연구용
Navitoclax (ABT-263) Bcl-2 억제제
제품 번호S1001
화학 구조
분자량: 974.61
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품질 관리
배치:
순도:
99.86%
99.86
함께 자주 사용되는 제품 Navitoclax (ABT-263)
세포 배양, 처리 및 작업 농도
| 세포주 | 분석 유형 | 농도 | 배양 시간 | 제형 | 활성 설명 | PMID |
|---|---|---|---|---|---|---|
| FL5.12 | Cytotoxicity assay | 24 h | EC50 = 0.0042 μM | 18841882 | ||
| FL5.12 | Cytotoxicity assay | 24 h | EC50 = 0.0059 μM | 18841882 | ||
| RS4:11 | Apoptosis assay | 6 h | EC50 = 0.014 μM | 24881567 | ||
| FDC-P1 | BCL-2 inhibition assay | 24 h | IC50 = 0.015 μM | 24881567 | ||
| NCI-H1963 | Cytotoxicity assay | 4 days | IC50 = 0.0266 μM | 23448298 | ||
| NCI-H187 | Cytotoxicity assay | 4 days | IC50 = 0.0384 μM | 23448298 | ||
| NCI-H1417 | Cytotoxicity assay | 4 days | IC50 = 0.0542 μM | 23448298 | ||
| FDC-P1 | BCL-xL inhibition assay | 24 h | IC50 = 0.06 μM | 24881567 | ||
| NCI-H146 | Cytotoxicity assay | 48 h | EC50 = 0.0867 μM | 18841882 | ||
| RS4:11 | Antiproliferative activity assay | EC50 = 0.112 μM | 28926247 | |||
| MOLT4 | Antiproliferative activity assay | EC50 = 0.303 μM | 28926247 | |||
| EoL-1-cell | Growth Inhibition Assay | IC50=0.00669 μM | SANGER | |||
| MV-4-11 | Growth Inhibition Assay | IC50=0.01586 μM | SANGER | |||
| NKM-1 | Growth Inhibition Assay | IC50=0.01699 μM | SANGER | |||
| ML-2 | Growth Inhibition Assay | IC50=0.01983 μM | SANGER | |||
| BV-173 | Growth Inhibition Assay | IC50=0.02314 μM | SANGER | |||
| RS4-11 | Growth Inhibition Assay | IC50=0.02587 μM | SANGER | |||
| HL-60 | Growth Inhibition Assay | IC50=0.02908 μM | SANGER | |||
| KY821 | Growth Inhibition Assay | IC50=0.02975 μM | SANGER | |||
| ECC10 | Growth Inhibition Assay | IC50=0.03792 μM | SANGER | |||
| NCI-H720 | Growth Inhibition Assay | IC50=0.04011 μM | SANGER | |||
| QIMR-WIL | Growth Inhibition Assay | IC50=0.04287 μM | SANGER | |||
| KG-1 | Growth Inhibition Assay | IC50=0.04486 μM | SANGER | |||
| TGW | Growth Inhibition Assay | IC50=0.04633 μM | SANGER | |||
| ATN-1 | Growth Inhibition Assay | IC50=0.04733 μM | SANGER | |||
| RH-18 | Growth Inhibition Assay | IC50=0.06048 μM | SANGER | |||
| EW-18 | Growth Inhibition Assay | IC50=0.06841 μM | SANGER | |||
| NB17 | Growth Inhibition Assay | IC50=0.07124 μM | SANGER | |||
| SK-NEP-1 | Growth Inhibition Assay | IC50=0.07213 μM | SANGER | |||
| P12-ICHIKAWA | Growth Inhibition Assay | IC50=0.07778 μM | SANGER | |||
| KARPAS-45 | Growth Inhibition Assay | IC50=0.07815 μM | SANGER | |||
| EW-3 | Growth Inhibition Assay | IC50=0.08053 μM | SANGER | |||
| NB13 | Growth Inhibition Assay | IC50=0.08203 μM | SANGER | |||
| NCI-H209 | Growth Inhibition Assay | IC50=0.08704 μM | SANGER | |||
| NCI-H1092 | Growth Inhibition Assay | IC50=0.10275 μM | SANGER | |||
| NH-12 | Growth Inhibition Assay | IC50=0.10744 μM | SANGER | |||
| 697 | Growth Inhibition Assay | IC50=0.10839 μM | SANGER | |||
| KE-37 | Growth Inhibition Assay | IC50=0.1137 μM | SANGER | |||
| MOLT-4 | Growth Inhibition Assay | IC50=0.15169 μM | SANGER | |||
| CHP-134 | Growth Inhibition Assay | IC50=0.16306 μM | SANGER | |||
| D-283MED | Growth Inhibition Assay | IC50=0.17686 μM | SANGER | |||
| LU-135 | Growth Inhibition Assay | IC50=0.18552 μM | SANGER | |||
| LU-134-A | Growth Inhibition Assay | IC50=0.18671 μM | SANGER | |||
| EM-2 | Growth Inhibition Assay | IC50=0.19918 μM | SANGER | |||
| LU-139 | Growth Inhibition Assay | IC50=0.20498 μM | SANGER | |||
| ALL-PO | Growth Inhibition Assay | IC50=0.21988 μM | SANGER | |||
| NB12 | Growth Inhibition Assay | IC50=0.23115 μM | SANGER | |||
| KP-N-YN | Growth Inhibition Assay | IC50=0.23573 μM | SANGER | |||
| BEN | Growth Inhibition Assay | IC50=0.23968 μM | SANGER | |||
| HCC1569 | Growth Inhibition Assay | IC50=0.25106 μM | SANGER | |||
| HuO9 | Growth Inhibition Assay | IC50=0.26715 μM | SANGER | |||
| WM-115 | Growth Inhibition Assay | IC50=0.27738 μM | SANGER | |||
| CCRF-CEM | Growth Inhibition Assay | IC50=0.33529 μM | SANGER | |||
