Home Proteases Proteasome 억제제 MG132

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MG132 Proteasome 억제제

제품 번호S2619

MG132 ((S,R,S)-(-)-MG132, Z-Leu-D-Leu-Leu-al)는 강력한 proteasome (ChTL, TL 및 PGPH) 억제제입니다. 이 화합물은 또한 칼파인(IC50=1.2 μM)을 억제합니다. 이는 파킨슨병 동물 모델을 유도하는 데 사용될 수 있습니다.
MG132 Proteasome 억제제 Chemical Structure

화학 구조

분자량: 475.62

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MG 132 Validation

Selleck의 MG-132는 Sigma의 유사 제품에 비해 현저히 더 큰 효과를 보였습니다. 이는 (S, R, S) - (-) - 2 구성을 사용했기 때문입니다.

P21 단백질은 유비퀴틴화 경로를 통해 분해될 수 있습니다. 프로테아좀 활동 억제는 P21 단백질 축적을 유발하므로 억제 효과가 강력할수록 P21 단백질이 더 많이 축적됩니다. (테스트 단백질: P21; 세포주: Hela; 처리 조건: MG-132 최종 농도 5μM, 6시간 처리)

품질 관리

배치: 순도: 99.69%
99.69

함께 자주 사용되는 제품 MG132

Cycloheximide

Cycloheximide is a protein synthesis inhibitor. It is used in combination with this compound to investigate whether the protein changes are due to the synthesis pathway or the proteasome degradation pathway.

Epoxomicin (BU-4061T)

Epoxomicin is a highly selective and irreversible proteasome inhibitor, which is used in conjunction with it to compare the efficacy differences of different proteasome inhibitors.

Cycloheximide

It and Cycloheximide co-treatment rescues the DM1 protein from degradation in HEK293 cells.

Y-27632 Dihydrochloride

This compound and Y-27632 2HCl treatment inhibits protrusion and increases maturation-promoting factor (MPF) activities, whereas mitogen-activated protein kinase (MAPK) activity remains unchanged in oocytes.

