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Bleomycin sulfate DNA 합성 억제제

Name: Bleomycin sulfate
Brand: Selleck Chemicals
SKU: S1214
Rating: 5 (163 reviews)

제품 번호S1214

Bleomycin sulfate는 글리코펩타이드 항생제이자 DNA 합성 억제제이며, UT-SCC-19A 세포에서 IC50이 4nM인 편평 세포 암종(SCC)에 대한 항암제입니다. Bleomycin sulfate는 DNA 합성 억제제입니다. Bleomycin (NSC125066) sulfate는 폐 섬유증 동물 모델을 유도하는 데 사용될 수 있습니다.

Bleomycin sulfate DNA/RNA Synthesis 억제제 Chemical Structure

화학 구조

분자량: 1512.62

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품질 관리

배치: 순도: 99.97%

99.97

함께 자주 사용되는 제품 Bleomycin sulfate

Y-27632 Dihydrochloride

Y-27632 2HCl prevents this compound induced injury in neonatal rats.

Z-VAD-FMK

Z-VAD-FMK protects the mice againts pneumopathy induced by it.

관련 타겟	CDK HSP PD-1/PD-L1 ROCK Wee1 Microtubule Associated Ras KRas Aurora Kinase Casein Kinase
기타 DNA/RNA Synthesis 억제제	CX-5461 (Pidnarulex) B02 SCR7 Favipiravir (T-705) EED226 RK-33 BMH-21 Triapine (3-AP) Carmofur YK-4-279

