE-1	Growth Inhibition Assay			IC50=41.8714 μM	SANGER
HuCCT1	Growth Inhibition Assay			IC50=42.5289 μM	SANGER
KYSE-510	Growth Inhibition Assay			IC50=43.1754 μM	SANGER
NCI-H358	Growth Inhibition Assay			IC50=44.0304 μM	SANGER
SW900	Growth Inhibition Assay			IC50=44.0758 μM	SANGER
CAS-1	Growth Inhibition Assay			IC50=44.0991 μM	SANGER
TE-8	Growth Inhibition Assay			IC50=44.5658 μM	SANGER
P12-ICHIKAWA	Growth Inhibition Assay			IC50=44.6112 μM	SANGER
YKG-1	Growth Inhibition Assay			IC50=44.781 μM	SANGER
SNU-C2B	Growth Inhibition Assay			IC50=44.7903 μM	SANGER
LCLC-103H	Growth Inhibition Assay			IC50=44.8703 μM	SANGER
U-87-MG	Growth Inhibition Assay			IC50=45.1022 μM	SANGER
HAL-01	Growth Inhibition Assay			IC50=45.1379 μM	SANGER
OVCAR-8	Growth Inhibition Assay			IC50=45.3564 μM	SANGER
KYSE-150	Growth Inhibition Assay			IC50=47.1052 μM	SANGER
OE33	Growth Inhibition Assay			IC50=47.1429 μM	SANGER
CAL-62	Growth Inhibition Assay			IC50=47.4068 μM	SANGER
TCCSUP	Growth Inhibition Assay			IC50=47.6264 μM	SANGER
H4	Growth Inhibition Assay			IC50=47.6621 μM	SANGER
CP66-MEL	Growth Inhibition Assay			IC50=48.0704 μM	SANGER
SNB75	Growth Inhibition Assay			IC50=48.1874 μM	SANGER
Mo-T	Growth Inhibition Assay			IC50=48.279 μM	SANGER
BT-549	Growth Inhibition Assay			IC50=48.3729 μM	SANGER
IGR-1	Growth Inhibition Assay			IC50=48.6645 μM	SANGER
NCI-H1299	Growth Inhibition Assay			IC50=48.7248 μM	SANGER
ALL-PO	Growth Inhibition Assay			IC50=49.9268 μM	SANGER
CLL	Function assay			Inhibition of DNA-PK autophosphorylation at Ser2056 residue in human CLL cells by Western blot method, IC50 = 0.03 μM.	22835870
HeLa	Function assay			Inhibition of DNA-PK autophosphorylation at S2056 in human HeLa cells, EC50 = 0.212 μM.	23855836
CHO	Function assay			Inhibition of human ERG expressed in cisapride treated CHO cells by Ion Works assay, IC50 = 14 μM.	23855836
A673	qHTS assay			qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for A673 cells	29435139
DAOY	qHTS assay			qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for DAOY cells	29435139
Saos-2	qHTS assay			qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Saos-2 cells	29435139
BT-37	qHTS assay			qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for BT-37 cells	29435139
RD	qHTS assay			qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for RD cells	29435139
BT-12	qHTS assay			qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for BT-12 cells	29435139
MG 63 (6-TG R)	qHTS assay			qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for MG 63 (6-TG R) cells	29435139
NB1643	qHTS assay			qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for NB1643 cells	29435139
OHS-50	qHTS assay			qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for OHS-50 cells	29435139
SJ-GBM2	qHTS assay			qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SJ-GBM2 cells	29435139
SK-N-MC	qHTS assay			qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-MC cells	29435139
NB-EBc1	qHTS assay			qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for NB-EBc1 cells	29435139
LAN-5	qHTS assay			qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for LAN-5 cells	29435139
Rh18	qHTS assay			qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh18 cells	29435139
INA-6	Function assay	10 uM	4 hrs	Inhibition of heat shock response in human INA-6 cells assessed as reduction in HSF-1 mediated upregulation of the HSP72 protein expression at 10 uM preincubated for 4 hrs followed by HSP90 inhibitor and HSR inducer NVP-AUY922 addition measured after 4 hr	28453931
INA-6	Function assay	10 uM	4 hrs	Inhibition of heat shock response in human INA-6 cells assessed as reduction in HSF-1 mediated upregulation of the HSP72 mRNA expression at 10 uM preincubated for 4 hrs followed by HSP90 inhibitor and HSR inducer NVP-AUY922 addition measured after 4 hrs b	28453931
INA-6	Function assay	10 uM	4 hrs	Downregulation of NVP-AUY922-induced HSF-1 protein expression in human INA-6 cells at 10 uM preincubated for 4 hrs followed by NVP-AUY922 addition measured after 4 hrs by Western blot method	28453931
INA-6	Function assay	10 uM	4 hrs	Inhibition of NVP-AUY922-induced HSF-1 phosphorylation in human INA-6 cells at 10 uM preincubated for 4 hrs followed by NVP-AUY922 addition measured after 4 hrs by Western blot method	28453931
INA-6	Function assay	10 uM	4 hrs	Downregulation of NVP-AUY922-induced HSF-1 mRNA expression in human INA-6 cells at 10 uM preincubated for 4 hrs followed by NVP-AUY922 addition measured after 4 hrs by RT-PCR method	28453931
클릭하여 더 많은 세포주 실험 데이터 보기

