연구용
Obatoclax Mesylate (GX15-070) Bcl-2 길항제
제품 번호S1057
화학 구조
분자량: 413.49
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품질 관리
배치:
순도:
99.85%
99.85
세포 배양, 처리 및 작업 농도
| 세포주 | 분석 유형 | 농도 | 배양 시간 | 제형 | 활성 설명 | PMID |
|---|---|---|---|---|---|---|
| KARPAS-45 | Growth Inhibition Assay | IC50=0.0000317 μM | SANGER | |||
| SK-MEL-30 | Growth Inhibition Assay | IC50=0.000355 μM | SANGER | |||
| NALM-6 | Growth Inhibition Assay | IC50=0.000356 μM | SANGER | |||
| KYSE-450 | Growth Inhibition Assay | IC50=0.000469 μM | SANGER | |||
| BHY | Growth Inhibition Assay | IC50=0.000601 μM | SANGER | |||
| GR-ST | Growth Inhibition Assay | IC50=0.000648 μM | SANGER | |||
| 786-0 | Growth Inhibition Assay | IC50=0.000776 μM | SANGER | |||
| C-33-A | Growth Inhibition Assay | IC50=0.000848 μM | SANGER | |||
| BHT-101 | Growth Inhibition Assay | IC50=0.00106 μM | SANGER | |||
| EB2 | Growth Inhibition Assay | IC50=0.00118 μM | SANGER | |||
| G-361 | Growth Inhibition Assay | IC50=0.00124 μM | SANGER | |||
| KE-37 | Growth Inhibition Assay | IC50=0.00128 μM | SANGER | |||
| MHH-PREB-1 | Growth Inhibition Assay | IC50=0.0014 μM | SANGER | |||
| MCF7 | Growth Inhibition Assay | IC50=0.00159 μM | SANGER | |||
| LOUCY | Growth Inhibition Assay | IC50=0.00175 μM | SANGER | |||
| EW-7 | Growth Inhibition Assay | IC50=0.00175 μM | SANGER | |||
| KYSE-510 | Growth Inhibition Assay | IC50=0.00233 μM | SANGER | |||
| SK-MEL-3 | Growth Inhibition Assay | IC50=0.00264 μM | SANGER | |||
| HAL-01 | Growth Inhibition Assay | IC50=0.00297 μM | SANGER | |||
| HCC2998 | Growth Inhibition Assay | IC50=0.00335 μM | SANGER | |||
| A375 | Growth Inhibition Assay | IC50=0.0035 μM | SANGER | |||
| MZ7-mel | Growth Inhibition Assay | IC50=0.00399 μM | SANGER | |||
| SH-4 | Growth Inhibition Assay | IC50=0.00417 μM | SANGER | |||
| HT-144 | Growth Inhibition Assay | IC50=0.0043 μM | SANGER | |||
| KYSE-140 | Growth Inhibition Assay | IC50=0.00435 μM | SANGER | |||
| PSN1 | Growth Inhibition Assay | IC50=0.00467 μM | SANGER | |||
| COLO-679 | Growth Inhibition Assay | IC50=0.00498 μM | SANGER | |||
| SW620 | Growth Inhibition Assay | IC50=0.00511 μM | SANGER | |||
| HGC-27 | Growth Inhibition Assay | IC50=0.00524 μM | SANGER | |||
| IGROV-1 | Growth Inhibition Assay | IC50=0.006 μM | SANGER | |||
| IGR-1 | Growth Inhibition Assay | IC50=0.00601 μM | SANGER | |||
| EW-1 | Growth Inhibition Assay | IC50=0.00651 μM | SANGER | |||
| 769-P | Growth Inhibition Assay | IC50=0.00678 μM | SANGER | |||
| HN | Growth Inhibition Assay | IC50=0.00679 μM | SANGER | |||
| SIG-M5 | Growth Inhibition Assay | IC50=0.0071 μM | SANGER | |||
| IST-MEL1 | Growth Inhibition Assay | IC50=0.00818 μM | SANGER | |||
| ST486 | Growth Inhibition Assay | IC50=0.00825 μM | SANGER | |||
| ES7 | Growth Inhibition Assay | IC50=0.00846 μM | SANGER | |||
| GAK | Growth Inhibition Assay | IC50=0.00848 μM | SANGER | |||
| BB30-HNC | Growth Inhibition Assay | IC50=0.00858 μM | SANGER | |||
| IPC-298 | Growth Inhibition Assay | IC50=0.00927 μM | SANGER | |||
| NKM-1 | Growth Inhibition Assay | IC50=0.00972 μM | SANGER | |||
| RKO | Growth Inhibition Assay | IC50=0.01044 μM | SANGER | |||
| ACN | Growth Inhibition Assay | IC50=0.01131 μM | SANGER | |||
| SW1417 | Growth Inhibition Assay | IC50=0.01225 μM | SANGER | |||
| SR | Growth Inhibition Assay | IC50=0.01235 μM | SANGER | |||
| SNG-M | Growth Inhibition Assay | IC50=0.01317 μM | SANGER | |||
| CAL-12T | Growth Inhibition Assay | IC50=0.01346 μM | SANGER | |||
| HSC-3 | Growth Inhibition Assay | IC50=0.01355 μM | SANGER | |||
| DOHH-2 | Growth Inhibition Assay | IC50=0.01412 μM | SANGER | |||
| NB69 | Growth Inhibition Assay | IC50=0.01565 μM | SANGER | |||
| LC-2-ad | Growth Inhibition Assay | IC50=0.01581 μM | SANGER | |||
| RVH-421 | Growth Inhibition Assay | IC50=0.01674 μM | SANGER | |||
| TGW | Growth Inhibition Assay | IC50=0.01739 μM | SANGER | |||
| HCC1569 | Growth Inhibition Assay | IC50=0.01797 μM | SANGER | |||
| CAL-85-1 | Growth Inhibition Assay | IC50=0.01832 μM | SANGER | |||
| RPMI-8402 | Growth Inhibition Assay | IC50=0.01858 μM | SANGER | |||
| THP-1 | Growth Inhibition Assay | IC50=0.01998 μM | SANGER | |||
| ONS-76 | Growth Inhibition Assay | IC50=0.02036 μM | SANGER | |||
| A2780 | Growth Inhibition Assay | IC50=0.02079 μM | SANGER | |||
| RPMI-2650 | Growth Inhibition Assay | IC50=0.02296 μM | SANGER | |||
| MEL-HO | Growth Inhibition Assay | IC50=0.02348 μM | SANGER | |||
| MC-CAR | Growth Inhibition Assay | IC50=0.02356 μM | SANGER | |||
| HSC-2 | Growth Inhibition Assay | IC50=0.02466 μM | SANGER | |||
| MEL-JUSO | Growth Inhibition Assay | IC50=0.02473 μM | SANGER | |||
| CAL-62 | Growth Inhibition Assay | IC50=0.02602 μM | SANGER | |||
| DMS-273 | Growth Inhibition Assay | IC50=0.02847 μM | SANGER | |||
| S-117 | Growth Inhibition Assay | IC50=0.02906 μM | SANGER | |||
| SUP-T1 | Growth Inhibition Assay | IC50=0.02949 μM | SANGER | |||
| MZ2-MEL | Growth Inhibition Assay | IC50=0.02959 μM | SANGER | |||
| KYSE-270 | Growth Inhibition Assay | IC50=0.02976 μM | SANGER | |||
| CMK | Growth Inhibition Assay | IC50=0.03023 μM | SANGER | |||
| 8505C | Growth Inhibition Assay | IC50=0.0304 μM | SANGER | |||
| NUGC-3 | Growth Inhibition Assay | IC50=0.03048 μM | SANGER | |||
| A101D | Growth Inhibition Assay | IC50=0.03055 μM | SANGER | |||
| G-401 | Growth Inhibition Assay | IC50=0.03093 μM | SANGER | |||
| OVCAR-8 | Growth Inhibition Assay | IC50=0.03107 μM | SANGER | |||
| IMR-5 | Growth Inhibition Assay | IC50=0.03244 μM | SANGER | |||
| DoTc2-4510 | Growth Inhibition Assay | IC50=0.03393 μM | SANGER | |||
| HOS | Growth Inhibition Assay | IC50=0.03473 μM | SANGER | |||
| HEC-1 | Growth Inhibition Assay | IC50=0.0368 μM | SANGER | |||
| SW756 | Growth Inhibition Assay | IC50=0.03821 μM | SANGER | |||
| NCI-H64 | Growth Inhibition Assay | IC50=0.03842 μM | SANGER | |||
| EW-16 | Growth Inhibition Assay | IC50=0.03909 μM | SANGER | |||