세포 배양, 처리 및 작업 농도

세포주	분석 유형	농도	배양 시간	활성 설명	PMID
F98	Growth Inhibition Assay	0–1000 μm	24 h	inhibits cell growth dose dependently	26088711
POLK WT	Growth Inhibition Assay			IC50=11.7 ± 1.7 μM	26031400
POLK KO	Growth Inhibition Assay			IC50=4.03 ± 1.92 μM	26031400
POLK CD	Growth Inhibition Assay			IC50=5.59 ± 1.00 μM	26031400
RLE/Abca3	Function Assay	0.4 μM	144 h	induces a morphological change from epithelial-like morphology to a wide, spread-out morphology	25760538
PMCs	Function Assay	0.1–2 μg/ml	24 h	causes a dose-dependent increase in the protein level of collagen-I	25595642
PMCs	Function Assay	0.2 μg/ml	24–72 h	induces increases in vimentin and α-SMA protein	25595642
PMCs	Function Assay	0.2 μg/ml	72 h	induces decreases in cytokeratin-8 and E-cadherin protein	25595642
PMCs	Function Assay	0.2 μg/ml	12/24/48 h	increases cell migration	25595642
IMR-32	Growth Inhibition Assay	7.5−120 µg/ml	12−48 h	IC50=60 µg/ml at the end of 24 hrs of incubation	25536345
HT1080	Growth Inhibition Assay	1 μM	24 h	leads to a G2/M delay	25518961
HT1080	Function Assay	1 μM	24 h	induces a potent global DNA damage response	25518961
HDFn	Cytotoxicity Assay		72 h	IC50=9.31%	25276792
THP-1	Cytotoxicity Assay		72 h	IC50=4.77%	25276792
HT-29	Cytotoxicity Assay		72 h	IC50=11.49%	25276792
HCT116	Cytotoxicity Assay		72 h	IC50=11.34%	25276792
A431	Growth Inhibition Assay	50-200 IU	48 h	inhibits cell growth dose dependently	25101299
T24	Growth Inhibition Assay	50-200 IU	48 h	inhibits cell growth dose dependently	25101299
AY-27	Growth Inhibition Assay	50-200 IU	48 h	inhibits cell growth dose dependently	25101299
A549	Function Assay	1 µg/mL	0-48 h	increases the expression of OPN mRNA	24963635
MLE12	Function Assay	1 µg/mL	0-48 h	increases the expression of OPN mRNA	24963635
Jurkat	Growth Inhibition Assay	20 μm	24 h	arrests the cell cycle at the G2 phase	24916893
HeLa	Growth Inhibition Assay			IC50=10.2 μM	24732397
C18-4	Growth Inhibition Assay	0-100 μM		inhibits cell growth dose dependently	24571982
BMG-1	Growth Inhibition Assay	40/80 μg/m	3 h	inhibits cell growth dose dependently	23906726
A459	Apoptosis Assay	10 mU	48 h	induces apoptosis	23902766
MOCK	Apoptosis Assay	10 mU	48 h	induces apoptosis	23902766
MMP1	Apoptosis Assay	10 mU	48 h	induces apoptosis	23902766
A549	Growth Inhibition Assay	200 μM	24 h	decreases cell viability significantly	23805793
HCT-116	Apoptosis Assay	3/7.5/15 μg/ml	48 h	reduces the level of BLH at high concentration	23708668
HeLa	Apoptosis Assay	3/7.5/15 μg/ml	48 h	reduces the level of BLH at high concentration	23708668
HCT116	Growth Inhibition Assay	0-100 μg/ml	48 h	inhibits cell growth dose dependently	23518201
NCM460	Growth Inhibition Assay	0-100 μg/ml	48 h	inhibits cell growth dose dependently	23518201
NT2	Growth Inhibition Assay		24 h	LD50=400 µg/ml	23386420
NT2	Growth Inhibition Assay		48 h	LD50=100 µg/ml	23386420
NT2	Growth Inhibition Assay		72 h	LD50=20 µg/ml	23386420
NT2	Apoptosis Assay	400 µg/ml	24 h	induces significant increases in caspase-3,8,9 activity	23386420
NTera-2	Function Assay	120 μg/ml	72 h	significantly increases 8-isoprostane levels	22825355
NCCIT	Function Assay	120 μg/ml	72 h	significantly increases 8-isoprostane levels	22825355
NTera-2	Function Assay	120 μg/ml	72 h	significantly increases TBARS levels	22825355
NCCIT	Function Assay	120 μg/ml	72 h	significantly increases TBARS levels	22825355
NCCIT	Function Assay	120 μg/ml	72 h	significantly decreases GSH levels	22825355
NTera-2	Function Assay	120 μg/ml	72 h	significantly increases Protein carbonyl levels	22825355
NCCIT	Function Assay	120 μg/ml	72 h	significantly increases Protein carbonyl levels	22825355
NTera-2	Function Assay	120 μg/ml	72 h	significantly increases LPO levels	22825355
NCCIT	Function Assay	120 μg/ml	72 h	significantly increases LPO levels	22825355
MDA-MB-468	Growth Inhibition Assay	0–200 μg/mL	24 h	inhibits cell growth dose dependently	22819196
231-H2N	Growth Inhibition Assay	0–200 μg/mL	24 h	inhibits cell growth dose dependently	22819196
A549	Function Assay	200/400 μM		results in a dose-responsive increase in ROS	22773697
A549	Function Assay	0-400 μM	2-48 h	causes more mtDNA than nDNA damage	22773697
A549	Function Assay	100 μM	0–48 h	causes caspase-3 activation	22773697
A549	Function Assay	100 μM	0–48 h	causes PKD1 cleavage	22773697
A549	Function Assay	100 μM	0–48 h	causes mitochondrial localization of Bax	22773697
A549	Function Assay	100 μM	0–48 h	decreases MMP and ATP levels	22773697
MCF-7/Her-18	Growth Inhibition Assay	0.42-1700 μg/mL	24 h	inhibits cell growth dose dependently	22621404
MCF-7	PDT/PCI Treatment	0.25 μg/ml.	1-4 h	shows significant (P < 0.05) cytotoxic effect	22591284
MDA-MB-231	PDT/PCI Treatment	0.25 μg/ml.	1-4 h	shows significant (P < 0.05) cytotoxic effect	22591284
MDA-MB-235	PDT/PCI Treatment	0.25 μg/ml.	1-4 h	shows significant (P < 0.05) cytotoxic effect	22591284
MCF-7	Growth Inhibition Assay	0-2 μg/ml.	24/48 h	EC50=1.2 μg/mL	22591284
NCCIT	Growth Inhibition Assay	20–140 μg/ml	72 h	LD50=120 μg/ml	22562160
NCCIT	Function Assay		72 h	significantly increases caspase-3 activity	22562160
NCCIT	Function Assay		72 h	significantly increases caspase-8 activity	22562160
NCCIT	Function Assay		72 h	significantly increases caspase-9 activity	22562160
NCCIT	Function Assay		72 h	significantly increases BAX level	22562160
NCCIT	Function Assay		72 h	significantly decreases the Bcl-2 content	22562160
NCCIT	Function Assay		72 h	significantly decreases the Cyt-c level	22562160
HeLa	Function Assay	30/70 μg/ml	24 h	increases the mRNA levels of p53，ATM,p21 and GADD45	22487937
MCF-7	Function Assay	30/70 μg/ml	24 h	increases the mRNA levels of p53，ATM,p21 and GADD45	22487937
HeLa	Cytotoxicity Assay	30/70 μg/ml	24 h	induces highly significant levels of fragmented DNA release into the cytoplasm	22487937
MCF-7	Cytotoxicity Assay	30/70 μg/ml	24 h	induces highly significant levels of fragmented DNA release into the cytoplasm	22487937
NT2	Growth Inhibition Assay	100-600 μg/ml	24 h	IC50=400 µg/ml	22469952
NT2	Function Assay	400 μg/ml	24 h	significantly increases caspase-3,8,9 activity	22469952
NT2	Function Assay	400 μg/ml	24 h	significantly increases BAX level	22469952
NT2	Function Assay	400 μg/ml	24 h	significantly decreases Bcl-2 level	22469952
CHO	Function Assay	2.5 μg/ml	18 h/6 d	induces persistence of chromosome damage	22230195
Jurkat	Growth Inhibition Assay	0-100 μg/ml	24 h	arrests the cell cycle at the G2 phase	22223332
Jurkat	Function Assay	30 μg/ml	24 h	increases the protein levels of cyclins D3, A and B1	22223332
Jurkat	Growth Inhibition Assay	0-100 μg/ml	24 h	inhibits cell proliferation in a dose-dependent manner with an IC50 value of 100μg/mL	22223332
Jurkat	Function Assay	30 μg/ml	24 h	increases the effect of pycnidione on phosphorylation levels of histone H2A.X	22223332
U2OS EGFPnls	Growth Inhibition Assay	0-2 μg/ml	24 h	inhibits cell growth dose dependently	21811007
