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Bortezomib Proteasome 억제제

Name: Bortezomib
Brand: Selleck Chemicals
SKU: S1013
Rating: 5 (1091 reviews)

제품 번호S1013

Bortezomib은 K_i가 0.6 nM인 강력한 20S proteasome 억제제입니다. 이는 정상 세포보다 종양 세포에 대해 유리한 선택성을 나타냅니다. 이 화합물은 NF-κB를 억제하고 ERK 인산화를 유도하여 Cathepsin B를 억제하고 난소암 및 기타 고형암에서 autophagy의 촉매 과정을 억제합니다.

Bortezomib Proteasome 억제제 Chemical Structure

화학 구조

분자량: 384.24

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품질 관리

배치: 순도: 99.97%

99.97

관련 타겟	HDAC Caspase Secretase MMP HCV Protease Cysteine Protease DPP Tyrosinase HIV Protease Serine Protease
기타 Proteasome 억제제	MG132 Celastrol Epoxomicin (BU-4061T) ONX-0914 (PR-957) Oprozomib Delanzomib VR23 Marizomib (Salinosporamide A) PI-1840 KSQ-4279 (USP1-IN-1)

세포 배양, 처리 및 작업 농도

세포주	분석 유형	농도	배양 시간	제형	활성 설명	PMID
NCI-H1838	Growth Inhibition Assay				IC50=4186.32 μM	SANGER
IMR-5	Growth Inhibition Assay				IC50=3409.62 μM	SANGER
TE-441-T	Growth Inhibition Assay				IC50=2521.7 μM	SANGER
U-698-M	Growth Inhibition Assay				IC50=2262.15 μM	SANGER
COLO-824	Growth Inhibition Assay				IC50=1261.78 μM	SANGER
P31-FUJ	Growth Inhibition Assay				IC50=1112.75 μM	SANGER
KY821	Growth Inhibition Assay				IC50=1036.04 μM	SANGER
RPMI-8866	Growth Inhibition Assay				IC50=1006.28 μM	SANGER
TC-YIK	Growth Inhibition Assay				IC50=781.01 nM	SANGER
MS-1	Growth Inhibition Assay				IC50=759.42 nM	SANGER
DMS-153	Growth Inhibition Assay				IC50=746.83 nM	SANGER
SUP-T1	Growth Inhibition Assay				IC50=686.04 nM	SANGER
SCC-15	Growth Inhibition Assay				IC50=667.47 nM	SANGER
MSTO-211H	Growth Inhibition Assay				IC50=574.26 nM	SANGER
J-RT3-T3-5	Growth Inhibition Assay				IC50=532.57 nM	SANGER
NCI-H889	Growth Inhibition Assay				IC50=461.92 nM	SANGER
CPC-N	Growth Inhibition Assay				IC50=403.77 nM	SANGER
COLO-668	Growth Inhibition Assay				IC50=403.57 nM	SANGER
NCI-H226	Growth Inhibition Assay				IC50=403.23 nM	SANGER
TUR	Growth Inhibition Assay				IC50=396.61 nM	SANGER
DEL	Growth Inhibition Assay				IC50=391.27 nM	SANGER
NCI-H1963	Growth Inhibition Assay				IC50=386.19 nM	SANGER
CA46	Growth Inhibition Assay				IC50=373.63 nM	SANGER
SNU-C1	Growth Inhibition Assay				IC50=362.09 nM	SANGER
THP-1	Growth Inhibition Assay				IC50=322.6 nM	SANGER
SCH	Growth Inhibition Assay				IC50=322.22 nM	SANGER
NCI-H1522	Growth Inhibition Assay				IC50=307.05 nM	SANGER
LNCaP-Clone-FGC	Growth Inhibition Assay				IC50=295.26 nM	SANGER
NCI-H2171	Growth Inhibition Assay				IC50=288.92 nM	SANGER
NCI-H187	Growth Inhibition Assay				IC50=287.08 nM	SANGER
KASUMI-1	Growth Inhibition Assay				IC50=283.05 nM	SANGER
SK-MEL-2	Growth Inhibition Assay				IC50=281.9 nM	SANGER
EW-22	Growth Inhibition Assay				IC50=263.75 nM	SANGER
NCI-H1299	Growth Inhibition Assay				IC50=261.71 nM	SANGER
COR-L279	Growth Inhibition Assay				IC50=252.17 nM	SANGER
NCI-H1155	Growth Inhibition Assay				IC50=230.32 nM	SANGER
NCI-H1395	Growth Inhibition Assay				IC50=210.13 nM	SANGER
KM-H2	Growth Inhibition Assay				IC50=197.05 nM	SANGER
NCI-H209	Growth Inhibition Assay				IC50=196.52 nM	SANGER
NCI-H510A	Growth Inhibition Assay				IC50=185.37 nM	SANGER
NCI-H1304	Growth Inhibition Assay				IC50=169.21 nM	SANGER
SCLC-21H	Growth Inhibition Assay				IC50=159.41 nM	SANGER
NCI-H524	Growth Inhibition Assay				IC50=159.1 nM	SANGER
MC116	Growth Inhibition Assay				IC50=148.85 nM	SANGER
BV-173	Growth Inhibition Assay				IC50=122.71 nM	SANGER
MHH-CALL-2	Growth Inhibition Assay				IC50=115.7 nM	SANGER
NCI-H1650	Growth Inhibition Assay				IC50=115.29 nM	SANGER
ST486	Growth Inhibition Assay				IC50=114.06 nM	SANGER
GR-ST	Growth Inhibition Assay				IC50=113.34 nM	SANGER
SIG-M5	Growth Inhibition Assay				IC50=105.06 nM	SANGER
NCI-H1770	Growth Inhibition Assay				IC50=102.49 nM	SANGER
RH-1	Growth Inhibition Assay				IC50=99.85 nM	SANGER
AM-38	Growth Inhibition Assay				IC50=88.08 nM	SANGER
RL	Growth Inhibition Assay				IC50=86.09 nM	SANGER
CAL-148	Growth Inhibition Assay				IC50=81.84 nM	SANGER
SK-N-FI	Growth Inhibition Assay				IC50=80.2 nM	SANGER
EW-11	Growth Inhibition Assay				IC50=78.52 nM	SANGER
EW-13	Growth Inhibition Assay				IC50=77.76 nM	SANGER
ALL-PO	Growth Inhibition Assay				IC50=77.66 nM	SANGER
KP-N-YS	Growth Inhibition Assay				IC50=76.74 nM	SANGER
KMS-12-PE	Growth Inhibition Assay				IC50=76.24 nM	SANGER
NCI-H128	Growth Inhibition Assay				IC50=74.77 nM	SANGER
NCI-H322M	Growth Inhibition Assay				IC50=66.11 nM	SANGER
BT-474	Growth Inhibition Assay				IC50=65 nM	SANGER
MRK-nu-1	Growth Inhibition Assay				IC50=61.82 nM	SANGER
YT	Growth Inhibition Assay				IC50=61.8 nM	SANGER
LP-1	Growth Inhibition Assay				IC50=61.28 nM	SANGER
P30-OHK	Growth Inhibition Assay				IC50=54.61 nM	SANGER
NCI-N87	Growth Inhibition Assay				IC50=54.18 nM	SANGER
TALL-1	Growth Inhibition Assay				IC50=53.91 nM	SANGER
MC-CAR	Growth Inhibition Assay				IC50=51.52 nM	SANGER
NCI-H720	Growth Inhibition Assay				IC50=51.11 nM	SANGER
RS4-11	Growth Inhibition Assay				IC50=50.88 nM	SANGER
DMS-79	Growth Inhibition Assay				IC50=50.71 nM	SANGER
NCI-H716	Growth Inhibition Assay				IC50=48.81 nM	SANGER
RPMI-6666	Growth Inhibition Assay				IC50=45.89 nM	SANGER
L-428	Growth Inhibition Assay				IC50=43.86 nM	SANGER
SKM-1	Growth Inhibition Assay				IC50=42.63 nM	SANGER
NCI-H2227	Growth Inhibition Assay				IC50=40.49 nM	SANGER
SHP-77	Growth Inhibition Assay				IC50=38.03 nM	SANGER
D-283MED	Growth Inhibition Assay				IC50=37.79 nM	SANGER
MDA-MB-134-VI	Growth Inhibition Assay				IC50=35.87 nM	SANGER
C8166	Growth Inhibition Assay				IC50=35.7 nM	SANGER
UACC-812	Growth Inhibition Assay				IC50=35.44 nM	SANGER
ES3	Growth Inhibition Assay				IC50=35.19 nM	SANGER
SK-MEL-1	Growth Inhibition Assay				IC50=35.17 nM	SANGER
KARPAS-422	Growth Inhibition Assay				IC50=35.04 nM	SANGER
NCI-H719	Growth Inhibition Assay				IC50=34.31 nM	SANGER
NCI-H526	Growth Inhibition Assay				IC50=32.54 nM	SANGER
EW-3	Growth Inhibition Assay				IC50=30.59 nM	SANGER
OCI-AML2	Growth Inhibition Assay				IC50=29.69 nM	SANGER
ECC4	Growth Inhibition Assay				IC50=28.79 nM	SANGER
WSU-NHL	Growth Inhibition Assay				IC50=28.39 nM	SANGER
NH-12	Growth Inhibition Assay				IC50=27.67 nM	SANGER
LU-165	Growth Inhibition Assay				IC50=26.72 nM	SANGER
REH	Growth Inhibition Assay				IC50=26.41 nM	SANGER
LS-1034	Growth Inhibition Assay				IC50=25.75 nM	SANGER
HDLM-2	Growth Inhibition Assay				IC50=24.54 nM	SANGER
EC-GI-10	Growth Inhibition Assay				IC50=24.23 nM	SANGER
IM-9	Growth Inhibition Assay				IC50=23.54 nM	SANGER
DOHH-2	Growth Inhibition Assay				IC50=23.45 nM	SANGER
SIMA	Growth Inhibition Assay				IC50=23.38 nM	SANGER
EW-12	Growth Inhibition Assay				IC50=23.17 nM	SANGER
HCC2157	Growth Inhibition Assay				IC50=23.13 nM	SANGER
NCI-H82	Growth Inhibition Assay				IC50=23.02 nM	SANGER
IST-MES1	Growth Inhibition Assay				IC50=22.77 nM	SANGER
NCI-H446	Growth Inhibition Assay				IC50=21.18 nM	SANGER
SF539	Growth Inhibition Assay				IC50=20.67 nM	SANGER
TE-6	Growth Inhibition Assay				IC50=20.08 nM	SANGER
HCC2218	Growth Inhibition Assay				IC50=19.5 nM	SANGER
DG-75	Growth Inhibition Assay				IC50=18.61 nM	SANGER
NCCIT	Growth Inhibition Assay				IC50=18.36 nM	SANGER
EoL-1-	Growth Inhibition Assay				IC50=18.31 nM	SANGER
EB2	Growth Inhibition Assay				IC50=18.08 nM	SANGER
NB14	Growth Inhibition Assay				IC50=17.98 nM	SANGER
EW-18	Growth Inhibition Assay				IC50=17.96 nM	SANGER
MFM-223	Growth Inhibition Assay				IC50=17.91 nM	SANGER
COLO-800	Growth Inhibition Assay				IC50=17.64 nM	SANGER
GOTO	Growth Inhibition Assay				IC50=17.06 nM	SANGER
NCI-H1436	Growth Inhibition Assay				IC50=17.01 nM	SANGER
U-87-MG	Growth Inhibition Assay				IC50=16.76 nM	SANGER
TGW	Growth Inhibition Assay				IC50=16.48 nM	SANGER
JAR	Growth Inhibition Assay				IC50=16.13 nM	SANGER
NB7	Growth Inhibition Assay				IC50=15.92 nM	SANGER
NCI-SNU-1	Growth Inhibition Assay				IC50=13.19 nM	SANGER
JVM-3	Growth Inhibition Assay				IC50=12.99 nM	SANGER
NCI-H1581	Growth Inhibition Assay				IC50=12.28 nM	SANGER
NCI-H23	Growth Inhibition Assay				IC50=12.12 nM	SANGER
HCC1599	Growth Inhibition Assay				IC50=11.91 nM	SANGER
ES5	Growth Inhibition Assay				IC50=10.38 nM	SANGER
NCI-H2081	Growth Inhibition Assay				IC50=10.09 nM	SANGER
CTB-1	Growth Inhibition Assay				IC50=9.67 nM	SANGER