| CAL-51 | Growth Inhibition Assay | IC50=0.04005 μM | SANGER | |||
| KYSE-150 | Growth Inhibition Assay | IC50=0.04011 μM | SANGER | |||
| SW1710 | Growth Inhibition Assay | IC50=0.04018 μM | SANGER | |||
| HuP-T4 | Growth Inhibition Assay | IC50=0.04118 μM | SANGER | |||
| LB373-MEL-D | Growth Inhibition Assay | IC50=0.04232 μM | SANGER | |||
| EW-13 | Growth Inhibition Assay | IC50=0.04406 μM | SANGER | |||
| HT-29 | Growth Inhibition Assay | IC50=0.0449 μM | SANGER | |||
| SCC-25 | Growth Inhibition Assay | IC50=0.04494 μM | SANGER | |||
| REH | Growth Inhibition Assay | IC50=0.04635 μM | SANGER | |||
| L-363 | Growth Inhibition Assay | IC50=0.04679 μM | SANGER | |||
| NCI-H1770 | Growth Inhibition Assay | IC50=0.04697 μM | SANGER | |||
| CHL-1 | Growth Inhibition Assay | IC50=0.04857 μM | SANGER | |||
| ES1 | Growth Inhibition Assay | IC50=0.04885 μM | SANGER | |||
| SCC-15 | Growth Inhibition Assay | IC50=0.04902 μM | SANGER | |||
| MRK-nu-1 | Growth Inhibition Assay | IC50=0.04936 μM | SANGER | |||
| PF-382 | Growth Inhibition Assay | IC50=0.04939 μM | SANGER | |||
| COLO-680N | Growth Inhibition Assay | IC50=0.05047 μM | SANGER | |||
| LK-2 | Growth Inhibition Assay | IC50=0.05063 μM | SANGER | |||
| NCI-H2342 | Growth Inhibition Assay | IC50=0.05117 μM | SANGER | |||
| HMV-II | Growth Inhibition Assay | IC50=0.05239 μM | SANGER | |||
| PC-14 | Growth Inhibition Assay | IC50=0.05252 μM | SANGER | |||
| COLO-320-HSR | Growth Inhibition Assay | IC50=0.05289 μM | SANGER | |||
| 697 | Growth Inhibition Assay | IC50=0.05323 μM | SANGER | |||
| NEC8 | Growth Inhibition Assay | IC50=0.0559 μM | SANGER | |||
| LCLC-97TM1 | Growth Inhibition Assay | IC50=0.05594 μM | SANGER | |||
| Daoy | Growth Inhibition Assay | IC50=0.05616 μM | SANGER | |||
| ETK-1 | Growth Inhibition Assay | IC50=0.05672 μM | SANGER | |||
| A388 | Growth Inhibition Assay | IC50=0.05695 μM | SANGER | |||
| COLO-205 | Growth Inhibition Assay | IC50=0.05716 μM | SANGER | |||
| SK-PN-DW | Growth Inhibition Assay | IC50=0.05729 μM | SANGER | |||
| SF268 | Growth Inhibition Assay | IC50=0.05756 μM | SANGER | |||
| OCI-AML2 | Growth Inhibition Assay | IC50=0.05777 μM | SANGER | |||
| GAMG | Growth Inhibition Assay | IC50=0.058 μM | SANGER | |||
| BCPAP | Growth Inhibition Assay | IC50=0.05892 μM | SANGER | |||
| BC-1 | Growth Inhibition Assay | IC50=0.06022 μM | SANGER | |||
| IA-LM | Growth Inhibition Assay | IC50=0.06053 μM | SANGER | |||
| NCI-H1299 | Growth Inhibition Assay | IC50=0.0613 μM | SANGER | |||
| COR-L23 | Growth Inhibition Assay | IC50=0.06134 μM | SANGER | |||
| KYSE-180 | Growth Inhibition Assay | IC50=0.06142 μM | SANGER | |||
| LOXIMVI | Growth Inhibition Assay | IC50=0.06188 μM | SANGER | |||
| BL-41 | Growth Inhibition Assay | IC50=0.06219 μM | SANGER | |||
| BL-70 | Growth Inhibition Assay | IC50=0.06302 μM | SANGER | |||
| NOS-1 | Growth Inhibition Assay | IC50=0.06411 μM | SANGER | |||
| NB13 | Growth Inhibition Assay | IC50=0.06421 μM | SANGER | |||
| CAL-27 | Growth Inhibition Assay | IC50=0.06464 μM | SANGER | |||
| CA46 | Growth Inhibition Assay | IC50=0.06537 μM | SANGER | |||
| SW962 | Growth Inhibition Assay | IC50=0.06569 μM | SANGER | |||
| NCI-H226 | Growth Inhibition Assay | IC50=0.06632 μM | SANGER | |||
| KYSE-70 | Growth Inhibition Assay | IC50=0.06945 μM | SANGER | |||
| Daudi | Growth Inhibition Assay | IC50=0.07081 μM | SANGER | |||
| SW626 | Growth Inhibition Assay | IC50=0.07204 μM | SANGER | |||
| ESS-1 | Growth Inhibition Assay | IC50=0.07246 μM | SANGER | |||
| YT | Growth Inhibition Assay | IC50=0.07345 μM | SANGER | |||
| P12-ICHIKAWA | Growth Inhibition Assay | IC50=0.07349 μM | SANGER | |||
| BxPC-3 | Growth Inhibition Assay | IC50=0.07458 μM | SANGER | |||
| CTV-1 | Growth Inhibition Assay | IC50=0.07517 μM | SANGER | |||
| MLMA | Growth Inhibition Assay | IC50=0.07534 μM | SANGER | |||
| WSU-NHL | Growth Inhibition Assay | IC50=0.07554 μM | SANGER | |||
| CTB-1 | Growth Inhibition Assay | IC50=0.07588 μM | SANGER | |||
| MMAC-SF | Growth Inhibition Assay | IC50=0.07668 μM | SANGER | |||
| 8-MG-BA | Growth Inhibition Assay | IC50=0.07801 μM | SANGER | |||
| NCI-H358 | Growth Inhibition Assay | IC50=0.07879 μM | SANGER | |||
| BFTC-905 | Growth Inhibition Assay | IC50=0.07909 μM | SANGER | |||
| NCI-H727 | Growth Inhibition Assay | IC50=0.08053 μM | SANGER | |||
| CHP-212 | Growth Inhibition Assay | IC50=0.08095 μM | SANGER | |||
| HOP-62 | Growth Inhibition Assay | IC50=0.08245 μM | SANGER | |||
| CESS | Growth Inhibition Assay | IC50=0.08269 μM | SANGER | |||
| HuCCT1 | Growth Inhibition Assay | IC50=0.08333 μM | SANGER | |||
| DEL | Growth Inhibition Assay | IC50=0.08347 μM | SANGER | |||
| 5637 | Growth Inhibition Assay | IC50=0.08367 μM | SANGER | |||
| RS4-11 | Growth Inhibition Assay | IC50=0.08497 μM | SANGER | |||
| KURAMOCHI | Growth Inhibition Assay | IC50=0.08509 μM | SANGER | |||
| A427 | Growth Inhibition Assay | IC50=0.08512 μM | SANGER | |||
| A3-KAW | Growth Inhibition Assay | IC50=0.08566 μM | SANGER | |||
| LS-123 | Growth Inhibition Assay | IC50=0.08719 μM | SANGER | |||
| LoVo | Growth Inhibition Assay | IC50=0.0872 μM | SANGER | |||
| PA-1 | Growth Inhibition Assay | IC50=0.08769 μM | SANGER | |||
| CP50-MEL-B | Growth Inhibition Assay | IC50=0.08793 μM | SANGER | |||
| A431 | Growth Inhibition Assay | IC50=0.08801 μM | SANGER | |||
| HCT-116 | Growth Inhibition Assay | IC50=0.08802 μM | SANGER | |||
| A4-Fuk | Growth Inhibition Assay | IC50=0.08947 μM | SANGER | |||
| RPMI-6666 | Growth Inhibition Assay | IC50=0.08967 μM | SANGER | |||
| Calu-6 | Growth Inhibition Assay | IC50=0.09029 μM | SANGER | |||
| KMOE-2 | Growth Inhibition Assay | IC50=0.09039 μM | SANGER | |||
| A704 | Growth Inhibition Assay | IC50=0.0915 μM | SANGER | |||
| HO-1-N-1 | Growth Inhibition Assay | IC50=0.09249 μM | SANGER | |||
| NCI-H2122 | Growth Inhibition Assay | IC50=0.09378 μM | SANGER | |||