U2OS KuEnls	Growth Inhibition Assay	0-2 μg/ml	24 h	inhibits cell growth dose dependently	21811007
MCF-7	Growth Inhibition Assay	0-400 μM	72 h	LC50=151.8 μM	21703291
MCF-7/Adr	Growth Inhibition Assay	0-400 μM	72 h	LC50=58.5 μM	21703291
WI-38	Function Assay	0/40/80 μg/ml	3 h	induces a concentration-dependent increase in the MN frequency	21599612
hBMSC	Function Assay	0/40/80 μg/ml	3 h	induces a concentration-dependent increase in the MN frequency	21599612
NCI-H23	Function Assay	0/40/80 μg/ml	3 h	induces a concentration-dependent increase in the MN frequency	21599612
A-549	Function Assay	0/40/80 μg/ml	3 h	induces a concentration-dependent increase in the MN frequency	21599612
PBL	Function Assay	0/40/80 μg/ml	3 h	induces a concentration-dependent increase in the MN frequency	21599612
pol β −/−	Growth Inhibition Assay	0.25-200 μg/ml	24 h	decreases cell viability with increasing concentrations	21251944
pol β +/+	Growth Inhibition Assay	0.25-200 μg/ml	24 h	decreases cell viability with increasing concentrations	21251944
pol β −/−	Function Assay	0-2.5 μg/ml	2 h	causes DNA damage	21251944
pol β +/+	Function Assay	0-2.5 μg/ml	2 h	causes DNA damage	21251944
pol β −/−	Function Assay	0-5 μg/ml	48 h	causes micronucleus dose and time dependently	21251944
pol β +/+	Function Assay	0-5 μg/ml	48 h	causes micronucleus dose and time dependently	21251944
TK6	Growth Inhibition Assay	25-150 μg/ml	96 h	inhibits cell growth dose dependently	21081487
TK6 sLUC+Apn1	Growth Inhibition Assay	25-150 μg/ml	96 h	inhibits cell growth dose dependently	21081487
TK6 sAPE1+Apn1	Growth Inhibition Assay	25-150 μg/ml	96 h	significantly inhibits cell growth dose dependently	21081487
HCT116	Growth Inhibition Assay	25-150 μg/ml	96 h	inhibits cell growth dose dependently	21081487
HCT116 sLUC+Apn1	Growth Inhibition Assay	25-150 μg/ml	96 h	inhibits cell growth dose dependently	21081487
HCT116 sAPE1+Apn1	Growth Inhibition Assay	25-150 μg/ml	96 h	significantly inhibits cell growth dose dependently	21081487
2SC/20	Function Assay		72 h	IC50 = 0.517 μM	12431060
HET-SR-2SC-LNM	Function Assay		72 h	IC50 = 0.519 μM	12431060
HepG2	Growth Inhibition Assay			GI50 = 1 μM	18068362
MCF-7	Function Assay		24 h	IC50 = 53 μM	12477361
COLO-668	Growth Inhibition Assay			IC50 = 0.0000218 μM	SANGER
CAL-51	Growth Inhibition Assay			IC50 = 0.000099 μM	SANGER
A427	Growth Inhibition Assay			IC50 = 0.000118 μM	SANGER
RMG-I	Growth Inhibition Assay			IC50 = 0.0001319 μM	SANGER
HUTU-80	Growth Inhibition Assay			IC50 = 0.0001358 μM	SANGER
NTERA-S-cl-D1	Growth Inhibition Assay			IC50 = 0.0001391 μM	SANGER
IST-SL2	Growth Inhibition Assay			IC50 = 0.0001732 μM	SANGER
CAL-85-1	Growth Inhibition Assay			IC50 = 0.0001777 μM	SANGER
SUP-T1	Growth Inhibition Assay			IC50 = 0.000251 μM	SANGER
HCC1937	Growth Inhibition Assay			IC50 = 0.000254 μM	SANGER
CAL-39	Growth Inhibition Assay			IC50 = 0.0003147 μM	SANGER
HAL-01	Growth Inhibition Assay			IC50 = 0.0004527 μM	SANGER
OVCAR-8	Growth Inhibition Assay			IC50 = 0.0004763 μM	SANGER
CESS	Growth Inhibition Assay			IC50 = 0.0005457 μM	SANGER
NCI-H650	Growth Inhibition Assay			IC50 = 0.0005873 μM	SANGER
MKN28	Growth Inhibition Assay			IC50 = 0.00108 μM	SANGER
RS4-11	Growth Inhibition Assay			IC50 = 0.001643 μM	SANGER
MFH-ino	Growth Inhibition Assay			IC50 = 0.002646 μM	SANGER
KYSE-150	Growth Inhibition Assay			IC50 = 0.002647 μM	SANGER
KGN	Growth Inhibition Assay			IC50 = 0.003712 μM	SANGER
HOP-62	Growth Inhibition Assay			IC50 = 0.004134 μM	SANGER
LU-99A	Growth Inhibition Assay			IC50 = 0.00422 μM	SANGER
RT4	Growth Inhibition Assay			IC50 = 0.005856 μM	SANGER
SK-UT-1	Growth Inhibition Assay			IC50 = 0.006293 μM	SANGER
HCC2998	Growth Inhibition Assay			IC50 = 0.006592 μM	SANGER
GT3TKB	Growth Inhibition Assay			IC50 = 0.00685 μM	SANGER
EW-16	Growth Inhibition Assay			IC50 = 0.006853 μM	SANGER
NKM-1	Growth Inhibition Assay			IC50 = 0.007647 μM	SANGER
HCC1806	Growth Inhibition Assay			IC50 = 0.008543 μM	SANGER
SW954	Growth Inhibition Assay			IC50 = 0.009572 μM	SANGER
MV-4-11	Growth Inhibition Assay			IC50 = 0.009908 μM	SANGER
LOUCY	Growth Inhibition Assay			IC50 = 0.009935 μM	SANGER
KS-1	Growth Inhibition Assay			IC50 = 0.01084 μM	SANGER
NMC-G1	Growth Inhibition Assay			IC50 = 0.01185 μM	SANGER
REH	Growth Inhibition Assay			IC50 = 0.01339 μM	SANGER
NCI-H2342	Growth Inhibition Assay			IC50 = 0.01383 μM	SANGER
BFTC-909	Growth Inhibition Assay			IC50 = 0.01383 μM	SANGER
EFM-19	Growth Inhibition Assay			IC50 = 0.01477 μM	SANGER
NCI-H1703	Growth Inhibition Assay			IC50 = 0.01612 μM	SANGER
BB30-HNC	Growth Inhibition Assay			IC50 = 0.01634 μM	SANGER
NCI-H1734	Growth Inhibition Assay			IC50 = 0.01742 μM	SANGER
SF295	Growth Inhibition Assay			IC50 = 0.02139 μM	SANGER
MKN45	Growth Inhibition Assay			IC50 = 0.02481 μM	SANGER
ES1	Growth Inhibition Assay			IC50 = 0.0267 μM	SANGER
NEC8	Growth Inhibition Assay			IC50 = 0.02685 μM	SANGER
CTB-1	Growth Inhibition Assay			IC50 = 0.02694 μM	SANGER
5637	Growth Inhibition Assay			IC50 = 0.02897 μM	SANGER
SR	Growth Inhibition Assay			IC50 = 0.02967 μM	SANGER
HCC38	Growth Inhibition Assay			IC50 = 0.03124 μM	SANGER
LB1047-RCC	Growth Inhibition Assay			IC50 = 0.03255 μM	SANGER
ES4	Growth Inhibition Assay			IC50 = 0.03826 μM	SANGER
MHH-ES-1	Growth Inhibition Assay			IC50 = 0.04357 μM	SANGER
LS-411N	Growth Inhibition Assay			IC50 = 0.05276 μM	SANGER
HT-144	Growth Inhibition Assay			IC50 = 0.05514 μM	SANGER
BPH-1	Growth Inhibition Assay			IC50 = 0.05909 μM	SANGER
HMV-II	Growth Inhibition Assay			IC50 = 0.06974 μM	SANGER
A375	Growth Inhibition Assay			IC50 = 0.0711 μM	SANGER
LoVo	Growth Inhibition Assay			IC50 = 0.07117 μM	SANGER
COR-L23	Growth Inhibition Assay			IC50 = 0.07548 μM	SANGER
G-402	Growth Inhibition Assay			IC50 = 0.07651 μM	SANGER
CCRF-CEM	Growth Inhibition Assay			IC50 = 0.07869 μM	SANGER
MKN1	Growth Inhibition Assay			IC50 = 0.07965 μM	SANGER
LC-2-ad	Growth Inhibition Assay			IC50 = 0.08036 μM	SANGER
ETK-1	Growth Inhibition Assay			IC50 = 0.0805 μM	SANGER
786-0	Growth Inhibition Assay			IC50 = 0.08084 μM	SANGER
SW13	Growth Inhibition Assay			IC50 = 0.08162 μM	SANGER
Daoy	Growth Inhibition Assay			IC50 = 0.08304 μM	SANGER
G-361	Growth Inhibition Assay			IC50 = 0.08831 μM	SANGER
HCT-15	Growth Inhibition Assay			IC50 = 0.0951 μM	SANGER
ARH-77	Growth Inhibition Assay			IC50 = 0.10452 μM	SANGER
NCI-H1299	Growth Inhibition Assay			IC50 = 0.10753 μM	SANGER
MEL-JUSO	Growth Inhibition Assay			IC50 = 0.10855 μM	SANGER
MIA-PaCa-2	Growth Inhibition Assay			IC50 = 0.11074 μM	SANGER
769-P	Growth Inhibition Assay			IC50 = 0.1228 μM	SANGER
MZ7-mel	Growth Inhibition Assay			IC50 = 0.1305 μM	SANGER
KG-1	Growth Inhibition Assay			IC50 = 0.13057 μM	SANGER
23132-87	Growth Inhibition Assay			IC50 = 0.13146 μM	SANGER
ML-2	Growth Inhibition Assay			IC50 = 0.13166 μM	SANGER
BOKU	Growth Inhibition Assay			IC50 = 0.13698 μM	SANGER
SW1573	Growth Inhibition Assay			IC50 = 0.13715 μM	SANGER
IMR-5	Growth Inhibition Assay			IC50 = 0.13736 μM	SANGER
PSN1	Growth Inhibition Assay			IC50 = 0.13888 μM	SANGER