| IST-SL1 | Growth Inhibition Assay | IC50=0.35343 μM | SANGER | |||
| BE-13 | Growth Inhibition Assay | IC50=0.36459 μM | SANGER | |||
| COR-L88 | Growth Inhibition Assay | IC50=0.3654 μM | SANGER | |||
| DOHH-2 | Growth Inhibition Assay | IC50=0.41023 μM | SANGER | |||
| A704 | Growth Inhibition Assay | IC50=0.4267 μM | SANGER | |||
| KNS-81-FD | Growth Inhibition Assay | IC50=0.44017 μM | SANGER | |||
| RPMI-8226 | Growth Inhibition Assay | IC50=0.45652 μM | SANGER | |||
| TGBC24TKB | Growth Inhibition Assay | IC50=0.45778 μM | SANGER | |||
| NCI-H1304 | Growth Inhibition Assay | IC50=0.46157 μM | SANGER | |||
| MOLT-13 | Growth Inhibition Assay | IC50=0.46613 μM | SANGER | |||
| EW-22 | Growth Inhibition Assay | IC50=0.46671 μM | SANGER | |||
| MS-1 | Growth Inhibition Assay | IC50=0.46933 μM | SANGER | |||
| RMG-I | Growth Inhibition Assay | IC50=0.49464 μM | SANGER | |||
| NTERA-S-cl-D1 | Growth Inhibition Assay | IC50=0.50019 μM | SANGER | |||
| NCI-H1048 | Growth Inhibition Assay | IC50=0.50953 μM | SANGER | |||
| SW1417 | Growth Inhibition Assay | IC50=0.55438 μM | SANGER | |||
| DB | Growth Inhibition Assay | IC50=0.5708 μM | SANGER | |||
| MEG-01 | Growth Inhibition Assay | IC50=0.5832 μM | SANGER | |||
| EW-13 | Growth Inhibition Assay | IC50=0.58341 μM | SANGER | |||
| LAMA-84 | Growth Inhibition Assay | IC50=0.59207 μM | SANGER | |||
| J-RT3-T3-5 | Growth Inhibition Assay | IC50=0.60808 μM | SANGER | |||
| MOLT-16 | Growth Inhibition Assay | IC50=0.65264 μM | SANGER | |||
| DU-4475 | Growth Inhibition Assay | IC50=0.65427 μM | SANGER | |||
| HAL-01 | Growth Inhibition Assay | IC50=0.72549 μM | SANGER | |||
| RD | Growth Inhibition Assay | IC50=0.75899 μM | SANGER | |||
| OAW-28 | Growth Inhibition Assay | IC50=0.7837 μM | SANGER | |||
| HCC38 | Growth Inhibition Assay | IC50=0.8019 μM | SANGER | |||
| NMC-G1 | Growth Inhibition Assay | IC50=0.81121 μM | SANGER | |||
| EW-16 | Growth Inhibition Assay | IC50=0.81328 μM | SANGER | |||
| DU-145 | Growth Inhibition Assay | IC50=0.89923 μM | SANGER | |||
| HPAF-II | Growth Inhibition Assay | IC50=0.92628 μM | SANGER | |||
| A427 | Growth Inhibition Assay | IC50=0.93022 μM | SANGER | |||
| PA-1 | Growth Inhibition Assay | IC50=0.95642 μM | SANGER | |||
| OAW-42 | Growth Inhibition Assay | IC50=0.96146 μM | SANGER | |||
| L-428 | Growth Inhibition Assay | IC50=1.0125 μM | SANGER | |||
| COLO-824 | Growth Inhibition Assay | IC50=1.01708 μM | SANGER | |||
| P30-OHK | Growth Inhibition Assay | IC50=1.04688 μM | SANGER | |||
| NCI-H2170 | Growth Inhibition Assay | IC50=1.0623 μM | SANGER | |||
| HCC2998 | Growth Inhibition Assay | IC50=1.07135 μM | SANGER | |||
| NB14 | Growth Inhibition Assay | IC50=1.13748 μM | SANGER | |||
| TGBC1TKB | Growth Inhibition Assay | IC50=1.14152 μM | SANGER | |||
| KP-N-YS | Growth Inhibition Assay | IC50=1.16236 μM | SANGER | |||
| CAL-120 | Growth Inhibition Assay | IC50=1.16429 μM | SANGER | |||
| SBC-1 | Growth Inhibition Assay | IC50=1.19053 μM | SANGER | |||
| C32 | Growth Inhibition Assay | IC50=1.19088 μM | SANGER | |||
| HCC2157 | Growth Inhibition Assay | IC50=1.19494 μM | SANGER | |||
| COLO-792 | Growth Inhibition Assay | IC50=1.20071 μM | SANGER | |||
| ES7 | Growth Inhibition Assay | IC50=1.27951 μM | SANGER | |||
| HEL | Growth Inhibition Assay | IC50=1.31029 μM | SANGER | |||
| ES4 | Growth Inhibition Assay | IC50=1.34998 μM | SANGER | |||
| NCI-SNU-1 | Growth Inhibition Assay | IC50=1.36555 μM | SANGER | |||
| MDA-MB-415 | Growth Inhibition Assay | IC50=1.3885 μM | SANGER | |||
| NCI-H2342 | Growth Inhibition Assay | IC50=1.40269 μM | SANGER | |||
| NB69 | Growth Inhibition Assay | IC50=1.46271 μM | SANGER | |||
| D-247MG | Growth Inhibition Assay | IC50=1.51122 μM | SANGER | |||
| SCC-4 | Growth Inhibition Assay | IC50=1.59887 μM | SANGER | |||
| HuH-7 | Growth Inhibition Assay | IC50=1.67293 μM | SANGER | |||