| U-698-M | Growth Inhibition Assay | IC50=0.09409 μM | SANGER | |||
| IST-SL2 | Growth Inhibition Assay | IC50=0.09468 μM | SANGER | |||
| TE-10 | Growth Inhibition Assay | IC50=0.09584 μM | SANGER | |||
| PANC-03-27 | Growth Inhibition Assay | IC50=0.09671 μM | SANGER | |||
| KYSE-410 | Growth Inhibition Assay | IC50=0.09797 μM | SANGER | |||
| TE-8 | Growth Inhibition Assay | IC50=0.09885 μM | SANGER | |||
| MN-60 | Growth Inhibition Assay | IC50=0.09897 μM | SANGER | |||
| NCI-H460 | Growth Inhibition Assay | IC50=0.1009 μM | SANGER | |||
| LB771-HNC | Growth Inhibition Assay | IC50=0.10255 μM | SANGER | |||
| ES4 | Growth Inhibition Assay | IC50=0.10264 μM | SANGER | |||
| HUTU-80 | Growth Inhibition Assay | IC50=0.10365 μM | SANGER | |||
| 647-V | Growth Inhibition Assay | IC50=0.10408 μM | SANGER | |||
| HTC-C3 | Growth Inhibition Assay | IC50=0.10432 μM | SANGER | |||
| NTERA-S-cl-D1 | Growth Inhibition Assay | IC50=0.10448 μM | SANGER | |||
| A2058 | Growth Inhibition Assay | IC50=0.10655 μM | SANGER | |||
| MZ1-PC | Growth Inhibition Assay | IC50=0.1083 μM | SANGER | |||
| J82 | Growth Inhibition Assay | IC50=0.10884 μM | SANGER | |||
| ARH-77 | Growth Inhibition Assay | IC50=0.11 μM | SANGER | |||
| Ca9-22 | Growth Inhibition Assay | IC50=0.11128 μM | SANGER | |||
| NCI-H1648 | Growth Inhibition Assay | IC50=0.11286 μM | SANGER | |||
| MC116 | Growth Inhibition Assay | IC50=0.11337 μM | SANGER | |||
| EoL-1-cell | Growth Inhibition Assay | IC50=0.11467 μM | SANGER | |||
| PANC-10-05 | Growth Inhibition Assay | IC50=0.11491 μM | SANGER | |||
| SF539 | Growth Inhibition Assay | IC50=0.11616 μM | SANGER | |||
| ES8 | Growth Inhibition Assay | IC50=0.11633 μM | SANGER | |||
| NCI-H810 | Growth Inhibition Assay | IC50=0.11664 μM | SANGER | |||
| J-RT3-T3-5 | Growth Inhibition Assay | IC50=0.1175 μM | SANGER | |||
| NY | Growth Inhibition Assay | IC50=0.11817 μM | SANGER | |||
| NCI-SNU-1 | Growth Inhibition Assay | IC50=0.12148 μM | SANGER | |||
| EFM-19 | Growth Inhibition Assay | IC50=0.12374 μM | SANGER | |||
| HCC1806 | Growth Inhibition Assay | IC50=0.12383 μM | SANGER | |||
| HCE-T | Growth Inhibition Assay | IC50=0.12531 μM | SANGER | |||
| HT-1376 | Growth Inhibition Assay | IC50=0.12668 μM | SANGER | |||
| BE-13 | Growth Inhibition Assay | IC50=0.12866 μM | SANGER | |||
| NCI-H520 | Growth Inhibition Assay | IC50=0.12867 μM | SANGER | |||
| SK-MES-1 | Growth Inhibition Assay | IC50=0.12913 μM | SANGER | |||
| SNU-423 | Growth Inhibition Assay | IC50=0.12914 μM | SANGER | |||
| Ramos-2G6-4C10 | Growth Inhibition Assay | IC50=0.12916 μM | SANGER | |||
| EW-18 | Growth Inhibition Assay | IC50=0.13026 μM | SANGER | |||
| NCI-H2087 | Growth Inhibition Assay | IC50=0.13027 μM | SANGER | |||
| COLO-792 | Growth Inhibition Assay | IC50=0.13165 μM | SANGER | |||
| QIMR-WIL | Growth Inhibition Assay | IC50=0.13223 μM | SANGER | |||
| ACHN | Growth Inhibition Assay | IC50=0.13247 μM | SANGER | |||
| RPMI-8866 | Growth Inhibition Assay | IC50=0.13261 μM | SANGER | |||
| SK-LU-1 | Growth Inhibition Assay | IC50=0.13449 μM | SANGER | |||
| SK-UT-1 | Growth Inhibition Assay | IC50=0.13628 μM | SANGER | |||
| MFE-296 | Growth Inhibition Assay | IC50=0.13864 μM | SANGER | |||
| RD | Growth Inhibition Assay | IC50=0.13997 μM | SANGER | |||
| LS-411N | Growth Inhibition Assay | IC50=0.14295 μM | SANGER | |||
| NCI-H747 | Growth Inhibition Assay | IC50=0.143 μM | SANGER | |||
| ES6 | Growth Inhibition Assay | IC50=0.1436 μM | SANGER | |||
| TE-1 | Growth Inhibition Assay | IC50=0.14407 μM | SANGER | |||
| SJSA-1 | Growth Inhibition Assay | IC50=0.14707 μM | SANGER | |||
| NCI-H1355 | Growth Inhibition Assay | IC50=0.15293 μM | SANGER | |||
| HEL | Growth Inhibition Assay | IC50=0.15447 μM | SANGER | |||
| 639-V | Growth Inhibition Assay | IC50=0.15596 μM | SANGER | |||
| AN3-CA | Growth Inhibition Assay | IC50=0.15639 μM | SANGER | |||
| SK-MEL-2 | Growth Inhibition Assay | IC50=0.15668 μM | SANGER | |||
| SW872 | Growth Inhibition Assay | IC50=0.16042 μM | SANGER | |||
| DU-4475 | Growth Inhibition Assay | IC50=0.16162 μM | SANGER | |||
| YKG-1 | Growth Inhibition Assay | IC50=0.16273 μM | SANGER | |||
| GT3TKB | Growth Inhibition Assay | IC50=0.16283 μM | SANGER | |||
| GB-1 | Growth Inhibition Assay | IC50=0.16424 μM | SANGER | |||
| KARPAS-422 | Growth Inhibition Assay | IC50=0.16574 μM | SANGER | |||
| ATN-1 | Growth Inhibition Assay | IC50=0.16656 μM | SANGER | |||
| HLE | Growth Inhibition Assay | IC50=0.16877 μM | SANGER | |||
| D-542MG | Growth Inhibition Assay | IC50=0.16986 μM | SANGER | |||
| EB-3 | Growth Inhibition Assay | IC50=0.1731 μM | SANGER | |||
| HCC1143 | Growth Inhibition Assay | IC50=0.17396 μM | SANGER | |||
| DJM-1 | Growth Inhibition Assay | IC50=0.17451 μM | SANGER | |||
| BT-474 | Growth Inhibition Assay | IC50=0.17489 μM | SANGER | |||
| BB65-RCC | Growth Inhibition Assay | IC50=0.17545 μM | SANGER | |||
| NCI-H292 | Growth Inhibition Assay | IC50=0.17601 μM | SANGER | |||
| MKN28 | Growth Inhibition Assay | IC50=0.17653 μM | SANGER | |||
| TK10 | Growth Inhibition Assay | IC50=0.17702 μM | SANGER | |||
| TYK-nu | Growth Inhibition Assay | IC50=0.17949 μM | SANGER | |||
| 8305C | Growth Inhibition Assay | IC50=0.17971 μM | SANGER | |||
| MV-4-11 | Growth Inhibition Assay | IC50=0.17977 μM | SANGER | |||
| NCI-H522 | Growth Inhibition Assay | IC50=0.18094 μM | SANGER | |||
| Hs-578-T | Growth Inhibition Assay | IC50=0.18292 μM | SANGER | |||
| LCLC-103H | Growth Inhibition Assay | IC50=0.18527 μM | SANGER | |||
| MHH-ES-1 | Growth Inhibition Assay | IC50=0.18629 μM | SANGER | |||
| NCI-H441 | Growth Inhibition Assay | IC50=0.19148 μM | SANGER | |||
| AM-38 | Growth Inhibition Assay | IC50=0.19225 μM | SANGER | |||
| SW1783 | Growth Inhibition Assay | IC50=0.19305 μM | SANGER | |||
| SK-HEP-1 | Growth Inhibition Assay | IC50=0.19637 μM | SANGER | |||