세포 배양, 처리 및 작업 농도

세포주 분석 유형 농도 배양 시간 제형 활성 설명 PMID
LP-1 Apoptosis Assay 300 nM 24 h DMSO Induces apoptosis by increasing cleaved PARP level and reducing Mcl-1 protein level 15958589
PC3 Growth Inhibition Assay 20 μM 48 h DMSO IC50=0.6 μM 16686537
PC12 Function Assay 100 μM  24 h DMSO Inhibits 6-OHDA- and H2O2-induced cytotoxicity 17158454
LPS-stimulated RAW264.7 cells Function Assay DMSO Inhibits NF-kappaB DNA binding 17407277
OCI-Ly3 Function Assay 10 μM  4 h DMSO Induces human IkappaBalpha stabilization with EC50 of 1 μM 18024113
A2780 cDDP Apoptosis Assay 24 h DMSO Induces apoptosis by inhibiting PTEN degradation 17684018
COS-7 Cytotoxic Assay 10 μM DMSO IC50<10 μM 18088097
HuH-7 Cytotoxic Assay 10 μM DMSO IC50<10 μM 18088097
Hepa-1c1c7 Function Assay 25 μM 6 h DMSO Increases Nrf2 protein level 20392544
IPC227F Cytotoxic Assay 1 μM 48 h DMSO IC50=0.077 μM 21924528
Calu6 Function Assay 10 μM 18 h DMSO Significantly accumulates frataxin precursor 23506486
IFN-gamma-induced RAW264.7 Function Assay DMSO Inhibits nitric oxide production with IC50 of 0.077 μM 22277277
HEK-293 Kinase Assay 2 and 20 μM 2 h DMSO Inhibits ChT-L activity with IC50 of 9 nM 23540790
MCF10A Growth Inhibition Assay 1 μM 72 h DMSO IC50=0.29 μM 24153206
MCF-7 Growth Inhibition Assay 1 μM 72 h DMSO IC50=0.13 μM 24153206
HeLa Kinase Assay 10 μM 1 h DMSO Induces PARP cleavage by inhibiting proseasome activity 24321833
MDA-MB-231 Growth Inhibition Assay 1 μM 72 h DMSO IC50=0.18 μM 24153206
293T Cytotoxic Assay 10 μM 72 h DMSO IC50<2 μM 24625088
293T Function Assay 10 μM 24 h DMSO Moderately induces heat-shock 24625088
NCI-H929 Cytotoxic Assay 1 μM 72 h DMSO IC50=0.17 μM 24625088
A-549 Cytotoxic Assay 40 μM 48 h DMSO IC50<10 μM 24697496
MCF-7 Cytotoxic Assay 40 μM 48 h DMSO IC50=7.3 μM 24697496
SW-480 Cytotoxic Assay 40 μM 48 h DMSO IC50=4 μM 24697496
HL-60 Cytotoxic Assay 40 μM 48 h DMSO IC50<10 μM 24697496
SMMC-7721 Cytotoxic Assay 40 μM 48 h DMSO IC50=7.1 μM 24697496
LPS-stimulated RAW264.7 cells Function Assay 25 μM DMSO Inhibits nitric oxide production with IC50 of 0.1 μM 24697496
lymphoblastoid Function assay IC50 = 0.002 μM 17996987
LCL Function assay 12 h IC50 = 0.002 μM 20687609
HL-60 Function assay IC50 = 0.068 μM 15780623
IPC227F Function assay 1 h IC50 = 0.077 μM 16220988
RAW264.7 Antiinflammatory activity assay 18 h IC50 = 0.08 μM 22620677
RAW264.7 Antiinflammatory activity assay 18 h IC50 = 0.1 μM 23819871
RAW264.7 Function assay IC50 = 0.1 μM 24597894
RAW264.7 Function assay 18 h IC50 = 0.1 μM 24219809
RAW264.7 Function assay 18 h IC50 = 0.15 μM 23327668
RAW264.7 Function assay 18 h IC50 = 0.15 μM 26757019
RAW264.7 Antiinflammatory activity assay 18 h IC50 = 0.18 μM 27203291
RAW264.7 Antiinflammatory activity assay 1 h IC50 = 0.2 μM 29338260
MDA-MB-231 Cytotoxicity assay IC50 = 0.25 μM 18598018
MCF7 Cytotoxicity assay IC50 = 0.3 μM 18598018
RAW264.7 Function assay 18 h IC50 = 0.35 μM 21044847
RAW264.7 Antiinflammatory activity assay IC50 = 0.439 μM 21561060
HEK293 Function assay 2 h IC50 = 0.6 μM 23540790
RAW264.7 Toxicity assay IC50 = 0.63 μM 22858297
lymphoblastoid Function assay IC50 = 1.077 μM 17996987
LCL Function assay 12 h IC50 = 1.077 μM 20687609
HL-60 Function assay IC50 = 1.4 μM 15780623
HL-60 Function assay IC50 = 4.5 μM 15780623
C8166 Growth Inhibition Assay IC50=345.338 μM SANGER
P30-OHK Growth Inhibition Assay IC50=283.847 μM SANGER
NCI-H1838 Growth Inhibition Assay IC50=271.456 μM SANGER
THP-1 Growth Inhibition Assay IC50=264.738 μM SANGER
MS-1 Growth Inhibition Assay IC50=239.121 μM SANGER
REH Growth Inhibition Assay IC50=236.626 μM SANGER
TE-441-T Growth Inhibition Assay IC50=199.739 μM SANGER
TALL-1 Growth Inhibition Assay IC50=198.304 μM SANGER
SF539 Growth Inhibition Assay IC50=192.728 μM SANGER
NCI-H187 Growth Inhibition Assay IC50=190.064 μM SANGER
NCI-H226 Growth Inhibition Assay IC50=188.866 μM SANGER
IMR-5 Growth Inhibition Assay IC50=181.571 μM SANGER
NCI-H1417 Growth Inhibition Assay IC50=180.331 μM SANGER
TUR Growth Inhibition Assay IC50=167.87 μM SANGER
NCI-H1770 Growth Inhibition Assay IC50=156.279 μM SANGER
MDA-MB-134-VI Growth Inhibition Assay IC50=148.268 μM SANGER
NB14 Growth Inhibition Assay IC50=147.082 μM SANGER
EW-12 Growth Inhibition Assay IC50=144.699 μM SANGER
SUP-T1 Growth Inhibition Assay IC50=143.708 μM SANGER
KP-N-YS Growth Inhibition Assay IC50=139.736 μM SANGER
BE-13 Growth Inhibition Assay IC50=134.044 μM SANGER
NCI-H510A Growth Inhibition Assay IC50=127.32 μM SANGER
DMS-153 Growth Inhibition Assay IC50=121.745 μM SANGER
SK-MEL-1 Growth Inhibition Assay IC50=118.009 μM SANGER
DMS-79 Growth Inhibition Assay IC50=117.382 μM SANGER
DG-75 Growth Inhibition Assay IC50=113.352 μM SANGER
MN-60 Growth Inhibition Assay IC50=109.69 μM SANGER
WSU-NHL Growth Inhibition Assay IC50=109.671 μM SANGER
BV-173 Growth Inhibition Assay IC50=108.728 μM SANGER
EW-22 Growth Inhibition Assay IC50=106.19 μM SANGER
NCI-H889 Growth Inhibition Assay IC50=104.242 μM SANGER
NCI-H446 Growth Inhibition Assay IC50=99.7588 μM SANGER
NCI-H720 Growth Inhibition Assay IC50=98.4061 μM SANGER
NB7 Growth Inhibition Assay IC50=95.7786 μM SANGER
EW-3 Growth Inhibition Assay IC50=94.9081 μM SANGER
ECC4 Growth Inhibition Assay IC50=93.8269 μM SANGER
KY821 Growth Inhibition Assay IC50=91.6551 μM SANGER
RPMI-8226 Growth Inhibition Assay IC50=84.2107 μM SANGER
LU-134-A Growth Inhibition Assay IC50=83.1351 μM SANGER
NCI-H716 Growth Inhibition Assay IC50=82.9075 μM SANGER
RS4-11 Growth Inhibition Assay IC50=82.2505 μM SANGER
COLO-668 Growth Inhibition Assay IC50=81.5884 μM SANGER
NCI-H2171 Growth Inhibition Assay IC50=79.4136 μM SANGER
NCI-H526 Growth Inhibition Assay IC50=78.5877 μM SANGER
NCI-H322M Growth Inhibition Assay IC50=78.3709 μM SANGER
HCC1187 Growth Inhibition Assay IC50=77.6122 μM SANGER
SK-NEP-1 Growth Inhibition Assay IC50=75.0754 μM SANGER
DOHH-2 Growth Inhibition Assay IC50=74.9514 μM SANGER
NCI-H1155 Growth Inhibition Assay IC50=74.9367 μM SANGER
HCC1599 Growth Inhibition Assay IC50=74.8732 μM SANGER
RPMI-8866 Growth Inhibition Assay IC50=74.7509 μM SANGER
ATN-1 Growth Inhibition Assay IC50=74.505 μM SANGER
NCI-H1436 Growth Inhibition Assay IC50=72.7456 μM SANGER
SCC-15 Growth Inhibition Assay IC50=72.34 μM SANGER
NCI-H82 Growth Inhibition Assay IC50=71.9507 μM SANGER
NCI-H1694 Growth Inhibition Assay IC50=71.032 μM SANGER
KARPAS-299 Growth Inhibition Assay IC50=70.4447 μM SANGER
NB5 Growth Inhibition Assay IC50=70.3468 μM SANGER
MHH-CALL-2 Growth Inhibition Assay IC50=70.06 μM SANGER
UACC-812 Growth Inhibition Assay IC50=69.5209 μM SANGER
NCI-H1522 Growth Inhibition Assay IC50=69.0047 μM SANGER
U-698-M Growth Inhibition Assay IC50=68.5687 μM SANGER
SK-MEL-2 Growth Inhibition Assay IC50=63.9892 μM SANGER
TGBC24TKB Growth Inhibition Assay IC50=62.1491 μM SANGER
LOXIMVI Growth Inhibition Assay IC50=61.8266 μM SANGER
NCI-H2196 Growth Inhibition Assay IC50=61.231 μM SANGER
SCH Growth Inhibition Assay IC50=60.9638 μM SANGER
RPMI-8402 Growth Inhibition Assay IC50=58.9526 μM SANGER
NCI-H1395 Growth Inhibition Assay IC50=58.8172 μM SANGER