LCLC-103H	Growth Inhibition Assay			IC50 = 0.14398 μM	SANGER
IGROV-1	Growth Inhibition Assay			IC50 = 0.14455 μM	SANGER
CHP-212	Growth Inhibition Assay			IC50 = 0.14774 μM	SANGER
RH-1	Growth Inhibition Assay			IC50 = 0.15221 μM	SANGER
MFE-296	Growth Inhibition Assay			IC50 = 0.15324 μM	SANGER
NCI-H2170	Growth Inhibition Assay			IC50 = 0.16242 μM	SANGER
Saos-2	Growth Inhibition Assay			IC50 = 0.17196 μM	SANGER
LB996-RCC	Growth Inhibition Assay			IC50 = 0.17534 μM	SANGER
LB2518-MEL	Growth Inhibition Assay			IC50 = 0.18225 μM	SANGER
PC-14	Growth Inhibition Assay			IC50 = 0.18269 μM	SANGER
ESS-1	Growth Inhibition Assay			IC50 = 0.18744 μM	SANGER
CAL-54	Growth Inhibition Assay			IC50 = 0.19067 μM	SANGER
A204	Growth Inhibition Assay			IC50 = 0.20037 μM	SANGER
639-V	Growth Inhibition Assay			IC50 = 0.21956 μM	SANGER
A2780	Growth Inhibition Assay			IC50 = 0.22019 μM	SANGER
MZ1-PC	Growth Inhibition Assay			IC50 = 0.22434 μM	SANGER
GDM-1	Growth Inhibition Assay			IC50 = 0.22845 μM	SANGER
HT-1080	Growth Inhibition Assay			IC50 = 0.23357 μM	SANGER
SK-CO-1	Growth Inhibition Assay			IC50 = 0.24652 μM	SANGER
SW1783	Growth Inhibition Assay			IC50 = 0.24925 μM	SANGER
PANC-10-05	Growth Inhibition Assay			IC50 = 0.25606 μM	SANGER
CAL-12T	Growth Inhibition Assay			IC50 = 0.25851 μM	SANGER
VA-ES-BJ	Growth Inhibition Assay			IC50 = 0.26047 μM	SANGER
MDA-MB-231	Growth Inhibition Assay			IC50 = 0.27307 μM	SANGER
IST-MEL1	Growth Inhibition Assay			IC50 = 0.27975 μM	SANGER
GAMG	Growth Inhibition Assay			IC50 = 0.28935 μM	SANGER
EW-13	Growth Inhibition Assay			IC50 = 0.29208 μM	SANGER
SW1710	Growth Inhibition Assay			IC50 = 0.29533 μM	SANGER
C3A	Growth Inhibition Assay			IC50 = 0.29644 μM	SANGER
PANC-03-27	Growth Inhibition Assay			IC50 = 0.31639 μM	SANGER
H4	Growth Inhibition Assay			IC50 = 0.32074 μM	SANGER
NCI-H358	Growth Inhibition Assay			IC50 = 0.37271 μM	SANGER
ACHN	Growth Inhibition Assay			IC50 = 0.37463 μM	SANGER
TE-8	Growth Inhibition Assay			IC50 = 0.37669 μM	SANGER
SK-MEL-30	Growth Inhibition Assay			IC50 = 0.37688 μM	SANGER
ES7	Growth Inhibition Assay			IC50 = 0.37754 μM	SANGER
DoTc2-4510	Growth Inhibition Assay			IC50 = 0.37834 μM	SANGER
C-4-II	Growth Inhibition Assay			IC50 = 0.38131 μM	SANGER
SNU-449	Growth Inhibition Assay			IC50 = 0.38851 μM	SANGER
GB-1	Growth Inhibition Assay			IC50 = 0.39011 μM	SANGER
SF539	Growth Inhibition Assay			IC50 = 0.39305 μM	SANGER
MEG-01	Growth Inhibition Assay			IC50 = 0.39549 μM	SANGER
BE-13	Growth Inhibition Assay			IC50 = 0.39872 μM	SANGER
ES6	Growth Inhibition Assay			IC50 = 0.40625 μM	SANGER
SJRH30	Growth Inhibition Assay			IC50 = 0.41411 μM	SANGER
SK-HEP-1	Growth Inhibition Assay			IC50 = 0.41493 μM	SANGER
SCC-25	Growth Inhibition Assay			IC50 = 0.41539 μM	SANGER
SW982	Growth Inhibition Assay			IC50 = 0.41743 μM	SANGER
NALM-6	Growth Inhibition Assay			IC50 = 0.42016 μM	SANGER
NCI-H522	Growth Inhibition Assay			IC50 = 0.42569 μM	SANGER
PF-382	Growth Inhibition Assay			IC50 = 0.42616 μM	SANGER
C-33-A	Growth Inhibition Assay			IC50 = 0.43178 μM	SANGER
GI-ME-N	Growth Inhibition Assay			IC50 = 0.44079 μM	SANGER
RPMI-6666	Growth Inhibition Assay			IC50 = 0.44505 μM	SANGER
LOXIMVI	Growth Inhibition Assay			IC50 = 0.45232 μM	SANGER
HCE-4	Growth Inhibition Assay			IC50 = 0.45316 μM	SANGER
DEL	Growth Inhibition Assay			IC50 = 0.47988 μM	SANGER
NCI-H1650	Growth Inhibition Assay			IC50 = 0.49938 μM	SANGER
HCC1395	Growth Inhibition Assay			IC50 = 0.50094 μM	SANGER
AGS	Growth Inhibition Assay			IC50 = 0.50253 μM	SANGER
NCI-H1651	Growth Inhibition Assay			IC50 = 0.5053 μM	SANGER
ES5	Growth Inhibition Assay			IC50 = 0.50539 μM	SANGER
NCI-H2122	Growth Inhibition Assay			IC50 = 0.50953 μM	SANGER
BC-3	Growth Inhibition Assay			IC50 = 0.521 μM	SANGER
RKO	Growth Inhibition Assay			IC50 = 0.52424 μM	SANGER
MHH-CALL-2	Growth Inhibition Assay			IC50 = 0.53464 μM	SANGER
HT-29	Growth Inhibition Assay			IC50 = 0.5355 μM	SANGER
SW48	Growth Inhibition Assay			IC50 = 0.54612 μM	SANGER
GOTO	Growth Inhibition Assay			IC50 = 0.54993 μM	SANGER
HD-MY-Z	Growth Inhibition Assay			IC50 = 0.5602 μM	SANGER
HOS	Growth Inhibition Assay			IC50 = 0.56023 μM	SANGER
EFO-27	Growth Inhibition Assay			IC50 = 0.57104 μM	SANGER
JVM-2	Growth Inhibition Assay			IC50 = 0.57224 μM	SANGER
SIG-M5	Growth Inhibition Assay			IC50 = 0.58605 μM	SANGER
HCC1569	Growth Inhibition Assay			IC50 = 0.60449 μM	SANGER
A101D	Growth Inhibition Assay			IC50 = 0.61972 μM	SANGER
CAKI-1	Growth Inhibition Assay			IC50 = 0.62043 μM	SANGER
SBC-5	Growth Inhibition Assay			IC50 = 0.62355 μM	SANGER
RPMI-2650	Growth Inhibition Assay			IC50 = 0.63315 μM	SANGER
QIMR-WIL	Growth Inhibition Assay			IC50 = 0.63656 μM	SANGER
NCI-H64	Growth Inhibition Assay			IC50 = 0.64101 μM	SANGER
NCI-SNU-5	Growth Inhibition Assay			IC50 = 0.64336 μM	SANGER
LXF-289	Growth Inhibition Assay			IC50 = 0.64425 μM	SANGER
HSC-3	Growth Inhibition Assay			IC50 = 0.68829 μM	SANGER
EB2	Growth Inhibition Assay			IC50 = 0.69103 μM	SANGER
J-RT3-T3-5	Growth Inhibition Assay			IC50 = 0.71228 μM	SANGER
KYSE-270	Growth Inhibition Assay			IC50 = 0.7169 μM	SANGER
A3-KAW	Growth Inhibition Assay			IC50 = 0.71692 μM	SANGER
TE-12	Growth Inhibition Assay			IC50 = 0.71885 μM	SANGER
MDA-MB-361	Growth Inhibition Assay			IC50 = 0.71909 μM	SANGER
T-24	Growth Inhibition Assay			IC50 = 0.71991 μM	SANGER
CHL-1	Growth Inhibition Assay			IC50 = 0.73154 μM	SANGER
LB2241-RCC	Growth Inhibition Assay			IC50 = 0.73825 μM	SANGER
NCI-H1437	Growth Inhibition Assay			IC50 = 0.74272 μM	SANGER
Ca9-22	Growth Inhibition Assay			IC50 = 0.74583 μM	SANGER
EGI-1	Growth Inhibition Assay			IC50 = 0.77232 μM	SANGER
J82	Growth Inhibition Assay			IC50 = 0.77431 μM	SANGER
TE-10	Growth Inhibition Assay			IC50 = 0.78312 μM	SANGER
Ca-Ski	Growth Inhibition Assay			IC50 = 0.79823 μM	SANGER
NCI-H292	Growth Inhibition Assay			IC50 = 0.80316 μM	SANGER
8305C	Growth Inhibition Assay			IC50 = 0.80431 μM	SANGER
A2058	Growth Inhibition Assay			IC50 = 0.80768 μM	SANGER
ACN	Growth Inhibition Assay			IC50 = 0.80834 μM	SANGER
DU-145	Growth Inhibition Assay			IC50 = 0.82255 μM	SANGER
SNG-M	Growth Inhibition Assay			IC50 = 0.83083 μM	SANGER
OAW-42	Growth Inhibition Assay			IC50 = 0.83182 μM	SANGER
MEL-HO	Growth Inhibition Assay			IC50 = 0.85021 μM	SANGER
ONS-76	Growth Inhibition Assay			IC50 = 0.85391 μM	SANGER
BV-173	Growth Inhibition Assay			IC50 = 0.85487 μM	SANGER
SNU-423	Growth Inhibition Assay			IC50 = 0.86739 μM	SANGER
MLMA	Growth Inhibition Assay			IC50 = 0.87048 μM	SANGER
A388	Growth Inhibition Assay			IC50 = 0.87718 μM	SANGER
NB69	Growth Inhibition Assay			IC50 = 0.92254 μM	SANGER
SNU-387	Growth Inhibition Assay			IC50 = 0.92472 μM	SANGER
U031	Growth Inhibition Assay			IC50 = 0.93436 μM	SANGER
NCI-H2228	Growth Inhibition Assay			IC50 = 0.95465 μM	SANGER
UM-UC-3	Growth Inhibition Assay			IC50 = 0.95561 μM	SANGER
ALL-PO	Growth Inhibition Assay			IC50 = 0.98627 μM	SANGER
HC-1	Growth Inhibition Assay			IC50 = 0.99291 μM	SANGER