DMS-114	Growth Inhibition Assay				IC50=9.62 nM	SANGER
SK-NEP-1	Growth Inhibition Assay				IC50=9.01 nM	SANGER
ATN-1	Growth Inhibition Assay				IC50=8.89 nM	SANGER
MLMA	Growth Inhibition Assay				IC50=8.85 nM	SANGER
NB6	Growth Inhibition Assay				IC50=8.48 nM	SANGER
MN-60	Growth Inhibition Assay				IC50=8.14 nM	SANGER
KG-1	Growth Inhibition Assay				IC50=7.94 nM	SANGER
L-363	Growth Inhibition Assay				IC50=7.7 nM	SANGER
NCI-SNU-16	Growth Inhibition Assay				IC50=7.65 nM	SANGER
NCI-H1694	Growth Inhibition Assay				IC50=7.58 nM	SANGER
LU-134-A	Growth Inhibition Assay				IC50=7.39 nM	SANGER
JVM-2	Growth Inhibition Assay				IC50=7.28 nM	SANGER
SU-DHL-1	Growth Inhibition Assay				IC50=7.24 nM	SANGER
NCI-H345	Growth Inhibition Assay				IC50=7.2 nM	SANGER
NB1	Growth Inhibition Assay				IC50=6.88 nM	SANGER
NCI-H2196	Growth Inhibition Assay				IC50=6.8 nM	SANGER
GDM-1	Growth Inhibition Assay				IC50=6.77 nM	SANGER
BC-3	Growth Inhibition Assay				IC50=6.61 nM	SANGER
D-502MG	Growth Inhibition Assay				IC50=6.37 nM	SANGER
LU-65	Growth Inhibition Assay				IC50=5.84 nM	SANGER
NCI-H1417	Growth Inhibition Assay				IC50=5.51 nM	SANGER
EW-1	Growth Inhibition Assay				IC50=5.31 nM	SANGER
SW962	Growth Inhibition Assay				IC50=5.21 nM	SANGER
NCI-SNU-5	Growth Inhibition Assay				IC50=5.17 nM	SANGER
LU-139	Growth Inhibition Assay				IC50=5.13 nM	SANGER
CHP-126	Growth Inhibition Assay				IC50=5.06 nM	SANGER
SBC-1	Growth Inhibition Assay				IC50=5.01 nM	SANGER
JiyoyeP-2003	Growth Inhibition Assay				IC50=5 nM	SANGER
MHH-NB-11	Growth Inhibition Assay				IC50=4.91 nM	SANGER
MHH-PREB-1	Growth Inhibition Assay				IC50=4.86 nM	SANGER
IST-SL1	Growth Inhibition Assay				IC50=4.68 nM	SANGER
HL-60	Growth Inhibition Assay				IC50=4.67 nM	SANGER
NALM-6	Growth Inhibition Assay				IC50=4.49 nM	SANGER
Raji	Growth Inhibition Assay				IC50=4.46 nM	SANGER
NOMO-1	Growth Inhibition Assay				IC50=4.33 nM	SANGER
TE-12	Growth Inhibition Assay				IC50=4.25 nM	SANGER
LB647-SCLC	Growth Inhibition Assay				IC50=4.22 nM	SANGER
OMC-1	Growth Inhibition Assay				IC50=4.18 nM	SANGER
NCI-H1648	Growth Inhibition Assay				IC50=4.13 nM	SANGER
K-562	Growth Inhibition Assay				IC50=4.12 nM	SANGER
NCI-H2141	Growth Inhibition Assay				IC50=4.05 nM	SANGER
HD-MY-Z	Growth Inhibition Assay				IC50=3.93 nM	SANGER
RCC10RGB	Growth Inhibition Assay				IC50=3.93 nM	SANGER
COLO-320-HSR	Growth Inhibition Assay				IC50=3.92 nM	SANGER
RL95-2	Growth Inhibition Assay				IC50=3.79 nM	SANGER
LC-1F	Growth Inhibition Assay				IC50=3.74 nM	SANGER
NMC-G1	Growth Inhibition Assay				IC50=3.68 nM	SANGER
COLO-684	Growth Inhibition Assay				IC50=3.66 nM	SANGER
DJM-1	Growth Inhibition Assay				IC50=3.63 nM	SANGER
EVSA-T	Growth Inhibition Assay				IC50=3.6 nM	SANGER
no-11	Growth Inhibition Assay				IC50=3.55 nM	SANGER
MZ1-PC	Growth Inhibition Assay				IC50=3.54 nM	SANGER
HCC1187	Growth Inhibition Assay				IC50=3.54 nM	SANGER
KARPAS-45	Growth Inhibition Assay				IC50=3.54 nM	SANGER
RPMI-8402	Growth Inhibition Assay				IC50=3.5 nM	SANGER
LOXIMVI	Growth Inhibition Assay				IC50=3.5 nM	SANGER
MEG-01	Growth Inhibition Assay				IC50=3.49 nM	SANGER
LAMA-84	Growth Inhibition Assay				IC50=3.49 nM	SANGER
COR-L88	Growth Inhibition Assay				IC50=3.47 nM	SANGER
TE-15	Growth Inhibition Assay				IC50=3.43 nM	SANGER
DB	Growth Inhibition Assay				IC50=3.41 nM	SANGER
LB996-RCC	Growth Inhibition Assay				IC50=3.4 nM	SANGER
NEC8	Growth Inhibition Assay				IC50=3.35 nM	SANGER
SK-N-DZ	Growth Inhibition Assay				IC50=3.26 nM	SANGER
CW-2	Growth Inhibition Assay				IC50=3.21 nM	SANGER
SK-PN-DW	Growth Inhibition Assay				IC50=3.14 nM	SANGER
CGTH-W-1	Growth Inhibition Assay				IC50=3.1 nM	SANGER
MONO-MAC-6	Growth Inhibition Assay				IC50=3.1 nM	SANGER
KARPAS-299	Growth Inhibition Assay				IC50=3.06 nM	SANGER
HT	Growth Inhibition Assay				IC50=3.02 nM	SANGER
SW954	Growth Inhibition Assay				IC50=2.9 nM	SANGER
MOLT-16	Growth Inhibition Assay				IC50=2.89 nM	SANGER
C2BBe1	Growth Inhibition Assay				IC50=2.89 nM	SANGER
ETK-1	Growth Inhibition Assay				IC50=2.84 nM	SANGER
CTV-1	Growth Inhibition Assay				IC50=2.8 nM	SANGER
EW-16	Growth Inhibition Assay				IC50=2.75 nM	SANGER
Mo-T	Growth Inhibition Assay				IC50=2.74 nM	SANGER
EB-3	Growth Inhibition Assay				IC50=2.66 nM	SANGER
LB1047-RCC	Growth Inhibition Assay				IC50=2.57 nM	SANGER
KNS-81-FD	Growth Inhibition Assay				IC50=2.48 nM	SANGER
NB69	Growth Inhibition Assay				IC50=2.46 nM	SANGER
NCI-H64	Growth Inhibition Assay				IC50=2.44 nM	SANGER
KU812	Growth Inhibition Assay				IC50=2.42 nM	SANGER
NCI-H748	Growth Inhibition Assay				IC50=2.39 nM	SANGER
ARH-77	Growth Inhibition Assay				IC50=2.38 nM	SANGER
SCC-3	Growth Inhibition Assay				IC50=2.37 nM	SANGER
RPMI-8226	Growth Inhibition Assay				IC50=2.35 nM	SANGER
NB10	Growth Inhibition Assay				IC50=2.32 nM	SANGER
BC-1	Growth Inhibition Assay				IC50=2.31 nM	SANGER
NB5	Growth Inhibition Assay				IC50=2.27 nM	SANGER
KMOE-2	Growth Inhibition Assay				IC50=2.23 nM	SANGER
SJSA-1	Growth Inhibition Assay				IC50=2.21 nM	SANGER
ES4	Growth Inhibition Assay				IC50=2.16 nM	SANGER
KGN	Growth Inhibition Assay				IC50=2.15 nM	SANGER
EKVX	Growth Inhibition Assay				IC50=2.14 nM	SANGER
MOLT-4	Growth Inhibition Assay				IC50=2.13 nM	SANGER
KE-37	Growth Inhibition Assay				IC50=2.13 nM	SANGER
HH	Growth Inhibition Assay				IC50=2.13 nM	SANGER
GT3TKB	Growth Inhibition Assay				IC50=2.12 nM	SANGER
BL-70	Growth Inhibition Assay				IC50=2.12 nM	SANGER
NOS-1	Growth Inhibition Assay				IC50=2.11 nM	SANGER
EW-24	Growth Inhibition Assay				IC50=2.08 nM	SANGER
LAN-6	Growth Inhibition Assay				IC50=2.05 nM	SANGER
NB17	Growth Inhibition Assay				IC50=2.04 nM	SANGER
LS-123	Growth Inhibition Assay				IC50=2.02 nM	SANGER
NB13	Growth Inhibition Assay				IC50=2 nM	SANGER
NKM-1	Growth Inhibition Assay				IC50=2 nM	SANGER
697	Growth Inhibition Assay				IC50=1.99 nM	SANGER
BE-13	Growth Inhibition Assay				IC50=1.93 nM	SANGER
MPP-89	Growth Inhibition Assay				IC50=1.89 nM	SANGER
Becker	Growth Inhibition Assay				IC50=1.83 nM	SANGER
MV-4-11	Growth Inhibition Assay				IC50=1.82 nM	SANGER
GB-1	Growth Inhibition Assay				IC50=1.81 nM	SANGER
NCI-H1092	Growth Inhibition Assay				IC50=1.8 nM	SANGER
NCI-H2126	Growth Inhibition Assay				IC50=1.8 nM	SANGER
LC4-1	Growth Inhibition Assay				IC50=1.79 nM	SANGER
U-266	Growth Inhibition Assay				IC50=1.76 nM	SANGER
KURAMOCHI	Growth Inhibition Assay				IC50=1.72 nM	SANGER
TGBC1TKB	Growth Inhibition Assay				IC50=1.71 nM	SANGER
EHEB	Growth Inhibition Assay				IC50=1.67 nM	SANGER
GCIY	Growth Inhibition Assay				IC50=1.62 nM	SANGER
HEL	Growth Inhibition Assay				IC50=1.61 nM	SANGER
NB12	Growth Inhibition Assay				IC50=1.56 nM	SANGER
NCI-H69	Growth Inhibition Assay				IC50=1.54 nM	SANGER
LS-411N	Growth Inhibition Assay				IC50=1.53 nM	SANGER
PF-382	Growth Inhibition Assay				IC50=1.47 nM	SANGER
CAS-1	Growth Inhibition Assay				IC50=1.37 nM	SANGER
L-540	Growth Inhibition Assay				IC50=1.37 nM	SANGER
ECC12	Growth Inhibition Assay				IC50=1.37 nM	SANGER
DU-4475	Growth Inhibition Assay				IC50=1.36 nM	SANGER
OPM-2	Growth Inhibition Assay				IC50=1.33 nM	SANGER
IST-SL2	Growth Inhibition Assay				IC50=1.31 nM	SANGER
Calu-6	Growth Inhibition Assay				IC50=1.29 nM	SANGER
CMK	Growth Inhibition Assay				IC50=1.29 nM	SANGER
A3-KAW	Growth Inhibition Assay				IC50=1.28 nM	SANGER
K5	Growth Inhibition Assay				IC50=1.28 nM	SANGER
KM12	Growth Inhibition Assay				IC50=1.27 nM	SANGER
SR	Growth Inhibition Assay				IC50=1.25 nM	SANGER
BL-41	Growth Inhibition Assay				IC50=1.25 nM	SANGER
Daudi	Growth Inhibition Assay				IC50=1.22 nM	SANGER
NCI-H1882	Growth Inhibition Assay				IC50=1.2 nM	SANGER
TE-8	Growth Inhibition Assay				IC50=1.19 nM	SANGER
HAL-01	Growth Inhibition Assay				IC50=1.18 nM	SANGER
EM-2	Growth Inhibition Assay				IC50=1.16 nM	SANGER
CCRF-CEM	Growth Inhibition Assay				IC50=1.13 nM	SANGER
D-392MG	Growth Inhibition Assay				IC50=1.1 nM	SANGER
MZ7-mel	Growth Inhibition Assay				IC50=1.09 nM	SANGER
VA-ES-BJ	Growth Inhibition Assay				IC50=1.09 nM	SANGER
SK-MM-2	Growth Inhibition Assay				IC50=1.09 nM	SANGER
LC-2-ad	Growth Inhibition Assay				IC50=1.08 nM	SANGER
RKO	Growth Inhibition Assay				IC50=1.06 nM	SANGER
TE-10	Growth Inhibition Assay				IC50=1.03 nM	SANGER