KP-N-RT-BM-1 Growth Inhibition Assay IC50=56.6638 μM SANGER
SW962 Growth Inhibition Assay IC50=54.8357 μM SANGER
TC-YIK Growth Inhibition Assay IC50=50.0363 μM SANGER
A3-KAW Growth Inhibition Assay IC50=49.8061 μM SANGER
HT Growth Inhibition Assay IC50=45.7007 μM SANGER
SW954 Growth Inhibition Assay IC50=47.4128 μM SANGER
CW-2 Growth Inhibition Assay IC50=44.8342 μM SANGER
EoL-1- Growth Inhibition Assay IC50=44.1568 μM SANGER
MPP-89 Growth Inhibition Assay IC50=42.5875 μM SANGER
MV-4-11 Growth Inhibition Assay IC50=42.9067 μM SANGER
SBC-1 Growth Inhibition Assay IC50=42.1806 μM SANGER
MLMA Growth Inhibition Assay IC50=41.7595 μM SANGER
DEL Growth Inhibition Assay IC50=41.4405 μM SANGER
LB996-RCC Growth Inhibition Assay IC50=40.8716 μM SANGER
NCI-H64 Growth Inhibition Assay IC50=40.0948 μM SANGER
MHH-PREB-1 Growth Inhibition Assay IC50=39.7388 μM SANGER
NCI-SNU-16 Growth Inhibition Assay IC50=38.5653 μM SANGER
LC-2-ad Growth Inhibition Assay IC50=39.4337 μM SANGER
RCC10RGB Growth Inhibition Assay IC50=38.2083 μM SANGER
NCI-H1299 Growth Inhibition Assay IC50=38.1603 μM SANGER
K-562 Growth Inhibition Assay IC50=37.0864 μM SANGER
CGTH-W-1 Growth Inhibition Assay IC50=36.9048 μM SANGER
KP-N-YN Growth Inhibition Assay IC50=34.9057 μM SANGER
TE-11 Growth Inhibition Assay IC50=34.4822 μM SANGER
L-428 Growth Inhibition Assay IC50=34.7536 μM SANGER
Ramos-2G6-4C10 Growth Inhibition Assay IC50=34.2993 μM SANGER
EW-13 Growth Inhibition Assay IC50=33.8969 μM SANGER
NB69 Growth Inhibition Assay IC50=33.6454 μM SANGER
EW-24 Growth Inhibition Assay IC50=32.3474 μM SANGER
L-363 Growth Inhibition Assay IC50=32.2144 μM SANGER
SNU-C1 Growth Inhibition Assay IC50=31.3126 μM SANGER
JAR Growth Inhibition Assay IC50=31.3799 μM SANGER
NCI-H2107 Growth Inhibition Assay IC50=31.2338 μM SANGER
NB6 Growth Inhibition Assay IC50=30.9503 μM SANGER
SIG-M5 Growth Inhibition Assay IC50=30.7952 μM SANGER
LNCaP-Clone-FGC Growth Inhibition Assay IC50=29.9281 μM SANGER
COLO-800 Growth Inhibition Assay IC50=28.2956 μM SANGER
ETK-1 Growth Inhibition Assay IC50=28.3446 μM SANGER
LU-165 Growth Inhibition Assay IC50=28.0861 μM SANGER
COR-L279 Growth Inhibition Assay IC50=26.7922 μM SANGER
U-87-MG Growth Inhibition Assay IC50=26.7644 μM SANGER
NCI-H1963 Growth Inhibition Assay IC50=26.0623 μM SANGER
ST486 Growth Inhibition Assay IC50=25.1113 μM SANGER
LS-123 Growth Inhibition Assay IC50=24.9012 μM SANGER
NB1 Growth Inhibition Assay IC50=24.6939 μM SANGER
CPC-N Growth Inhibition Assay IC50=24.0201 μM SANGER
EHEB Growth Inhibition Assay IC50=21.6731 μM SANGER
CHP-126 Growth Inhibition Assay IC50=21.6181 μM SANGER
GR-ST Growth Inhibition Assay IC50=21.417 μM SANGER
NCI-H345 Growth Inhibition Assay IC50=21.0643 μM SANGER
RPMI-6666 Growth Inhibition Assay IC50=21.3602 μM SANGER
HDLM-2 Growth Inhibition Assay IC50=20.8821 μM SANGER
NCI-H1304 Growth Inhibition Assay IC50=21.0311 μM SANGER
IM-9 Growth Inhibition Assay IC50=20.6224 μM SANGER
P31-FUJ Growth Inhibition Assay IC50=20.4753 μM SANGER
HL-60 Growth Inhibition Assay IC50=20.1965 μM SANGER
KMOE-2 Growth Inhibition Assay IC50=19.6482 μM SANGER
J-RT3-T3-5 Growth Inhibition Assay IC50=19.4066 μM SANGER
MOLT-4 Growth Inhibition Assay IC50=18.8208 μM SANGER
Daudi Growth Inhibition Assay IC50=18.9231 μM SANGER
CAL-148 Growth Inhibition Assay IC50=17.9796 μM SANGER
HCC2157 Growth Inhibition Assay IC50=17.4755 μM SANGER
LS-1034 Growth Inhibition Assay IC50=17.6818 μM SANGER
BOKU Growth Inhibition Assay IC50=15.9608 μM SANGER
GOTO Growth Inhibition Assay IC50=16.9617 μM SANGER
COLO-824 Growth Inhibition Assay IC50=14.7994 μM SANGER
BC-3 Growth Inhibition Assay IC50=15.398 μM SANGER
MSTO-211H Growth Inhibition Assay IC50=14.7448 μM SANGER
JVM-2 Growth Inhibition Assay IC50=14.7735 μM SANGER
DB Growth Inhibition Assay IC50=13.9885 μM SANGER
697 Growth Inhibition Assay IC50=14.4511 μM SANGER
TE-12 Growth Inhibition Assay IC50=13.6994 μM SANGER
NCI-N87 Growth Inhibition Assay IC50=13.736 μM SANGER
EB2 Growth Inhibition Assay IC50=13.8505 μM SANGER
MHH-NB-11 Growth Inhibition Assay IC50=13.2902 μM SANGER
KU812 Growth Inhibition Assay IC50=13.6124 μM SANGER
NB13 Growth Inhibition Assay IC50=12.9783 μM SANGER
MRK-nu-1 Growth Inhibition Assay IC50=13.195 μM SANGER
COR-L88 Growth Inhibition Assay IC50=12.9382 μM SANGER
K5 Growth Inhibition Assay IC50=12.9462 μM SANGER
KARPAS-422 Growth Inhibition Assay IC50=12.7496 μM SANGER
LU-139 Growth Inhibition Assay IC50=12.9026 μM SANGER
NOS-1 Growth Inhibition Assay IC50=12.0345 μM SANGER
AM-38 Growth Inhibition Assay IC50=12.5633 μM SANGER
A498 Growth Inhibition Assay IC50=12.7069 μM SANGER
SK-MM-2 Growth Inhibition Assay IC50=11.8061 μM SANGER
NCI-H524 Growth Inhibition Assay IC50=11.9822 μM SANGER
EW-11 Growth Inhibition Assay IC50=11.5186 μM SANGER
TGBC1TKB Growth Inhibition Assay IC50=11.4102 μM SANGER
NCI-H1648 Growth Inhibition Assay IC50=11.0965 μM SANGER
SR Growth Inhibition Assay IC50=11.0185 μM SANGER
EC-GI-10 Growth Inhibition Assay IC50=10.7031 μM SANGER
SCLC-21H Growth Inhibition Assay IC50=10.6596 μM SANGER
NCI-SNU-1 Growth Inhibition Assay IC50=10.4969 μM SANGER
CA46 Growth Inhibition Assay IC50=10.361 μM SANGER
NH-12 Growth Inhibition Assay IC50=10.2433 μM SANGER
CTV-1 Growth Inhibition Assay IC50=10.0979 μM SANGER
IST-MEL1 Growth Inhibition Assay IC50=9.74198 μM SANGER
JiyoyeP-2003 Growth Inhibition Assay IC50=9.29317 μM SANGER
SJSA-1 Growth Inhibition Assay IC50=9.09091 μM SANGER
MC116 Growth Inhibition Assay IC50=8.9794 μM SANGER
D-283MED Growth Inhibition Assay IC50=8.91719 μM SANGER
OMC-1 Growth Inhibition Assay IC50=8.52191 μM SANGER
RL95-2 Growth Inhibition Assay IC50=8.10842 μM SANGER
NB10 Growth Inhibition Assay IC50=7.99556 μM SANGER
MZ1-PC Growth Inhibition Assay IC50=7.86558 μM SANGER
LB1047-RCC Growth Inhibition Assay IC50=7.72231 μM SANGER
SK-N-DZ Growth Inhibition Assay IC50=7.71089 μM SANGER
NOMO-1 Growth Inhibition Assay IC50=7.24254 μM SANGER
SHP-77 Growth Inhibition Assay IC50=7.2243 μM SANGER
OCI-AML2 Growth Inhibition Assay IC50=7.00326 μM SANGER
NALM-6 Growth Inhibition Assay IC50=6.86754 μM SANGER
KASUMI-1 Growth Inhibition Assay IC50=6.84787 μM SANGER
EM-2 Growth Inhibition Assay IC50=6.67099 μM SANGER
NMC-G1 Growth Inhibition Assay IC50=6.71895 μM SANGER
SK-N-FI Growth Inhibition Assay IC50=6.45854 μM SANGER
U-266 Growth Inhibition Assay IC50=6.51926 μM SANGER
HUTU-80 Growth Inhibition Assay IC50=6.36897 μM SANGER
TGW Growth Inhibition Assay IC50=6.45593 μM SANGER
A4-Fuk Growth Inhibition Assay IC50=6.08118 μM SANGER
NCI-H1581 Growth Inhibition Assay IC50=6.23849 μM SANGER
ARH-77 Growth Inhibition Assay IC50=5.67087 μM SANGER
ALL-PO Growth Inhibition Assay IC50=5.63795 μM SANGER
GCIY Growth Inhibition Assay IC50=5.47236 μM SANGER
Calu-6 Growth Inhibition Assay IC50=5.622 μM SANGER
SIMA Growth Inhibition Assay IC50=5.30765 μM SANGER
RL Growth Inhibition Assay IC50=5.37541 μM SANGER
RKO Growth Inhibition Assay IC50=5.23422 μM SANGER
NCI-H209 Growth Inhibition Assay IC50=5.19352 μM SANGER
BT-474 Growth Inhibition Assay IC50=5.23102 μM SANGER