SK-LU-1	Growth Inhibition Assay			IC50 = 0.99868 μM	SANGER
TK10	Growth Inhibition Assay			IC50 = 0.99868 μM	SANGER
8505C	Growth Inhibition Assay			IC50 = 1.03998 μM	SANGER
NCCIT	Growth Inhibition Assay			IC50 = 1.06873 μM	SANGER
NCI-H510A	Growth Inhibition Assay			IC50 = 1.09156 μM	SANGER
NUGC-3	Growth Inhibition Assay			IC50 = 1.13021 μM	SANGER
DJM-1	Growth Inhibition Assay			IC50 = 1.13172 μM	SANGER
MCF7	Growth Inhibition Assay			IC50 = 1.16584 μM	SANGER
GI-1	Growth Inhibition Assay			IC50 = 1.20001 μM	SANGER
NCI-H747	Growth Inhibition Assay			IC50 = 1.21374 μM	SANGER
RPMI-7951	Growth Inhibition Assay			IC50 = 1.24443 μM	SANGER
RCM-1	Growth Inhibition Assay			IC50 = 1.26178 μM	SANGER
CHP-126	Growth Inhibition Assay			IC50 = 1.26806 μM	SANGER
DU-4475	Growth Inhibition Assay			IC50 = 1.26828 μM	SANGER
NCI-H526	Growth Inhibition Assay			IC50 = 1.27996 μM	SANGER
FTC-133	Growth Inhibition Assay			IC50 = 1.29359 μM	SANGER
NOS-1	Growth Inhibition Assay			IC50 = 1.30544 μM	SANGER
HuP-T4	Growth Inhibition Assay			IC50 = 1.3128 μM	SANGER
YT	Growth Inhibition Assay			IC50 = 1.31567 μM	SANGER
SF268	Growth Inhibition Assay			IC50 = 1.31797 μM	SANGER
KYSE-70	Growth Inhibition Assay			IC50 = 1.37884 μM	SANGER
ES8	Growth Inhibition Assay			IC50 = 1.39853 μM	SANGER
MC-CAR	Growth Inhibition Assay			IC50 = 1.39929 μM	SANGER
SW626	Growth Inhibition Assay			IC50 = 1.40825 μM	SANGER
BCPAP	Growth Inhibition Assay			IC50 = 1.43514 μM	SANGER
MRK-nu-1	Growth Inhibition Assay			IC50 = 1.45252 μM	SANGER
SK-PN-DW	Growth Inhibition Assay			IC50 = 1.45278 μM	SANGER
8-MG-BA	Growth Inhibition Assay			IC50 = 1.47953 μM	SANGER
MG-63	Growth Inhibition Assay			IC50 = 1.48966 μM	SANGER
LCLC-97TM1	Growth Inhibition Assay			IC50 = 1.49578 μM	SANGER
MDA-MB-175-VII	Growth Inhibition Assay			IC50 = 1.51005 μM	SANGER
697	Growth Inhibition Assay			IC50 = 1.57595 μM	SANGER
SW837	Growth Inhibition Assay			IC50 = 1.60642 μM	SANGER
ES3	Growth Inhibition Assay			IC50 = 1.60859 μM	SANGER
EHEB	Growth Inhibition Assay			IC50 = 1.60861 μM	SANGER
SNB75	Growth Inhibition Assay			IC50 = 1.60892 μM	SANGER
Daudi	Growth Inhibition Assay			IC50 = 1.67096 μM	SANGER
MES-SA	Growth Inhibition Assay			IC50 = 1.67344 μM	SANGER
LK-2	Growth Inhibition Assay			IC50 = 1.68921 μM	SANGER
647-V	Growth Inhibition Assay			IC50 = 1.73341 μM	SANGER
MOLT-4	Growth Inhibition Assay			IC50 = 1.77334 μM	SANGER
OCUB-M	Growth Inhibition Assay			IC50 = 1.81357 μM	SANGER
EW-1	Growth Inhibition Assay			IC50 = 1.81784 μM	SANGER
BHY	Growth Inhibition Assay			IC50 = 1.82747 μM	SANGER
Raji	Growth Inhibition Assay			IC50 = 1.84743 μM	SANGER
KYSE-510	Growth Inhibition Assay			IC50 = 1.85749 μM	SANGER
KYSE-450	Growth Inhibition Assay			IC50 = 1.93424 μM	SANGER
SW962	Growth Inhibition Assay			IC50 = 1.95452 μM	SANGER
MHH-NB-11	Growth Inhibition Assay			IC50 = 2.00542 μM	SANGER
PA-1	Growth Inhibition Assay			IC50 = 2.01527 μM	SANGER
KURAMOCHI	Growth Inhibition Assay			IC50 = 2.03812 μM	SANGER
SU-DHL-1	Growth Inhibition Assay			IC50 = 2.04945 μM	SANGER
AU565	Growth Inhibition Assay			IC50 = 2.05402 μM	SANGER
MC116	Growth Inhibition Assay			IC50 = 2.11053 μM	SANGER
A431	Growth Inhibition Assay			IC50 = 2.11197 μM	SANGER
OE19	Growth Inhibition Assay			IC50 = 2.14352 μM	SANGER
CAL-33	Growth Inhibition Assay			IC50 = 2.14602 μM	SANGER
KP-4	Growth Inhibition Assay			IC50 = 2.17066 μM	SANGER
SJSA-1	Growth Inhibition Assay			IC50 = 2.18726 μM	SANGER
COLO-800	Growth Inhibition Assay			IC50 = 2.20714 μM	SANGER
NH-12	Growth Inhibition Assay			IC50 = 2.20811 μM	SANGER
IPC-298	Growth Inhibition Assay			IC50 = 2.21227 μM	SANGER
OCI-AML2	Growth Inhibition Assay			IC50 = 2.25537 μM	SANGER
HH	Growth Inhibition Assay			IC50 = 2.28651 μM	SANGER
BFTC-905	Growth Inhibition Assay			IC50 = 2.31888 μM	SANGER
RT-112	Growth Inhibition Assay			IC50 = 2.31957 μM	SANGER
SNU-C2B	Growth Inhibition Assay			IC50 = 2.32484 μM	SANGER
IGR-1	Growth Inhibition Assay			IC50 = 2.34633 μM	SANGER
NCI-H2087	Growth Inhibition Assay			IC50 = 2.34738 μM	SANGER
EoL-1-cell	Growth Inhibition Assay			IC50 = 2.41593 μM	SANGER
SCC-4	Growth Inhibition Assay			IC50 = 2.4302 μM	SANGER
HuH-7	Growth Inhibition Assay			IC50 = 2.43456 μM	SANGER
HSC-2	Growth Inhibition Assay			IC50 = 2.46672 μM	SANGER
NCI-H23	Growth Inhibition Assay			IC50 = 2.46688 μM	SANGER
AN3-CA	Growth Inhibition Assay			IC50 = 2.55034 μM	SANGER
NCI-H2009	Growth Inhibition Assay			IC50 = 2.56438 μM	SANGER
NCI-H1792	Growth Inhibition Assay			IC50 = 2.56683 μM	SANGER
RVH-421	Growth Inhibition Assay			IC50 = 2.57186 μM	SANGER
SK-LMS-1	Growth Inhibition Assay			IC50 = 2.65761 μM	SANGER
COLO-679	Growth Inhibition Assay			IC50 = 2.66172 μM	SANGER
VMRC-RCZ	Growth Inhibition Assay			IC50 = 2.68962 μM	SANGER
NCI-H28	Growth Inhibition Assay			IC50 = 2.73884 μM	SANGER
HT-1197	Growth Inhibition Assay			IC50 = 2.74098 μM	SANGER
OE33	Growth Inhibition Assay			IC50 = 2.75256 μM	SANGER
BT-20	Growth Inhibition Assay			IC50 = 2.767 μM	SANGER
NCI-H661	Growth Inhibition Assay			IC50 = 2.78722 μM	SANGER
HCE-T	Growth Inhibition Assay			IC50 = 2.83188 μM	SANGER
HGC-27	Growth Inhibition Assay			IC50 = 2.83636 μM	SANGER
NCI-SNU-1	Growth Inhibition Assay			IC50 = 2.84084 μM	SANGER
A253	Growth Inhibition Assay			IC50 = 2.85522 μM	SANGER
HCT-116	Growth Inhibition Assay			IC50 = 2.88305 μM	SANGER
CAPAN-1	Growth Inhibition Assay			IC50 = 2.92149 μM	SANGER
MZ2-MEL	Growth Inhibition Assay			IC50 = 2.94674 μM	SANGER
NCI-N87	Growth Inhibition Assay			IC50 = 2.96422 μM	SANGER
NCI-H2052	Growth Inhibition Assay			IC50 = 2.96513 μM	SANGER
DMS-273	Growth Inhibition Assay			IC50 = 2.98076 μM	SANGER
MC-IXC	Growth Inhibition Assay			IC50 = 2.99693 μM	SANGER
OS-RC-2	Growth Inhibition Assay			IC50 = 3.02325 μM	SANGER
TYK-nu	Growth Inhibition Assay			IC50 = 3.03067 μM	SANGER
EW-7	Growth Inhibition Assay			IC50 = 3.05866 μM	SANGER
SK-MES-1	Growth Inhibition Assay			IC50 = 3.07459 μM	SANGER
SF126	Growth Inhibition Assay			IC50 = 3.08914 μM	SANGER
LB647-SCLC	Growth Inhibition Assay			IC50 = 3.14297 μM	SANGER
SCC-3	Growth Inhibition Assay			IC50 = 3.20606 μM	SANGER
TE-15	Growth Inhibition Assay			IC50 = 3.22315 μM	SANGER
M14	Growth Inhibition Assay			IC50 = 3.22456 μM	SANGER
COLO-205	Growth Inhibition Assay			IC50 = 3.24454 μM	SANGER
YKG-1	Growth Inhibition Assay			IC50 = 3.25583 μM	SANGER
SAS	Growth Inhibition Assay			IC50 = 3.26145 μM	SANGER
G-401	Growth Inhibition Assay			IC50 = 3.2899 μM	SANGER
CAL-62	Growth Inhibition Assay			IC50 = 3.34045 μM	SANGER
HCC1599	Growth Inhibition Assay			IC50 = 3.36875 μM	SANGER
JiyoyeP-2003	Growth Inhibition Assay			IC50 = 3.38494 μM	SANGER
IA-LM	Growth Inhibition Assay			IC50 = 3.4017 μM	SANGER
COLO-320-HSR	Growth Inhibition Assay			IC50 = 3.43354 μM	SANGER
SW872	Growth Inhibition Assay			IC50 = 3.45241 μM	SANGER
SW620	Growth Inhibition Assay			IC50 = 3.55738 μM	SANGER
M059J	Growth Inhibition Assay			IC50 = 3.76703 μM	SANGER
KYSE-180	Growth Inhibition Assay			IC50 = 3.79836 μM	SANGER