| A388 | Growth Inhibition Assay | IC50=1.68724 μM | SANGER | |||
| Calu-3 | Growth Inhibition Assay | IC50=1.70697 μM | SANGER | |||
| NCI-H1648 | Growth Inhibition Assay | IC50=1.71418 μM | SANGER | |||
| NCI-H2052 | Growth Inhibition Assay | IC50=1.72201 μM | SANGER | |||
| Ramos-2G6-4C10 | Growth Inhibition Assay | IC50=1.73656 μM | SANGER | |||
| DEL | Growth Inhibition Assay | IC50=1.74692 μM | SANGER | |||
| SNU-423 | Growth Inhibition Assay | IC50=1.78157 μM | SANGER | |||
| COR-L23 | Growth Inhibition Assay | IC50=1.79874 μM | SANGER | |||
| OMC-1 | Growth Inhibition Assay | IC50=1.86016 μM | SANGER | |||
| EW-11 | Growth Inhibition Assay | IC50=1.95657 μM | SANGER | |||
| HSC-3 | Growth Inhibition Assay | IC50=1.96365 μM | SANGER | |||
| MLMA | Growth Inhibition Assay | IC50=1.96677 μM | SANGER | |||
| RCM-1 | Growth Inhibition Assay | IC50=2.00399 μM | SANGER | |||
| MFE-280 | Growth Inhibition Assay | IC50=2.02848 μM | SANGER | |||
| ES8 | Growth Inhibition Assay | IC50=2.25471 μM | SANGER | |||
| TE-11 | Growth Inhibition Assay | IC50=2.29473 μM | SANGER | |||
| HuO-3N1 | Growth Inhibition Assay | IC50=2.4878 μM | SANGER | |||
| MHH-NB-11 | Growth Inhibition Assay | IC50=2.51158 μM | SANGER | |||
| TGBC11TKB | Growth Inhibition Assay | IC50=2.57681 μM | SANGER | |||
| HOP-92 | Growth Inhibition Assay | IC50=2.58743 μM | SANGER | |||
| IGR-1 | Growth Inhibition Assay | IC50=2.62035 μM | SANGER | |||
| GOTO | Growth Inhibition Assay | IC50=2.65377 μM | SANGER | |||
| NCI-H1650 | Growth Inhibition Assay | IC50=2.72215 μM | SANGER | |||
| NCI-H1581 | Growth Inhibition Assay | IC50=2.79681 μM | SANGER | |||
| NCI-H2405 | Growth Inhibition Assay | IC50=2.82782 μM | SANGER | |||
| U-118-MG | Growth Inhibition Assay | IC50=2.96491 μM | SANGER | |||
| DoTc2-4510 | Growth Inhibition Assay | IC50=3.01417 μM | SANGER | |||
| NCI-H596 | Growth Inhibition Assay | IC50=3.04997 μM | SANGER | |||
| MPP-89 | Growth Inhibition Assay | IC50=3.05666 μM | SANGER | |||
| GCIY | Growth Inhibition Assay | IC50=3.20491 μM | SANGER | |||
| SW626 | Growth Inhibition Assay | IC50=3.24543 μM | SANGER | |||
| OCI-AML2 | Growth Inhibition Assay | IC50=3.31272 μM | SANGER | |||
| NBsusSR | Growth Inhibition Assay | IC50=3.34938 μM | SANGER | |||
| AN3-CA | Growth Inhibition Assay | IC50=3.44238 μM | SANGER | |||
| EFM-19 | Growth Inhibition Assay | IC50=3.48339 μM | SANGER | |||
| RVH-421 | Growth Inhibition Assay | IC50=3.56877 μM | SANGER | |||
| 5637 | Growth Inhibition Assay | IC50=3.61103 μM | SANGER | |||
| PANC-08-13 | Growth Inhibition Assay | IC50=3.63472 μM | SANGER | |||
| H9 | Growth Inhibition Assay | IC50=3.67144 μM | SANGER | |||
| KARPAS-299 | Growth Inhibition Assay | IC50=3.67361 μM | SANGER | |||
| TE-5 | Growth Inhibition Assay | IC50=3.70709 μM | SANGER | |||
| NOS-1 | Growth Inhibition Assay | IC50=3.79834 μM | SANGER | |||
| HH | Growth Inhibition Assay | IC50=3.83868 μM | SANGER | |||
| 769-P | Growth Inhibition Assay | IC50=3.8951 μM | SANGER | |||
| CHP-212 | Growth Inhibition Assay | IC50=3.92549 μM | SANGER | |||
| NCI-H82 | Growth Inhibition Assay | IC50=3.95936 μM | SANGER | |||
| Mo-T | Growth Inhibition Assay | IC50=4.04312 μM | SANGER | |||
| BB65-RCC | Growth Inhibition Assay | IC50=4.04399 μM | SANGER | |||
| SW1990 | Growth Inhibition Assay | IC50=4.05908 μM | SANGER | |||
| LK-2 | Growth Inhibition Assay | IC50=4.11293 μM | SANGER | |||
| ES5 | Growth Inhibition Assay | IC50=4.13985 μM | SANGER | |||
| JVM-3 | Growth Inhibition Assay | IC50=4.18222 μM | SANGER | |||
| RPMI-7951 | Growth Inhibition Assay | IC50=4.22413 μM | SANGER | |||
| Calu-6 | Growth Inhibition Assay | IC50=4.27881 μM | SANGER | |||
| LC-2-ad | Growth Inhibition Assay | IC50=4.29568 μM | SANGER | |||
| SW954 | Growth Inhibition Assay | IC50=4.2966 μM | SANGER | |||
| H-EMC-SS | Growth Inhibition Assay | IC50=4.31831 μM | SANGER | |||
| ES3 | Growth Inhibition Assay | IC50=4.35441 μM | SANGER | |||