EB-3 Growth Inhibition Assay IC50=5.03041 μM SANGER
GT3TKB Growth Inhibition Assay IC50=5.17662 μM SANGER
HAL-01 Growth Inhibition Assay IC50=4.57034 μM SANGER
LP-1 Growth Inhibition Assay IC50=4.72371 μM SANGER
BC-1 Growth Inhibition Assay IC50=5.00447 μM SANGER
LB647-SCLC Growth Inhibition Assay IC50=4.56308 μM SANGER
ES5 Growth Inhibition Assay IC50=4.40255 μM SANGER
ES3 Growth Inhibition Assay IC50=4.32824 μM SANGER
YT Growth Inhibition Assay IC50=4.35424 μM SANGER
NCI-H1650 Growth Inhibition Assay IC50=4.15797 μM SANGER
D-336MG Growth Inhibition Assay IC50=4.01166 μM SANGER
TE-6 Growth Inhibition Assay IC50=3.94561 μM SANGER
NKM-1 Growth Inhibition Assay IC50=3.77378 μM SANGER
COLO-320-HSR Growth Inhibition Assay IC50=3.75634 μM SANGER
SKM-1 Growth Inhibition Assay IC50=3.71376 μM SANGER
KMS-12-PE Growth Inhibition Assay IC50=3.67723 μM SANGER
SNB75 Growth Inhibition Assay IC50=3.60103 μM SANGER
NB12 Growth Inhibition Assay IC50=3.59888 μM SANGER
MEG-01 Growth Inhibition Assay IC50=3.5968 μM SANGER
HCC2218 Growth Inhibition Assay IC50=3.46937 μM SANGER
NCI-H748 Growth Inhibition Assay IC50=3.44266 μM SANGER
RH-1 Growth Inhibition Assay IC50=3.38748 μM SANGER
SCC-3 Growth Inhibition Assay IC50=3.10848 μM SANGER
ES4 Growth Inhibition Assay IC50=3.06111 μM SANGER
KG-1 Growth Inhibition Assay IC50=2.88791 μM SANGER
SW982 Growth Inhibition Assay IC50=2.5148 μM SANGER
MFM-223 Growth Inhibition Assay IC50=2.50871 μM SANGER
HCE-T Growth Inhibition Assay IC50=2.44883 μM SANGER
ECC12 Growth Inhibition Assay IC50=2.3794 μM SANGER
KM-H2 Growth Inhibition Assay IC50=2.29043 μM SANGER
MC-CAR Growth Inhibition Assay IC50=2.2295 μM SANGER
QIMR-WIL Growth Inhibition Assay IC50=2.16762 μM SANGER
no-11 Growth Inhibition Assay IC50=2.03104 μM SANGER
DJM-1 Growth Inhibition Assay IC50=2.02552 μM SANGER
EW-18 Growth Inhibition Assay IC50=2.02337 μM SANGER
IST-SL2 Growth Inhibition Assay IC50=2.01252 μM SANGER
JVM-3 Growth Inhibition Assay IC50=1.93904 μM SANGER
TE-15 Growth Inhibition Assay IC50=1.92373 μM SANGER
BB30-HNC Growth Inhibition Assay IC50=1.72685 μM SANGER
SU-DHL-1 Growth Inhibition Assay IC50=1.71281 μM SANGER
LS-411N Growth Inhibition Assay IC50=1.69807 μM SANGER
NCI-H2141 Growth Inhibition Assay IC50=1.67317 μM SANGER
D-502MG Growth Inhibition Assay IC50=1.67211 μM SANGER
NCI-H2227 Growth Inhibition Assay IC50=1.61561 μM SANGER
LC-1F Growth Inhibition Assay IC50=1.55198 μM SANGER
NCI-H2081 Growth Inhibition Assay IC50=1.55196 μM SANGER
GI-1 Growth Inhibition Assay IC50=1.47131 μM SANGER
DMS-114 Growth Inhibition Assay IC50=1.44539 μM SANGER
Raji Growth Inhibition Assay IC50=1.4185 μM SANGER
IST-MES1 Growth Inhibition Assay IC50=1.40208 μM SANGER
HC-1 Growth Inhibition Assay IC50=1.3817 μM SANGER
NCI-H128 Growth Inhibition Assay IC50=1.35814 μM SANGER
EW-16 Growth Inhibition Assay IC50=1.31347 μM SANGER
HCE-4 Growth Inhibition Assay IC50=1.30221 μM SANGER
SW684 Growth Inhibition Assay IC50=1.28659 μM SANGER
NCI-H719 Growth Inhibition Assay IC50=1.27411 μM SANGER
PSN1 Growth Inhibition Assay IC50=1.27016 μM SANGER
IA-LM Growth Inhibition Assay IC50=1.24116 μM SANGER
NCI-H23 Growth Inhibition Assay IC50=1.2041 μM SANGER
MFH-ino Growth Inhibition Assay IC50=1.17501 μM SANGER
LU-65 Growth Inhibition Assay IC50=1.12753 μM SANGER
KURAMOCHI Growth Inhibition Assay IC50=1.12374 μM SANGER
L-540 Growth Inhibition Assay IC50=1.11839 μM SANGER
ES1 Growth Inhibition Assay IC50=1.07921 μM SANGER
KGN Growth Inhibition Assay IC50=1.05045 μM SANGER
KARPAS-45 Growth Inhibition Assay IC50=1.04016 μM SANGER
EKVX Growth Inhibition Assay IC50=1.03442 μM SANGER
SF126 Growth Inhibition Assay IC50=0.98971 μM SANGER
TE-10 Growth Inhibition Assay IC50=0.9643 μM SANGER
HCC2998 Growth Inhibition Assay IC50=0.93854 μM SANGER
COLO-684 Growth Inhibition Assay IC50=0.90658 μM SANGER
ES7 Growth Inhibition Assay IC50=0.8965 μM SANGER
KM12 Growth Inhibition Assay IC50=0.85466 μM SANGER
Becker Growth Inhibition Assay IC50=0.79621 μM SANGER
CTB-1 Growth Inhibition Assay IC50=0.77955 μM SANGER
GB-1 Growth Inhibition Assay IC50=0.72124 μM SANGER
SNU-C2B Growth Inhibition Assay IC50=0.70739 μM SANGER
NCI-SNU-5 Growth Inhibition Assay IC50=0.69545 μM SANGER
BL-70 Growth Inhibition Assay IC50=0.69388 μM SANGER
NCI-H1355 Growth Inhibition Assay IC50=0.68619 μM SANGER
LS-513 Growth Inhibition Assay IC50=0.66751 μM SANGER
SW872 Growth Inhibition Assay IC50=0.65729 μM SANGER
SF268 Growth Inhibition Assay IC50=0.65641 μM SANGER
NCI-H2126 Growth Inhibition Assay IC50=0.62669 μM SANGER
TE-9 Growth Inhibition Assay IC50=0.61033 μM SANGER
NCI-H1882 Growth Inhibition Assay IC50=0.59036 μM SANGER
BB65-RCC Growth Inhibition Assay IC50=0.56811 μM SANGER
MONO-MAC-6 Growth Inhibition Assay IC50=0.53611 μM SANGER
Mo-T Growth Inhibition Assay IC50=0.51762 μM SANGER
EVSA-T Growth Inhibition Assay IC50=0.49911 μM SANGER
BB49-HNC Growth Inhibition Assay IC50=0.49096 μM SANGER
A704 Growth Inhibition Assay IC50=0.48692 μM SANGER
OS-RC-2 Growth Inhibition Assay IC50=0.47972 μM SANGER
CCRF-CEM Growth Inhibition Assay IC50=0.47674 μM SANGER
KALS-1 Growth Inhibition Assay IC50=0.46584 μM SANGER
TE-1 Growth Inhibition Assay IC50=0.45119 μM SANGER
LC4-1 Growth Inhibition Assay IC50=0.43607 μM SANGER
NB17 Growth Inhibition Assay IC50=0.4297 μM SANGER
8-MG-BA Growth Inhibition Assay IC50=0.39837 μM SANGER
NCI-H1092 Growth Inhibition Assay IC50=0.38844 μM SANGER
NCI-H747 Growth Inhibition Assay IC50=0.37103 μM SANGER
GDM-1 Growth Inhibition Assay IC50=0.35104 μM SANGER
TE-8 Growth Inhibition Assay IC50=0.34279 μM SANGER
HH Growth Inhibition Assay IC50=0.32897 μM SANGER
NCCIT Growth Inhibition Assay IC50=0.31783 μM SANGER
KLE Growth Inhibition Assay IC50=0.31306 μM SANGER
LAN-6 Growth Inhibition Assay IC50=0.313 μM SANGER
CMK Growth Inhibition Assay IC50=0.3112 μM SANGER
KNS-81-FD Growth Inhibition Assay IC50=0.30323 μM SANGER
MOLT-16 Growth Inhibition Assay IC50=0.29524 μM SANGER
K052 Growth Inhibition Assay IC50=0.2899 μM SANGER
C2BBe1 Growth Inhibition Assay IC50=0.27907 μM SANGER
CP67-MEL Growth Inhibition Assay IC50=0.2673 μM SANGER
MZ7-mel Growth Inhibition Assay IC50=0.26374 μM SANGER
LOUCY Growth Inhibition Assay IC50=0.25456 μM SANGER
TK10 Growth Inhibition Assay IC50=0.25435 μM SANGER
RXF393 Growth Inhibition Assay IC50=0.25015 μM SANGER
ES8 Growth Inhibition Assay IC50=0.24763 μM SANGER
COLO-829 Growth Inhibition Assay IC50=0.24257 μM SANGER
LB373-MEL-D Growth Inhibition Assay IC50=0.24198 μM SANGER
HD-MY-Z Growth Inhibition Assay IC50=0.23303 μM SANGER
SK-PN-DW Growth Inhibition Assay IC50=0.2319 μM SANGER
ACN Growth Inhibition Assay IC50=0.22638 μM SANGER
VA-ES-BJ Growth Inhibition Assay IC50=0.22257 μM SANGER
SK-UT-1 Growth Inhibition Assay IC50=0.22049 μM SANGER
LAMA-84 Growth Inhibition Assay IC50=0.21851 μM SANGER
EW-1 Growth Inhibition Assay IC50=0.21047 μM SANGER
GAK Growth Inhibition Assay IC50=0.20534 μM SANGER
IST-SL1 Growth Inhibition Assay IC50=0.20094 μM SANGER
DU-4475 Growth Inhibition Assay IC50=0.19658 μM SANGER