| OAW-28 | Growth Inhibition Assay | IC50=0.20178 μM | SANGER | |||
| TE-15 | Growth Inhibition Assay | IC50=0.20252 μM | SANGER | |||
| HCE-4 | Growth Inhibition Assay | IC50=0.20284 μM | SANGER | |||
| JiyoyeP-2003 | Growth Inhibition Assay | IC50=0.20336 μM | SANGER | |||
| OVCAR-4 | Growth Inhibition Assay | IC50=0.20628 μM | SANGER | |||
| SNU-449 | Growth Inhibition Assay | IC50=0.20797 μM | SANGER | |||
| SBC-5 | Growth Inhibition Assay | IC50=0.21215 μM | SANGER | |||
| T84 | Growth Inhibition Assay | IC50=0.21248 μM | SANGER | |||
| LP-1 | Growth Inhibition Assay | IC50=0.21302 μM | SANGER | |||
| MG-63 | Growth Inhibition Assay | IC50=0.21382 μM | SANGER | |||
| OAW-42 | Growth Inhibition Assay | IC50=0.21478 μM | SANGER | |||
| L-540 | Growth Inhibition Assay | IC50=0.21598 μM | SANGER | |||
| RH-1 | Growth Inhibition Assay | IC50=0.22242 μM | SANGER | |||
| HCT-15 | Growth Inhibition Assay | IC50=0.22484 μM | SANGER | |||
| OCUB-M | Growth Inhibition Assay | IC50=0.22488 μM | SANGER | |||
| GP5d | Growth Inhibition Assay | IC50=0.22528 μM | SANGER | |||
| NCI-H2030 | Growth Inhibition Assay | IC50=0.22734 μM | SANGER | |||
| ML-2 | Growth Inhibition Assay | IC50=0.22889 μM | SANGER | |||
| CAL-39 | Growth Inhibition Assay | IC50=0.22936 μM | SANGER | |||
| MIA-PaCa-2 | Growth Inhibition Assay | IC50=0.23287 μM | SANGER | |||
| TE-9 | Growth Inhibition Assay | IC50=0.2332 μM | SANGER | |||
| LB2518-MEL | Growth Inhibition Assay | IC50=0.23372 μM | SANGER | |||
| DB | Growth Inhibition Assay | IC50=0.23438 μM | SANGER | |||
| NCI-H596 | Growth Inhibition Assay | IC50=0.23571 μM | SANGER | |||
| SW1990 | Growth Inhibition Assay | IC50=0.23946 μM | SANGER | |||
| P30-OHK | Growth Inhibition Assay | IC50=0.2405 μM | SANGER | |||
| ALL-PO | Growth Inhibition Assay | IC50=0.24169 μM | SANGER | |||
| Saos-2 | Growth Inhibition Assay | IC50=0.24571 μM | SANGER | |||
| MFH-ino | Growth Inhibition Assay | IC50=0.24692 μM | SANGER | |||
| OE33 | Growth Inhibition Assay | IC50=0.2511 μM | SANGER | |||
| Calu-3 | Growth Inhibition Assay | IC50=0.25297 μM | SANGER | |||
| HT | Growth Inhibition Assay | IC50=0.25621 μM | SANGER | |||
| LXF-289 | Growth Inhibition Assay | IC50=0.25984 μM | SANGER | |||
| KGN | Growth Inhibition Assay | IC50=0.26089 μM | SANGER | |||
| NCI-H1417 | Growth Inhibition Assay | IC50=0.26524 μM | SANGER | |||
| SF126 | Growth Inhibition Assay | IC50=0.27302 μM | SANGER | |||
| SAS | Growth Inhibition Assay | IC50=0.27308 μM | SANGER | |||
| 22RV1 | Growth Inhibition Assay | IC50=0.27378 μM | SANGER | |||
| GI-1 | Growth Inhibition Assay | IC50=0.27487 μM | SANGER | |||
| ES3 | Growth Inhibition Assay | IC50=0.27763 μM | SANGER | |||
| NB1 | Growth Inhibition Assay | IC50=0.27876 μM | SANGER | |||
| NCI-H650 | Growth Inhibition Assay | IC50=0.28302 μM | SANGER | |||
| IST-MES1 | Growth Inhibition Assay | IC50=0.28554 μM | SANGER | |||
| UM-UC-3 | Growth Inhibition Assay | IC50=0.2914 μM | SANGER | |||
| CAL-120 | Growth Inhibition Assay | IC50=0.29631 μM | SANGER | |||
| UACC-62 | Growth Inhibition Assay | IC50=0.30241 μM | SANGER | |||
| TE-11 | Growth Inhibition Assay | IC50=0.30249 μM | SANGER | |||
| MKN1 | Growth Inhibition Assay | IC50=0.3036 μM | SANGER | |||
| KS-1 | Growth Inhibition Assay | IC50=0.30526 μM | SANGER | |||
| GCIY | Growth Inhibition Assay | IC50=0.31002 μM | SANGER | |||
| OVCAR-5 | Growth Inhibition Assay | IC50=0.31106 μM | SANGER | |||
| U-266 | Growth Inhibition Assay | IC50=0.31147 μM | SANGER | |||
| Calu-1 | Growth Inhibition Assay | IC50=0.31289 μM | SANGER | |||
| SK-LMS-1 | Growth Inhibition Assay | IC50=0.31429 μM | SANGER | |||
| COLO-741 | Growth Inhibition Assay | IC50=0.31614 μM | SANGER | |||
| RPMI-8226 | Growth Inhibition Assay | IC50=0.31641 μM | SANGER | |||
| KM12 | Growth Inhibition Assay | IC50=0.3183 μM | SANGER | |||
| NMC-G1 | Growth Inhibition Assay | IC50=0.3186 μM | SANGER | |||
| SJRH30 | Growth Inhibition Assay | IC50=0.32052 μM | SANGER | |||
| COR-L105 | Growth Inhibition Assay | IC50=0.32218 μM | SANGER | |||
| IM-9 | Growth Inhibition Assay | IC50=0.33021 μM | SANGER | |||
| TE-12 | Growth Inhibition Assay | IC50=0.33317 μM | SANGER | |||
| KG-1 | Growth Inhibition Assay | IC50=0.33432 μM | SANGER | |||
| U251 | Growth Inhibition Assay | IC50=0.33456 μM | SANGER | |||
| EFO-27 | Growth Inhibition Assay | IC50=0.33951 μM | SANGER | |||
| EW-24 | Growth Inhibition Assay | IC50=0.33984 μM | SANGER | |||
| SF295 | Growth Inhibition Assay | IC50=0.33999 μM | SANGER | |||
| MC-IXC | Growth Inhibition Assay | IC50=0.345 μM | SANGER | |||
| NCI-H2405 | Growth Inhibition Assay | IC50=0.34732 μM | SANGER | |||
| NCI-H2009 | Growth Inhibition Assay | IC50=0.34739 μM | SANGER | |||
| LB1047-RCC | Growth Inhibition Assay | IC50=0.35815 μM | SANGER | |||
| KNS-81-FD | Growth Inhibition Assay | IC50=0.36667 μM | SANGER | |||
| HOP-92 | Growth Inhibition Assay | IC50=0.3683 μM | SANGER | |||
| L-428 | Growth Inhibition Assay | IC50=0.37016 μM | SANGER | |||
| C3A | Growth Inhibition Assay | IC50=0.37379 μM | SANGER | |||
| NCI-H1792 | Growth Inhibition Assay | IC50=0.37655 μM | SANGER | |||
| HuH-7 | Growth Inhibition Assay | IC50=0.3791 μM | SANGER | |||
| AGS | Growth Inhibition Assay | IC50=0.38638 μM | SANGER | |||
| HT-1197 | Growth Inhibition Assay | IC50=0.3946 μM | SANGER | |||
| CGTH-W-1 | Growth Inhibition Assay | IC50=0.39913 μM | SANGER | |||
| KNS-42 | Growth Inhibition Assay | IC50=0.40045 μM | SANGER | |||
| HuO-3N1 | Growth Inhibition Assay | IC50=0.40055 μM | SANGER | |||
| VMRC-RCZ | Growth Inhibition Assay | IC50=0.40303 μM | SANGER | |||
| SW954 | Growth Inhibition Assay | IC50=0.40335 μM | SANGER | |||
| MES-SA | Growth Inhibition Assay | IC50=0.40505 μM | SANGER | |||
| Ca-Ski | Growth Inhibition Assay | IC50=0.40524 μM | SANGER | |||
| SW13 | Growth Inhibition Assay | IC50=0.40626 μM | SANGER | |||