TE-1	Growth Inhibition Assay				IC50=1.03 nM	SANGER
PSN1	Growth Inhibition Assay				IC50=1.01 nM	SANGER
SW872	Growth Inhibition Assay				IC50=0.996 nM	SANGER
HC-1	Growth Inhibition Assay				IC50=0.975 nM	SANGER
KALS-1	Growth Inhibition Assay				IC50=0.925 nM	SANGER
SF268	Growth Inhibition Assay				IC50=0.923 nM	SANGER
IST-MEL1	Growth Inhibition Assay				IC50=0.917 nM	SANGER
RXF393	Growth Inhibition Assay				IC50=0.914 nM	SANGER
SNB75	Growth Inhibition Assay				IC50=0.912 nM	SANGER
NCI-H1355	Growth Inhibition Assay				IC50=0.895 nM	SANGER
TE-5	Growth Inhibition Assay				IC50=0.865 nM	SANGER
QIMR-WIL	Growth Inhibition Assay				IC50=0.889 nM	SANGER
SK-LMS-1	Growth Inhibition Assay				IC50=0.854 nM	SANGER
SW684	Growth Inhibition Assay				IC50=0.821 nM	SANGER
ML-2	Growth Inhibition Assay				IC50=0.821 nM	SANGER
D-263MG	Growth Inhibition Assay				IC50=0.807 nM	SANGER
LB2241-RCC	Growth Inhibition Assay				IC50=0.804 nM	SANGER
GI-1	Growth Inhibition Assay				IC50=0.764 nM	SANGER
ES7	Growth Inhibition Assay				IC50=0.766 nM	SANGER
LS-513	Growth Inhibition Assay				IC50=0.739 nM	SANGER
KINGS-1	Growth Inhibition Assay				IC50=0.722 nM	SANGER
UACC-257	Growth Inhibition Assay				IC50=0.71 nM	SANGER
LB373-MEL-D	Growth Inhibition Assay				IC50=0.7 nM	SANGER
SF126	Growth Inhibition Assay				IC50=0.701 nM	SANGER
Ramos-2G6-4C10	Growth Inhibition Assay				IC50=0.693 nM	SANGER
TK10	Growth Inhibition Assay				IC50=0.679 nM	SANGER
D-336MG	Growth Inhibition Assay				IC50=0.657 nM	SANGER
BB49-HNC	Growth Inhibition Assay				IC50=0.652 nM	SANGER
HOP-62	Growth Inhibition Assay				IC50=0.647 nM	SANGER
LB831-BLC	Growth Inhibition Assay				IC50=0.641 nM	SANGER
GI-ME-N	Growth Inhibition Assay				IC50=0.634 nM	SANGER
A4-Fuk	Growth Inhibition Assay				IC50=0.623 nM	SANGER
HT-144	Growth Inhibition Assay				IC50=0.576 nM	SANGER
COLO-829	Growth Inhibition Assay				IC50=0.614 nM	SANGER
NCI-H747	Growth Inhibition Assay				IC50=0.539 nM	SANGER
CESS	Growth Inhibition Assay				IC50=0.538 nM	SANGER
HUTU-80	Growth Inhibition Assay				IC50=0.533 nM	SANGER
DSH1	Growth Inhibition Assay				IC50=0.48 nM	SANGER
LB771-HNC	Growth Inhibition Assay				IC50=0.474 nM	SANGER
CP66-MEL	Growth Inhibition Assay				IC50=0.473 nM	SANGER
OCUB-M	Growth Inhibition Assay				IC50=0.447 nM	SANGER
MFH-ino	Growth Inhibition Assay				IC50=0.443 nM	SANGER
OS-RC-2	Growth Inhibition Assay				IC50=0.44 nM	SANGER
HCE-T	Growth Inhibition Assay				IC50=0.439 nM	SANGER
ES1	Growth Inhibition Assay				IC50=0.43 nM	SANGER
LB2518-MEL	Growth Inhibition Assay				IC50=0.425 nM	SANGER
ACN	Growth Inhibition Assay				IC50=0.417 nM	SANGER
D-247MG	Growth Inhibition Assay				IC50=0.413 nM	SANGER
HCC2998	Growth Inhibition Assay				IC50=0.412 nM	SANGER
MZ2-MEL	Growth Inhibition Assay				IC50=0.407 nM	SANGER
ES8	Growth Inhibition Assay				IC50=0.4 nM	SANGER
A388	Growth Inhibition Assay				IC50=0.356 nM	SANGER
KS-1	Growth Inhibition Assay				IC50=0.34 nM	SANGER
BB30-HNC	Growth Inhibition Assay				IC50=0.335 nM	SANGER
ONS-76	Growth Inhibition Assay				IC50=0.33 nM	SANGER
D-542MG	Growth Inhibition Assay				IC50=0.329 nM	SANGER
BB65-RCC	Growth Inhibition Assay				IC50=0.304 nM	SANGER
LOUCY	Growth Inhibition Assay				IC50=0.293 nM	SANGER
OVCAR-4	Growth Inhibition Assay				IC50=0.289 nM	SANGER
LXF-289	Growth Inhibition Assay				IC50=0.269 nM	SANGER
KNS-42	Growth Inhibition Assay				IC50=0.258 nM	SANGER
8-MG-BA	Growth Inhibition Assay				IC50=0.25 nM	SANGER
NTERA-S-cl-D1	Growth Inhibition Assay				IC50=0.243 nM	SANGER
A101D	Growth Inhibition Assay				IC50=0.225 nM	SANGER
MMAC-SF	Growth Inhibition Assay				IC50=0.216 nM	SANGER
no-10	Growth Inhibition Assay				IC50=0.21 nM	SANGER
A253	Growth Inhibition Assay				IC50=0.208 nM	SANGER
TE-9	Growth Inhibition Assay				IC50=0.182 nM	SANGER
SH-4	Growth Inhibition Assay				IC50=0.173 nM	SANGER
SK-UT-1	Growth Inhibition Assay				IC50=0.163 nM	SANGER
ES6	Growth Inhibition Assay				IC50=0.0021 nM	SANGER
human PBMC	Function Assay	100 nM	24 h		Induces IL-8 release	25791477
U937	Function Assay	100 nM	6 h		Induces IL-8 expression in LPS-stimulated U937 macrophages	25791477
HH	Migration Assay	100 nM	24 h	DMSO	Reduces cell migration by 80–91%	25681335
Hut-78	Migration Assay	100 nM	24 h	DMSO	Reduces cell migration by 80–90%	25681335
HH	Function Assay	100 nM	24 h	DMSO	downregulates TGF-β1 and IL-12 expression	25681335
H9	Function Assay	100 nM	24 h	DMSO	Downregulates TGF-β1 and IL-11 expression	25681335
Hut-78	Function Assay	100 nM	24 h	DMSO	Downregulates TGF-β1 and IL-10 expression	25681335
H1299	Apoptosis Assay	80 nM	24 h	DMSO	Sensitizes NSCLC cells to MSC-derived iC9-induced apoptosis	25323693
BLM	Autophagy Assay	10 nM	12 h		Induces formation of autophagosomes	23079083
A375	Autophagy Assay	10 nM	12 h		Induces formation of autophagosomes	23079083
BLM	Apoptosis Assay	10 nM	24 h		Induces cell apoptosis	23079083
A375	Apoptosis Assay	10 nM	24 h		Induces cell apoptosis	23079083
RAW 264.7	Growth Inhibition Assay	100 nM	48 h		Reduces cell viability	22427154
SNK-6	Antiviral Assay	1 μM	24 h		Induces lytic infection of EBV	21170988
KAI-3	Antiviral Assay	1 μM	24 h		Induces lytic infection of EBV	21170988
SNT-16	Antiviral Assay	1 μM	24 h		Induces lytic infection of EBV	21170988
SNT-13	Antiviral Assay	1 μM	24 h		Induces lytic infection of EBV	21170988
KHYG-1	Apoptosis Assay	1 μM	6 h		Induces cell apoptosis	21170988
KAI-3	Apoptosis Assay	1 μM	6 h		Induces cell apoptosis	21170988
Jurkat	Apoptosis Assay	1 μM	6 h		Induces cell apoptosis	21170988
SNT-16	Apoptosis Assay	1 μM	6 h		Induces cell apoptosis	21170988
KHYG-1	Growth Inhibition Assay	1 μM	24 h		Reduces cell viability	21170988
SNK-6	Growth Inhibition Assay	1 μM	24 h		Reduces cell viability	21170988
KAI-3	Growth Inhibition Assay	1 μM	24 h		Reduces cell viability	21170988
Jurkat	Growth Inhibition Assay	1 μM	24 h		Reduces cell viability	21170988
SNT-16	Growth Inhibition Assay	1 μM	24 h		Reduces cell viability	21170988
SNT-13	Growth Inhibition Assay	1 μM	24 h		Reduces cell viability	21170988
BJAB	Growth Inhibition Assay	1 μM	24 h		Reduces cell viability	21170988
LCL-2	Growth Inhibition Assay	1 μM	24 h		Reduces cell viability	21170988
LCL-1	Growth Inhibition Assay	1 μM	24 h		Reduces cell viability	21170988
Raji	Growth Inhibition Assay	1 μM	24 h		Reduces cell viability	21170988
BaF/3-p210	Function Assay	6 nM	24 h		Reduces the phosphorylation and the activity of Rb	20305692
BaF/3-p210	Function Assay	6 nM	48 h		Induces a slight G1 cell-cycle arrest	20305692
BaF/3	Function Assay	6 nM	48 h		Induces a great G1 cell-cycle arrest	20305692
TCC-S	Growth Inhibition Assay	100 nM	48 h		IC50=2.8 nM	20305692
BaF/3-p210	Growth Inhibition Assay	100 nM	48 h		IC50=4.7 nM	20305692
BaF/3	Growth Inhibition Assay	100 nM	48 h		IC50=6.2 nM	20305692
RPMI 8226	Function Assay	20 nM	8 h		Induces DNA synthesis	19436050
OPM2	Function Assay	20 nM	8 h		Significantly enhances NF-κB activity	19436050
INA6	Function Assay	20 nM	8 h		Significantly enhances NF-κB activity	19436050
OPM1	Function Assay	20 nM	8 h		Significantly enhances NF-κB activity	19436050
U266	Function Assay	20 nM	8 h		Significantly enhances NF-κB activity	19436050
MM.1S	Function Assay	20 nM	8 h		Significantly enhances NF-κB activity	19436050
RPMI 8226	Function Assay	20 nM	8 h		Significantly enhances NF-κB activity	19436050
CHLA-255	Function Assay	10 nM	24 h		Modestly reduces cells in the G0/G1 phase	17689684
NB-1691	Function Assay	10 nM	24 h		Significantly reduces cells in the G0/G1 phase	17689684
SK-N-AS	Growth Inhibition Assay	1 μM	72 h		Inhibits cell proliferation to 10%	17689684
CHLA-255	Growth Inhibition Assay	1 μM	72 h		Inhibits cell proliferation to 2%	17689684
NB-1691	Growth Inhibition Assay	1 μM	72 h		Inhibits cell proliferation to 5%	17689684
HKe-3	Apoptosis Assay	50 nM	48 h	DMSO	Induces cell apoptosis	16778179
HCT116	Apoptosis Assay	50 nM	48 h	DMSO	Induces cell apoptosis	16778179
T29Kt1	Apoptosis Assay	50 nM	48 h	DMSO	Induces cell apoptosis	16778179
T29	Apoptosis Assay	50 nM	48 h	DMSO	Induces cell apoptosis	16778179
LNCap-Pro5	Function Assay	1 μM	4 h	DMSO	Stabilizes p53	14612532
H460	Function Assay	100 nM	24 h	DMSO	Induces G2-M-phase arrest and tubulin assembly-disassembly	12631620