LB831-BLC Growth Inhibition Assay IC50=0.1934 μM SANGER
GI-ME-N Growth Inhibition Assay IC50=0.19306 μM SANGER
SK-LMS-1 Growth Inhibition Assay IC50=0.19303 μM SANGER
D-392MG Growth Inhibition Assay IC50=0.19115 μM SANGER
HEL Growth Inhibition Assay IC50=0.18517 μM SANGER
MZ2-MEL Growth Inhibition Assay IC50=0.17559 μM SANGER
CESS Growth Inhibition Assay IC50=0.1706 μM SANGER
PF-382 Growth Inhibition Assay IC50=0.16706 μM SANGER
A253 Growth Inhibition Assay IC50=0.16128 μM SANGER
D-263MG Growth Inhibition Assay IC50=0.16006 μM SANGER
CAS-1 Growth Inhibition Assay IC50=0.15482 μM SANGER
NCI-H69 Growth Inhibition Assay IC50=0.15141 μM SANGER
KINGS-1 Growth Inhibition Assay IC50=0.1479 μM SANGER
TE-5 Growth Inhibition Assay IC50=0.14278 μM SANGER
LB2241-RCC Growth Inhibition Assay IC50=0.14247 μM SANGER
HT-144 Growth Inhibition Assay IC50=0.13895 μM SANGER
KE-37 Growth Inhibition Assay IC50=0.13278 μM SANGER
ONS-76 Growth Inhibition Assay IC50=0.12935 μM SANGER
NEC8 Growth Inhibition Assay IC50=0.11995 μM SANGER
UACC-257 Growth Inhibition Assay IC50=0.11927 μM SANGER
ML-2 Growth Inhibition Assay IC50=0.11806 μM SANGER
HOP-62 Growth Inhibition Assay IC50=0.10949 μM SANGER
OVCAR-4 Growth Inhibition Assay IC50=0.10938 μM SANGER
OPM-2 Growth Inhibition Assay IC50=0.10474 μM SANGER
A388 Growth Inhibition Assay IC50=0.09065 μM SANGER
no-10 Growth Inhibition Assay IC50=0.08909 μM SANGER
LB771-HNC Growth Inhibition Assay IC50=0.08036 μM SANGER
CP66-MEL Growth Inhibition Assay IC50=0.075 μM SANGER
MMAC-SF Growth Inhibition Assay IC50=0.07268 μM SANGER
D-247MG Growth Inhibition Assay IC50=0.07209 μM SANGER
LXF-289 Growth Inhibition Assay IC50=0.07066 μM SANGER
BL-41 Growth Inhibition Assay IC50=0.06947 μM SANGER
KS-1 Growth Inhibition Assay IC50=0.06458 μM SANGER
D-542MG Growth Inhibition Assay IC50=0.05957 μM SANGER
NTERA-S-cl-D1 Growth Inhibition Assay IC50=0.05772 μM SANGER
DSH1 Growth Inhibition Assay IC50=0.05289 μM SANGER
KNS-42 Growth Inhibition Assay IC50=0.04441 μM SANGER
SH-4 Growth Inhibition Assay IC50=0.0431 μM SANGER
LB2518-MEL Growth Inhibition Assay IC50=0.0376 μM SANGER
OCUB-M Growth Inhibition Assay IC50=0.03737 μM SANGER
A101D Growth Inhibition Assay IC50=0.03279 μM SANGER
ES6 Growth Inhibition Assay IC50=0.01306 μM SANGER
MFH-ino Growth Inhibition Assay IC50=0.1111 μM SANGER
TE-8 Growth Inhibition Assay IC50=0.27009 μM SANGER
A101D Growth Inhibition Assay IC50=0.30094 μM SANGER
ES6 Growth Inhibition Assay IC50=0.33014 μM SANGER
HT-144 Growth Inhibition Assay IC50=0.33422 μM SANGER
RPMI-8226 Growth Inhibition Assay IC50=0.4231 μM SANGER
NTERA-S-cl-D1 Growth Inhibition Assay IC50=0.42592 μM SANGER
ML-2 Growth Inhibition Assay IC50=0.47349 μM SANGER
LB831-BLC Growth Inhibition Assay IC50=0.47626 μM SANGER
BE-13 Growth Inhibition Assay IC50=0.56207 μM SANGER
HH Growth Inhibition Assay IC50=0.57053 μM SANGER
PF-382 Growth Inhibition Assay IC50=0.58379 μM SANGER
SH-4 Growth Inhibition Assay IC50=0.60509 μM SANGER
no-10 Growth Inhibition Assay IC50=0.60813 μM SANGER
KINGS-1 Growth Inhibition Assay IC50=0.62764 μM SANGER
KE-37 Growth Inhibition Assay IC50=0.63942 μM SANGER
TGBC1TKB Growth Inhibition Assay IC50=0.68642 μM SANGER
NCI-H747 Growth Inhibition Assay IC50=0.71274 μM SANGER
MONO-MAC-6 Growth Inhibition Assay IC50=0.7182 μM SANGER
LC4-1 Growth Inhibition Assay IC50=0.74747 μM SANGER
DSH1 Growth Inhibition Assay IC50=0.75792 μM SANGER
OPM-2 Growth Inhibition Assay IC50=0.75837 μM SANGER
CP66-MEL Growth Inhibition Assay IC50=0.83646 μM SANGER
LB2241-RCC Growth Inhibition Assay IC50=0.87076 μM SANGER
EM-2 Growth Inhibition Assay IC50=0.87844 μM SANGER
ONS-76 Growth Inhibition Assay IC50=0.89904 μM SANGER
RKO Growth Inhibition Assay IC50=0.93176 μM SANGER
RS4-11 Growth Inhibition Assay IC50=0.95567 μM SANGER
KS-1 Growth Inhibition Assay IC50=0.97175 μM SANGER
HEL Growth Inhibition Assay IC50=1.07025 μM SANGER
LB771-HNC Growth Inhibition Assay IC50=1.07291 μM SANGER
KGN Growth Inhibition Assay IC50=1.17566 μM SANGER
NMC-G1 Growth Inhibition Assay IC50=1.18954 μM SANGER
C2BBe1 Growth Inhibition Assay IC50=1.20033 μM SANGER
HCC1599 Growth Inhibition Assay IC50=1.25589 μM SANGER
TK10 Growth Inhibition Assay IC50=1.28397 μM SANGER
IST-SL1 Growth Inhibition Assay IC50=1.30754 μM SANGER
Raji Growth Inhibition Assay IC50=1.46531 μM SANGER
KALS-1 Growth Inhibition Assay IC50=1.46658 μM SANGER
BB49-HNC Growth Inhibition Assay IC50=1.49911 μM SANGER
LB996-RCC Growth Inhibition Assay IC50=1.55279 μM SANGER
NCI-H1092 Growth Inhibition Assay IC50=1.58368 μM SANGER
DEL Growth Inhibition Assay IC50=1.5921 μM SANGER
HT Growth Inhibition Assay IC50=1.70043 μM SANGER
TE-5 Growth Inhibition Assay IC50=1.83901 μM SANGER
RPMI-6666 Growth Inhibition Assay IC50=1.85897 μM SANGER
JVM-2 Growth Inhibition Assay IC50=1.95209 μM SANGER
Daudi Growth Inhibition Assay IC50=2.05459 μM SANGER
NCI-SNU-5 Growth Inhibition Assay IC50=2.07059 μM SANGER
BL-41 Growth Inhibition Assay IC50=2.11804 μM SANGER
OMC-1 Growth Inhibition Assay IC50=2.15065 μM SANGER
HCC2157 Growth Inhibition Assay IC50=2.15677 μM SANGER
MLMA Growth Inhibition Assay IC50=2.18576 μM SANGER
LB373-MEL-D Growth Inhibition Assay IC50=2.23667 μM SANGER
KURAMOCHI Growth Inhibition Assay IC50=2.25183 μM SANGER
697 Growth Inhibition Assay IC50=2.26226 μM SANGER
KARPAS-422 Growth Inhibition Assay IC50=2.30393 μM SANGER
CCRF-CEM Growth Inhibition Assay IC50=2.31255 μM SANGER
A3-KAW Growth Inhibition Assay IC50=2.38186 μM SANGER
KARPAS-299 Growth Inhibition Assay IC50=2.38967 μM SANGER
LAMA-84 Growth Inhibition Assay IC50=2.45622 μM SANGER
SCC-3 Growth Inhibition Assay IC50=2.47955 μM SANGER
SW872 Growth Inhibition Assay IC50=2.60022 μM SANGER
KNS-81-FD Growth Inhibition Assay IC50=2.67382 μM SANGER
NCCIT Growth Inhibition Assay IC50=2.67795 μM SANGER
ACN Growth Inhibition Assay IC50=2.84394 μM SANGER
CAS-1 Growth Inhibition Assay IC50=2.86126 μM SANGER
GB-1 Growth Inhibition Assay IC50=2.88421 μM SANGER
EW-16 Growth Inhibition Assay IC50=2.98023 μM SANGER
LB647-SCLC Growth Inhibition Assay IC50=3.0086 μM SANGER
KM-H2 Growth Inhibition Assay IC50=3.14413 μM SANGER
Becker Growth Inhibition Assay IC50=3.20254 μM SANGER
MMAC-SF Growth Inhibition Assay IC50=3.21082 μM SANGER
BC-1 Growth Inhibition Assay IC50=3.24287 μM SANGER
GR-ST Growth Inhibition Assay IC50=3.59266 μM SANGER
SCC-15 Growth Inhibition Assay IC50=3.59326 μM SANGER
KP-N-YS Growth Inhibition Assay IC50=3.62126 μM SANGER
A253 Growth Inhibition Assay IC50=3.76302 μM SANGER
JiyoyeP-2003 Growth Inhibition Assay IC50=3.82083 μM SANGER
LAN-6 Growth Inhibition Assay IC50=3.85926 μM SANGER
VA-ES-BJ Growth Inhibition Assay IC50=3.96369 μM SANGER
MPP-89 Growth Inhibition Assay IC50=3.98406 μM SANGER
K-562 Growth Inhibition Assay IC50=3.9918 μM SANGER
KASUMI-1 Growth Inhibition Assay IC50=3.99677 μM SANGER
THP-1 Growth Inhibition Assay IC50=4.04835 μM SANGER
DOHH-2 Growth Inhibition Assay IC50=4.06592 μM SANGER
EW-1 Growth Inhibition Assay IC50=4.19255 μM SANGER
K5 Growth Inhibition Assay IC50=4.26164 μM SANGER
SR Growth Inhibition Assay IC50=4.3002 μM SANGER
