연구용
Favipiravir (T-705) RNA 중합효소 억제제
제품 번호S7975
화학 구조
분자량: 157.1
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품질 관리
배치:
순도:
99.97%
99.97
| 관련 타겟 | HDAC PARP ATM/ATR DNA-PK WRN Topoisomerase PPAR Sirtuin Casein Kinase eIF |
|---|---|
| 기타 DNA/RNA Synthesis 억제제 | CX-5461 (Pidnarulex) B02 SCR7 EED226 RK-33 BMH-21 Triapine (3-AP) Carmofur YK-4-279 Halofuginone |
세포 배양, 처리 및 작업 농도
| 세포주 | 분석 유형 | 농도 | 배양 시간 | 제형 | 활성 설명 | PMID |
|---|---|---|---|---|---|---|
| MDCK | Antiviral assay | 3 days | Antiviral activity against adamantane-, Influenza A virus (A/Ann Arbor/6/1960(H2N2)) infected in MDCK cells assessed as inhibition of viral replication after 3 days by microscopic analysis using crystal violet stain, EC50 = 0.38 μM. | 20350949 | ||
| MDCK | Antiviral assay | 3 days | Antiviral activity against adamantane-resistant , Influenza A virus (A/New York/34/2008(H1N1)) harboring M2 L26I mutant infected in MDCK cells assessed as inhibition of viral replication after 3 days by microscopic analysi, EC50 = 0.19 μM. | 20350949 | ||
| MDCK | Antiviral assay | 3 days | Antiviral activity against adamantane-resistant,Influenza A virus (A/Florida/01/2009(H3N2)) harboring M2 S31N mutant infected in MDCK cells assessed as inhibition of viral replication after 3 days by microscopic analysis, EC50 = 0.45 μM. | 20350949 | ||
| MDCK | Antiviral assay | 3 days | Antiviral activity against, adamantane-resistant Influenza B virus B/Memphis/20/1996 harboring neuraminidase R152K mutant infected in MDCK cells assessed as inhibition of viral replication after 3 days by microscopic ana, EC50 = 0.57 μM. | 20350949 | ||
| MDCK | Antiviral assay | 3 days | Antiviral activity against adamantane-， Influenza A virus (A/Swine/South Dakota/03/2008(H1N1)) infected in MDCK cells assessed as inhibition of viral replication after 3 days by microscopic analysis using crystal violet, EC50 = 0.83 μM. | 20350949 | ||
| MDCK | Antiviral assay | 3 days | Antiviral activity against adamantane-susceptible ,Influenza A virus (A/Brazil/1633/2008(H1N1)) harboring neuraminidase Q136K mutant infected in MDCK cells assessed as inhibition of viral replication after 3 days by micros, EC50 = 0.83 μM. | 20350949 | ||
| MDCK | Antiviral assay | 3 days | Antiviral activity against adamantane-resistant,Influenza A virus (A/pdm/California/05/2009 (H1N1)) harboring M2 V28I, S31N mutant infected in MDCK cells assessed as inhibition of viral replication after 3 days by micros, EC50 = 0.83 μM. | 20350949 | ||
| MDCK | Antiviral assay | 3 days | Antiviral activity against adamantane-resistant,Influenza A virus (A/pdm/New York/18/2009 (H1N1)) harboring M2 V28I, S31N mutant infected in MDCK cells assessed as inhibition of viral replication after 3 days by microsco, EC50 = 0.89 μM. | 20350949 | ||
| MDCK | Antiviral assay | 3 days | Antiviral activity against adamantane-, Influenza A virus (A/turkey/Minnesota/833/1980(H4N2)) harboring neuraminidase E119G mutant infected in MDCK cells assessed as inhibition of viral replication after 3 days , EC50 = 0.89 μM. | 20350949 | ||
| MDCK | Antiviral assay | 3 days | Antiviral activity against adamantane-, Influenza A virus (A/turkey/Minnesota/833/1980(H4N2)) infected in MDCK cells assessed as inhibition of viral replication after 3 days by microscopic analysis using crystal violet , EC50 = 0.96 μM. | 20350949 | ||
| MDCK | Antiviral assay | Antiviral activity against, adamantane-resistant Influenza A virus (A/Bethesda/956/2006(H3N2)) harboring neuraminidase R292K mutant and M2 S31N mutant infected in MDCK cells assessed as inhibition of viral replication af, EC50 = 1.21 μM. | 20350949 | |||