H322	Growth Inhibition Assay	10 μM	72 h	DMSO	IC50=620 nM	12631620
H358	Growth Inhibition Assay	10 μM	72 h	DMSO	IC50=70 nM	12631620
H460	Growth Inhibition Assay	10 μM	72 h	DMSO	IC50=100 nM	12631620
RPMI8226/LR5	Growth Inhibition Assay	500 ng/ml	48 h	DMSO	Inhibits cell growth	12631619
U266/dox4	Growth Inhibition Assay	500 ng/ml	48 h	DMSO	Inhibits cell growth	12631619
U266/LR7	Growth Inhibition Assay	500 ng/ml	48 h	DMSO	Inhibits cell growth	12631619
WAD-1	Growth Inhibition Assay	500 ng/ml	48 h	DMSO	Inhibits cell growth	12631619
ARH77	Growth Inhibition Assay	500 ng/ml	48 h	DMSO	Inhibits cell growth	12631619
U266	Growth Inhibition Assay	500 ng/ml	48 h	DMSO	Inhibits cell growth	12631619
H460	Function Assay	10 μM	24 h	DMSO	Induces Bcl-2 phosphorylation and cleavage correlated with G2-M phase arrest	12492117
UM-SCC-11B	Growth Inhibition Assay	100 nM	72 h	DMSO	Inhibits cell viability	11350913
UM-SCC-9	Growth Inhibition Assay	100 nM	72 h	DMSO	Inhibits cell viability	11350913
B7E3	Growth Inhibition Assay	100 nM	72 h	DMSO	Inhibits cell viability	11350913
B4B8	Growth Inhibition Assay	100 nM	72 h	DMSO	Inhibits cell viability	11350913
PAM-LY2	Growth Inhibition Assay	100 nM	72 h	DMSO	Inhibits cell viability	11350913
PAM 212	Growth Inhibition Assay	100 nM	72 h	DMSO	Inhibits cell viability	11350913
PAM-LY2	Function Assay	100 nM	12 h	DMSO	Inhibits NF-κB activation	11350913
Hs Sultan	Growth Inhibition Assay	100 nM	48 h	DMSO	IC50=20 nM	11306489
IM-9	Growth Inhibition Assay	100 nM	48 h	DMSO	IC50=6 nM	11306489
U266	Growth Inhibition Assay	100 nM	48 h	DMSO	IC50=3 nM	11306489
LR5	Growth Inhibition Assay	100 nM	48 h	DMSO	IC50=20 nM	11306489
MR20	Growth Inhibition Assay	100 nM	48 h	DMSO	IC50=20 nM	11306489
Dox40	Growth Inhibition Assay	100 nM	48 h	DMSO	IC50=40 nM	11306489
RPMI8226	Growth Inhibition Assay	100 nM	48 h	DMSO	IC50=30 nM	11306489
OVCA 429	Function Assay	300 nM	48 h	DMSO	Disrupts intact multicellular tumor spheroids	10999766
MCF-7	Cytotoxic Assay	50 μM	48 h	DMSO	Kills cells by more than 99%	10499643
FSCLL	Cytotoxicity assay		24 hrs		CC50 = 0.004 μM	21634429
HEK293	Cytotoxicity assay		24 hrs		CC50 = 0.347 μM	21634429
Glioma (HF2303)	Cytotoxicity assay		72 hrs		EC50 = 0.0007 μM	26288699
Glioma (HF2476)	Cytotoxicity assay		72 hrs		EC50 = 0.0007 μM	26288699
Glioma (HF2876)	Cytotoxicity assay		72 hrs		EC50 = 0.0007 μM	26288699
Glioma (HF2885)	Cytotoxicity assay		72 hrs		EC50 = 0.0007 μM	26288699
Glioma (HF3013)	Cytotoxicity assay		72 hrs		EC50 = 0.0007 μM	26288699
Glioma (HF2381)	Cytotoxicity assay		72 hrs		EC50 = 0.0007 μM	26288699
Glioma (HF2790)	Cytotoxicity assay		72 hrs		EC50 = 0.0007 μM	26288699
HepG2	Cytotoxicity assay		48 hrs		EC50 = 0.01 μM	29800827
Molt4	Function assay				EC50 = 0.021 μM	18247547
Molt4	Function assay				EC50 = 0.021 μM	22503349
HL60	Function assay		10 mins		ED50 = 0.0025 μM	19422206
HL60	Function assay		10 mins		ED50 = 0.0025 μM	21973101
RPMI8226	Growth inhibition assay				GI50 = 0.00023 μM	24946214
CCRF-CEM	Growth inhibition assay				GI50 = 0.00035 μM	24946214
MDA-MB-435	Growth inhibition assay				GI50 = 0.00044 μM	24946214
MALME-3M	Growth inhibition assay				GI50 = 0.00045 μM	24946214
NCI-H226	Growth inhibition assay				GI50 = 0.00046 μM	24946214
SK-MEL-28	Growth inhibition assay				GI50 = 0.00046 μM	24946214
A498	Growth inhibition assay				GI50 = 0.00048 μM	24946214
MOLT4	Growth inhibition assay				GI50 = 0.00051 μM	24946214
OVCAR3	Growth inhibition assay				GI50 = 0.00054 μM	24946214
SW620	Growth inhibition assay				GI50 = 0.00055 μM	24946214
MCF7	Growth inhibition assay				GI50 = 0.00055 μM	24946214
BT549	Growth inhibition assay				GI50 = 0.00055 μM	24946214
UACC257	Growth inhibition assay				GI50 = 0.00059 μM	24946214
SF539	Growth inhibition assay				GI50 = 0.00059 μM	24946214
HCC2998	Growth inhibition assay				GI50 = 0.0006 μM	24946214
HCT116	Growth inhibition assay				GI50 = 0.0006 μM	24946214
T47D	Growth inhibition assay				GI50 = 0.0006 μM	24946214
CAKI-1	Growth inhibition assay				GI50 = 0.00066 μM	24946214
SK-MEL-5	Growth inhibition assay				GI50 = 0.00068 μM	24946214
RXF393	Growth inhibition assay				GI50 = 0.00071 μM	24946214
LOXIMVI	Growth inhibition assay				GI50 = 0.00078 μM	24946214
ACHN	Growth inhibition assay				GI50 = 0.00079 μM	24946214
SR	Growth inhibition assay				GI50 = 0.00085 μM	24946214
UACC62	Growth inhibition assay				GI50 = 0.00091 μM	24946214
M14	Growth inhibition assay				GI50 = 0.00093 μM	24946214
HT-29	Growth inhibition assay				GI50 = 0.00095 μM	24946214
HOP92	Growth inhibition assay				GI50 = 0.001 μM	24946214
NCI-H23	Growth inhibition assay				GI50 = 0.001 μM	24946214
TK10	Growth inhibition assay				GI50 = 0.001 μM	24946214
CEM	Antiproliferative assay		72 hrs		GI50 = 0.001 μM	28441582
U266	Antiproliferative assay		72 hrs		GI50 = 0.001 μM	28441582
Hs 578T	Growth inhibition assay				GI50 = 0.00102 μM	24946214
UO31	Growth inhibition assay				GI50 = 0.00105 μM	24946214
SK-MEL-2	Growth inhibition assay				GI50 = 0.00107 μM	24946214
SN12C	Growth inhibition assay				GI50 = 0.0011 μM	24946214
K562	Growth inhibition assay				GI50 = 0.00117 μM	24946214
SF268	Growth inhibition assay				GI50 = 0.00117 μM	24946214
COLO205	Growth inhibition assay				GI50 = 0.00123 μM	24946214
MDA-MB-231	Growth inhibition assay				GI50 = 0.00126 μM	24946214
NCI-H522	Growth inhibition assay				GI50 = 0.00144 μM	24946214
786-0	Growth inhibition assay				GI50 = 0.00144 μM	24946214
MDA-MB-468	Growth inhibition assay				GI50 = 0.00148 μM	24946214
HCT15	Growth inhibition assay				GI50 = 0.00151 μM	24946214
U251	Growth inhibition assay				GI50 = 0.00155 μM	24946214
OVCAR5	Growth inhibition assay				GI50 = 0.00155 μM	24946214
KM12	Growth inhibition assay				GI50 = 0.0017 μM	24946214
SF295	Growth inhibition assay				GI50 = 0.0017 μM	24946214
DU145	Growth inhibition assay				GI50 = 0.0017 μM	24946214
HL-60(TB)	Growth inhibition assay				GI50 = 0.0019 μM	24946214
OVCAR4	Growth inhibition assay				GI50 = 0.00195 μM	24946214
SNB19	Growth inhibition assay				GI50 = 0.00204 μM	24946214
SNB75	Growth inhibition assay				GI50 = 0.00204 μM	24946214
IGROV1	Growth inhibition assay				GI50 = 0.00224 μM	24946214
OVCAR8	Growth inhibition assay				GI50 = 0.00263 μM	24946214
PC3	Growth inhibition assay				GI50 = 0.00263 μM	24946214
EKVX	Growth inhibition assay				GI50 = 0.00302 μM	24946214
A549/ATCC	Growth inhibition assay				GI50 = 0.00309 μM	24946214
HOP62	Growth inhibition assay				GI50 = 0.00447 μM	24946214
NCI-H460	Growth inhibition assay				GI50 = 0.00447 μM	24946214
K562	Antiproliferative assay		72 hrs		GI50 = 0.007 μM	28441582
NCI-ADR-RES	Growth inhibition assay				GI50 = 0.0123 μM	24946214
SKOV3	Growth inhibition assay				GI50 = 0.0138 μM	24946214
NCI-H322M	Growth inhibition assay				GI50 = 0.0178 μM	24946214
DLD1	Function assay		6 hrs		IC50 = 0.0002 μM	22206869
DLD1	Function assay		6 hrs		IC50 = 0.0009 μM	22206869
HCT116	Cytotoxicity assay		72 hrs		IC50 = 0.001 μM	28634039
HCT116	Antiproliferative assay		72 hrs		IC50 = 0.0014 μM	27769033
HepG2	Antiproliferative assay		72 hrs		IC50 = 0.00161 μM	27769033
SKOV3	Antiproliferative assay		72 hrs		IC50 = 0.00162 μM	27769033
A2780	Cytotoxicity assay				IC50 = 0.0017 μM	18247547
DOGUM	Cytotoxicity assay		72 hrs		IC50 = 0.002 μM	23031590
U266	Cytotoxicity assay		72 hrs		IC50 = 0.00245 μM	19537716
A549	Antiproliferative assay		72 hrs		IC50 = 0.0025 μM	28182990
HL60	Antiproliferative assay		72 hrs		IC50 = 0.0032 μM	28182990
RPMI18226	Cytotoxicity assay		72 hrs		IC50 = 0.0035 μM	21077681
HL60	Cytotoxicity assay		72 hrs		IC50 = 0.0035 μM	21077681
RPMI8226	Cytotoxicity assay		72 hrs		IC50 = 0.00388 μM	26965867
HL60	Function assay		2 hrs		IC50 = 0.004 μM	27769033
U266	Function assay		1 hr		IC50 = 0.004 μM	28441582
HL60	Function assay		2 hrs		IC50 = 0.004 μM	28634039
SEM	Function assay		2 hrs		IC50 = 0.00443 μM	30365892
HL60	Cytotoxicity assay		72 hrs		IC50 = 0.0055 μM	19537716
U266	Cytotoxicity assay		72 hrs		IC50 = 0.00573 μM	26965867
MGC803	Antiproliferative assay		72 hrs		IC50 = 0.005782 μM	27769033
GUMBUS	Cytotoxicity assay		72 hrs		IC50 = 0.006 μM	23031590
ARH77	Cytotoxicity assay		72 hrs		IC50 = 0.00607 μM	26965867
SW480	Cytotoxicity assay		72 hrs		IC50 = 0.0061 μM	20158184