NCI-H719 Growth Inhibition Assay IC50=4.36265 μM SANGER
A388 Growth Inhibition Assay IC50=4.39507 μM SANGER
HCC2218 Growth Inhibition Assay IC50=4.44812 μM SANGER
EB2 Growth Inhibition Assay IC50=4.5114 μM SANGER
UACC-257 Growth Inhibition Assay IC50=4.51454 μM SANGER
LC-1F Growth Inhibition Assay IC50=4.63784 μM SANGER
NB1 Growth Inhibition Assay IC50=4.8413 μM SANGER
NCI-H748 Growth Inhibition Assay IC50=4.90737 μM SANGER
NALM-6 Growth Inhibition Assay IC50=4.92582 μM SANGER
NB7 Growth Inhibition Assay IC50=5.04589 μM SANGER
ECC4 Growth Inhibition Assay IC50=5.05273 μM SANGER
no-11 Growth Inhibition Assay IC50=5.16913 μM SANGER
COLO-824 Growth Inhibition Assay IC50=5.40415 μM SANGER
LXF-289 Growth Inhibition Assay IC50=5.40704 μM SANGER
MOLT-4 Growth Inhibition Assay IC50=5.48599 μM SANGER
NCI-H1355 Growth Inhibition Assay IC50=5.63865 μM SANGER
ATN-1 Growth Inhibition Assay IC50=5.76359 μM SANGER
NOS-1 Growth Inhibition Assay IC50=5.85194 μM SANGER
PSN1 Growth Inhibition Assay IC50=5.90945 μM SANGER
NOMO-1 Growth Inhibition Assay IC50=5.99228 μM SANGER
NCI-H23 Growth Inhibition Assay IC50=6.10875 μM SANGER
LB1047-RCC Growth Inhibition Assay IC50=6.3288 μM SANGER
ES8 Growth Inhibition Assay IC50=6.36816 μM SANGER
LS-1034 Growth Inhibition Assay IC50=6.55658 μM SANGER
MDA-MB-134-VI Growth Inhibition Assay IC50=6.64033 μM SANGER
MZ1-PC Growth Inhibition Assay IC50=6.674 μM SANGER
ES4 Growth Inhibition Assay IC50=6.92652 μM SANGER
SNB75 Growth Inhibition Assay IC50=7.20588 μM SANGER
P30-OHK Growth Inhibition Assay IC50=7.21282 μM SANGER
Calu-6 Growth Inhibition Assay IC50=7.27563 μM SANGER
MHH-PREB-1 Growth Inhibition Assay IC50=7.32929 μM SANGER
DU-4475 Growth Inhibition Assay IC50=7.57964 μM SANGER
U-698-M Growth Inhibition Assay IC50=7.85992 μM SANGER
IM-9 Growth Inhibition Assay IC50=8.12437 μM SANGER
QIMR-WIL Growth Inhibition Assay IC50=8.13337 μM SANGER
NB5 Growth Inhibition Assay IC50=8.23226 μM SANGER
RPMI-8402 Growth Inhibition Assay IC50=8.27928 μM SANGER
MZ2-MEL Growth Inhibition Assay IC50=8.46677 μM SANGER
SK-MEL-2 Growth Inhibition Assay IC50=8.5574 μM SANGER
NCI-H69 Growth Inhibition Assay IC50=8.79201 μM SANGER
CMK Growth Inhibition Assay IC50=8.84538 μM SANGER
MV-4-11 Growth Inhibition Assay IC50=8.86801 μM SANGER
MEG-01 Growth Inhibition Assay IC50=8.88154 μM SANGER
NCI-H1581 Growth Inhibition Assay IC50=9.15716 μM SANGER
MZ7-mel Growth Inhibition Assay IC50=9.27307 μM SANGER
SJSA-1 Growth Inhibition Assay IC50=9.52951 μM SANGER
SKM-1 Growth Inhibition Assay IC50=9.61824 μM SANGER
YT Growth Inhibition Assay IC50=9.83673 μM SANGER
LS-123 Growth Inhibition Assay IC50=10.1011 μM SANGER
NCI-H720 Growth Inhibition Assay IC50=10.2198 μM SANGER
NH-12 Growth Inhibition Assay IC50=10.2432 μM SANGER
NKM-1 Growth Inhibition Assay IC50=10.5981 μM SANGER
HUTU-80 Growth Inhibition Assay IC50=10.616 μM SANGER
TUR Growth Inhibition Assay IC50=10.8222 μM SANGER
NB14 Growth Inhibition Assay IC50=11.7876 μM SANGER
CESS Growth Inhibition Assay IC50=12.0629 μM SANGER
ES5 Growth Inhibition Assay IC50=12.1105 μM SANGER
EB-3 Growth Inhibition Assay IC50=12.4485 μM SANGER
SNU-C1 Growth Inhibition Assay IC50=12.6517 μM SANGER
CA46 Growth Inhibition Assay IC50=12.9298 μM SANGER
NCI-H1304 Growth Inhibition Assay IC50=13.0111 μM SANGER
NCI-H1522 Growth Inhibition Assay IC50=13.2394 μM SANGER
ST486 Growth Inhibition Assay IC50=13.3147 μM SANGER
D-263MG Growth Inhibition Assay IC50=13.565 μM SANGER
L-540 Growth Inhibition Assay IC50=13.6084 μM SANGER
LOUCY Growth Inhibition Assay IC50=13.7564 μM SANGER
EW-3 Growth Inhibition Assay IC50=13.8253 μM SANGER
HCC1187 Growth Inhibition Assay IC50=13.8349 μM SANGER
KU812 Growth Inhibition Assay IC50=14.0902 μM SANGER
NCI-H1963 Growth Inhibition Assay IC50=14.1004 μM SANGER
SCH Growth Inhibition Assay IC50=14.1615 μM SANGER
NCI-H1417 Growth Inhibition Assay IC50=14.3226 μM SANGER
NCI-H2081 Growth Inhibition Assay IC50=14.5781 μM SANGER
WSU-NHL Growth Inhibition Assay IC50=14.6373 μM SANGER
CGTH-W-1 Growth Inhibition Assay IC50=15.0867 μM SANGER
TE-12 Growth Inhibition Assay IC50=15.1938 μM SANGER
OCUB-M Growth Inhibition Assay IC50=15.3376 μM SANGER
ES3 Growth Inhibition Assay IC50=15.6556 μM SANGER
GOTO Growth Inhibition Assay IC50=15.8269 μM SANGER
SW962 Growth Inhibition Assay IC50=15.8866 μM SANGER
BC-3 Growth Inhibition Assay IC50=16.566 μM SANGER
GT3TKB Growth Inhibition Assay IC50=17.0105 μM SANGER
SK-N-DZ Growth Inhibition Assay IC50=17.1644 μM SANGER
LU-65 Growth Inhibition Assay IC50=17.6506 μM SANGER
EC-GI-10 Growth Inhibition Assay IC50=18.0735 μM SANGER
ARH-77 Growth Inhibition Assay IC50=18.3741 μM SANGER
BB65-RCC Growth Inhibition Assay IC50=18.5752 μM SANGER
NCI-H1648 Growth Inhibition Assay IC50=18.6376 μM SANGER
SK-NEP-1 Growth Inhibition Assay IC50=18.7023 μM SANGER
NCI-H64 Growth Inhibition Assay IC50=18.944 μM SANGER
TE-15 Growth Inhibition Assay IC50=18.9815 μM SANGER
LNCaP-Clone-FGC Growth Inhibition Assay IC50=19.3517 μM SANGER
ES7 Growth Inhibition Assay IC50=19.46 μM SANGER
NCI-H2141 Growth Inhibition Assay IC50=19.5619 μM SANGER
U-87-MG Growth Inhibition Assay IC50=19.6307 μM SANGER
GAK Growth Inhibition Assay IC50=19.7956 μM SANGER
TE-9 Growth Inhibition Assay IC50=20.0459 μM SANGER
TE-1 Growth Inhibition Assay IC50=20.8915 μM SANGER
DMS-79 Growth Inhibition Assay IC50=20.9557 μM SANGER
GDM-1 Growth Inhibition Assay IC50=21.0468 μM SANGER
NCI-H1650 Growth Inhibition Assay IC50=21.2129 μM SANGER
D-283MED Growth Inhibition Assay IC50=21.4585 μM SANGER
HD-MY-Z Growth Inhibition Assay IC50=22.3294 μM SANGER
EW-13 Growth Inhibition Assay IC50=22.4135 μM SANGER
8-MG-BA Growth Inhibition Assay IC50=22.956 μM SANGER
A498 Growth Inhibition Assay IC50=23.2708 μM SANGER
NCI-H524 Growth Inhibition Assay IC50=23.8942 μM SANGER
D-247MG Growth Inhibition Assay IC50=23.9489 μM SANGER
IST-MES1 Growth Inhibition Assay IC50=24.239 μM SANGER
NCI-H1838 Growth Inhibition Assay IC50=24.9878 μM SANGER
SK-UT-1 Growth Inhibition Assay IC50=25.1851 μM SANGER
LS-513 Growth Inhibition Assay IC50=25.5136 μM SANGER
MHH-NB-11 Growth Inhibition Assay IC50=25.9507 μM SANGER
TALL-1 Growth Inhibition Assay IC50=26.5085 μM SANGER
RCC10RGB Growth Inhibition Assay IC50=26.5486 μM SANGER
L-363 Growth Inhibition Assay IC50=26.6166 μM SANGER
MC-CAR Growth Inhibition Assay IC50=26.6901 μM SANGER
KNS-42 Growth Inhibition Assay IC50=26.8177 μM SANGER
LB2518-MEL Growth Inhibition Assay IC50=27.479 μM SANGER
SF126 Growth Inhibition Assay IC50=27.6883 μM SANGER
BV-173 Growth Inhibition Assay IC50=27.8955 μM SANGER
C8166 Growth Inhibition Assay IC50=27.9353 μM SANGER
SU-DHL-1 Growth Inhibition Assay IC50=28.9415 μM SANGER
LP-1 Growth Inhibition Assay IC50=29.1543 μM SANGER
SK-PN-DW Growth Inhibition Assay IC50=29.2129 μM SANGER
RL95-2 Growth Inhibition Assay IC50=29.5637 μM SANGER
GCIY Growth Inhibition Assay IC50=29.7428 μM SANGER
NCI-H1770 Growth Inhibition Assay IC50=29.9399 μM SANGER
KY821 Growth Inhibition Assay IC50=30.5434 μM SANGER
NB13 Growth Inhibition Assay IC50=30.9584 μM SANGER