| NCI-H1437 | Growth Inhibition Assay | IC50=0.40805 μM | SANGER | |||
| U-118-MG | Growth Inhibition Assay | IC50=0.40904 μM | SANGER | |||
| NCI-H1734 | Growth Inhibition Assay | IC50=0.42013 μM | SANGER | |||
| HDLM-2 | Growth Inhibition Assay | IC50=0.42033 μM | SANGER | |||
| AU565 | Growth Inhibition Assay | IC50=0.42468 μM | SANGER | |||
| FADU | Growth Inhibition Assay | IC50=0.42649 μM | SANGER | |||
| OS-RC-2 | Growth Inhibition Assay | IC50=0.43083 μM | SANGER | |||
| CAMA-1 | Growth Inhibition Assay | IC50=0.43626 μM | SANGER | |||
| MONO-MAC-6 | Growth Inhibition Assay | IC50=0.43849 μM | SANGER | |||
| LB831-BLC | Growth Inhibition Assay | IC50=0.44371 μM | SANGER | |||
| SW982 | Growth Inhibition Assay | IC50=0.44528 μM | SANGER | |||
| SCC-3 | Growth Inhibition Assay | IC50=0.44579 μM | SANGER | |||
| C32 | Growth Inhibition Assay | IC50=0.45229 μM | SANGER | |||
| BFTC-909 | Growth Inhibition Assay | IC50=0.45299 μM | SANGER | |||
| MEG-01 | Growth Inhibition Assay | IC50=0.45373 μM | SANGER | |||
| M14 | Growth Inhibition Assay | IC50=0.45979 μM | SANGER | |||
| MPP-89 | Growth Inhibition Assay | IC50=0.46256 μM | SANGER | |||
| HCC1937 | Growth Inhibition Assay | IC50=0.46384 μM | SANGER | |||
| SW837 | Growth Inhibition Assay | IC50=0.46722 μM | SANGER | |||
| DU-145 | Growth Inhibition Assay | IC50=0.46729 μM | SANGER | |||
| LB996-RCC | Growth Inhibition Assay | IC50=0.47054 μM | SANGER | |||
| C8166 | Growth Inhibition Assay | IC50=0.474 μM | SANGER | |||
| MOLT-4 | Growth Inhibition Assay | IC50=0.47734 μM | SANGER | |||
| DMS-53 | Growth Inhibition Assay | IC50=0.47809 μM | SANGER | |||
| TE-5 | Growth Inhibition Assay | IC50=0.48305 μM | SANGER | |||
| KYSE-520 | Growth Inhibition Assay | IC50=0.48343 μM | SANGER | |||
| Detroit562 | Growth Inhibition Assay | IC50=0.4886 μM | SANGER | |||
| SIMA | Growth Inhibition Assay | IC50=0.49417 μM | SANGER | |||
| NCI-H1651 | Growth Inhibition Assay | IC50=0.4967 μM | SANGER | |||
| HCC1599 | Growth Inhibition Assay | IC50=0.49955 μM | SANGER | |||
| ABC-1 | Growth Inhibition Assay | IC50=0.50496 μM | SANGER | |||
| CAL-33 | Growth Inhibition Assay | IC50=0.50844 μM | SANGER | |||
| OPM-2 | Growth Inhibition Assay | IC50=0.50937 μM | SANGER | |||
| RPMI-7951 | Growth Inhibition Assay | IC50=0.50957 μM | SANGER | |||
| HT-1080 | Growth Inhibition Assay | IC50=0.51119 μM | SANGER | |||
| LC4-1 | Growth Inhibition Assay | IC50=0.51403 μM | SANGER | |||
| OVCAR-3 | Growth Inhibition Assay | IC50=0.5157 μM | SANGER | |||
| CAPAN-1 | Growth Inhibition Assay | IC50=0.52288 μM | SANGER | |||
| SK-OV-3 | Growth Inhibition Assay | IC50=0.52434 μM | SANGER | |||
| HuP-T3 | Growth Inhibition Assay | IC50=0.52827 μM | SANGER | |||
| NCI-H838 | Growth Inhibition Assay | IC50=0.52849 μM | SANGER | |||
| K5 | Growth Inhibition Assay | IC50=0.53201 μM | SANGER | |||
| CAL-72 | Growth Inhibition Assay | IC50=0.53387 μM | SANGER | |||
| NH-12 | Growth Inhibition Assay | IC50=0.53959 μM | SANGER | |||
| SNB75 | Growth Inhibition Assay | IC50=0.5573 μM | SANGER | |||
| BPH-1 | Growth Inhibition Assay | IC50=0.56344 μM | SANGER | |||
| NOMO-1 | Growth Inhibition Assay | IC50=0.56372 μM | SANGER | |||
| G-402 | Growth Inhibition Assay | IC50=0.56499 μM | SANGER | |||
| NCI-H2052 | Growth Inhibition Assay | IC50=0.56741 μM | SANGER | |||
| RCM-1 | Growth Inhibition Assay | IC50=0.57166 μM | SANGER | |||
| COR-L279 | Growth Inhibition Assay | IC50=0.57185 μM | SANGER | |||
| A253 | Growth Inhibition Assay | IC50=0.57525 μM | SANGER | |||
| SK-MM-2 | Growth Inhibition Assay | IC50=0.57679 μM | SANGER | |||
| NCI-H1703 | Growth Inhibition Assay | IC50=0.59427 μM | SANGER | |||
| UACC-257 | Growth Inhibition Assay | IC50=0.59487 μM | SANGER | |||
| KALS-1 | Growth Inhibition Assay | IC50=0.60011 μM | SANGER | |||
| ES5 | Growth Inhibition Assay | IC50=0.6048 μM | SANGER | |||
| MHH-CALL-2 | Growth Inhibition Assay | IC50=0.60888 μM | SANGER | |||
| ChaGo-K-1 | Growth Inhibition Assay | IC50=0.61229 μM | SANGER | |||
| TGBC1TKB | Growth Inhibition Assay | IC50=0.6198 μM | SANGER | |||
| KU-19-19 | Growth Inhibition Assay | IC50=0.64586 μM | SANGER | |||
| COLO-684 | Growth Inhibition Assay | IC50=0.65611 μM | SANGER | |||
| LS-1034 | Growth Inhibition Assay | IC50=0.65819 μM | SANGER | |||
| RT-112 | Growth Inhibition Assay | IC50=0.66587 μM | SANGER | |||
| Capan-2 | Growth Inhibition Assay | IC50=0.66622 μM | SANGER | |||
| HSC-4 | Growth Inhibition Assay | IC50=0.66698 μM | SANGER | |||
| COLO-824 | Growth Inhibition Assay | IC50=0.67823 μM | SANGER | |||
| NCI-H2170 | Growth Inhibition Assay | IC50=0.68258 μM | SANGER | |||
| GDM-1 | Growth Inhibition Assay | IC50=0.68494 μM | SANGER | |||
| KP-4 | Growth Inhibition Assay | IC50=0.69573 μM | SANGER | |||
| VA-ES-BJ | Growth Inhibition Assay | IC50=0.69986 μM | SANGER | |||
| KM-H2 | Growth Inhibition Assay | IC50=0.70091 μM | SANGER | |||
| HH | Growth Inhibition Assay | IC50=0.70662 μM | SANGER | |||
| DK-MG | Growth Inhibition Assay | IC50=0.71016 μM | SANGER | |||
| VM-CUB-1 | Growth Inhibition Assay | IC50=0.71259 μM | SANGER | |||
| COLO-829 | Growth Inhibition Assay | IC50=0.71985 μM | SANGER | |||
| OMC-1 | Growth Inhibition Assay | IC50=0.72104 μM | SANGER | |||
| NB12 | Growth Inhibition Assay | IC50=0.72504 μM | SANGER | |||
| NCI-H28 | Growth Inhibition Assay | IC50=0.74083 μM | SANGER | |||
| A673 | Growth Inhibition Assay | IC50=0.75177 μM | SANGER | |||
| LB2241-RCC | Growth Inhibition Assay | IC50=0.76087 μM | SANGER | |||
| CCRF-CEM | Growth Inhibition Assay | IC50=0.77052 μM | SANGER | |||
| NCI-H510A | Growth Inhibition Assay | IC50=0.77186 μM | SANGER | |||
| SW48 | Growth Inhibition Assay | IC50=0.77333 μM | SANGER | |||
| NCI-H2081 | Growth Inhibition Assay | IC50=0.78147 μM | SANGER | |||
| RMG-I | Growth Inhibition Assay | IC50=0.78212 μM | SANGER | |||
| LU-99A | Growth Inhibition Assay | IC50=0.78413 μM | SANGER | |||