MDA-MB-231	Antiproliferative assay		72 hrs		IC50 = 0.0065 μM	28182990
HL60	Function assay		2 hrs		IC50 = 0.00667 μM	30365892
A549	Cytotoxicity assay		72 hrs		IC50 = 0.0067 μM	20158184
RPMI8226	Antiproliferative assay		72 hrs		IC50 = 0.0067 μM	28182990
5TGM1	Cytotoxicity assay		48 to 72 hrs		IC50 = 0.00678 μM	24119559
HL60	Cytotoxicity assay		72 hrs		IC50 = 0.0069 μM	19747832
PC3	Cytotoxicity assay		72 hrs		IC50 = 0.007 μM	20158184
DOGUM	Cytotoxicity assay		72 hrs		IC50 = 0.007 μM	23031590
HL60	Cytotoxicity assay		72 hrs		IC50 = 0.0071 μM	20158184
MKN45	Antiproliferative assay		72 hrs		IC50 = 0.00715 μM	27769033
HepG2	Cytotoxicity assay		72 hrs		IC50 = 0.0075 μM	20158184
HL60	Antiproliferative assay		72 hrs		IC50 = 0.0076 μM	27769033
RPMI8226	Cytotoxic activity against human		72 hrs		IC50 = 0.00796 μM	24767818
HL60	Cytotoxicity assay		72 hrs		IC50 = 0.008 μM	28634039
MGC803	Cytotoxicity assay		72 hrs		IC50 = 0.008 μM	28634039
SKOV3/TR	Function assay		4 days		IC50 = 0.008 μM	29767973
PC3	Cytotoxicity assay		72 hrs		IC50 = 0.0083 μM	21077681
U266	Cytotoxicity assay		72 hrs		IC50 = 0.0088 μM	20158184
RPMI8226	Cytotoxicity assay				IC50 = 0.0088 μM	20727746
RPMI8226	Cytotoxicity assay		48 to 72 hrs		IC50 = 0.0095 μM	24119559
ARH77	Cytotoxicity assay		72 hrs		IC50 = 0.00957 μM	29934218
HEK293	Function assay		3 hrs		IC50 = 0.01 μM	20875739
HCT116	Cytotoxicity assay		72 hrs		IC50 = 0.01 μM	23547757
NCI-H929	Cytotoxicity assay		72 hrs		IC50 = 0.01085 μM	24767818
CCRF-CEM	Antiproliferative assay		72 hrs		IC50 = 0.011 μM	26231162
RPMI8226	Cytotoxicity assay		72 hrs		IC50 = 0.0112 μM	29934218
U266B1	Cytotoxicity assay		72 hrs		IC50 = 0.01163 μM	29934218
BxPC3	Cytotoxicity assay		72 hrs		IC50 = 0.0118 μM	19747832
293T	Antiproliferative assay		72 hrs		IC50 = 0.012 μM	28191850
U266	Cytotoxicity assay		72 hrs		IC50 = 0.0122 μM	19747832
SW480	Cytotoxicity assay		72 hrs		IC50 = 0.0123 μM	21077681
SKOV3	Cytotoxicity assay		4 days		IC50 = 0.0129 μM	29767973
A549	Cytotoxicity assay		72 hrs		IC50 = 0.0139 μM	21077681
HEK293	Function assay		30 mins		IC50 = 0.014 μM	21044847
RPMI8266	Antiproliferative assay		72 hrs		IC50 = 0.0144 μM	26231162
BxPC3	Cytotoxicity assay		72 hrs		IC50 = 0.0162 μM	20158184
MDA-MB-231	Antiproliferative assay		72 hrs		IC50 = 0.01665 μM	27769033
TOV21G	Antiproliferative assay		72 hrs		IC50 = 0.0167 μM	26231162
MDA-MB-231	Cytotoxicity assay		72 hrs		IC50 = 0.017 μM	28634039
BxPC3	Cytotoxicity assay		72 hrs		IC50 = 0.0194 μM	21077681
HeLa	Growth inhibition assay		72 hrs		IC50 = 0.02 μM	19428245
RKO	Antiproliferative assay		72 hrs		IC50 = 0.0208 μM	26231162
MCF7	Antiproliferative assay		3 days		IC50 = 0.025 μM	28557430
Bel7404	Antiproliferative assay		72 hrs		IC50 = 0.02504 μM	27769033
HepG2	Cytotoxicity assay		72 hrs		IC50 = 0.0252 μM	21077681
HEK293	Function assay		24 hrs		IC50 = 0.027 μM	21634429
HCT116	Antiproliferative assay		72 hrs		IC50 = 0.027 μM	26231162
SUP-B15	Function assay		2 hrs		IC50 = 0.02809 μM	30365892
A431	Antiproliferative assay		72 hrs		IC50 = 0.0282 μM	26231162
A2780	Antiproliferative assay		72 hrs		IC50 = 0.0289 μM	28182990
HL60	Function assay		2 hrs		IC50 = 0.03 μM	27769033
HL60	Function assay		2 hrs		IC50 = 0.03 μM	28634039
HEK293	Function assay		6 hrs		IC50 = 0.03 μM	28919340
WM266.4	Cytotoxicity assay		72 hrs		IC50 = 0.035 μM	22206869
GUMBUS	Cytotoxicity assay		72 hrs		IC50 = 0.035 μM	23031590
HepG2	Cytotoxicity assay		72 hrs		IC50 = 0.0375 μM	19537716
95-D	Cytotoxicity assay		72 hrs		IC50 = 0.038 μM	28634039
95-D	Antiproliferative assay		72 hrs		IC50 = 0.03818 μM	27769033
SW480	Cytotoxicity assay		72 hrs		IC50 = 0.05 μM	19537716
KB	Cytotoxicity assay		72 hrs		IC50 = 0.0595 μM	19537716
SKOV3	Cytotoxicity assay		72 hrs		IC50 = 0.0668 μM	21077681
SW1990	Antiproliferative assay		72 hrs		IC50 = 0.07906 μM	27769033
HeLa	Cytotoxicity assay		72 hrs		IC50 = 0.092 μM	19537716
A549	Antiproliferative assay		72 hrs		IC50 = 0.092 μM	28191850
H460	Cytotoxicity assay		72 hrs		IC50 = 0.115 μM	19537716
SKOV3	Cytotoxicity assay		72 hrs		IC50 = 0.13 μM	19537716
SKOV3	Cytotoxicity assay		72 hrs		IC50 = 0.151 μM	20158184
A549	Cytotoxicity assay		72 hrs		IC50 = 0.255 μM	19537716
HL60	Function assay		2 hrs		IC50 = 0.44 μM	27769033
HL60	Function assay		2 hrs		IC50 = 0.44 μM	28634039
H460	Cytotoxicity assay		72 hrs		IC50 = 0.78 μM	20158184
BGC823	Cytotoxicity assay		72 hrs		IC50 = 0.88 μM	19537716
MCF7	Antiproliferative assay		72 hrs		IC50 = 18.37 μM	29426629
A549	Antiproliferative assay		72 hrs		IC50 = 2.13573 μM	27769033
A549	Cytotoxicity assay		72 hrs		IC50 = 2.14 μM	28634039
BGC823	Cytotoxicity assay		72 hrs		IC50 = 2.89 μM	19747832
MDA-MB-231	Antiproliferative assay		72 hrs		IC50 = 3.125 μM	29426629
BCG823	Cytotoxicity assay		72 hrs		IC50 = 3.29 μM	20158184
A549	Antiproliferative assay		72 hrs		IC50 = 9.318 μM	29426629
Calu6	Cytotoxicity assay		72 hrs		LC50 = 0.0061 μM	20875739
HEK293T	Antiproliferative assay		48 hrs		LC50 = 0.016 μM	29843100
LO2	Antiproliferative assay		48 hrs		LC50 = 0.398 μM	29843100
NCI-H929	Cytotoxicity assay		48 hrs		LD50 = 0.0066 μM	27994734
U266	Cytotoxicity assay		48 hrs		LD50 = 0.018 μM	27994734
LCL	Cytotoxicity assay		48 hrs		LD50 = 0.02 μM	27994734
MDA-MB-468	Cytotoxicity assay		48 hrs		LD50 = 0.037 μM	27994734
RD-ES	Cytotoxicity assay		48 hrs		LD50 = 0.04 μM	27994734
WE68	Cytotoxicity assay		48 hrs		LD50 = 0.1 μM	27994734
IMR90	Cytotoxicity assay		48 hrs		LD50 = 0.13 μM	27994734
KGN	Cytotoxicity assay		48 hrs		LD50 = 0.18 μM	27994734
HNDF	Cytotoxicity assay		48 hrs		LD50 = 0.48 μM	27994734
MCF10A	Cytotoxicity assay		48 hrs		LD50 = 1.5 μM	27994734
SKOV3	Cytotoxicity assay		48 hrs		LD50 = 1.6 μM	27994734
MCF7	Cytotoxicity assay		48 hrs		LD50 = 9.8 μM	27994734
HL60	Function assay	100 nM			Inhibition of chymotrypsin-like activity of proteasome in human HL60 cells at 100 nM	19655762
HeLa	Function assay	5 nM	8 hrs		Inhibition of proteasome activity in human HeLa cells assessed as induction of ubiquitinG76V-FL reporter level at 5 nM after 8 hrs by luciferase assay	21186794
HeLa	Function assay	1 uM	8 hrs		Inhibition of proteasome activity in human HeLa cells assessed as induction of ubiquitinG76V-FL reporter level at 1 uM after 8 hrs by luciferase assay	21186794
LN229	Function assay	100 nM	1 hr		Inhibition of HIF1alpha expression in human LN229 cells assessed as reduction of HIF-1alpha accumulation at 100 nM preincubated for 1 hr under normoxia condition followed by 24 hrs incubation under hypoxia condition by Western blotting	21831638
LN229	Function assay	20 uM	1 hr		Inhibition of hypoxia-induced HIF1alpha accumulation in human LN229 cells at 20 uM after 1 hr preincubation measured after 24 hrs by Western blot analysis	22032632
U1	Function assay	10 uM	24 hr		Inhibition of NF-kappaB-mediated viral replication in Homo sapiens (human) U1 cells infected with X4 tropic HIV1 NL4-3 at 10 uM after 24 hr by RT-PCR analysis in presence of TNF-alpha	23290051
Calu6	Function assay	10 uM	18 hrs		Inhibition of His-tagged Frataxin (unknown origin)/Ubiquitin interaction expressed in human Calu6 cells assessed as increase in frataxin (1-210) precursor level at 10 uM after 18 hrs by Western blotting analysis	23506486
HCT116	Function assay				Inhibition of proteasome in human HCT116 cells assessed as accumulation of p53 by Western blotting analysis	23547757
HCT116	Apoptosis assay				Induction of apoptosis in human HCT116 cells assessed as induction of PARP cleavage by Western blotting analysis	23547757
HCT116	Cell cycle assay		24 hrs		Cell cycle arrest in human HCT116 cells assessed as accumulation at G2/M phase after 24 hrs by propidium iodide staining-based flow cytometric analysis	23547757
HEK293	Cytotoxicity assay	0.0001 uM to 100 uM	48 hrs		Cytotoxicity against human HEK293 cells expressing murine FAP at 0.0001 uM to 100 uM after 48 hrs by CellTiter-Blue assay	23594271
A549	Function assay	0.025 to 0.5 uM	24 hrs		Induction of cell death in human A549 cells assessed as accumulation of poly-ubiquitinated proteins at 0.025 to 0.5 uM after 24 hrs by immunoblot assay	25639862
A549	Function assay	0.025 to 0.5 uM	24 hrs		Induction of cell death in human A549 cells assessed as stabilization of p53 at 0.025 to 0.5 uM after 24 hrs by immunoblot assay	25639862