BxPC-3	Growth Inhibition Assay			IC50 = 3.80576 μM	SANGER
D-283MED	Growth Inhibition Assay			IC50 = 3.81218 μM	SANGER
KYSE-140	Growth Inhibition Assay			IC50 = 3.89603 μM	SANGER
BC-1	Growth Inhibition Assay			IC50 = 3.91812 μM	SANGER
HLE	Growth Inhibition Assay			IC50 = 3.99693 μM	SANGER
MN-60	Growth Inhibition Assay			IC50 = 4.05162 μM	SANGER
NCI-H1304	Growth Inhibition Assay			IC50 = 4.1047 μM	SANGER
IM-9	Growth Inhibition Assay			IC50 = 4.13195 μM	SANGER
NOMO-1	Growth Inhibition Assay			IC50 = 4.20151 μM	SANGER
SW1990	Growth Inhibition Assay			IC50 = 4.24402 μM	SANGER
NCI-H2405	Growth Inhibition Assay			IC50 = 4.27798 μM	SANGER
LAMA-84	Growth Inhibition Assay			IC50 = 4.28656 μM	SANGER
CGTH-W-1	Growth Inhibition Assay			IC50 = 4.30277 μM	SANGER
EFO-21	Growth Inhibition Assay			IC50 = 4.33027 μM	SANGER
U251	Growth Inhibition Assay			IC50 = 4.36314 μM	SANGER
OVCAR-4	Growth Inhibition Assay			IC50 = 4.41035 μM	SANGER
HO-1-N-1	Growth Inhibition Assay			IC50 = 4.41781 μM	SANGER
CaR-1	Growth Inhibition Assay			IC50 = 4.44726 μM	SANGER
CCF-STTG1	Growth Inhibition Assay			IC50 = 4.56209 μM	SANGER
MONO-MAC-6	Growth Inhibition Assay			IC50 = 4.59384 μM	SANGER
CAL-148	Growth Inhibition Assay			IC50 = 4.60119 μM	SANGER
OVCAR-5	Growth Inhibition Assay			IC50 = 4.74899 μM	SANGER
NCI-H460	Growth Inhibition Assay			IC50 = 4.75506 μM	SANGER
HuP-T3	Growth Inhibition Assay			IC50 = 4.79184 μM	SANGER
SK-OV-3	Growth Inhibition Assay			IC50 = 4.88426 μM	SANGER
VM-CUB-1	Growth Inhibition Assay			IC50 = 4.91668 μM	SANGER
CTV-1	Growth Inhibition Assay			IC50 = 4.92002 μM	SANGER
AM-38	Growth Inhibition Assay			IC50 = 4.94112 μM	SANGER
GCT	Growth Inhibition Assay			IC50 = 4.99065 μM	SANGER
NCI-H2347	Growth Inhibition Assay			IC50 = 5.11661 μM	SANGER
DB	Growth Inhibition Assay			IC50 = 5.11905 μM	SANGER
FADU	Growth Inhibition Assay			IC50 = 5.13773 μM	SANGER
Calu-1	Growth Inhibition Assay			IC50 = 5.13779 μM	SANGER
NCI-H2030	Growth Inhibition Assay			IC50 = 5.21763 μM	SANGER
DOHH-2	Growth Inhibition Assay			IC50 = 5.28851 μM	SANGER
NCI-H1770	Growth Inhibition Assay			IC50 = 5.29092 μM	SANGER
P12-ICHIKAWA	Growth Inhibition Assay			IC50 = 5.54575 μM	SANGER
HT	Growth Inhibition Assay			IC50 = 5.55505 μM	SANGER
CAL-120	Growth Inhibition Assay			IC50 = 5.56142 μM	SANGER
DBTRG-05MG	Growth Inhibition Assay			IC50 = 5.67305 μM	SANGER
COLO-680N	Growth Inhibition Assay			IC50 = 5.7583 μM	SANGER
HT-3	Growth Inhibition Assay			IC50 = 5.77714 μM	SANGER
NY	Growth Inhibition Assay			IC50 = 5.91176 μM	SANGER
NCI-H838	Growth Inhibition Assay			IC50 = 5.94757 μM	SANGER
NCI-H1618	Growth Inhibition Assay			IC50 = 5.98557 μM	SANGER
TE-11	Growth Inhibition Assay			IC50 = 6.08459 μM	SANGER
Calu-3	Growth Inhibition Assay			IC50 = 6.19074 μM	SANGER
ST486	Growth Inhibition Assay			IC50 = 6.39405 μM	SANGER
EW-11	Growth Inhibition Assay			IC50 = 6.41293 μM	SANGER
TE-1	Growth Inhibition Assay			IC50 = 6.42507 μM	SANGER
NB5	Growth Inhibition Assay			IC50 = 6.72078 μM	SANGER
DMS-114	Growth Inhibition Assay			IC50 = 6.78617 μM	SANGER
KYSE-520	Growth Inhibition Assay			IC50 = 6.78887 μM	SANGER
SIMA	Growth Inhibition Assay			IC50 = 6.93011 μM	SANGER
KM-H2	Growth Inhibition Assay			IC50 = 6.96614 μM	SANGER
WM-115	Growth Inhibition Assay			IC50 = 7.09344 μM	SANGER
P30-OHK	Growth Inhibition Assay			IC50 = 7.09585 μM	SANGER
22RV1	Growth Inhibition Assay			IC50 = 7.32932 μM	SANGER
BHT-101	Growth Inhibition Assay			IC50 = 7.34054 μM	SANGER
COR-L105	Growth Inhibition Assay			IC50 = 7.36534 μM	SANGER
Calu-6	Growth Inhibition Assay			IC50 = 7.67159 μM	SANGER
C8166	Growth Inhibition Assay			IC50 = 7.77036 μM	SANGER
SH-4	Growth Inhibition Assay			IC50 = 7.84755 μM	SANGER
RPMI-8866	Growth Inhibition Assay			IC50 = 7.9095 μM	SANGER
TE-5	Growth Inhibition Assay			IC50 = 7.96408 μM	SANGER
CAL-27	Growth Inhibition Assay			IC50 = 8.07296 μM	SANGER
KYSE-410	Growth Inhibition Assay			IC50 = 8.1465 μM	SANGER
NCI-H1355	Growth Inhibition Assay			IC50 = 8.20414 μM	SANGER
LB831-BLC	Growth Inhibition Assay			IC50 = 8.38272 μM	SANGER
SK-MEL-2	Growth Inhibition Assay			IC50 = 8.48548 μM	SANGER
JEG-3	Growth Inhibition Assay			IC50 = 8.5506 μM	SANGER
NCI-H441	Growth Inhibition Assay			IC50 = 9.04985 μM	SANGER
KM12	Growth Inhibition Assay			IC50 = 9.18802 μM	SANGER
OAW-28	Growth Inhibition Assay			IC50 = 9.20646 μM	SANGER
HOP-92	Growth Inhibition Assay			IC50 = 9.26 μM	SANGER
HT-1376	Growth Inhibition Assay			IC50 = 9.73755 μM	SANGER
Ramos-2G6-4C10	Growth Inhibition Assay			IC50 = 9.88105 μM	SANGER
NCI-H727	Growth Inhibition Assay			IC50 = 10.3102 μM	SANGER
A673	Growth Inhibition Assay			IC50 = 10.4566 μM	SANGER
A704	Growth Inhibition Assay			IC50 = 10.6436 μM	SANGER
HEL	Growth Inhibition Assay			IC50 = 10.8362 μM	SANGER
HuCCT1	Growth Inhibition Assay			IC50 = 10.9343 μM	SANGER
U-87-MG	Growth Inhibition Assay			IC50 = 11.0572 μM	SANGER
LC4-1	Growth Inhibition Assay			IC50 = 11.1604 μM	SANGER
SW756	Growth Inhibition Assay			IC50 = 11.3757 μM	SANGER
NCI-H1882	Growth Inhibition Assay			IC50 = 11.455 μM	SANGER
NB1	Growth Inhibition Assay			IC50 = 11.5965 μM	SANGER
KALS-1	Growth Inhibition Assay			IC50 = 11.7421 μM	SANGER
OMC-1	Growth Inhibition Assay			IC50 = 11.8941 μM	SANGER
Detroit562	Growth Inhibition Assay			IC50 = 11.931 μM	SANGER
PANC-08-13	Growth Inhibition Assay			IC50 = 12.0521 μM	SANGER
TE-6	Growth Inhibition Assay			IC50 = 12.3857 μM	SANGER
GCIY	Growth Inhibition Assay			IC50 = 12.7546 μM	SANGER
U-698-M	Growth Inhibition Assay			IC50 = 13.0065 μM	SANGER
PC-3	Growth Inhibition Assay			IC50 = 13.3146 μM	SANGER
T84	Growth Inhibition Assay			IC50 = 13.4592 μM	SANGER
NCI-H596	Growth Inhibition Assay			IC50 = 13.5755 μM	SANGER
D-392MG	Growth Inhibition Assay			IC50 = 13.5799 μM	SANGER
NB10	Growth Inhibition Assay			IC50 = 13.8464 μM	SANGER
BL-41	Growth Inhibition Assay			IC50 = 14.1975 μM	SANGER
HDLM-2	Growth Inhibition Assay			IC50 = 14.3177 μM	SANGER
LAN-6	Growth Inhibition Assay			IC50 = 14.6341 μM	SANGER
CMK	Growth Inhibition Assay			IC50 = 14.7963 μM	SANGER
MDA-MB-453	Growth Inhibition Assay			IC50 = 15.4155 μM	SANGER
GP5d	Growth Inhibition Assay			IC50 = 15.636 μM	SANGER
TCCSUP	Growth Inhibition Assay			IC50 = 15.9419 μM	SANGER
NCI-H520	Growth Inhibition Assay			IC50 = 16.0521 μM	SANGER
ChaGo-K-1	Growth Inhibition Assay			IC50 = 16.3642 μM	SANGER
COLO-741	Growth Inhibition Assay			IC50 = 16.4227 μM	SANGER
NCI-H1693	Growth Inhibition Assay			IC50 = 16.565 μM	SANGER
DG-75	Growth Inhibition Assay			IC50 = 16.9142 μM	SANGER
CAMA-1	Growth Inhibition Assay			IC50 = 17.5247 μM	SANGER
LNCaP-Clone-FGC	Growth Inhibition Assay			IC50 = 18.3155 μM	SANGER
EW-3	Growth Inhibition Assay			IC50 = 18.5014 μM	SANGER
TUR	Growth Inhibition Assay			IC50 = 18.8518 μM	SANGER
NCI-H446	Growth Inhibition Assay			IC50 = 18.8813 μM	SANGER
ATN-1	Growth Inhibition Assay			IC50 = 18.9202 μM	SANGER
LU-65	Growth Inhibition Assay			IC50 = 19.4673 μM	SANGER
ABC-1	Growth Inhibition Assay			IC50 = 19.6679 μM	SANGER