화학 정보, 보관 및 안정성

분자량	413.49	화학식	C₂₅H₁₉NO₃S	보관 (수령일로부터)	3년-20°C분말
CAS 번호	503468-95-9	SDF 다운로드		원액 보관	1년-80°C용매에 보관 1개월-20°C용매에 보관
동의어	N/A			Smiles	C1COCCN1C2=CC(=O)C3=C(O2)C(=CC=C3)C4=CC=CC5=C4SC6=CC=CC=C56

용해도

In vitro
배치:

DMSO : 5 mg/mL (12.09 mM)
(수분으로 오염된 DMSO는 용해도를 감소시킬 수 있습니다. 신선하고 무수 DMSO를 사용하십시오.)

Water : Insoluble

Ethanol : Insoluble

DMSO : 3 mg/mL (7.25 mM)
(수분으로 오염된 DMSO는 용해도를 감소시킬 수 있습니다. 신선하고 무수 DMSO를 사용하십시오.)

Water : Insoluble

Ethanol : Insoluble

DMSO : 15 mg/mL (36.27 mM)
(수분으로 오염된 DMSO는 용해도를 감소시킬 수 있습니다. 신선하고 무수 DMSO를 사용하십시오.)

Water : Insoluble

Ethanol : Insoluble

DMSO : 3 mg/mL (7.25 mM)
(수분으로 오염된 DMSO는 용해도를 감소시킬 수 있습니다. 신선하고 무수 DMSO를 사용하십시오.)

Water : Insoluble

Ethanol : Insoluble

DMSO : 3 mg/mL (7.25 mM)
(수분으로 오염된 DMSO는 용해도를 감소시킬 수 있습니다. 신선하고 무수 DMSO를 사용하십시오.)

Water : Insoluble

Ethanol : Insoluble

몰농도 계산기

질량	농도	부피	분자량
=	×	×

희석 계산기 분자량 계산기

In vivo 배치:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O Selleck 연구소에서 검증되었습니다. 이 제형에 대한 조정이 필요한 경우 맞춤 테스트를 위해 당사 영업팀에 문의하십시오.	0.750mg/ml (1.81mM)	Taking the 1 mL working solution as an example, add 50 μL of 15 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O Selleck 연구소에서 검증되었습니다. 이 제형에 대한 조정이 필요한 경우 맞춤 테스트를 위해 당사 영업팀에 문의하십시오.	0.500mg/ml (1.21mM)	Taking the 1 mL working solution as an example, add 50 μL of 10 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify it; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.

생체 내 제형 계산기 (투명한 용액)

1단계: 아래 정보 입력 (권장: 실험 중 손실을 고려하여 추가 동물 포함)

투여량: mg/kg 동물 평균 체중: g 동물당 투여량:μL 동물 수:

2단계: 생체 내 제형 입력 (이것은 계산기일 뿐 제형이 아닙니다. 용해도 섹션에 생체 내 제형이 없는 경우 먼저 당사에 문의하십시오.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

계산 결과:

작업 농도: mg/ml;

DMSO 원액 준비 방법: mg 약물 사전 용해 μL DMSO ( 원액 농도 mg/mL, 농도가 해당 약물 배치의 DMSO 용해도를 초과하는 경우 먼저 당사에 문의하십시오. )

생체 내 제형 준비 방법: 취하다 μL DMSO 원액, 다음 추가μL PEG300, 혼합하고 투명하게 한 다음 추가μL Tween 80, 혼합하고 투명하게 한 다음 추가 μL ddH₂O, 혼합하고 투명하게 합니다.