| MDCK | Antiviral assay | 3 days | Antiviral activity against adamantane-resistant ,Influenza A virus (A/pdm/Mexico/4604/2009 (H1N1)) harboring M2 V28I, S31N mutant infected in MDCK cells assessed as inhibition of viral replication after 3 days by microsco, EC50 = 1.21 μM. | 20350949 | ||
| MDCK | Antiviral assay | 3 days | Antiviral activity against adamantane-resistant,Influenza B virus B/Memphis/20/1996 infected in MDCK cells assessed as inhibition of viral replication after 3 days by microscopic analysis using crystal violet stain, EC50 = 1.21 μM. | 20350949 | ||
| MDCK | Antiviral assay | Antiviral activity against adamantane，Influenza A virus (A/chicken/Vietnam/NCVD103/2007 clade 2.3.4 (H5N1)) harboring neuraminidase I222T mutant infected in MDCK cells assessed as inhibition of viral replication after, EC50 = 1.27 μM. | 20350949 | |||
| MDCK | Antiviral assay | Inhibition of viral replication of influenza A virus (A/Hong Kong/213/03(H5N1)) and influenza A virus (A/Ann Arbor/6/60(H2N2)) hybrid virus in MDCK cells by virus yield reduction assay, EC90 = 1.3 μM. | 17194832 | |||
| MDCK | Antiviral assay | 1 hr | Antiviral activity against Influenza B virus (B/Brisbane/60/2008) infected in MDCK cells assessed as inhibition of virus-induced cytopathogenicity at 1 hr post-infection measured after 3 days by fluorescein-diacetate based fluorimetric analysis, EC50 = 1.32 μM. | 23419738 | ||
| MDCK | Antiviral assay | Antiviral activity against adamantane-, Influenza A virus (A/Vietnam/HN30408/2005 N294S clade 1 (H5N1)) harboring M2 L26I, S31N mutant and neuraminidase N294S mutant infected in MDCK cells assessed as inhibition of viral , EC50 = 1.341 μM. | 20350949 | |||
| MDCK | Antiviral assay | 3 days | Antiviral activity against adamantane-resistant,Influenza A virus (A/pdm/California/07/2009 (H1N1)) harboring M2 V28I, S31N mutant infected in MDCK cells assessed as inhibition of viral replication after 3 days by micros, EC50 = 1.4 μM. | 20350949 | ||
| MDCK | Antiviral assay | 3 days | Antiviral activity against adamantane-resistant,Influenza B virus (B/Rochester/01/2001) infected in MDCK cells assessed as inhibition of viral replication after 3 days by microscopic analysis using crystal violet stain, EC50 = 1.4 μM. | 20350949 | ||
| MDCK | Antiviral assay | 3 days | Antiviral activity against adamantane-， Influenza A virus (A/Georgia/17/2006(H1N1)) infected in MDCK cells assessed as inhibition of viral replication after 3 days by microscopic analysis using crystal violet stain, EC50 = 1.46 μM. | 20350949 | ||
| MDCK | Antiviral assay | 3 days | Antiviral activity against adamantane-,Influenza A virus (A/turkey/VA/4529/2002 (H7N2)) infected in MDCK cells assessed as inhibition of viral replication after 3 days by microscopic analysis using crystal violet stain, EC50 = 1.53 μM. | 20350949 | ||
| MDCK | Antiviral assay | 3 days | Antiviral activity against adamantane-,Influenza A virus (A/Florida/21/2008(H1N1)) harboring neuraminidase H274Y mutant infected in MDCK cells assessed as inhibition of viral replication after 3 days by microsc, EC50 = 1.59 μM. | 20350949 | ||
| MDCK | Antiviral assay | 3 days | Antiviral activity against adamantane-，Influenza A virus (A/duck/Vietnam/NCVD93/2007 clade 2.3.4 (H5N1)) infected in MDCK cells assessed as inhibition of viral replication after 3 days by microscopic analysis using cry, EC50 = 1.59 μM. | 20350949 | ||
| MDCK | Antiviral assay | 3 days | Antiviral activity against, adamantane-resistant Influenza B virus (B/Rochester/01/2001) harboring neuraminidase D198N mutant infected in MDCK cells assessed as inhibition of viral replication after 3 days by microscopic, EC50 = 1.72 μM. | 20350949 | ||