NCI-H1648	Growth Inhibition Assay			IC50 = 20.3205 μM	SANGER
Caov-3	Growth Inhibition Assay			IC50 = 20.4613 μM	SANGER
NCI-H1563	Growth Inhibition Assay			IC50 = 20.6061 μM	SANGER
KLE	Growth Inhibition Assay			IC50 = 21.24 μM	SANGER
MMAC-SF	Growth Inhibition Assay			IC50 = 21.327 μM	SANGER
BB65-RCC	Growth Inhibition Assay			IC50 = 21.4262 μM	SANGER
EB-3	Growth Inhibition Assay			IC50 = 21.8331 μM	SANGER
SK-MEL-3	Growth Inhibition Assay			IC50 = 22.1755 μM	SANGER
NCI-H2196	Growth Inhibition Assay			IC50 = 22.8494 μM	SANGER
GR-ST	Growth Inhibition Assay			IC50 = 23.0977 μM	SANGER
SK-MM-2	Growth Inhibition Assay			IC50 = 23.239 μM	SANGER
SK-MEL-24	Growth Inhibition Assay			IC50 = 23.2952 μM	SANGER
LS-123	Growth Inhibition Assay			IC50 = 23.4283 μM	SANGER
SW1463	Growth Inhibition Assay			IC50 = 23.4421 μM	SANGER
L-540	Growth Inhibition Assay			IC50 = 23.5493 μM	SANGER
Capan-2	Growth Inhibition Assay			IC50 = 24.2155 μM	SANGER
NCI-H1838	Growth Inhibition Assay			IC50 = 24.5232 μM	SANGER
TE-441-T	Growth Inhibition Assay			IC50 = 24.6153 μM	SANGER
A4-Fuk	Growth Inhibition Assay			IC50 = 25.288 μM	SANGER
COR-L279	Growth Inhibition Assay			IC50 = 25.3526 μM	SANGER
KE-37	Growth Inhibition Assay			IC50 = 25.9179 μM	SANGER
NCI-H1755	Growth Inhibition Assay			IC50 = 26.001 μM	SANGER
KP-N-YN	Growth Inhibition Assay			IC50 = 26.337 μM	SANGER
COLO-792	Growth Inhibition Assay			IC50 = 26.4052 μM	SANGER
Becker	Growth Inhibition Assay			IC50 = 26.9253 μM	SANGER
no-10	Growth Inhibition Assay			IC50 = 27.0943 μM	SANGER
NCI-H1793	Growth Inhibition Assay			IC50 = 27.172 μM	SANGER
HCC1143	Growth Inhibition Assay			IC50 = 27.1918 μM	SANGER
KARPAS-299	Growth Inhibition Assay			IC50 = 27.2024 μM	SANGER
HEC-1	Growth Inhibition Assay			IC50 = 27.3627 μM	SANGER
SCC-15	Growth Inhibition Assay			IC50 = 27.6315 μM	SANGER
LS-513	Growth Inhibition Assay			IC50 = 28.9662 μM	SANGER
HN	Growth Inhibition Assay			IC50 = 29.1374 μM	SANGER
MOLT-16	Growth Inhibition Assay			IC50 = 29.5165 μM	SANGER
KP-N-YS	Growth Inhibition Assay			IC50 = 30.2856 μM	SANGER
NCI-H1417	Growth Inhibition Assay			IC50 = 30.3916 μM	SANGER
RPMI-8402	Growth Inhibition Assay			IC50 = 30.7398 μM	SANGER
WSU-NHL	Growth Inhibition Assay			IC50 = 31.634 μM	SANGER
SK-NEP-1	Growth Inhibition Assay			IC50 = 31.88 μM	SANGER
HCC1187	Growth Inhibition Assay			IC50 = 32.9082 μM	SANGER
PFSK-1	Growth Inhibition Assay			IC50 = 33.4435 μM	SANGER
TE-9	Growth Inhibition Assay			IC50 = 33.9766 μM	SANGER
NCI-H209	Growth Inhibition Assay			IC50 = 34.3161 μM	SANGER
HL-60	Growth Inhibition Assay			IC50 = 35.2849 μM	SANGER
LS-1034	Growth Inhibition Assay			IC50 = 35.3757 μM	SANGER
NCI-H2141	Growth Inhibition Assay			IC50 = 36.1155 μM	SANGER
COLO-678	Growth Inhibition Assay			IC50 = 36.2389 μM	SANGER
NB13	Growth Inhibition Assay			IC50 = 36.744 μM	SANGER
COLO-829	Growth Inhibition Assay			IC50 = 36.9718 μM	SANGER
BB49-HNC	Growth Inhibition Assay			IC50 = 38.7612 μM	SANGER
NCI-H1623	Growth Inhibition Assay			IC50 = 39.0477 μM	SANGER
A172	Growth Inhibition Assay			IC50 = 39.7268 μM	SANGER
MPP-89	Growth Inhibition Assay			IC50 = 39.8805 μM	SANGER
ME-180	Growth Inhibition Assay			IC50 = 40.8628 μM	SANGER
LU-165	Growth Inhibition Assay			IC50 = 41.7959 μM	SANGER
LU-134-A	Growth Inhibition Assay			IC50 = 41.8216 μM	SANGER
HCC2218	Growth Inhibition Assay			IC50 = 41.8898 μM	SANGER
NCI-H1694	Growth Inhibition Assay			IC50 = 43.8822 μM	SANGER
BEN	Growth Inhibition Assay			IC50 = 46.0431 μM	SANGER
RERF-LC-MS	Growth Inhibition Assay			IC50 = 48.6853 μM	SANGER
LC-1F	Growth Inhibition Assay			IC50 = 49.4076 μM	SANGER
L-428	Growth Inhibition Assay			IC50 = 52.3358 μM	SANGER
CPC-N	Growth Inhibition Assay			IC50 = 52.489 μM	SANGER
COLO-824	Growth Inhibition Assay			IC50 = 53.329 μM	SANGER
IST-SL1	Growth Inhibition Assay			IC50 = 54.5851 μM	SANGER
NCI-H810	Growth Inhibition Assay			IC50 = 55.1277 μM	SANGER
LB373-MEL-D	Growth Inhibition Assay			IC50 = 56.4075 μM	SANGER
ECC4	Growth Inhibition Assay			IC50 = 56.7007 μM	SANGER
TT	Growth Inhibition Assay			IC50 = 59.1501 μM	SANGER
D-542MG	Growth Inhibition Assay			IC50 = 60.2794 μM	SANGER
T98G	Growth Inhibition Assay			IC50 = 63.7348 μM	SANGER
U-118-MG	Growth Inhibition Assay			IC50 = 65.6647 μM	SANGER
TGW	Growth Inhibition Assay			IC50 = 65.7504 μM	SANGER
MKN7	Growth Inhibition Assay			IC50 = 66.5296 μM	SANGER
MDA-MB-415	Growth Inhibition Assay			IC50 = 67.3338 μM	SANGER
SNU-475	Growth Inhibition Assay			IC50 = 67.5008 μM	SANGER
MDA-MB-468	Growth Inhibition Assay			IC50 = 67.5522 μM	SANGER
KU812	Growth Inhibition Assay			IC50 = 67.9601 μM	SANGER
RCC10RGB	Growth Inhibition Assay			IC50 = 70.5644 μM	SANGER
K5	Growth Inhibition Assay			IC50 = 72.3646 μM	SANGER
NCI-H1155	Growth Inhibition Assay			IC50 = 73.2129 μM	SANGER
COR-L88	Growth Inhibition Assay			IC50 = 73.4243 μM	SANGER
TGBC1TKB	Growth Inhibition Assay			IC50 = 74.14 μM	SANGER
NCI-H748	Growth Inhibition Assay			IC50 = 75.1768 μM	SANGER
EW-18	Growth Inhibition Assay			IC50 = 75.8498 μM	SANGER
NCI-H226	Growth Inhibition Assay			IC50 = 77.3602 μM	SANGER
HTC-C3	Growth Inhibition Assay			IC50 = 77.8428 μM	SANGER
CAS-1	Growth Inhibition Assay			IC50 = 81.0296 μM	SANGER
SNU-C1	Growth Inhibition Assay			IC50 = 81.9941 μM	SANGER
NB12	Growth Inhibition Assay			IC50 = 82.3997 μM	SANGER
AsPC-1	Growth Inhibition Assay			IC50 = 82.5028 μM	SANGER
HCC1954	Growth Inhibition Assay			IC50 = 84.163 μM	SANGER
EM-2	Growth Inhibition Assay			IC50 = 84.7528 μM	SANGER
CA46	Growth Inhibition Assay			IC50 = 84.8498 μM	SANGER
no-11	Growth Inhibition Assay			IC50 = 85.5708 μM	SANGER
DK-MG	Growth Inhibition Assay			IC50 = 85.7672 μM	SANGER
HuO-3N1	Growth Inhibition Assay			IC50 = 87.8298 μM	SANGER
S-117	Growth Inhibition Assay			IC50 = 90.2444 μM	SANGER
C2BBe1	Growth Inhibition Assay			IC50 = 91.8016 μM	SANGER
THP-1	Growth Inhibition Assay			IC50 = 92.4868 μM	SANGER
HCC2157	Growth Inhibition Assay			IC50 = 93.3592 μM	SANGER
EW-24	Growth Inhibition Assay			IC50 = 95.3316 μM	SANGER
UACC-812	Growth Inhibition Assay			IC50 = 99.5951 μM	SANGER
NCI-H720	Growth Inhibition Assay			IC50 = 103.351 μM	SANGER
NCI-H69	Growth Inhibition Assay			IC50 = 103.909 μM	SANGER
OPM-2	Growth Inhibition Assay			IC50 = 104.066 μM	SANGER
RD	Growth Inhibition Assay			IC50 = 105.698 μM	SANGER
NCI-H1581	Growth Inhibition Assay			IC50 = 110.224 μM	SANGER
OVCAR-3	Growth Inhibition Assay			IC50 = 123.332 μM	SANGER
HCC70	Growth Inhibition Assay			IC50 = 125.868 μM	SANGER
GAK	Growth Inhibition Assay			IC50 = 126.132 μM	SANGER
K-562	Growth Inhibition Assay			IC50 = 126.227 μM	SANGER
UACC-893	Growth Inhibition Assay			IC50 = 129.777 μM	SANGER
SKG-IIIa	Growth Inhibition Assay			IC50 = 136.469 μM	SANGER
SHP-77	Growth Inhibition Assay			IC50 = 142.135 μM	SANGER
D-263MG	Growth Inhibition Assay			IC50 = 142.206 μM	SANGER
Mewo	Growth Inhibition Assay			IC50 = 147.962 μM	SANGER
MSTO-211H	Growth Inhibition Assay			IC50 = 149.459 μM	SANGER
클릭하여 더 많은 세포주 실험 데이터 보기