생체 내 제형 준비 방법: 취하다 μL DMSO 원액, 다음 추가 μL 옥수수 기름, 혼합하고 투명하게 합니다.

참고: 1. 다음 용매를 추가하기 전에 액체가 투명한지 확인하십시오.
2. 용매를 순서대로 추가해야 합니다. 다음 용매를 추가하기 전에 이전 추가에서 얻은 용액이 투명한 용액인지 확인해야 합니다. 와동, 초음파 또는 뜨거운 물 중탕과 같은 물리적 방법을 사용하여 용해를 도울 수 있습니다.

작용 메커니즘

Targets/IC₅₀/Ki	DNA-PK (Cell-free assay) 14 nM mTOR (cell-free assay) 1.7 μM PI3K (cell-free assay) 5 μM
시험관 내(In vitro)	NU7441 (KU-57788)은 전리 방사선 유발 DNA 손상 후 γH2AX foci의 지속성을 증가시킵니다. 이는 (0.5 μM 또는 1 μM) SW620 및 LoVo 세포 모두에서 전리 방사선 및 독소루비신에 의해 유도된 G2-M 축적을 현저히 증가시킵니다. 이 화합물은 독소루비신 및 전리 방사선 유발 DNA 이중 가닥 손상의 지속성을 유발하며, DNA-PK-능숙한 M059-Fus-1 및 DNA-PK-결핍 M059 J 인간 종양 세포에서 상동 재조합 활동을 약간 감소시킵니다. 이는 폴리머라제 η가 없는 세포와 폴리머라제 η를 발현하는 세포 모두에서 UV 유발 RPA p34 과인산화를 용량 의존적으로 억제합니다. NU7441은 -유발 γH2AX foci 수준을 증가시키고 만성 림프구성 백혈병 세포에서 -유발 세포 사멸을 correspondingly 감소시킵니다. 또한 만성 림프구성 백혈병 세포에서 -유발 DNA-PKcs 자가인산화 및 복구를 억제합니다. 이 화합물은 Cas9 매개 DNA 절단 후 NHEJ 빈도를 줄이는 동시에 HDR 속도를 증가시킵니다.
생체 내(In vivo)	NU7441 (KU-57788)을 10 mg/kg 용량으로 복강 내 투여하면 최소 4시간 동안 유지되며 독성이 없고 SW620 이종이식편을 가진 마우스에서 유도된 종양 성장 지연을 2배 증가시킵니다.
참조	[1] https://pubmed.ncbi.nlm.nih.gov/15546735/ [2] https://pubmed.ncbi.nlm.nih.gov/16707462/ [3] https://pubmed.ncbi.nlm.nih.gov/21630086/ [4] https://pubmed.ncbi.nlm.nih.gov/16520097/ [5] https://pubmed.ncbi.nlm.nih.gov/18559621/ [6] https://pubmed.ncbi.nlm.nih.gov/21083655/ [7] https://pubmed.ncbi.nlm.nih.gov/26307031/

적용 분야

방법	바이오마커	이미지	PMID
Western blot	p-DNA-PKcs / DNA-PKcs / p-ATM / ATM / p-ATR / ATR / Ku70 / p-CHK1 / p-CHK2/ p-AKT / RAD51 p-mTOR(Ser2448) / mTOR / p-S6K(Thr389)		29344644

기술 지원

취급 설명서

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자주 묻는 질문

질문 1:
Could you please suggest formulations of it for in vivo injection?

답변:
We tested the following formulation for in vivo use: 4% DMSO+30% PEG 300+5% Tween 80+ddH2O up to 1mg/mL. It is a clear solution.

질문 2:
Previous aliquots were clear and colorless while this time, it becomes yellow when the powder was dissolved in DMSO? Could you advice on this?

답변:
It is normal and usually doesn't interfere with the function due to slight color variation caused by different processing.

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):