| MDCK | Antiviral assay | 3 days | Antiviral activity against adamantane-, Influenza A virus (A/Brazil/1067/2008(H1N1)) infected in MDCK cells assessed as inhibition of viral replication after 3 days by microscopic analysis using crystal violet stain, EC50 = 1.85 μM. | 20350949 | ||
| MDCK | Antiviral assay | 1 hr | Antiviral activity against Influenza B virus (B/Lee/40) infected in MDCK cells assessed as inhibition of virus-induced cytopathogenicity at 1 hr post-infection measured after 3 days by fluorescein-diacetate based fluorimetric analysis, EC50 = 1.93 μM. | 23419738 | ||
| MDCK | Antiviral assay | 1 hr | Antiviral activity against Influenza B virus (B/Panama/45/1990) infected in MDCK cells assessed as inhibition of virus-induced cytopathogenicity at 1 hr post-infection measured after 3 days by fluorescein-diacetate based fluorimetric analysis, EC50 = 1.94 μM. | 23419738 | ||
| MDCK | Antiviral assay | 3 days | Antiviral activity against adamantane-resistant，Influenza A virus (A/pdm/California/04/2009 (H1N1)) harboring M2 V28I, S31N mutant infected in MDCK cells assessed as inhibition of viral replication after 3 days by micros, EC50 = 1.97 μM. | 20350949 | ||
| MDCK | Antiviral assay | 3 days | Antiviral activity against adamantane-,Influenza A virus (A/swine/Michigan/09/2007 (H1N2)) harboring M2 V27I, V28D mutant infected in MDCK cells assessed as inhibition of viral replication after 3 days by microscopic a, EC50 = 2.23 μM. | 20350949 | ||
| MDCK | Antiviral assay | 3 days | Antiviral activity against adamantane-,Influenza A virus (A/Ecuador/5179/2008(H1N1)) infected in MDCK cells assessed as inhibition of viral replication after 3 days by microscopic analysis using crystal violet stain, EC50 = 2.48 μM. | 20350949 | ||
| MDCK | Antiviral assay | 3 days | Antiviral activity against adamantane-,Influenza A virus (A/Georgia/20/2006(H1N1)) harboring neuraminidase H274Y mutant infected in MDCK cells assessed as inhibition of viral replication after 3 days by microsc, EC50 = 2.55 μM. | 20350949 | ||
| MDCK | Antiviral assay | Inhibition of viral replication of influenza A virus (A/Hong Kong/213/03(H5N1)) and influenza A virus (A/Ann Arbor/6/60(H2N2)) hybrid virus in MDCK cells by neutral red uptake assay, EC50 = 2.6 μM. | 17194832 | |||
| MDCK | Antiviral assay | Inhibition of influenza A virus (A/duck/Minnesota/1525/1981 (H5N1)) replication in MDCK cells by virus yield reduction assay, EC90 = 2.6 μM. | 17194832 | |||
| MDCK | Antiviral assay | 24 hrs | Antiviral activity against Influenza A virus A/WSN/33(H1N1) infected in MDCK cells assessed as inhibition of neuraminidase activity using 2'-(4-methylumbelliferyl)-alpha-D-N-acetylneuraminic acid substrate pretreated with cells for 24 hrs followed by vira, EC50 = 2.7 μM. | 27120583 | ||
| MDCK | Antiviral assay | 1 hr | Antiviral activity against Influenza B virus (B/Taiwan/2/62) infected in MDCK cells assessed as inhibition of virus-induced cytopathogenicity at 1 hr post-infection measured after 3 days by fluorescein-diacetate based fluorimetric analysis, EC50 = 2.84 μM. | 23419738 | ||
| MDCK | Antiviral assay | 3 days | Antiviral activity against adamantane-resistant,Influenza A virus (A/Wisconsin/16/2008(H1N1)) harboring neuraminidase H274Y mutant infected in MDCK cells assessed as inhibition of viral replication after 3 days by micros, EC50 = 2.87 μM. | 20350949 | ||
| MDCK | Antiviral assay | 3 days | Antiviral activity against adamantane-, Influenza A virus (A/Idaho/01/2009(H1N1)) harboring neuraminidase H274Y mutant infected in MDCK cells assessed as inhibition of viral replication after 3 days by microscopic analysi, EC50 = 2.93 μM. | 20350949 | ||
| MDCK | Antiviral assay | Antiviral activity against, adamantane-resistant Influenza A virus (A/Luhansk/18/2008(H1N1)) harboring neuraminidase H274Y mutant and M2 G34E mutant infected in MDCK cells assessed as inhibition of viral replication afte, EC50 = 2.93 μM. | 20350949 | |||