A549	Function assay	0.025 to 0.1 uM	24 hrs		Induction of cell death in human A549 cells assessed as accumulation of Noxa at 0.025 to 0.1 uM after 24 hrs by immunoblot assay	25639862
AMO1	Antitumor assay	1 mg/kg			Antitumor activity against human AMO1 cells xenografted in nude SCID beige mouse assessed as tumor growth inhibition at 1 mg/kg, iv administered twice per week	26565666
MCF7	Function assay	35 nM	4 hrs		Inhibition of 26S proteasome in human MCF7 cells assessed as accumulation of high molecular weight polyubiquitin-conjugated proteins at 35 nM after 4 hrs by Western blot analysis	27994734
MDA-MB-468	Function assay	35 nM	4 hrs		Inhibition of 26S proteasome in human MDA-MB-468 cells assessed as accumulation of high molecular weight polyubiquitin-conjugated proteins at 35 nM after 4 hrs by Western blot analysis	27994734
MDA-MB-231	Function assay	1 uM			Inhibition of trypsin like activity of 26S proteasome derived from human MDA-MB-231 cells at 1 uM	28291344
MDA-MB-231	Function assay	1 uM			Inhibition of caspase like activity of 26S proteasome derived from human MDA-MB-231 cells at 1 uM	28291344
MDA-MB-231	Function assay	1 uM			Inhibition of chymotrypsin like activity of 26S proteasome derived from human MDA-MB-231 cells at 1 uM	28291344
SK-N-SH	Cytotoxicity assay	0.1 to 1 uM	24 hrs		Cytotoxicity against human SK-N-SH cells assessed as reduction in cell viability at 0.1 to 1 uM after 24 hrs by MTT assay	29269255
MYCN2	Cytotoxicity assay	0.1 to 1 uM	24 hrs		Cytotoxicity against human MYCN2 cells assessed as reduction in cell viability at 0.1 to 1 uM after 24 hrs by MTT assay	29269255
U266	Apoptosis assay	2.5 nM	24 hrs		Induction of apoptosis in human U266 cells at 2.5 nM after 24 hrs by Annexin V/propidium iodide staining based flow cytometry	29304284
RPMI8226	Apoptosis assay	2.5 nM	24 hrs		Induction of apoptosis in human RPMI8226 cells at 2.5 nM after 24 hrs by Annexin V/propidium iodide staining based flow cytometry	29304284
NCI-H929	Apoptosis assay	2.5 nM	24 hrs		Induction of apoptosis in human NCI-H929 cells at 2.5 nM after 24 hrs by Annexin V/propidium iodide staining based flow cytometry	29304284
TC32	qHTS assay				qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for TC32 cells	29435139
U-2 OS	qHTS assay				qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for U-2 OS cells	29435139
A673	qHTS assay				qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for A673 cells	29435139
DAOY	qHTS assay				qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for DAOY cells	29435139
Saos-2	qHTS assay				qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Saos-2 cells	29435139
BT-37	qHTS assay				qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for BT-37 cells	29435139
RD	qHTS assay				qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for RD cells	29435139
SK-N-SH	qHTS assay				qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-SH cells	29435139
BT-12	qHTS assay				qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for BT-12 cells	29435139
MG 63 (6-TG R)	qHTS assay				qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for MG 63 (6-TG R) cells	29435139
NB1643	qHTS assay				qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for NB1643 cells	29435139
OHS-50	qHTS assay				qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for OHS-50 cells	29435139
BT-12	qHTS assay				qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for BT-12 cells	29435139
fibroblast	qHTS assay				qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for control Hh wild type fibroblast cells	29435139
LAN-5	qHTS assay				qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for LAN-5 cells	29435139
DAOY	qHTS assay				qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for DAOY cells	29435139
NB-EBc1	qHTS assay				qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for NB-EBc1 cells	29435139
Rh41	qHTS assay				qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh41 cells	29435139
SK-N-SH	qHTS assay				qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for SK-N-SH cells	29435139
Rh30	qHTS assay				qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh30 cells	29435139
A673	qHTS assay				qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for A673 cells)	29435139
BT-37	qHTS assay				qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for BT-37 cells	29435139
MG 63 (6-TG R)	qHTS assay				qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for MG 63 (6-TG R) cells	29435139
Rh30	qHTS assay				qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for Rh30 cells	29435139
fibroblast	qHTS assay				qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for control Hh wild type fibroblast cells	29435139
U-2 OS	qHTS assay				qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for U-2 OS cells	29435139
OHS-50	qHTS assay				qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for OHS-50 cells	29435139
SK-N-SH	qHTS assay				qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Orthogonal 3D viability screen for SK-N-SH cells	29435139
Rh41	qHTS assay				qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for Rh41 cells	29435139
RD	qHTS assay				qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for RD cells	29435139
Daoy	qHTS assay				qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Orthogonal 3D viability screen for Daoy cells	29435139
TC32	qHTS assay				qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Orthogonal 3D caspase screen for TC32 cells	29435139
TC32	qHTS assay				qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Orthogonal 3D viability screen for TC32 cells	29435139
MG 63 (6-TG R)	qHTS assay				qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Orthogonal 3D viability screen for MG 63 (6-TG R) cells	29435139
SJ-GBM2	qHTS assay				qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SJ-GBM2 cells	29435139
SK-N-MC	qHTS assay				qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-MC cells	29435139
NB-EBc1	qHTS assay				qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for NB-EBc1 cells	29435139
LAN-5	qHTS assay				qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for LAN-5 cells	29435139
Rh18	qHTS assay				qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh18 cells	29435139
NB1643	qHTS assay				qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for NB1643 cells	29435139
SK-N-MC	qHTS assay				qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for SK-N-MC cells	29435139
SJ-GBM2	qHTS assay				qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for SJ-GBM2 cells	29435139
TC32	qHTS assay				qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for TC32 cells	29435139
Rh18	qHTS assay				qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for Rh18 cells	29435139
Saos-2	qHTS assay				qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for Saos-2 cells	29435139
SJ-GBM2	qHTS assay				qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Orthogonal 3D viability screen for SJ-GBM2 cells	29435139
RD	qHTS assay				qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Orthogonal 3D viability screen for RD cells	29435139
HL60	Function assay	1 to 100 nM	24 hrs		Inhibition of proteasome in human HL60 cells assessed as increase in cleaved PARP expression at 1 to 100 nM after 24 hrs by immunoblot assay	30365892
SUP-B15	Function assay	1 to 100 nM	24 hrs		Inhibition of proteasome in imatinib-resistant human SUP-B15 cells assessed as increase in cleaved PARP expression at 1 to 100 nM after 24 hrs by immunoblot assay	30365892
SEM	Function assay	1 to 100 nM	24 hrs		Inhibition of proteasome in human SEM cells assessed as increase in cleaved PARP expression at 1 to 100 nM after 24 hrs by immunoblot assay	30365892
SEM	Function assay	10 nM	18 hrs		Inhibition of proteasome in human SEM cells assessed as increase in aggresome accumulation at 10 nM after 18 hrs by by FACS analysis	30365892
SEM	Function assay	10 nM	18 hrs		Inhibition of proteasome in human SEM cells assessed as increase in aggresome accumulation at 10 nM after 18 hrs by fluorescence microscopic method	30365892
HepG2	Cell viability assay				HepG2 cells viability qHTS for Zika virus inhibitors	33229545
클릭하여 더 많은 세포주 실험 데이터 보기