| no-11 | Growth Inhibition Assay | IC50=4.35554 μM | SANGER | |||
| LAN-6 | Growth Inhibition Assay | IC50=4.45189 μM | SANGER | |||
| FTC-133 | Growth Inhibition Assay | IC50=4.5395 μM | SANGER | |||
| 8505C | Growth Inhibition Assay | IC50=4.5423 μM | SANGER | |||
| SW620 | Growth Inhibition Assay | IC50=4.57057 μM | SANGER | |||
| BCPAP | Growth Inhibition Assay | IC50=4.63481 μM | SANGER | |||
| SK-LU-1 | Growth Inhibition Assay | IC50=4.66089 μM | SANGER | |||
| NCI-H1623 | Growth Inhibition Assay | IC50=4.70228 μM | SANGER | |||
| C2BBe1 | Growth Inhibition Assay | IC50=4.74008 μM | SANGER | |||
| GP5d | Growth Inhibition Assay | IC50=4.78388 μM | SANGER | |||
| NB6 | Growth Inhibition Assay | IC50=4.86204 μM | SANGER | |||
| MDA-MB-157 | Growth Inhibition Assay | IC50=4.8876 μM | SANGER | |||
| UMC-11 | Growth Inhibition Assay | IC50=4.88964 μM | SANGER | |||
| HCC1419 | Growth Inhibition Assay | IC50=4.90063 μM | SANGER | |||
| NCI-H2029 | Growth Inhibition Assay | IC50=4.94185 μM | SANGER | |||
| LXF-289 | Growth Inhibition Assay | IC50=5.03719 μM | SANGER | |||
| KINGS-1 | Growth Inhibition Assay | IC50=5.07744 μM | SANGER | |||
| HD-MY-Z | Growth Inhibition Assay | IC50=5.23969 μM | SANGER | |||
| ESS-1 | Growth Inhibition Assay | IC50=5.25597 μM | SANGER | |||
| GI-1 | Growth Inhibition Assay | IC50=5.27926 μM | SANGER | |||
| RPMI-2650 | Growth Inhibition Assay | IC50=5.3616 μM | SANGER | |||
| IA-LM | Growth Inhibition Assay | IC50=5.39871 μM | SANGER | |||
| KP-4 | Growth Inhibition Assay | IC50=5.46334 μM | SANGER | |||
| G-402 | Growth Inhibition Assay | IC50=5.51865 μM | SANGER | |||
| OS-RC-2 | Growth Inhibition Assay | IC50=5.52604 μM | SANGER | |||
| NCI-H1155 | Growth Inhibition Assay | IC50=5.54955 μM | SANGER | |||
| OE19 | Growth Inhibition Assay | IC50=5.68624 μM | SANGER | |||
| U-2-OS | Growth Inhibition Assay | IC50=5.89013 μM | SANGER | |||
| SCC-15 | Growth Inhibition Assay | IC50=5.93662 μM | SANGER | |||
| NCI-H630 | Growth Inhibition Assay | IC50=5.99404 μM | SANGER | |||
| PFSK-1 | Growth Inhibition Assay | IC50=6.05259 μM | SANGER | |||
| NCI-H1770 | Growth Inhibition Assay | IC50=6.20874 μM | SANGER | |||
| SK-MEL-3 | Growth Inhibition Assay | IC50=6.42915 μM | SANGER | |||
| LB1047-RCC | Growth Inhibition Assay | IC50=6.47625 μM | SANGER | |||
| NCI-H446 | Growth Inhibition Assay | IC50=6.62925 μM | SANGER | |||
| SW780 | Growth Inhibition Assay | IC50=6.70185 μM | SANGER | |||
| NEC8 | Growth Inhibition Assay | IC50=6.7663 μM | SANGER | |||
| NOMO-1 | Growth Inhibition Assay | IC50=6.78111 μM | SANGER | |||
| COLO-668 | Growth Inhibition Assay | IC50=6.84387 μM | SANGER | |||
| MC116 | Growth Inhibition Assay | IC50=6.93897 μM | SANGER | |||
| HCC1937 | Growth Inhibition Assay | IC50=6.99251 μM | SANGER | |||
| NCI-N87 | Growth Inhibition Assay | IC50=7.19293 μM | SANGER | |||
| COLO-320-HSR | Growth Inhibition Assay | IC50=7.22738 μM | SANGER | |||
| HCC1806 | Growth Inhibition Assay | IC50=7.26044 μM | SANGER | |||
| OVCAR-3 | Growth Inhibition Assay | IC50=7.33038 μM | SANGER | |||
| NUGC-3 | Growth Inhibition Assay | IC50=7.39694 μM | SANGER | |||
| SW1783 | Growth Inhibition Assay | IC50=7.43175 μM | SANGER | |||
| GCT | Growth Inhibition Assay | IC50=7.56906 μM | SANGER | |||
| NCI-H2126 | Growth Inhibition Assay | IC50=7.73625 μM | SANGER | |||
| MEL-HO | Growth Inhibition Assay | IC50=7.77054 μM | SANGER | |||
| CAPAN-1 | Growth Inhibition Assay | IC50=7.77357 μM | SANGER | |||
| SW756 | Growth Inhibition Assay | IC50=7.78333 μM | SANGER | |||
| SKG-IIIa | Growth Inhibition Assay | IC50=7.81892 μM | SANGER | |||
| HCE-T | Growth Inhibition Assay | IC50=7.87783 μM | SANGER | |||
| Ca-Ski | Growth Inhibition Assay | IC50=7.99383 μM | SANGER | |||
| COLO-684 | Growth Inhibition Assay | IC50=8.01818 μM | SANGER | |||
| KYSE-70 | Growth Inhibition Assay | IC50=8.07729 μM | SANGER | |||