| MDCK | Antiviral assay | 3 days | Antiviral activity against adamantane-,Influenza B virus (B/Illinois/03/2008) harboring neuraminidase E119A mutant infected in MDCK cells assessed as inhibition of viral replication after 3 days by microscopic analysis u, EC50 = 3 μM. | 20350949 | ||
| MDCK | Antiviral assay | 3 days | Antiviral activity against adamantane-,Influenza A virus (A/Washington/10/2008(H1N1)) harboring M2 S31N mutant infected in MDCK cells assessed as inhibition of viral replication after 3 days by microscopic anal, EC50 = 3.25 μM. | 20350949 | ||
| MDCK | Antiviral assay | Antiviral activity against adamantane-susceptible , Influenza A virus (A/duck/Vietnam/NCVD94/2007 clade 2.3.4 (H5N1)) harboring neuraminidase I117V mutant infected in MDCK cells assessed as inhibition of viral replication a, EC50 = 3.38 μM. | 20350949 | |||
| MDCK | Antiviral assay | 3 days | Antiviral activity against adamantane-,Influenza A virus (A/California/27/2007(H1N1)) infected in MDCK cells assessed as inhibition of viral replication after 3 days by microscopic analysis using crystal violet stain, EC50 = 3.63 μM. | 20350949 | ||
| MDCK | Antiviral assay | Inhibition of viral replication of influenza A virus (A/Vietnam/1203/2004 (H5N1)) and influenza A virus (A/Ann Arbor/6/60(H2N2)) hybrid virus in MDCK cells by virus yield reduction assay, EC90 = 3.8 μM. | 17194832 | |||
| MDCK | Antiviral assay | Antiviral activity against, adamantane-resistant Influenza A virus (A/Texas/12/2007 (clone)(H3N2)) harboring neuraminidase E119I mutant and harboring M2 S31N mutant infected in MDCK cells assessed as inhibition of viral , EC50 = 3.95 μM. | 20350949 | |||
| MDCK | Antiviral assay | 3 days | Antiviral activity against adamantane-resistant, Influenza B virus (B/Illinois/47/2005) infected in MDCK cells assessed as inhibition of viral replication after 3 days by microscopic analysis using crystal violet stain, EC50 = 4.01 μM. | 20350949 | ||
| MDCK | Antiviral assay | 3 days | Antiviral activity against adamantane-resistant,Influenza A virus (A/New Hampshire/01/2009(H3N2)) harboring M2 S31N mutant infected in MDCK cells assessed as inhibition of viral replication after 3 days by microscopic an, EC50 = 4.08 μM. | 20350949 | ||
| MDCK | Antiviral assay | Antiviral activity against, adamantane-resistant Influenza A virus (A/Vietnam/HN30408/2005 H274Y clade 1 (H5N1)) harboring M2 L26I, S31N mutant and neuraminidase H274Y mutant infected in MDCK cells assessed as inhibition, EC50 = 4.14 μM. | 20350949 | |||
| MDCK | Antiviral assay | 3 days | Antiviral activity against adamantane-resistant,Influenza A virus (A/Massachusetts/03/2009(H3N2)) harboring M2 S31N mutant infected in MDCK cells assessed as inhibition of viral replication after 3 days by microscopic an, EC50 = 4.2 μM. | 20350949 | ||
| MDCK | Antiviral assay | 3 days | Antiviral activity against adamantane-resistant,Influenza A virus (A/Washington/01/2007(H3N2)) harboring M2 S31N mutant infected in MDCK cells assessed as inhibition of viral replication after 3 days by microscopic analy, EC50 = 4.46 μM. | 20350949 | ||
| MDCK | Antiviral assay | Inhibition of influenza A virus (A/duck/Minnesota/1525/1981 (H5N1)) replication in MDCK cells by neutral red uptake assay, EC50 = 4.5 μM. | 17194832 | |||
| MDCK | Antiviral assay | 3 days | Antiviral activity against adamantane-,Influenza A virus (A/Swine/Texas/14/2008 (H1N1)) harboring M2 V27T, V28D mutant infected in MDCK cells assessed as inhibition of viral replication after 3 days by microscopic anal, EC50 = 4.52 μM. | 20350949 | ||