| KP-N-YS | Growth Inhibition Assay | IC50=0.78921 μM | SANGER | |||
| MDA-MB-231 | Growth Inhibition Assay | IC50=0.80131 μM | SANGER | |||
| U031 | Growth Inhibition Assay | IC50=0.81423 μM | SANGER | |||
| EVSA-T | Growth Inhibition Assay | IC50=0.81672 μM | SANGER | |||
| MDA-MB-157 | Growth Inhibition Assay | IC50=0.82271 μM | SANGER | |||
| EHEB | Growth Inhibition Assay | IC50=0.82276 μM | SANGER | |||
| KINGS-1 | Growth Inhibition Assay | IC50=0.82555 μM | SANGER | |||
| 23132-87 | Growth Inhibition Assay | IC50=0.82843 μM | SANGER | |||
| EFO-21 | Growth Inhibition Assay | IC50=0.84089 μM | SANGER | |||
| DOK | Growth Inhibition Assay | IC50=0.848 μM | SANGER | |||
| NCI-H2171 | Growth Inhibition Assay | IC50=0.8496 μM | SANGER | |||
| NCI-SNU-5 | Growth Inhibition Assay | IC50=0.8557 μM | SANGER | |||
| SK-N-DZ | Growth Inhibition Assay | IC50=0.85943 μM | SANGER | |||
| SNU-C2B | Growth Inhibition Assay | IC50=0.86801 μM | SANGER | |||
| CP66-MEL | Growth Inhibition Assay | IC50=0.8711 μM | SANGER | |||
| SN12C | Growth Inhibition Assay | IC50=0.88637 μM | SANGER | |||
| A172 | Growth Inhibition Assay | IC50=0.88698 μM | SANGER | |||
| NCI-H2347 | Growth Inhibition Assay | IC50=0.88753 μM | SANGER | |||
| NCI-H2228 | Growth Inhibition Assay | IC50=0.89339 μM | SANGER | |||
| SNU-387 | Growth Inhibition Assay | IC50=0.90264 μM | SANGER | |||
| SK-MEL-24 | Growth Inhibition Assay | IC50=0.91344 μM | SANGER | |||
| MDA-MB-468 | Growth Inhibition Assay | IC50=0.9173 μM | SANGER | |||
| NCI-H1694 | Growth Inhibition Assay | IC50=0.91876 μM | SANGER | |||
| CCF-STTG1 | Growth Inhibition Assay | IC50=0.92637 μM | SANGER | |||
| K052 | Growth Inhibition Assay | IC50=0.94047 μM | SANGER | |||
| NCI-H446 | Growth Inhibition Assay | IC50=0.9501 μM | SANGER | |||
| MFE-280 | Growth Inhibition Assay | IC50=0.96291 μM | SANGER | |||
| KU812 | Growth Inhibition Assay | IC50=0.99389 μM | SANGER | |||
| MDA-MB-361 | Growth Inhibition Assay | IC50=0.99777 μM | SANGER | |||
| Raji | Growth Inhibition Assay | IC50=1.02267 μM | SANGER | |||
| TE-6 | Growth Inhibition Assay | IC50=1.03566 μM | SANGER | |||
| CAL-148 | Growth Inhibition Assay | IC50=1.04443 μM | SANGER | |||
| NCI-H1963 | Growth Inhibition Assay | IC50=1.04553 μM | SANGER | |||
| SK-N-AS | Growth Inhibition Assay | IC50=1.04685 μM | SANGER | |||
| RERF-LC-MS | Growth Inhibition Assay | IC50=1.06349 μM | SANGER | |||
| BEN | Growth Inhibition Assay | IC50=1.07137 μM | SANGER | |||
| CAS-1 | Growth Inhibition Assay | IC50=1.09123 μM | SANGER | |||
| SW780 | Growth Inhibition Assay | IC50=1.09181 μM | SANGER | |||
| LU-65 | Growth Inhibition Assay | IC50=1.0941 μM | SANGER | |||
| D-283MED | Growth Inhibition Assay | IC50=1.12272 μM | SANGER | |||
| HCC2157 | Growth Inhibition Assay | IC50=1.13642 μM | SANGER | |||
| RCC10RGB | Growth Inhibition Assay | IC50=1.14006 μM | SANGER | |||
| PLC-PRF-5 | Growth Inhibition Assay | IC50=1.15229 μM | SANGER | |||
| H4 | Growth Inhibition Assay | IC50=1.15439 μM | SANGER | |||
| TUR | Growth Inhibition Assay | IC50=1.15752 μM | SANGER | |||
| NCI-H2141 | Growth Inhibition Assay | IC50=1.18946 μM | SANGER | |||
| PFSK-1 | Growth Inhibition Assay | IC50=1.20532 μM | SANGER | |||
| SK-MEL-28 | Growth Inhibition Assay | IC50=1.23221 μM | SANGER | |||
| SCC-9 | Growth Inhibition Assay | IC50=1.23665 μM | SANGER | |||
| T47D | Growth Inhibition Assay | IC50=1.23696 μM | SANGER | |||
| TCCSUP | Growth Inhibition Assay | IC50=1.25029 μM | SANGER | |||
| SU-DHL-1 | Growth Inhibition Assay | IC50=1.25118 μM | SANGER | |||
| HL-60 | Growth Inhibition Assay | IC50=1.25588 μM | SANGER | |||
| NCI-H1436 | Growth Inhibition Assay | IC50=1.26149 μM | SANGER | |||
| DMS-114 | Growth Inhibition Assay | IC50=1.26632 μM | SANGER | |||
| BOKU | Growth Inhibition Assay | IC50=1.28095 μM | SANGER | |||
| MS-1 | Growth Inhibition Assay | IC50=1.29069 μM | SANGER | |||
| NCI-H661 | Growth Inhibition Assay | IC50=1.30478 μM | SANGER | |||
| HT-3 | Growth Inhibition Assay | IC50=1.30529 μM | SANGER | |||
| CAL-54 | Growth Inhibition Assay | IC50=1.30725 μM | SANGER | |||
| SW1463 | Growth Inhibition Assay | IC50=1.31872 μM | SANGER | |||
| COLO-668 | Growth Inhibition Assay | IC50=1.33056 μM | SANGER | |||
| PANC-08-13 | Growth Inhibition Assay | IC50=1.33803 μM | SANGER | |||
| BB49-HNC | Growth Inhibition Assay | IC50=1.3401 μM | SANGER | |||
| M059J | Growth Inhibition Assay | IC50=1.35832 μM | SANGER | |||
| NCCIT | Growth Inhibition Assay | IC50=1.37988 μM | SANGER | |||
| LN-405 | Growth Inhibition Assay | IC50=1.39264 μM | SANGER | |||
| UMC-11 | Growth Inhibition Assay | IC50=1.39996 μM | SANGER | |||
| NB5 | Growth Inhibition Assay | IC50=1.41227 μM | SANGER | |||
| TE-441-T | Growth Inhibition Assay | IC50=1.42817 μM | SANGER | |||
| ME-180 | Growth Inhibition Assay | IC50=1.44392 μM | SANGER | |||
| HCC70 | Growth Inhibition Assay | IC50=1.46096 μM | SANGER | |||
| no-10 | Growth Inhibition Assay | IC50=1.46181 μM | SANGER | |||
| JEG-3 | Growth Inhibition Assay | IC50=1.50132 μM | SANGER | |||
| no-11 | Growth Inhibition Assay | IC50=1.50882 μM | SANGER | |||
| CHP-126 | Growth Inhibition Assay | IC50=1.56691 μM | SANGER | |||
| EGI-1 | Growth Inhibition Assay | IC50=1.58025 μM | SANGER | |||
| D-392MG | Growth Inhibition Assay | IC50=1.5963 μM | SANGER | |||
| RT4 | Growth Inhibition Assay | IC50=1.59637 μM | SANGER | |||
| A204 | Growth Inhibition Assay | IC50=1.59801 μM | SANGER | |||
| NCI-H1304 | Growth Inhibition Assay | IC50=1.63591 μM | SANGER | |||
| Becker | Growth Inhibition Assay | IC50=1.64241 μM | SANGER | |||
| OE19 | Growth Inhibition Assay | IC50=1.65518 μM | SANGER | |||
| EKVX | Growth Inhibition Assay | IC50=1.65618 μM | SANGER | |||
| KLE | Growth Inhibition Assay | IC50=1.65714 μM | SANGER | |||
| K-562 | Growth Inhibition Assay | IC50=1.67037 μM | SANGER | |||