| TI-73 | Growth Inhibition Assay | IC50=8.25851 μM | SANGER | |||
| BT-20 | Growth Inhibition Assay | IC50=8.26052 μM | SANGER | |||
| MHH-ES-1 | Growth Inhibition Assay | IC50=8.51834 μM | SANGER | |||
| TE-12 | Growth Inhibition Assay | IC50=8.59931 μM | SANGER | |||
| YH-13 | Growth Inhibition Assay | IC50=8.61008 μM | SANGER | |||
| SF126 | Growth Inhibition Assay | IC50=8.83865 μM | SANGER | |||
| J82 | Growth Inhibition Assay | IC50=8.90038 μM | SANGER | |||
| RCC10RGB | Growth Inhibition Assay | IC50=8.99561 μM | SANGER | |||
| SK-UT-1 | Growth Inhibition Assay | IC50=9.04945 μM | SANGER | |||
| LB2241-RCC | Growth Inhibition Assay | IC50=9.19137 μM | SANGER | |||
| LB996-RCC | Growth Inhibition Assay | IC50=9.1989 μM | SANGER | |||
| EPLC-272H | Growth Inhibition Assay | IC50=9.37657 μM | SANGER | |||
| CTV-1 | Growth Inhibition Assay | IC50=9.56532 μM | SANGER | |||
| HSC-2 | Growth Inhibition Assay | IC50=9.5755 μM | SANGER | |||
| SK-MEL-28 | Growth Inhibition Assay | IC50=9.61893 μM | SANGER | |||
| MMAC-SF | Growth Inhibition Assay | IC50=9.6875 μM | SANGER | |||
| CP50-MEL-B | Growth Inhibition Assay | IC50=9.75782 μM | SANGER | |||
| HT-1080 | Growth Inhibition Assay | IC50=9.77739 μM | SANGER | |||
| HEC-1 | Growth Inhibition Assay | IC50=10.3352 μM | SANGER | |||
| AGS | Growth Inhibition Assay | IC50=10.374 μM | SANGER | |||
| GAMG | Growth Inhibition Assay | IC50=10.5162 μM | SANGER | |||
| SW48 | Growth Inhibition Assay | IC50=10.5189 μM | SANGER | |||
| U031 | Growth Inhibition Assay | IC50=10.5908 μM | SANGER | |||
| OVCAR-5 | Growth Inhibition Assay | IC50=10.6429 μM | SANGER | |||
| SF295 | Growth Inhibition Assay | IC50=10.6704 μM | SANGER | |||
| BHT-101 | Growth Inhibition Assay | IC50=10.7177 μM | SANGER | |||
| VMRC-RCZ | Growth Inhibition Assay | IC50=11.3201 μM | SANGER | |||
| ACHN | Growth Inhibition Assay | IC50=11.4211 μM | SANGER | |||
| NCI-H526 | Growth Inhibition Assay | IC50=11.5043 μM | SANGER | |||
| MN-60 | Growth Inhibition Assay | IC50=11.539 μM | SANGER | |||
| NCI-H2291 | Growth Inhibition Assay | IC50=11.5466 μM | SANGER | |||
| SCC-25 | Growth Inhibition Assay | IC50=11.7556 μM | SANGER | |||
| SK-MEL-2 | Growth Inhibition Assay | IC50=11.7637 μM | SANGER | |||
| SN12C | Growth Inhibition Assay | IC50=11.9355 μM | SANGER | |||
| NCI-H69 | Growth Inhibition Assay | IC50=12.4234 μM | SANGER | |||
| ME-180 | Growth Inhibition Assay | IC50=12.7054 μM | SANGER | |||
| MC-IXC | Growth Inhibition Assay | IC50=12.7518 μM | SANGER | |||
| NCI-H2347 | Growth Inhibition Assay | IC50=12.7614 μM | SANGER | |||
| M059J | Growth Inhibition Assay | IC50=12.7727 μM | SANGER | |||
| A2058 | Growth Inhibition Assay | IC50=12.8681 μM | SANGER | |||
| VA-ES-BJ | Growth Inhibition Assay | IC50=12.8785 μM | SANGER | |||
| Ca9-22 | Growth Inhibition Assay | IC50=12.9451 μM | SANGER | |||
| KNS-42 | Growth Inhibition Assay | IC50=12.9984 μM | SANGER | |||
| LoVo | Growth Inhibition Assay | IC50=13.2313 μM | SANGER | |||
| AM-38 | Growth Inhibition Assay | IC50=13.2566 μM | SANGER | |||
| NB5 | Growth Inhibition Assay | IC50=13.3752 μM | SANGER | |||
| L-363 | Growth Inhibition Assay | IC50=13.4033 μM | SANGER | |||
| SK-MEL-30 | Growth Inhibition Assay | IC50=14.0645 μM | SANGER | |||
| NCI-H1563 | Growth Inhibition Assay | IC50=14.6039 μM | SANGER | |||
| NCI-H2228 | Growth Inhibition Assay | IC50=14.6077 μM | SANGER | |||
| MFM-223 | Growth Inhibition Assay | IC50=15.1813 μM | SANGER | |||
| LB831-BLC | Growth Inhibition Assay | IC50=15.2767 μM | SANGER | |||
| SW872 | Growth Inhibition Assay | IC50=15.3086 μM | SANGER | |||
| NCI-H522 | Growth Inhibition Assay | IC50=15.3306 μM | SANGER | |||
| EW-1 | Growth Inhibition Assay | IC50=15.5462 μM | SANGER | |||
| HN | Growth Inhibition Assay | IC50=15.5942 μM | SANGER | |||
| SW837 | Growth Inhibition Assay | IC50=15.7847 μM | SANGER | |||
| SCC-9 | Growth Inhibition Assay | IC50=15.8114 μM | SANGER | |||