화학 정보, 보관 및 안정성

분자량	384.24	화학식	C₁₉H₂₅BN₄O₄	보관 (수령일로부터)	3 years-20°C （in the dark）powder
CAS 번호	179324-69-7	SDF 다운로드		원액 보관	1년-80°C용매에 보관 1개월-20°C용매에 보관
동의어	LDP-341, MLM341, NSC 681239,PS-341, BTZ			Smiles	B(C(CC(C)C)NC(=O)C(CC1=CC=CC=C1)NC(=O)C2=NC=CN=C2)(O)O

용해도

In vitro
배치:

DMSO : 77 mg/mL (200.39 mM)
(수분으로 오염된 DMSO는 용해도를 감소시킬 수 있습니다. 신선하고 무수 DMSO를 사용하십시오.)

Water : Insoluble

Ethanol : Insoluble

DMSO : 77 mg/mL (200.39 mM)
(수분으로 오염된 DMSO는 용해도를 감소시킬 수 있습니다. 신선하고 무수 DMSO를 사용하십시오.)

Water : Insoluble

Ethanol : Insoluble

DMSO : 76 mg/mL (197.79 mM)
(수분으로 오염된 DMSO는 용해도를 감소시킬 수 있습니다. 신선하고 무수 DMSO를 사용하십시오.)