| MDA-MB-175-VII | Growth Inhibition Assay | IC50=1.68997 μM | SANGER | |||
| NCI-H716 | Growth Inhibition Assay | IC50=1.69304 μM | SANGER | |||
| Caov-3 | Growth Inhibition Assay | IC50=1.69413 μM | SANGER | |||
| HCC1187 | Growth Inhibition Assay | IC50=1.70545 μM | SANGER | |||
| CAKI-1 | Growth Inhibition Assay | IC50=1.72292 μM | SANGER | |||
| MOLT-16 | Growth Inhibition Assay | IC50=1.73307 μM | SANGER | |||
| PC-3 | Growth Inhibition Assay | IC50=1.7508 μM | SANGER | |||
| DV-90 | Growth Inhibition Assay | IC50=1.75585 μM | SANGER | |||
| RXF393 | Growth Inhibition Assay | IC50=1.77294 μM | SANGER | |||
| SK-NEP-1 | Growth Inhibition Assay | IC50=1.82339 μM | SANGER | |||
| HCC1419 | Growth Inhibition Assay | IC50=1.82692 μM | SANGER | |||
| BV-173 | Growth Inhibition Assay | IC50=1.82995 μM | SANGER | |||
| MKN7 | Growth Inhibition Assay | IC50=1.8922 μM | SANGER | |||
| LAN-6 | Growth Inhibition Assay | IC50=1.89553 μM | SANGER | |||
| Mo-T | Growth Inhibition Assay | IC50=1.90039 μM | SANGER | |||
| HCC1395 | Growth Inhibition Assay | IC50=1.92863 μM | SANGER | |||
| HC-1 | Growth Inhibition Assay | IC50=1.9347 μM | SANGER | |||
| HPAF-II | Growth Inhibition Assay | IC50=1.94418 μM | SANGER | |||
| CPC-N | Growth Inhibition Assay | IC50=1.98002 μM | SANGER | |||
| MKN45 | Growth Inhibition Assay | IC50=1.99119 μM | SANGER | |||
| NCI-H1693 | Growth Inhibition Assay | IC50=2.00433 μM | SANGER | |||
| SHP-77 | Growth Inhibition Assay | IC50=2.00533 μM | SANGER | |||
| NCI-H1522 | Growth Inhibition Assay | IC50=2.01724 μM | SANGER | |||
| SW1573 | Growth Inhibition Assay | IC50=2.022 μM | SANGER | |||
| DBTRG-05MG | Growth Inhibition Assay | IC50=2.06087 μM | SANGER | |||
| SCC-4 | Growth Inhibition Assay | IC50=2.1431 μM | SANGER | |||
| DMS-153 | Growth Inhibition Assay | IC50=2.16668 μM | SANGER | |||
| MDA-MB-415 | Growth Inhibition Assay | IC50=2.1752 μM | SANGER | |||
| NCI-H2126 | Growth Inhibition Assay | IC50=2.22888 μM | SANGER | |||
| MDA-MB-453 | Growth Inhibition Assay | IC50=2.2332 μM | SANGER | |||
| U-87-MG | Growth Inhibition Assay | IC50=2.28592 μM | SANGER | |||
| LNCaP-Clone-FGC | Growth Inhibition Assay | IC50=2.30102 μM | SANGER | |||
| NCI-H1581 | Growth Inhibition Assay | IC50=2.32105 μM | SANGER | |||
| BC-3 | Growth Inhibition Assay | IC50=2.36509 μM | SANGER | |||
| HCC38 | Growth Inhibition Assay | IC50=2.38447 μM | SANGER | |||
| HCC2218 | Growth Inhibition Assay | IC50=2.40809 μM | SANGER | |||
| RO82-W-1 | Growth Inhibition Assay | IC50=2.4125 μM | SANGER | |||
| C2BBe1 | Growth Inhibition Assay | IC50=2.41578 μM | SANGER | |||
| LAMA-84 | Growth Inhibition Assay | IC50=2.57368 μM | SANGER | |||
| GMS-10 | Growth Inhibition Assay | IC50=2.57611 μM | SANGER | |||
| GCT | Growth Inhibition Assay | IC50=2.58694 μM | SANGER | |||
| SK-CO-1 | Growth Inhibition Assay | IC50=2.6166 μM | SANGER | |||
| NCI-H526 | Growth Inhibition Assay | IC50=2.6345 μM | SANGER | |||
| SW1088 | Growth Inhibition Assay | IC50=2.77839 μM | SANGER | |||
| HT55 | Growth Inhibition Assay | IC50=2.78695 μM | SANGER | |||
| NB10 | Growth Inhibition Assay | IC50=2.81748 μM | SANGER | |||
| UACC-893 | Growth Inhibition Assay | IC50=2.85749 μM | SANGER | |||
| NCI-H1618 | Growth Inhibition Assay | IC50=2.88153 μM | SANGER | |||
| NCI-H1092 | Growth Inhibition Assay | IC50=3.07812 μM | SANGER | |||
| SBC-1 | Growth Inhibition Assay | IC50=3.08553 μM | SANGER | |||
| NCI-H1623 | Growth Inhibition Assay | IC50=3.0934 μM | SANGER | |||
| SiHa | Growth Inhibition Assay | IC50=3.11977 μM | SANGER | |||
| D-263MG | Growth Inhibition Assay | IC50=3.14788 μM | SANGER | |||
| NCI-H1573 | Growth Inhibition Assay | IC50=3.19641 μM | SANGER | |||
| NCI-H82 | Growth Inhibition Assay | IC50=3.34439 μM | SANGER | |||
| NCI-H2196 | Growth Inhibition Assay | IC50=3.35008 μM | SANGER | |||
| MFM-223 | Growth Inhibition Assay | IC50=3.37351 μM | SANGER | |||
| COLO-678 | Growth Inhibition Assay | IC50=3.38186 μM | SANGER | |||
| EW-3 | Growth Inhibition Assay | IC50=3.4095 μM | SANGER | |||
| MHH-NB-11 | Growth Inhibition Assay | IC50=3.44069 μM | SANGER | |||
| EM-2 | Growth Inhibition Assay | IC50=3.6398 μM | SANGER | |||
| FTC-133 | Growth Inhibition Assay | IC50=3.65458 μM | SANGER | |||
| NCI-H209 | Growth Inhibition Assay | IC50=3.67653 μM | SANGER | |||
| TGBC24TKB | Growth Inhibition Assay | IC50=3.68355 μM | SANGER | |||
| LC-1F | Growth Inhibition Assay | IC50=3.71764 μM | SANGER | |||
| C-4-II | Growth Inhibition Assay | IC50=3.75643 μM | SANGER | |||
| NCI-H1650 | Growth Inhibition Assay | IC50=3.78455 μM | SANGER | |||
| JVM-2 | Growth Inhibition Assay | IC50=3.93639 μM | SANGER | |||
| CaR-1 | Growth Inhibition Assay | IC50=3.97617 μM | SANGER | |||
| MDA-MB-134-VI | Growth Inhibition Assay | IC50=4.02952 μM | SANGER | |||
| NCI-H719 | Growth Inhibition Assay | IC50=4.15388 μM | SANGER | |||
| GOTO | Growth Inhibition Assay | IC50=4.29705 μM | SANGER | |||
| NCI-N87 | Growth Inhibition Assay | IC50=4.38821 μM | SANGER | |||
| NB6 | Growth Inhibition Assay | IC50=4.42509 μM | SANGER | |||
| DSH1 | Growth Inhibition Assay | IC50=4.47116 μM | SANGER | |||
| BT-20 | Growth Inhibition Assay | IC50=4.49002 μM | SANGER | |||
| NCI-H1882 | Growth Inhibition Assay | IC50=4.5057 μM | SANGER | |||
| WM-115 | Growth Inhibition Assay | IC50=4.50881 μM | SANGER | |||
| SKG-IIIa | Growth Inhibition Assay | IC50=4.6777 μM | SANGER | |||
| NCI-H69 | Growth Inhibition Assay | IC50=4.70275 μM | SANGER | |||
| MSTO-211H | Growth Inhibition Assay | IC50=4.83565 μM | SANGER | |||
| Mewo | Growth Inhibition Assay | IC50=4.96313 μM | SANGER | |||
| GI-ME-N | Growth Inhibition Assay | IC50=5.00509 μM | SANGER | |||
| T98G | Growth Inhibition Assay | IC50=5.06508 μM | SANGER | |||
| ECC4 | Growth Inhibition Assay | IC50=5.09372 μM | SANGER | |||
| EW-11 | Growth Inhibition Assay | IC50=5.18099 μM | SANGER | |||
| COLO-800 | Growth Inhibition Assay | IC50=5.19349 μM | SANGER | |||