| MKN7 | Growth Inhibition Assay | IC50=15.9732 μM | SANGER | |||
| KYSE-410 | Growth Inhibition Assay | IC50=16.591 μM | SANGER | |||
| SK-N-DZ | Growth Inhibition Assay | IC50=16.6116 μM | SANGER | |||
| COR-L105 | Growth Inhibition Assay | IC50=16.6528 μM | SANGER | |||
| LB2518-MEL | Growth Inhibition Assay | IC50=16.8389 μM | SANGER | |||
| OVCAR-4 | Growth Inhibition Assay | IC50=16.8862 μM | SANGER | |||
| TK10 | Growth Inhibition Assay | IC50=16.9473 μM | SANGER | |||
| KNS-62 | Growth Inhibition Assay | IC50=16.9777 μM | SANGER | |||
| RPMI-8866 | Growth Inhibition Assay | IC50=17.1732 μM | SANGER | |||
| HuP-T4 | Growth Inhibition Assay | IC50=17.2495 μM | SANGER | |||
| CGTH-W-1 | Growth Inhibition Assay | IC50=17.5219 μM | SANGER | |||
| T-24 | Growth Inhibition Assay | IC50=17.5347 μM | SANGER | |||
| HT-3 | Growth Inhibition Assay | IC50=17.5914 μM | SANGER | |||
| KS-1 | Growth Inhibition Assay | IC50=17.673 μM | SANGER | |||
| NCI-H1792 | Growth Inhibition Assay | IC50=17.798 μM | SANGER | |||
| ABC-1 | Growth Inhibition Assay | IC50=17.8141 μM | SANGER | |||
| BPH-1 | Growth Inhibition Assay | IC50=18.1685 μM | SANGER | |||
| A431 | Growth Inhibition Assay | IC50=18.4127 μM | SANGER | |||
| T98G | Growth Inhibition Assay | IC50=18.5157 μM | SANGER | |||
| BHY | Growth Inhibition Assay | IC50=18.869 μM | SANGER | |||
| Capan-2 | Growth Inhibition Assay | IC50=18.9078 μM | SANGER | |||
| MDA-MB-175-VII | Growth Inhibition Assay | IC50=18.9209 μM | SANGER | |||
| CAL-27 | Growth Inhibition Assay | IC50=19.0487 μM | SANGER | |||
| AsPC-1 | Growth Inhibition Assay | IC50=19.8657 μM | SANGER | |||
| KU812 | Growth Inhibition Assay | IC50=19.9573 μM | SANGER | |||
| NCI-H441 | Growth Inhibition Assay | IC50=20.001 μM | SANGER | |||
| Mewo | Growth Inhibition Assay | IC50=20.1288 μM | SANGER | |||
| SK-MEL-24 | Growth Inhibition Assay | IC50=20.1477 μM | SANGER | |||
| NCI-H727 | Growth Inhibition Assay | IC50=20.2704 μM | SANGER | |||
| EKVX | Growth Inhibition Assay | IC50=20.606 μM | SANGER | |||
| RT-112 | Growth Inhibition Assay | IC50=20.6122 μM | SANGER | |||
| CAMA-1 | Growth Inhibition Assay | IC50=20.9803 μM | SANGER | |||
| SW900 | Growth Inhibition Assay | IC50=21.0149 μM | SANGER | |||
| NCI-H23 | Growth Inhibition Assay | IC50=21.1277 μM | SANGER | |||
| SK-PN-DW | Growth Inhibition Assay | IC50=21.1649 μM | SANGER | |||
| BB30-HNC | Growth Inhibition Assay | IC50=21.2745 μM | SANGER | |||
| VM-CUB-1 | Growth Inhibition Assay | IC50=21.3536 μM | SANGER | |||
| IST-MEL1 | Growth Inhibition Assay | IC50=21.3692 μM | SANGER | |||
| CTB-1 | Growth Inhibition Assay | IC50=21.4755 μM | SANGER | |||
| LCLC-103H | Growth Inhibition Assay | IC50=22.1582 μM | SANGER | |||
| PANC-03-27 | Growth Inhibition Assay | IC50=22.5169 μM | SANGER | |||
| HTC-C3 | Growth Inhibition Assay | IC50=22.5555 μM | SANGER | |||
| TE-8 | Growth Inhibition Assay | IC50=23.2565 μM | SANGER | |||
| NCI-H292 | Growth Inhibition Assay | IC50=25.3536 μM | SANGER | |||
| COLO-680N | Growth Inhibition Assay | IC50=25.6329 μM | SANGER | |||
| KYSE-520 | Growth Inhibition Assay | IC50=25.644 μM | SANGER | |||
| NB10 | Growth Inhibition Assay | IC50=26.3117 μM | SANGER | |||
| NCI-H661 | Growth Inhibition Assay | IC50=26.4713 μM | SANGER | |||
| GMS-10 | Growth Inhibition Assay | IC50=26.8638 μM | SANGER | |||
| NCI-H2122 | Growth Inhibition Assay | IC50=26.9998 μM | SANGER | |||
| OVCAR-8 | Growth Inhibition Assay | IC50=27.0638 μM | SANGER | |||
| DJM-1 | Growth Inhibition Assay | IC50=27.1454 μM | SANGER | |||
| UACC-893 | Growth Inhibition Assay | IC50=27.9878 μM | SANGER | |||
| C8166 | Growth Inhibition Assay | IC50=28.6938 μM | SANGER | |||
| NCI-H1693 | Growth Inhibition Assay | IC50=28.6975 μM | SANGER | |||
| TYK-nu | Growth Inhibition Assay | IC50=30.0345 μM | SANGER | |||
| SW1710 | Growth Inhibition Assay | IC50=30.126 μM | SANGER | |||