Water : Insoluble

Ethanol : Insoluble

DMSO : 76 mg/mL (197.79 mM)
(수분으로 오염된 DMSO는 용해도를 감소시킬 수 있습니다. 신선하고 무수 DMSO를 사용하십시오.)

Water : Insoluble

Ethanol : Insoluble

DMSO : 76 mg/mL (197.79 mM)
(수분으로 오염된 DMSO는 용해도를 감소시킬 수 있습니다. 신선하고 무수 DMSO를 사용하십시오.)

Water : Insoluble

Ethanol : Insoluble

몰농도 계산기

질량	농도	부피	분자량
=	×	×

희석 계산기 분자량 계산기

In vivo 배치:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 40%PEG 300 2 5%Tween80 3 50% ddH2O Selleck 연구소에서 검증되었습니다. 이 제형에 대한 조정이 필요한 경우 맞춤 테스트를 위해 당사 영업팀에 문의하십시오.	2.000mg/ml (5.21mM)	Taking the 1 mL working solution as an example, add 50 μL of 40 mg/mL clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify; add 50 μL of Tween-80 to the above system, mix evenly to clarify; Then continue to add 500 μL ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 40%PEG 300 2 5%Tween80 3 50% ddH2O Selleck 연구소에서 검증되었습니다. 이 제형에 대한 조정이 필요한 경우 맞춤 테스트를 위해 당사 영업팀에 문의하십시오.	5.000mg/ml (13.01mM)	Taking the 1 mL working solution as an example, add 50 μL of 100 mg/mL clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify; add 50 μL of Tween-80 to the above system, mix evenly to clarify; Then continue to add 500 μL ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

생체 내 제형 계산기 (투명한 용액)

1단계: 아래 정보 입력 (권장: 실험 중 손실을 고려하여 추가 동물 포함)

투여량: mg/kg 동물 평균 체중: g 동물당 투여량:μL 동물 수:

2단계: 생체 내 제형 입력 (이것은 계산기일 뿐 제형이 아닙니다. 용해도 섹션에 생체 내 제형이 없는 경우 먼저 당사에 문의하십시오.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

계산 결과:

작업 농도: mg/ml;

DMSO 원액 준비 방법: mg 약물 사전 용해 μL DMSO ( 원액 농도 mg/mL, 농도가 해당 약물 배치의 DMSO 용해도를 초과하는 경우 먼저 당사에 문의하십시오. )

생체 내 제형 준비 방법: 취하다 μL DMSO 원액, 다음 추가μL PEG300, 혼합하고 투명하게 한 다음 추가μL Tween 80, 혼합하고 투명하게 한 다음 추가 μL ddH₂O, 혼합하고 투명하게 합니다.

생체 내 제형 준비 방법: 취하다 μL DMSO 원액, 다음 추가 μL 옥수수 기름, 혼합하고 투명하게 합니다.

참고: 1. 다음 용매를 추가하기 전에 액체가 투명한지 확인하십시오.
2. 용매를 순서대로 추가해야 합니다. 다음 용매를 추가하기 전에 이전 추가에서 얻은 용액이 투명한 용액인지 확인해야 합니다. 와동, 초음파 또는 뜨거운 물 중탕과 같은 물리적 방법을 사용하여 용해를 도울 수 있습니다.

작용 메커니즘

Targets/IC₅₀/Ki	NF-κB 20S proteasome (Cell-free assay) 0.6 nM(Ki)
시험관 내(In vitro)	붕산 디펩티드인 Bortezomib은 잘못 접힌 단백질 분해에 주로 기능하며 세포 주기 조절에 필수적인 26S Proteasome의 고도로 선택적이고 가역적인 억제제입니다. 이 화합물에 노출되면 p21, p27 및 p53뿐만 아니라 세포자멸사 촉진 Bid 및 Bax 단백질, 카베올린-1, 그리고 핵 인자 κB 유도 세포 생존 경로의 활성화를 방지하는 억제제 κB-α를 안정화시키는 것으로 나타났습니다. 또한 세포자멸사 촉진 c-Jun-NH2 말단 키나아제 및 소포체 스트레스 반응의 활성화를 촉진합니다. 이러한 세포 단백질 수준의 변화는 암세포의 증식, 이동 억제 및 세포자멸사 촉진으로 이어집니다. 이 화학 물질은 세포 내로 침투하여 ~0.1 μM의 농도로 장수명 단백질의 Proteasome 매개 세포내 단백질 분해를 50% 억제하는 것으로 나타났습니다. 미국 국립암연구소(NCI)의 여러 인체 종양에서 유래한 60개 암세포주 전체 패널에 걸쳐 이 화합물의 평균 50% 성장 억제 값은 7 nM입니다. PC-3 세포를 8시간 동안 (100 nM) 처리하면 G2-M기에 세포가 축적되고, G1기 세포 수가 이에 상응하여 감소합니다. 이는 24시간 및 48시간에 PC-3 세포를 각각 100 nM 및 20 nM의 IC50으로 사멸시킵니다. 이 물질은 처리 후 16-24시간에 핵 응축을 유도합니다. 이 처리는 24시간에 100 nM의 낮은 농도에서도 효과적인 시간 의존적 방식으로 PARP 절단을 유도합니다.
키나아제 분석	동역학적 방법
키나아제 분석	전형적인 동역학적 실행에서, 2.00 mL의 분석 완충액(20 mM HEPES, 0.5 mM EDTA, 0.035% SDS, pH 7.8)과 DMSO에 있는 Suc-Leu-Leu-Val-Tyr-AMC를 3 mL 형광 큐벳에 첨가하고, 큐벳을 형광 분광 광도계의 재킷형 셀 홀더에 놓습니다. 반응 온도는 순환식 항온수조에 의해 37℃로 유지됩니다. 반응 용액이 열 평형에 도달한 후 (5분), 1 μL-10 μL의 스톡 효소 용액을 큐벳에 첨가합니다. 반응 진행은 펩타이드-AMC 기질에서 AMC의 분해에 수반되는 440 nm (λ_ex= 380 nm)에서 형광 방출 증가에 의해 모니터링됩니다.
생체 내(In vivo)	단일 제제로서 Bortezomib의 항암 효과는 다발성 골수종, 성인 T-세포 백혈병, 폐암, 유방암, 전립선암, 췌장암, 두경부암, 결장암 및 흑색종의 이종이식 모델에서 입증되었습니다. 이 화합물을 1.0 mg/kg 용량으로 18일간 매일 경구 투여하면 루이스 폐암 모델에서 종양 성장 지연 및 전이 수 감소를 유발합니다. 이 화합물은 최대 5 mg/kg의 단일 용량으로 유방암 세포의 생존 분획을 유의하게 감소시켰습니다. 이 화학 물질을 1.0 mg/kg 용량으로 4주 동안 매주 투여하면 전립선암 생쥐 이종이식 모델에서 종양 성장이 60% 감소합니다. 이 물질을 1.0 mg/kg 용량으로 4주 동안 처리하면 췌장암 생쥐 이종이식 성장률이 72% 또는 84% 감소하고, 종양 세포 세포자멸사가 증가합니다. 이 화합물을 1.0 mg/kg 용량으로 처리하면 인간 형질세포종 이종이식 성장이 유의하게 억제되고, 종양 세포 세포자멸사 및 전체 생존율이 증가하며, 종양 혈관 신생이 감소합니다.
참조	[1] https://pubmed.ncbi.nlm.nih.gov/10363983/ [2] https://pubmed.ncbi.nlm.nih.gov/15929791/ [3] https://pubmed.ncbi.nlm.nih.gov/12208752/ [4] https://pubmed.ncbi.nlm.nih.gov/8672420/ [5] https://pubmed.ncbi.nlm.nih.gov/11306489/ [6] https://pubmed.ncbi.nlm.nih.gov/22016836/

적용 분야

방법	바이오마커	PMID
Western blot	phospho-PERK / ATF-4 GRP-78 / GADD-34 pro-caspase-12 / pro-caspase-3 pro-caspase-9 p-IκBα / IκBα COX-2 / cIAP2	15509775
Immunofluorescence	Vimentin Ubiquitin	19010849
Growth inhibition assay	Cell viability	20571067
ELISA	IL-8	24085292

임상시험 정보

(데이터 출처 https://clinicaltrials.gov, 업데이트 날짜 2024-05-22)

NCT 번호	모집	조건	스폰서/협력자	시작일	단계
NCT05599880	Recruiting	Relapsed/Refractory Immune Thrombocytopenia	Seoul National University Hospital	July 7 2023	Phase 2
NCT05781425	Recruiting	Chemotherapy-induced Peripheral Neuropathy	Odense University Hospital\|Aarhus University Hospital\|Sygehus Lillebaelt\|University of Southern Denmark	May 12 2023	--
NCT05383547	Unknown status	Bortezomib\|Glomerulonephritis\|MN\|MPGN\|FSGS\|IgA Nephropathy	Ruijin Hospital	August 2 2022	Not Applicable
NCT04915248	Recruiting	Plasmablastic Lymphoma	Fondazione Italiana Linfomi - ETS\|Janssen-Cilag S.p.A.	July 11 2022	Phase 2
NCT04656951	Recruiting	Multiple Myeloma	University of Cologne\|Janssen-Cilag G.m.b.H	June 1 2021	Phase 2

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자주 묻는 질문

질문 1:
On your website, it is mentioned that it should be prepared at a concentration of 5 mg/ml in 2% DMSO/30% PEG300/ddH2O for in vivo use. But on the product sheet we received with the compound, it is mentioned: 5mg/ml in 0.5% methylcellulose, 0.2% tween 80. So which is the correct preparation buffer?

답변:
S1013 This compound in 2% DMSO+30% PEG 300+ddH2O at 5 mg/ml is a clear solution, and it in 0.5% methylcellulose+0.2% Tween 80 is a suspension. Please choose the suitable vehicle according to your administration route. When you prepare the clear solution, please dissolve it in DMSO first, make sure it dissolves well, warm it up to 45 degree and/or sonicate if necessary, then add PEG, mix well, and finally add water.

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