BB30-HNC Growth Inhibition Assay IC50=31.0823 μM SANGER
EW-24 Growth Inhibition Assay IC50=32.3473 μM SANGER
GI-1 Growth Inhibition Assay IC50=33.7814 μM SANGER
OVCAR-4 Growth Inhibition Assay IC50=34.065 μM SANGER
HC-1 Growth Inhibition Assay IC50=34.4958 μM SANGER
NCI-H209 Growth Inhibition Assay IC50=34.7578 μM SANGER
COLO-829 Growth Inhibition Assay IC50=35.1091 μM SANGER
NCI-H1395 Growth Inhibition Assay IC50=35.8459 μM SANGER
HOP-62 Growth Inhibition Assay IC50=36.8021 μM SANGER
NCI-H2171 Growth Inhibition Assay IC50=36.9848 μM SANGER
LS-411N Growth Inhibition Assay IC50=36.9919 μM SANGER
ETK-1 Growth Inhibition Assay IC50=37.05 μM SANGER
KMOE-2 Growth Inhibition Assay IC50=37.2234 μM SANGER
EKVX Growth Inhibition Assay IC50=37.3946 μM SANGER
SF539 Growth Inhibition Assay IC50=38.6705 μM SANGER
RL Growth Inhibition Assay IC50=38.6818 μM SANGER
MOLT-16 Growth Inhibition Assay IC50=38.9944 μM SANGER
NCI-H128 Growth Inhibition Assay IC50=39.5567 μM SANGER
SHP-77 Growth Inhibition Assay IC50=39.7722 μM SANGER
EVSA-T Growth Inhibition Assay IC50=40.0164 μM SANGER
DB Growth Inhibition Assay IC50=40.4441 μM SANGER
TE-441-T Growth Inhibition Assay IC50=40.7601 μM SANGER
NCI-SNU-16 Growth Inhibition Assay IC50=40.7771 μM SANGER
ALL-PO Growth Inhibition Assay IC50=40.8264 μM SANGER
P31-FUJ Growth Inhibition Assay IC50=41.0485 μM SANGER
EW-24 Growth Inhibition Assay IC50=41.4224 μM SANGER
LC-2-ad Growth Inhibition Assay IC50=41.7115 μM SANGER
AM-38 Growth Inhibition Assay IC50=43.4398 μM SANGER
COLO-684 Growth Inhibition Assay IC50=43.4687 μM SANGER
L-428 Growth Inhibition Assay IC50=44.6708 μM SANGER
RXF393 Growth Inhibition Assay IC50=44.7331 μM SANGER
MRK-nu-1 Growth Inhibition Assay IC50=45.9253 μM SANGER
TE-10 Growth Inhibition Assay IC50=46.4915 μM SANGER
Ramos-2G6-4C10 Growth Inhibition Assay IC50=46.5661 μM SANGER
NCI-H1694 Growth Inhibition Assay IC50=46.8105 μM SANGER
A4-Fuk Growth Inhibition Assay IC50=47.7106 μM SANGER
REH Growth Inhibition Assay IC50=47.8793 μM SANGER
CAL-148 Growth Inhibition Assay IC50=49.101 μM SANGER
KARPAS-45 Growth Inhibition Assay IC50=51.0359 μM SANGER
NEC8 Growth Inhibition Assay IC50=51.178 μM SANGER
NCI-H446 Growth Inhibition Assay IC50=54.3092 μM SANGER
SF268 Growth Inhibition Assay IC50=56.4043 μM SANGER
EoL-1-cell Growth Inhibition Assay IC50=57.0315 μM SANGER
IST-MEL1 Growth Inhibition Assay IC50=58.6442 μM SANGER
OS-RC-2 Growth Inhibition Assay IC50=58.6841 μM SANGER
BL-70 Growth Inhibition Assay IC50=58.8002 μM SANGER
GI-ME-N Growth Inhibition Assay IC50=59.7717 μM SANGER
SK-LMS-1 Growth Inhibition Assay IC50=60.4282 μM SANGER
RH-1 Growth Inhibition Assay IC50=61.2697 μM SANGER
D-336MG Growth Inhibition Assay IC50=61.2933 μM SANGER
NCI-H2196 Growth Inhibition Assay IC50=62.2931 μM SANGER
IST-SL2 Growth Inhibition Assay IC50=65.0102 μM SANGER
DG-75 Growth Inhibition Assay IC50=65.873 μM SANGER
SK-MEL-1 Growth Inhibition Assay IC50=66.8299 μM SANGER
SK-N-FI Growth Inhibition Assay IC50=67.97 μM SANGER
SCLC-21H Growth Inhibition Assay IC50=69.6286 μM SANGER
KM12 Growth Inhibition Assay IC50=70.1607 μM SANGER
TE-6 Growth Inhibition Assay IC50=71.6266 μM SANGER
HCE-T Growth Inhibition Assay IC50=72.7372 μM SANGER
ES1 Growth Inhibition Assay IC50=75.1944 μM SANGER
SK-MM-2 Growth Inhibition Assay IC50=75.8461 μM SANGER
SW954 Growth Inhibition Assay IC50=78.0688 μM SANGER
LU-139 Growth Inhibition Assay IC50=78.4739 μM SANGER
SBC-1 Growth Inhibition Assay IC50=79.7008 μM SANGER
K052 Growth Inhibition Assay IC50=81.9603 μM SANGER
SIG-M5 Growth Inhibition Assay IC50=82.9596 μM SANGER
TGW Growth Inhibition Assay IC50=84.6867 μM SANGER
LU-134-A Growth Inhibition Assay IC50=85.9404 μM SANGER
OCI-AML2 Growth Inhibition Assay IC50=86.8607 μM SANGER
LOXIMVI Growth Inhibition Assay IC50=88.1676 μM SANGER
MC116 Growth Inhibition Assay IC50=88.8718 μM SANGER
JAR Growth Inhibition Assay IC50=89.0582 μM SANGER
BT-474 Growth Inhibition Assay IC50=97.7609 μM SANGER
IMR-5 Growth Inhibition Assay IC50=99.7585 μM SANGER
HL-60 Growth Inhibition Assay IC50=102.901 μM SANGER
NCI-H1882 Growth Inhibition Assay IC50=103.457 μM SANGER
NB17 Growth Inhibition Assay IC50=106.528 μM SANGER
NCI-H2126 Growth Inhibition Assay IC50=107.635 μM SANGER
J-RT3-T3-5 Growth Inhibition Assay IC50=108.33 μM SANGER
NB69 Growth Inhibition Assay IC50=112.333 μM SANGER
JVM-3 Growth Inhibition Assay IC50=113.512 μM SANGER
NCI-H226 Growth Inhibition Assay IC50=114.376 μM SANGER
CTV-1 Growth Inhibition Assay IC50=115.234 μM SANGER
KMS-12-PE Growth Inhibition Assay IC50=115.583 μM SANGER
DMS-153 Growth Inhibition Assay IC50=117.411 μM SANGER
NCI-H1436 Growth Inhibition Assay IC50=118.868 μM SANGER
DJM-1 Growth Inhibition Assay IC50=119.978 μM SANGER
CTB-1 Growth Inhibition Assay IC50=123.948 μM SANGER
RPMI-8866 Growth Inhibition Assay IC50=134.232 μM SANGER
NB6 Growth Inhibition Assay IC50=135.081 μM SANGER
NCI-H510A Growth Inhibition Assay IC50=135.852 μM SANGER
HAL-01 Growth Inhibition Assay IC50=136.429 μM SANGER
COLO-668 Growth Inhibition Assay IC50=136.607 μM SANGER
NB10 Growth Inhibition Assay IC50=139.732 μM SANGER
U-266 Growth Inhibition Assay IC50=146.561 μM SANGER
D-502MG Growth Inhibition Assay IC50=148.717 μM SANGER
HDLM-2 Growth Inhibition Assay IC50=165.958 μM SANGER
MN-60 Growth Inhibition Assay IC50=167.261 μM SANGER
SW684 Growth Inhibition Assay IC50=182.57 μM SANGER
COR-L279 Growth Inhibition Assay IC50=186.961 μM SANGER
CPC-N Growth Inhibition Assay IC50=188.945 μM SANGER
NCI-SNU-1 Growth Inhibition Assay IC50=201.087 μM SANGER
COLO-320-HSR Growth Inhibition Assay IC50=209.004 μM SANGER
NCI-H889 Growth Inhibition Assay IC50=209.602 μM SANGER
MHH-CALL-2 Growth Inhibition Assay IC50=230.298 μM SANGER
COR-L88 Growth Inhibition Assay IC50=231.162 μM SANGER
CHP-126 Growth Inhibition Assay IC50=237.146 μM SANGER
NCI-H82 Growth Inhibition Assay IC50=240.731 μM SANGER
SUP-T1 Growth Inhibition Assay IC50=243.062 μM SANGER
NCI-H345 Growth Inhibition Assay IC50=246.503 μM SANGER
LU-165 Growth Inhibition Assay IC50=247.336 μM SANGER
DMS-114 Growth Inhibition Assay IC50=253.811 μM SANGER
NCI-H716 Growth Inhibition Assay IC50=259.637 μM SANGER
SIMA Growth Inhibition Assay IC50=312.028 μM SANGER
NCI-H526 Growth Inhibition Assay IC50=312.685 μM SANGER
NH-12 Growth Inhibition Assay IC50=316.901 μM SANGER
MS-1 Growth Inhibition Assay IC50=327.666 μM SANGER
MFM-223 Growth Inhibition Assay IC50=340.486 μM SANGER
EW-11 Growth Inhibition Assay IC50=348.123 μM SANGER
KG-1 Growth Inhibition Assay IC50=387.778 μM SANGER
NCI-H1155 Growth Inhibition Assay IC50=414.626 μM SANGER
NCI-H187 Growth Inhibition Assay IC50=428.541 μM SANGER
MSTO-211H Growth Inhibition Assay IC50=434.624 μM SANGER
NCI-H322M Growth Inhibition Assay IC50=452.677 μM SANGER
CW-2 Growth Inhibition Assay IC50=483.609 μM SANGER
COLO-800 Growth Inhibition Assay IC50=525.413 μM SANGER
EW-12 Growth Inhibition Assay IC50=557.847 μM SANGER
EW-18 Growth Inhibition Assay IC50=672.665 μM SANGER
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화학 정보, 보관 및 안정성