| MDCK | Antiviral assay | 3 days | Antiviral activity against adamantane-susceptible,Influenza A virus (A/Santiago/5248/2008(H1N1)) harboring neuraminidase D198E mutant infected in MDCK cells assessed as inhibition of viral replication after 3 days by micr, EC50 = 4.7 μM. | 20350949 | ||
| MDCK | Antiviral assay | 1 hr | Antiviral activity against Influenza A virus (A/Hong kong/8/1968(H2N3)) infected in MDCK cells assessed as inhibition of virus-induced cytopathogenicity at 1 hr post-infection measured after 3 days by fluorescein-diacetate based fluorimetric analysis, EC50 = 4.71 μM. | 23419738 | ||
| MDCK | Antiviral assay | 3 days | Antiviral activity against adamantane-,Influenza A virus (A/New Jersey/15/2007(H1N1)) harboring neuraminidase H274Y mutant infected in MDCK cells assessed as inhibition of viral replication after 3 days by micr, EC50 = 4.9 μM. | 20350949 | ||
| Vero | Antiviral assay | 7 to 8 days | Antiviral activity against Junin virus Candid-1 in Vero cells assessed as inhibition of virus-induced visual cytopathic effect after 7 to 8 days, EC50 = 5 μM. | 17606691 | ||
| MDCK | Antiviral assay | 3 days | Antiviral activity against adamantane-,Influenza A virus (A/North Carolina/02/ 2009(H1N1)) harboring M2 S31N mutant infected in MDCK cells assessed as inhibition of viral replication after 3 days by microscopic, EC50 = 5.03 μM. | 20350949 | ||
| MDCK | Antiviral assay | 3 days | Antiviral activity against, adamantane-resistant Influenza B virus (B/Michigan/20/2005) harboring neuraminidase H274Y mutant infected in MDCK cells assessed as inhibition of viral replication after 3 days by microscopic , EC50 = 5.03 μM. | 20350949 | ||
| MDCK | Antiviral assay | 3 days | Antiviral activity against adamantane-resistant,Influenza A virus (A/Vietnam/1203/2004 clade 1 (H5N1)) harboring M2 L26I, S31N mutant infected in MDCK cells assessed as inhibition of viral replication after 3 days by mic, EC50 = 5.22 μM. | 20350949 | ||
| MDCK | Antiviral assay | Antiviral activity agains, adamantane-resistant Influenza A virus (A/Texas/12/2007 (clone)(H3N2)) harboring neuraminidase E119V mutant and harboring M2 S31N mutant infected in MDCK cells assessed as inhibition of viral , EC50 = 5.22 μM. | 20350949 | |||
| MDCK | Antiviral assay | 3 days | Antiviral activity against adamantane-resistant Influenza B virus (B/New York/22/2008) infected in MDCK cells assessed as inhibition of viral replication after 3 days by microscopic analysis using crystal violet stain, EC50 = 5.3 μM. | 20350949 | ||
| MDCK | Antiviral assay | 3 days | Antiviral activity against, adamantane-resistant Influenza A virus (A/Wuhan/395/1995-like (H3N2)) harboring neuraminidase E119V mutant infected in MDCK cells assessed as inhibition of viral replication after 3 days by mi, EC50 = 5.41 μM. | 20350949 | ||
| MDCK | Antiviral assay | 3 days | Antiviral activity against adamantane-resistant, Influenza A virus (A/Wuhan/395/1995-like (H3N2)) infected in MDCK cells assessed as inhibition of viral replication after 3 days by microscopic analysis using crystal viole, EC50 = 5.99 μM. | 20350949 | ||
| Vero | Antiviral assay | 7 to 8 days | Antiviral activity against Pichinde virus An 4763 in Vero cells assessed as inhibition of virus-induced visual cytopathic effect after 7 to 8 days, EC50 = 6 μM. | 17606691 | ||
| Vero | Antiviral assay | 7 to 8 days | Antiviral activity against Tacaribe virus TRVL11573 in Vero cells assessed as inhibition of virus-induced visual cytopathic effect after 7 to 8 days, EC50 = 6 μM. | 17606691 | ||
| MDCK | Antiviral assay | Antiviral activity against, adamantane-resistant Influenza A virus (A/pdm/Washington/29/2009 (H1N1)) harboring M2 V28I, S31N mutant and neuraminidase H274Y mutant infected in MDCK cells assessed as inhibition of viral re, EC50 = 6.62 μM. | 20350949 | |||