| NCI-H1755 | Growth Inhibition Assay | IC50=5.23027 μM | SANGER | |||
| KMS-12-PE | Growth Inhibition Assay | IC50=5.35085 μM | SANGER | |||
| HCC1954 | Growth Inhibition Assay | IC50=5.85971 μM | SANGER | |||
| NCI-H187 | Growth Inhibition Assay | IC50=5.92989 μM | SANGER | |||
| LU-165 | Growth Inhibition Assay | IC50=5.99002 μM | SANGER | |||
| YAPC | Growth Inhibition Assay | IC50=5.99068 μM | SANGER | |||
| LU-139 | Growth Inhibition Assay | IC50=6.08368 μM | SANGER | |||
| D-502MG | Growth Inhibition Assay | IC50=6.32047 μM | SANGER | |||
| IST-SL1 | Growth Inhibition Assay | IC50=6.53948 μM | SANGER | |||
| DG-75 | Growth Inhibition Assay | IC50=6.88786 μM | SANGER | |||
| NCI-H1155 | Growth Inhibition Assay | IC50=6.95581 μM | SANGER | |||
| EFE-184 | Growth Inhibition Assay | IC50=7.31695 μM | SANGER | |||
| AsPC-1 | Growth Inhibition Assay | IC50=7.48807 μM | SANGER | |||
| SW948 | Growth Inhibition Assay | IC50=7.58395 μM | SANGER | |||
| NCI-H524 | Growth Inhibition Assay | IC50=9.58628 μM | SANGER | |||
| KOSC-2 | Growth Inhibition Assay | IC50=9.62834 μM | SANGER | |||
| T-24 | Growth Inhibition Assay | IC50=9.94415 μM | SANGER | |||
| NCI-H748 | Growth Inhibition Assay | IC50=10.6397 μM | SANGER | |||
| NCI-H23 | Growth Inhibition Assay | IC50=10.6442 μM | SANGER | |||
| UACC-812 | Growth Inhibition Assay | IC50=11.717 μM | SANGER | |||
| SCLC-21H | Growth Inhibition Assay | IC50=12.1551 μM | SANGER | |||
| NCI-SNU-16 | Growth Inhibition Assay | IC50=13.1258 μM | SANGER | |||
| HD-MY-Z | Growth Inhibition Assay | IC50=14.6363 μM | SANGER | |||
| SK-N-FI | Growth Inhibition Assay | IC50=14.8912 μM | SANGER | |||
| LB647-SCLC | Growth Inhibition Assay | IC50=15.7195 μM | SANGER | |||
| NCI-H345 | Growth Inhibition Assay | IC50=17.343 μM | SANGER | |||
| NCI-H1563 | Growth Inhibition Assay | IC50=18.7601 μM | SANGER | |||
| RL | Growth Inhibition Assay | IC50=21.2656 μM | SANGER | |||
| KY821 | Growth Inhibition Assay | IC50=22.0553 μM | SANGER | |||
| JVM-3 | Growth Inhibition Assay | IC50=25.0413 μM | SANGER | |||
| NCI-H1793 | Growth Inhibition Assay | IC50=28.5499 μM | SANGER | |||
| LU-134-A | Growth Inhibition Assay | IC50=30.2037 μM | SANGER | |||
| NCI-H1395 | Growth Inhibition Assay | IC50=32.2431 μM | SANGER | |||
| NCI-H1993 | Growth Inhibition Assay | IC50=32.8218 μM | SANGER | |||
| P31-FUJ | Growth Inhibition Assay | IC50=33.4899 μM | SANGER | |||
| LS-513 | Growth Inhibition Assay | IC50=35.8879 μM | SANGER | |||
| SK-MEL-1 | Growth Inhibition Assay | IC50=40.3499 μM | SANGER | |||
| SW684 | Growth Inhibition Assay | IC50=43.9661 μM | SANGER | |||
| COR-L88 | Growth Inhibition Assay | IC50=44.0665 μM | SANGER | |||
| NCI-H889 | Growth Inhibition Assay | IC50=45.0087 μM | SANGER | |||
| TALL-1 | Growth Inhibition Assay | IC50=46.1199 μM | SANGER | |||
| KARPAS-299 | Growth Inhibition Assay | IC50=47.1993 μM | SANGER | |||
| 클릭하여 더 많은 세포주 실험 데이터 보기 | ||||||
화학 정보, 보관 및 안정성
| 분자량 | 413.49 | 화학식 | C20H19N3O.CH4O3S |
보관 (수령일로부터) | |
|---|---|---|---|---|---|
| CAS 번호 | 803712-79-0 | SDF 다운로드 | 원액 보관 |
|
|
| 동의어 | N/A | Smiles | CC1=CC(=C(N1)C=C2C(=CC(=C3C=C4C=CC=CC4=N3)N2)OC)C.CS(=O)(=O)O | ||
용해도
|
In vitro |
DMSO
: 83 mg/mL
(200.73 mM)
Water : Insoluble Ethanol : Insoluble |
몰농도 계산기
희석 계산기
분자량 계산기
|
In vivo |
|||||
생체 내 제형 계산기 (투명한 용액)
1단계: 아래 정보 입력 (권장: 실험 중 손실을 고려하여 추가 동물 포함)
mg/kg
g
μL
2단계: 생체 내 제형 입력 (이것은 계산기일 뿐 제형이 아닙니다. 용해도 섹션에 생체 내 제형이 없는 경우 먼저 당사에 문의하십시오.)
% DMSO
%
% Tween 80
% ddH2O
%DMSO
%
계산 결과:
작업 농도: mg/ml;
DMSO 원액 준비 방법: mg 약물 사전 용해 μL DMSO ( 원액 농도 mg/mL, 농도가 해당 약물 배치의 DMSO 용해도를 초과하는 경우 먼저 당사에 문의하십시오. )
생체 내 제형 준비 방법: 취하다 μL DMSO 원액, 다음 추가μL PEG300, 혼합하고 투명하게 한 다음 추가μL Tween 80, 혼합하고 투명하게 한 다음 추가 μL ddH2O, 혼합하고 투명하게 합니다.
생체 내 제형 준비 방법: 취하다 μL DMSO 원액, 다음 추가 μL 옥수수 기름, 혼합하고 투명하게 합니다.
참고: 1. 다음 용매를 추가하기 전에 액체가 투명한지 확인하십시오.
2. 용매를 순서대로 추가해야 합니다. 다음 용매를 추가하기 전에 이전 추가에서 얻은 용액이 투명한 용액인지 확인해야 합니다. 와동, 초음파 또는 뜨거운 물 중탕과 같은 물리적 방법을 사용하여 용해를 도울 수 있습니다.
작용 메커니즘
| 특징 |
Potential 1st-in-class small molecule antagonist of Bcl-2 designed to inhibit all relevant Bcl-2 family members, including Mcl-1.
|
|---|---|
| Targets/IC50/Ki |
Bcl-2
(Cell-free assay) 0.22 μM(Ki)
|
| 시험관 내(In vitro) |
Obatoclax는 SK-Mel5 세포에서 5 μM 농도로 Mcl-1의 Bak 회복을 완전히 억제하고, KB/Bcl-2 세포에서 Mcl-1에 의해 부여된 ABT-373 유도 Apoptosis 저항성을 극복합니다. Obatoclax는 Bcl-2, Bcl-xL 및 Mcl-1을 포함한 광범위한 Bcl-2 계열 구성원에 결합하는 BH3 모방체입니다. Obatoclax는 Mcl-1 포켓 활성화 후 Bak의 올리고머화 및 사이토크롬 c 방출에 의해 매개되는 Apoptosis 유발을 통해 BH3 도메인을 독특하게 대체합니다. Obatoclax는 Bcl-xL이 없거나 발현이 낮은 세포주에서 Bcl-xL에 민감합니다. 강하게 발현되는 모든 세포주에서 Mcl-1, Bcl-2 및 Bcl-xL에 대한 낮은 세포 독성을 보입니다. Obatoclax는 다발성 골수종(MM) 세포주(KMS12PE, KMS18, MY5 등)를 52 ~ 1100 nM 범위의 IC50 값으로 억제하며, 세포 독성 약제에 저항성을 나타내는 IL-6 또는 IGF-1의 존재 하에서도 150 nM 농도에서 억제 효과가 저해되지 않습니다. Obatoclax는 PANC-1 및 BxPC-3 세포에서 Bcl-2/Bcl-xL 또는 Mcl-1 단백질로부터 Bak 및 Bim을 격리 해제하여 TRAIL(종양 괴사 인자 관련 Apoptosis 유도 리간드) 매개 Apoptosis를 강화합니다. |
| 키나아제 분석 |
Bcl-2 결합 친화도 계산
|
|
SIE 스코어링 함수를 사용하여 Obatoclax가 BCL-2에 결합하는 예측 결합 친화도를 계산합니다. 계산의 신뢰도를 결정하는 대조군으로서, BCL-2에 대한 실험적으로 측정된 결합 친화도를 가진 12가지 소분자 세트에 대해 예측 결합 친화도(Ki)를 계산합니다.
|
|
| 생체 내(In vivo) |
Obatoclax는 또한 0.5 mg/kg 용량으로 인간 C33A 자궁경부암 종양을 가진 SCID 마우스에서 높은 항종양 활동을 보입니다. |
참조 |
|
적용 분야
| 방법 | 바이오마커 | 이미지 | PMID |
|---|---|---|---|
| Western blot | Cyclin D1 / p27 Kip1 p-Cyclin D1 p-GSK3β / GSK3β / p-ERK / ERK / p-p38 / p38 |
|
28382170 |
| Growth inhibition assay | Cell proliferation Cell viability |
|
28035994 |
임상시험 정보
(데이터 출처 https://clinicaltrials.gov, 업데이트 날짜 2024-05-22)
| NCT 번호 | 모집 | 조건 | 스폰서/협력자 | 시작일 | 단계 |
|---|---|---|---|---|---|
| NCT00438178 | Completed | Hematological Malignancies |
Gemin X|Teva Branded Pharmaceutical Products R&D Inc. |
October 2005 | Phase 1 |
| NCT00600964 | Completed | Chronic Lymphocytic Leukemia |
Gemin X|Teva Branded Pharmaceutical Products R&D Inc. |
September 2004 | Phase 1 |
기술 지원
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