분자량 475.62 화학식

C26H41N3O5

 보관 (수령일로부터)
CAS 번호 1211877-36-9 SDF 다운로드 원액 보관

동의어 (S,R,S)-(-)-MG-132, Z-Leu-D-Leu-Leu-al Smiles CC(C)CC(C=O)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)OCC1=CC=CC=C1

용해도

In vitro
배치:

DMSO : 95 mg/mL (199.73 mM)
(수분으로 오염된 DMSO는 용해도를 감소시킬 수 있습니다. 신선하고 무수 DMSO를 사용하십시오.)

Ethanol : 95 mg/mL

Water : Insoluble

몰농도 계산기

질량 농도 부피 분자량
희석 계산기 분자량 계산기

In vivo
배치:

생체 내 제형 계산기 (투명한 용액)

1단계: 아래 정보 입력 (권장: 실험 중 손실을 고려하여 추가 동물 포함)

mg/kg g μL

2단계: 생체 내 제형 입력 (이것은 계산기일 뿐 제형이 아닙니다. 용해도 섹션에 생체 내 제형이 없는 경우 먼저 당사에 문의하십시오.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

계산 결과:

작업 농도: mg/ml;

DMSO 원액 준비 방법: mg 약물 사전 용해 μL DMSO ( 원액 농도 mg/mL, 농도가 해당 약물 배치의 DMSO 용해도를 초과하는 경우 먼저 당사에 문의하십시오. )

생체 내 제형 준비 방법: 취하다 μL DMSO 원액, 다음 추가μL PEG300, 혼합하고 투명하게 한 다음 추가μL Tween 80, 혼합하고 투명하게 한 다음 추가 μL ddH2O, 혼합하고 투명하게 합니다.

생체 내 제형 준비 방법: 취하다 μL DMSO 원액, 다음 추가 μL 옥수수 기름, 혼합하고 투명하게 합니다.

참고: 1. 다음 용매를 추가하기 전에 액체가 투명한지 확인하십시오.
2. 용매를 순서대로 추가해야 합니다. 다음 용매를 추가하기 전에 이전 추가에서 얻은 용액이 투명한 용액인지 확인해야 합니다. 와동, 초음파 또는 뜨거운 물 중탕과 같은 물리적 방법을 사용하여 용해를 도울 수 있습니다.

작용 메커니즘

Targets/IC50/Ki
ChTL
(Cell-free assay)
0.22 μM
시험관 내(In vitro)

MG-132는 20S proteasome의 ZLLL-MCA 분해 활동을 억제하는 데 있어 ZLLal보다 1000배 이상 높은 활성을 보이며, IC50은 100 nM 대 110 μM입니다. 이 화합물은 또한 칼파인을 IC50 1.2 μM로 억제합니다. 이 화학 물질은 최적 농도 20 nM에서 PC12 세포의 신경돌기 성장을 유도하며, ZLLal보다 500배 더 강력한 효능을 보입니다. 이 화합물 (10 μM)은 proteasome 매개 IκBα 분해 억제를 통해 A549 세포에서 TNF-α 유도 NF-κB 활성화, 인터루킨-8 (IL-8) 유전자 전사 및 IL-8 단백질 방출을 강력하게 억제합니다. 이 화학 처리법은 26S proteasome 억제를 통해 KIM-2 세포에서 p53 의존성 세포자멸사를 강력하게 유도합니다. BzLLLCOCHO 또는 PS-341과 달리, 이 화합물 처리는 26S proteasome의 키모트립신 유사 (CT-L) 및 펩티딜글루타밀 펩타이드 가수분해 (PGPH) 활성에는 약한 억제를 유도하지만, 다발성 골수종 세포 (U266 및 OPM-2)는 BzLLLCOCHO보다 이 화학 물질에 의한 세포자멸사 유도에 더 민감합니다. 이 화합물 (1 μM)은 AP-1 계열 구성원 c-Fos 및 c-Jun을 활성화하여 TRAIL 내성 전립선암 세포를 감작시키고, 이는 차례로 항세포자멸사 분자 c-FLIP(L)를 억제합니다. 이 화학 물질은 이노시톨 헥사키스포스페이트 (IP6)가 PC3 및 DU145 안드로겐 비의존성 전립선암 (AIPCa) 세포주 모두에서 세포 대사 활동을 감소시키는 능력을 크게 향상시킵니다.

키나아제 분석
20S proteasome에 대한 MG-132의 억제 활성 측정
20S proteasome 억제 분석을 위한 반응 혼합물은 0.1 M Tris-아세테이트, pH 7.0, 20S proteasome, MG-132 및 디메틸 설폭사이드에 용해된 25 μM 기질을 최종 부피 1 mL로 포함합니다. 37 °C에서 15분 동안 배양한 후, 0.1 mL의 10% SDS와 0.9 mL의 0.1M Tris 아세테이트, pH 9.0을 첨가하여 반응을 중지시킵니다. 반응 생성물의 형광을 측정합니다. 20S proteasome에 대한 IC50을 결정하기 위해 다양한 농도의 이 화합물이 분석 혼합물에 포함됩니다.
생체 내(In vivo)

MG-132 투여는 mdx 마우스의 골격근 섬유에서 디스트로핀, β-디스트로글리칸, α-b디스트로글리칸 및 α-사르코글리칸의 발현 수준과 혈장막 국소화를 효과적으로 회복시키고, 근육막 손상을 감소시키며, 근육 영양증의 조직병리학적 징후를 개선합니다. 이 화합물로 치료하면 근육 특이적 유비퀴틴 리가제 atrogin-1/MAFbx 및 MuRF-1 mRNA를 하향 조절함으로써 마우스의 고정 유발 골격근 위축이 유의하게 감소합니다.

참조
  • [4] https://pubmed.ncbi.nlm.nih.gov/16778216/
  • [5] https://pubmed.ncbi.nlm.nih.gov/17332355/
  • [6] https://pubmed.ncbi.nlm.nih.gov/18941459/
  • [7] https://pubmed.ncbi.nlm.nih.gov/14507673/
  • [8] https://pubmed.ncbi.nlm.nih.gov/21843349/
  • [9] https://pubmed.ncbi.nlm.nih.gov/20112914/

적용 분야

방법 바이오마커 이미지 PMID
Western Blot Bcr-Abl Ac-histone H3 Cleaved-caspase3 Cleaved-PARP ASCL1 CgA Nrf2 HO-1
S2619-WB1
26722260
Immunofluorescence C2GnT-M / NMIIA AGS3 / Vimentin Bak
S2619-IF2
22525330
Growth inhibition assay Apoptosis assay Cell viability cell proliferation
S2619-apoptosis1
20557369
ELISA IL-8 IL-1beta
S2619-ELISA1
11160671

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질문 1:
I want to know whether it contains EDTA or other chelating agent in this product?

답변:
It does not contain EDTA or other chelating agent.