| MDCK | Antiviral assay | 1 hr | 3 days | Antiviral activity against Influenza A virus (A/Taiwan/1/1986(H1N1)) infected in MDCK cells assessed as inhibition of virus-induced cytopathogenicity at 1 hr post-infection measured after 3 days by fluorescein-diacetate based fluorimetric analysis, EC50 = 6.95 μM. | 23419738 | |
| MDCK | Antiviral assay | Inhibition of Influenza A virus (A/gull/Pennsylvania/4175/83 (H5N1)) replication in MDCK cells by virus yield reduction assay, EC90 = 7.7 μM. | 17194832 | |||
| MDCK | Antiviral assay | 3 days | Antiviral activity against Influenza virus B/Ned/537/05 infected in MDCK cells assessed as reduction in viral replication at 3 days post infection by formazan-based MTS assay, EC50 = 8.3 μM. | 29906392 | ||
| MDCK | Antiviral assay | 3 days | Antiviral activity against Influenza virus B/Ned/537/05 infected in MDCK cells assessed as reduction in viral replication at 3 days post infection by microscopic analysis, EC50 = 9 μM. | 29906392 | ||
| MDCK | Antiviral assay | 3 days | Antiviral activity against adamantane-resistant,Influenza A virus (A/New York/107/2003(H7N2)) harboring M2 V28A, S31N mutant infected in MDCK cells assessed as inhibition of viral replication after 3 days by microscopic , EC50 = 10.2 μM. | 20350949 | ||
| MDCK | Antiviral assay | Inhibition of Influenza A virus (A/gull/Pennsylvania/4175/83 (H5N1)) replication in MDCK cells by neutral red uptake assay, EC50 = 11.5 μM. | 17194832 | |||
| MDCK | Antiviral assay | Inhibition of viral replication of influenza A virus (A/Vietnam/1203/2004 (H5N1)) and influenza A virus (A/Ann Arbor/6/60(H2N2)) hybrid virus in MDCK cells by neutral red uptake assay, EC50 = 12.1 μM. | 17194832 | |||
| Vero-A | Antiviral assay | Antiviral activity against Chikungunya virus venturini isolate (Italy 2008) infected in African green monkey Vero-A cells assessed as inhibition of viral-induced cytopathic effect measured on day 7 post infection by MTS/PMS assay, EC50 = 16 μM. | 28689975 | |||
| MDCK | Antiviral assay | Antiviral activity against oseltamivir-susceptible, adamantane-resistant Influenza A virus (A/pdm/Illinois/10/2009(H1N1)) harboring M2 V28I, S31N mutant and neuraminidase H274Y mutant infected in MDCK cells assessed as inhibition of viral repli, EC50 = 22.48 μM. | 20350949 | |||
| MDCK | Antiviral assay | 3 days | Antiviral activity against Influenza virus A/X-31 infected in MDCK cells assessed as reduction in viral replication at 3 days post infection by microscopic analysis, EC50 = 24 μM. | 29906392 | ||
| Vero-A | Antiviral assay | Antiviral activity against Chikungunya virus 899 infected in African green monkey Vero-A cells assessed as inhibition of viral-induced cytopathic effect measured on day 7 post infection by MTS/PMS assay, EC50 = 25 μM. | 28689975 | |||
| Vero-A | Antiviral assay | Antiviral activity against Chikungunya virus LR2006-OPY1 infected in African green monkey Vero-A cells assessed as inhibition of viral-induced cytopathic effect measured on day 7 post infection by MTS/PMS assay, EC50 = 25 μM. | 28689975 | |||
| MDCK | Antiviral assay | 3 days | Antiviral activity against Influenza virus A/X-31 infected in MDCK cells assessed as reduction in viral replication at 3 days post infection by formazan-based MTS assay, EC50 = 26 μM. | 29906392 | ||
| MDCK | Antiviral assay | Antiviral activity against 0.001 MOI adamantane-resistant,oseltamivir-susceptible Influenza A virus (A/pdm/Mexico/4604/2009(H1N1)) harboring M2 V28I, S31N mutant infected in MDCK cells assessed as determination of viral titer in cell culture at, NULL = NULL μM. | 20350949 | |||