| A375 | Growth Inhibition Assay | IC50=30.3243 μM | SANGER | |||
| HMV-II | Growth Inhibition Assay | IC50=31.3592 μM | SANGER | |||
| NCI-H2087 | Growth Inhibition Assay | IC50=31.6352 μM | SANGER | |||
| CAL-54 | Growth Inhibition Assay | IC50=31.7241 μM | SANGER | |||
| HCC70 | Growth Inhibition Assay | IC50=32.1387 μM | SANGER | |||
| ES1 | Growth Inhibition Assay | IC50=32.3062 μM | SANGER | |||
| NCI-H1355 | Growth Inhibition Assay | IC50=33.204 μM | SANGER | |||
| CFPAC-1 | Growth Inhibition Assay | IC50=33.2332 μM | SANGER | |||
| MKN28 | Growth Inhibition Assay | IC50=33.3809 μM | SANGER | |||
| HDLM-2 | Growth Inhibition Assay | IC50=33.6931 μM | SANGER | |||
| PANC-10-05 | Growth Inhibition Assay | IC50=34.1014 μM | SANGER | |||
| SAS | Growth Inhibition Assay | IC50=34.4565 μM | SANGER | |||
| HCC1395 | Growth Inhibition Assay | IC50=34.7186 μM | SANGER | |||
| 8305C | Growth Inhibition Assay | IC50=35.8415 μM | SANGER | |||
| KM12 | Growth Inhibition Assay | IC50=36.7547 μM | SANGER | |||
| SW1116 | Growth Inhibition Assay | IC50=37.5992 μM | SANGER | |||
| SK-MEL-1 | Growth Inhibition Assay | IC50=38.3389 μM | SANGER | |||
| HCC2218 | Growth Inhibition Assay | IC50=38.6519 μM | SANGER | |||
| T84 | Growth Inhibition Assay | IC50=38.7409 μM | SANGER | |||
| ETK-1 | Growth Inhibition Assay | IC50=39.022 μM | SANGER | |||
| COLO-800 | Growth Inhibition Assay | IC50=39.3868 μM | SANGER | |||
| CAL-12T | Growth Inhibition Assay | IC50=39.5281 μM | SANGER | |||
| ACN | Growth Inhibition Assay | IC50=40.4911 μM | SANGER | |||
| SJSA-1 | Growth Inhibition Assay | IC50=41.1596 μM | SANGER | |||
| PSN1 | Growth Inhibition Assay | IC50=41.1749 μM | SANGER | |||
| D-566MG | Growth Inhibition Assay | IC50=41.2086 μM | SANGER | |||
| EGI-1 | Growth Inhibition Assay | IC50=42.428 μM | SANGER | |||
| A204 | Growth Inhibition Assay | IC50=42.6388 μM | SANGER | |||
| Saos-2 | Growth Inhibition Assay | IC50=42.8369 μM | SANGER | |||
| SNU-C2B | Growth Inhibition Assay | IC50=43.6878 μM | SANGER | |||
| HLE | Growth Inhibition Assay | IC50=44.0856 μM | SANGER | |||
| SW1463 | Growth Inhibition Assay | IC50=44.9971 μM | SANGER | |||
| DSH1 | Growth Inhibition Assay | IC50=45.0033 μM | SANGER | |||
| MCF7 | Growth Inhibition Assay | IC50=45.5051 μM | SANGER | |||
| K5 | Growth Inhibition Assay | IC50=45.9405 μM | SANGER | |||
| NCI-H358 | Growth Inhibition Assay | IC50=47.215 μM | SANGER | |||
| NCI-H2030 | Growth Inhibition Assay | IC50=47.2374 μM | SANGER | |||
| SW948 | Growth Inhibition Assay | IC50=47.464 μM | SANGER | |||
| BALL-1 | Growth Inhibition Assay | IC50=47.6168 μM | SANGER | |||
| TE-9 | Growth Inhibition Assay | IC50=47.9581 μM | SANGER | |||
| SK-N-FI | Growth Inhibition Assay | IC50=48.0358 μM | SANGER | |||
| KALS-1 | Growth Inhibition Assay | IC50=48.1289 μM | SANGER | |||
| HO-1-N-1 | Growth Inhibition Assay | IC50=48.7445 μM | SANGER | |||
| NCI-H2452 | Growth Inhibition Assay | IC50=49.1152 μM | SANGER | |||
| OC-314 | Growth Inhibition Assay | IC50=49.6834 μM | SANGER | |||
| 클릭하여 더 많은 세포주 실험 데이터 보기 | ||||||
화학 정보, 보관 및 안정성
| 분자량 | 974.61 | 화학식 | C47H55ClF3N5O6S3 |
보관 (수령일로부터) | |
|---|---|---|---|---|---|
| CAS 번호 | 923564-51-6 | SDF 다운로드 | 원액 보관 |
|
|
| 동의어 | N/A | Smiles | CC1(CCC(=C(C1)CN2CCN(CC2)C3=CC=C(C=C3)C(=O)NS(=O)(=O)C4=CC(=C(C=C4)NC(CCN5CCOCC5)CSC6=CC=CC=C6)S(=O)(=O)C(F)(F)F)C7=CC=C(C=C7)Cl)C | ||
용해도
|
In vitro |
DMSO
: 100 mg/mL
(102.6 mM)
Water : Insoluble Ethanol : Insoluble |
몰농도 계산기
희석 계산기
분자량 계산기
|
In vivo |
|||||
생체 내 제형 계산기 (투명한 용액)
1단계: 아래 정보 입력 (권장: 실험 중 손실을 고려하여 추가 동물 포함)
mg/kg
g
μL
2단계: 생체 내 제형 입력 (이것은 계산기일 뿐 제형이 아닙니다. 용해도 섹션에 생체 내 제형이 없는 경우 먼저 당사에 문의하십시오.)
% DMSO
%
% Tween 80
% ddH2O
%DMSO
%
계산 결과:
작업 농도: mg/ml;
DMSO 원액 준비 방법: mg 약물 사전 용해 μL DMSO ( 원액 농도 mg/mL, 농도가 해당 약물 배치의 DMSO 용해도를 초과하는 경우 먼저 당사에 문의하십시오. )
생체 내 제형 준비 방법: 취하다 μL DMSO 원액, 다음 추가μL PEG300, 혼합하고 투명하게 한 다음 추가μL Tween 80, 혼합하고 투명하게 한 다음 추가 μL ddH2O, 혼합하고 투명하게 합니다.