| MDCK | Antiviral assay | Antiviral activity against 0.001 MOI adamantane-resistant,oseltamivir-susceptible Influenza A virus (A/pdm/California/04/2009(H1N1)) harboring M2 V28I, S31N mutant infected in MDCK cells assessed as determination of viral titer in cell culture , NULL = NULL μM. | 20350949 | |||
| MDCK | Antiviral assay | 128 uM | Antiviral activity against adamantane-resistant,oseltamivir-susceptible Influenza A virus (A/pdm/Mexico/4604/2009(H1N1)) harboring M2 V28I, S31N mutant infected in MDCK cells assessed as determination of viral titer in cell culture at 128 uM af, NULL = NULL μM. | 20350949 | ||
| MDCK | Antiviral assay | 128 uM | Antiviral activity against adamantane-resistant,oseltamivir-susceptible Influenza A virus (A/pdm/California/04/2009(H1N1)) harboring M2 V28I, S31N mutant infected in MDCK cells assessed as determination of viral titer in cell culture at 128 uM , NULL = NULL μM. | 20350949 | ||
| Vero | Antiviral assay | 6400 uM | up to 12 hrs | Antiviral activity against Yellow fever virus 17D infected in African green monkey Vero cells assessed as time required for inhibition of viral replication at 6400 uM up to 12 hrs post-viral infection, NULL = NULL μM. | 18955536 | |
| MDCK | Antiviral assay | 0 to 2 hrs | Inhibition of influenza A virus infected in MDCK cells assessed as inhibition of viral load treated with compound at 0 to 2 hrs post-infection by RT-qPCR method based time of addition assay, NULL = NULL μM. | 30192544 | ||
| MDCK | Antiviral assay | 5 to 8 hrs | Inhibition of influenza A virus infected in MDCK cells assessed as inhibition of viral load treated with compound at 5 to 8 hrs post-infection by RT-qPCR method based time of addition assay, NULL = NULL μM. | 30192544 | ||
| MDCK | Antiviral assay | 0 to 10 hrs | Inhibition of influenza A virus infected in MDCK cells assessed as inhibition of viral load treated with compound at 0 to 10 hrs post-infection by RT-qPCR method based time of addition assay, NULL = NULL μM. | 30192544 | ||
| MDCK | Antiviral assay | 2 to 5 hrs | Inhibition of influenza A virus infected in MDCK cells assessed as inhibition of viral load treated with compound at 2 to 5 hrs post-infection by RT-qPCR method based time of addition assay, NULL = NULL μM. | 30192544 | ||
| MDCK | Antiviral assay | 10 uM | up to 8 hrs | Antiviral activity against Influenza A virus (A/chicken/Hubei/327/2004(H5N1)) infected in MDCK cells assessed as inhibition of early stages of viral replication at 10 uM up to 8 hrs by crystal violet staining based plaque reduction assay dependent time-of, NULL = NULL μM. | 30292897 | |
| MDCK | Antiviral assay | 100 uM | 12 hrs | Antiviral activity against Influenza virus A/X-31 infected in MDCK cells assessed as inhibition of one cycle viral RNA synthesis at 100 uM preincubated with cells for 12 hrs followed by viral infection measured after 10 hrs post infection by RT-qPCR metho, NULL = NULL μM. | 29906392 | |
| MDCK | Antiviral assay | 250 uM | 10 hrs | Antiviral activity against Influenza virus A/X-31 infected in MDCK cells assessed as inhibition of one cycle viral RNA sytheis at 250 uM added together with virus and measured at 10 hrs post infection by RT-qPCR method, NULL = NULL μM. | 29906392 | |
| 클릭하여 더 많은 세포주 실험 데이터 보기 | ||||||
화학 정보, 보관 및 안정성
| 분자량 | 157.1 | 화학식 | C5H4FN3O2 |
보관 (수령일로부터) | |
|---|---|---|---|---|---|
| CAS 번호 | 259793-96-9 | SDF 다운로드 | 원액 보관 |
|
|
| 동의어 | N/A | Smiles | C1=C(N=C(C(=O)N1)C(=O)N)F | ||
용해도
|
In vitro |
DMSO
: 31 mg/mL
(197.32 mM)
Water : 2 mg/mL Ethanol : 2 mg/mL |
몰농도 계산기
희석 계산기
분자량 계산기
|
In vivo |
|||||
생체 내 제형 계산기 (투명한 용액)
1단계: 아래 정보 입력 (권장: 실험 중 손실을 고려하여 추가 동물 포함)
mg/kg
g
μL
2단계: 생체 내 제형 입력 (이것은 계산기일 뿐 제형이 아닙니다. 용해도 섹션에 생체 내 제형이 없는 경우 먼저 당사에 문의하십시오.)