생체 내 제형 준비 방법: 취하다 μL DMSO 원액, 다음 추가 μL 옥수수 기름, 혼합하고 투명하게 합니다.
참고: 1. 다음 용매를 추가하기 전에 액체가 투명한지 확인하십시오.
2. 용매를 순서대로 추가해야 합니다. 다음 용매를 추가하기 전에 이전 추가에서 얻은 용액이 투명한 용액인지 확인해야 합니다. 와동, 초음파 또는 뜨거운 물 중탕과 같은 물리적 방법을 사용하여 용해를 도울 수 있습니다.
작용 메커니즘
| Targets/IC50/Ki |
Bcl-xL
(Cell-free assay) <=0.5 nM(Ki)
Bcl-2
(Cell-free assay) <=1 nM(Ki)
Bcl-w
(Cell-free assay) <=1 nM(Ki)
|
|---|---|
| 시험관 내(In vitro) |
ABT-737과 구조적으로 관련된 Navitoclax (ABT-263)는 Bcl-2/Bcl-xL과 프로-아폽토시스 단백질 간의 상호작용을 방해합니다. 생존 촉진 Bcl-2 계열 구성원의 과발현은 종양 유지, 진행 및 화학요법 내성과 흔히 관련이 있습니다. 이는 Bcl-2 또는 Bcl-xL의 과발현으로 인한 보호를 EC50 값 60 nM 및 20 nM으로 각각 나타냅니다. 이 화합물은 가장 민감한 세포주(H146)에 대해 110 nM의 50% 성장 억제(EC50)를 보이는 광범위한 세포 활성을 나타내며, 가장 덜 민감한 세포주(H82)에서는 22 μM의 EC50을 나타냅니다. EC50 값이 400 nM 미만인 네 가지 세포주(H146, H889, H1963 및 H1417)는 ABT-737에도 매우 민감하며, 가장 저항성 있는 두 세포주(H1048 및 H82)도 ABT-263에 유사하게 저항합니다.
|
| 키나아제 분석 |
친화도 결정
|
|
Navitoclax (ABT-263)의 Bcl-2 계열의 다른 isoforms에 대한 결합 친화도(Ki 또는 IC50)는 경쟁 형광 편광 분석으로 결정됩니다. 다음 펩타이드 프로브/단백질 쌍이 사용됩니다: f-bad (1 nM) 및 Bcl-xL (6 nM), f-Bax (1 nM) 및 Bcl-2 (10 nM), f-Bax (1 nM) 및 Bcl-w (40 nM), f-Noxa (2 nM) 및 Mcl-1 (40 nM), 그리고 f-Bax (1 nM) 및 Bcl-2-A1 (15 nM). Bcl-xL에 대한 결합 친화도는 시간 분해 형광 공명 에너지 전달 분석을 사용하여 결정됩니다. Bcl-xL (1 nM, His 태그)은 200 nM의 f-Bak, 1 nM의 Tb-표지 항-His 항체 및 이 화합물과 실온에서 30분 동안 혼합됩니다. 형광은 Envision 플레이트 리더에서 340/35 nm 여기 필터와 520/525 (f-Bak) 및 495/510 nm (Tb-표지 항-His 항체) 방출 필터를 사용하여 측정됩니다.
|
|
| 생체 내(In vivo) |
Navitoclax (ABT-263)는 H345 이종이식 모델에서 100 mg/kg/일로 투여했을 때 유의미한 항종양 효능을 보였으며, 80%의 TGI와 치료 종양의 20%에서 종양 부피가 최소 50% 감소함을 나타냈습니다. 이 화합물의 단독 경구 투여는 소세포 폐암 및 급성 림프모구 백혈병의 이종이식 모델에서 완전한 종양 퇴행을 유발합니다. 공격성 B세포 림프종 및 다발성 골수종의 이종이식 모델에서 ABT-263은 단독으로 미미하거나 활동이 없었으나, 임상적으로 관련된 치료 요법의 효능을 유의미하게 향상시켰습니다.
|
참조 |
|
적용 분야
| 방법 | 바이오마커 | 이미지 | PMID |
|---|---|---|---|
| Western blot | STAT3 / pSTAT3 / STAT6 / pSTAT6 / Mcl-1 / Cleaved Mcl-1 / Bcl-xl / Bim / puma / Bik / Bax / PARP / c-Myc caspase3 / cleaved caspase 3 |
|
26811457 |
| Growth inhibition assay | Cell viability |
|
25685063 |
임상시험 정보
(데이터 출처 https://clinicaltrials.gov, 업데이트 날짜 2024-05-22)
| NCT 번호 | 모집 | 조건 | 스폰서/협력자 | 시작일 | 단계 |
|---|---|---|---|---|---|
| NCT05358639 | Recruiting | High Grade Serous Carcinoma|Triple Negative Breast Cancer|Ovarian Cancer |
Sunnybrook Health Sciences Centre|Exactis Innovation|Centre hospitalier de l''Université de Montréal (CHUM)|Princess Margaret Hospital Canada |
November 9 2022 | Phase 1 |
| NCT04480086 | Terminated | Myelofibrosis (MF) |
AbbVie |
March 17 2021 | Phase 1 |
| NCT04454658 | Active not recruiting | Myelofibrosis (MF) |
AbbVie |
November 11 2020 | Phase 1 |
기술 지원
자주 묻는 질문
질문 1:
Could you tell me if it can go through the hemato-encephalic barrier? This compound has the catalog number S1001.
답변:
According to the paper: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3223694/, it cannot cross the brain-blood barrier.
제품은 연구용으로만 사용됩니다. 인체에는 사용하지 마십시오. 환자에게 판매하지 않습니다.
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