% DMSO
%
% Tween 80
% ddH2O
%DMSO
%
계산 결과:
작업 농도: mg/ml;
DMSO 원액 준비 방법: mg 약물 사전 용해 μL DMSO ( 원액 농도 mg/mL, 농도가 해당 약물 배치의 DMSO 용해도를 초과하는 경우 먼저 당사에 문의하십시오. )
생체 내 제형 준비 방법: 취하다 μL DMSO 원액, 다음 추가μL PEG300, 혼합하고 투명하게 한 다음 추가μL Tween 80, 혼합하고 투명하게 한 다음 추가 μL ddH2O, 혼합하고 투명하게 합니다.
생체 내 제형 준비 방법: 취하다 μL DMSO 원액, 다음 추가 μL 옥수수 기름, 혼합하고 투명하게 합니다.
참고: 1. 다음 용매를 추가하기 전에 액체가 투명한지 확인하십시오.
2. 용매를 순서대로 추가해야 합니다. 다음 용매를 추가하기 전에 이전 추가에서 얻은 용액이 투명한 용액인지 확인해야 합니다. 와동, 초음파 또는 뜨거운 물 중탕과 같은 물리적 방법을 사용하여 용해를 도울 수 있습니다.
작용 메커니즘
| Targets/IC50/Ki |
RNA-dependent RNA polymerase
|
|---|---|
| 시험관 내(In vitro) |
Favipiravir (T-705)은 인플루엔자 A 바이러스에 대해 0.013 ~ 0.48 μg/ml, 인플루엔자 B 바이러스에 대해 0.039 ~ 0.089 μg/ml, 인플루엔자 C 바이러스에 대해 0.030 ~ 0.057 μg/ml 범위의 IC50 값을 가진 항인플루엔자 바이러스 활성을 보입니다. 포유류 세포주(MDCK 세포, Vero 세포, HEL 세포, A549 세포, HeLa 세포 및 HEp-2 세포)에서 1,000 μg/ml까지의 농도에서 세포 독성을 보이지 않습니다. 계절성 인플루엔자 A (H1N1) 바이러스에 감염된 MDCK 세포에서 이 화합물은 치명적인 돌연변이를 유도합니다.
|
| 생체 내(In vivo) |
Favipiravir (T-705)은 200 mg/kg/day (p.o.)로 투여했을 때 인플루엔자 바이러스에 감염된 쥐를 사망으로부터 보호합니다. 에볼라 바이러스에 실험적으로 감염된 쥐에서 이 화합물은 바이러스 생산을 효율적으로 차단하여 치료 시작 후 2일 및 6일에 각각 95% 및 99.6%의 항바이러스 효과를 달성합니다.
|
참조 |
|
적용 분야
| 방법 | 바이오마커 | 이미지 | PMID |
|---|---|---|---|
| Growth inhibition assay | Survival Cell viability |
|
26711718 |
| IHC | H&E Staining NiV nucleoprotein LASV antigen H&E stain |
|
29765101 |
| Immunofluorescence | rNiV-Gluc |
|
29765101 |
임상시험 정보
(데이터 출처 https://clinicaltrials.gov, 업데이트 날짜 2024-05-22)
| NCT 번호 | 모집 | 조건 | 스폰서/협력자 | 시작일 | 단계 |
|---|---|---|---|---|---|
| NCT06024421 | Recruiting | Infectious Disease|Pharmacology |
Institut National de la Santé Et de la Recherche Médicale France|FUJIFILM Toyama Chemical Co. Ltd. |
April 2024 | Phase 1 |
| NCT05940545 | Recruiting | CCHF |
Liverpool School of Tropical Medicine |
July 12 2023 | Phase 1|Phase 2 |
| NCT04907682 | Completed | Lassa Fever |
Bernhard Nocht Institute for Tropical Medicine|University of Hamburg-Eppendorf|Alliance for International Medical Action|Institut National de la Santé Et de la Recherche Médicale France|University of Bordeaux|Federal Medical Centre Owo|Irrua Specialist Teaching Hospital |
July 30 2021 | Phase 2 |
기술 지원
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