화학 정보, 보관 및 안정성

분자량	1512.62	화학식	C₅₅H₈₅N₁₇O₂₅S₄	보관 (수령일로부터)	3년-20°C분말
CAS 번호	9041-93-4	SDF 다운로드		원액 보관	1년-80°C용매에 보관 1개월-20°C용매에 보관
동의어	NSC125066 sulfate			Smiles	CC1=C(N=C(N=C1N)C(CC(=O)N)NCC(C(=O)N)N)C(=O)NC(C(C2=CN=CN2)OC3C(C(C(C(O3)CO)O)O)OC4C(C(C(C(O4)CO)O)OC(=O)N)O)C(=O)NC(C)C(C(C)C(=O)NC(C(C)O)C(=O)NCCC5=NC(=CS5)C6=NC(=CS6)C(=O)NCCC[S+](C)C)O.OS(=O)(=O)[O-]

용해도

In vitro
배치:

DMSO : 100 mg/mL (66.11 mM)
(수분으로 오염된 DMSO는 용해도를 감소시킬 수 있습니다. 신선하고 무수 DMSO를 사용하십시오.)

Water : 100 mg/mL

Ethanol : Insoluble

DMSO : 100 mg/mL (66.11 mM)
(수분으로 오염된 DMSO는 용해도를 감소시킬 수 있습니다. 신선하고 무수 DMSO를 사용하십시오.)

Water : 25 mg/mL

Ethanol : Insoluble

DMSO : 100 mg/mL (66.11 mM)
(수분으로 오염된 DMSO는 용해도를 감소시킬 수 있습니다. 신선하고 무수 DMSO를 사용하십시오.)

Water : 100 mg/mL

Ethanol : Insoluble

Water : 100 mg/mL

DMSO : 50 mg/mL (33.05 mM)
(수분으로 오염된 DMSO는 용해도를 감소시킬 수 있습니다. 신선하고 무수 DMSO를 사용하십시오.)

Ethanol : Insoluble

DMSO : 100 mg/mL (66.11 mM)
(수분으로 오염된 DMSO는 용해도를 감소시킬 수 있습니다. 신선하고 무수 DMSO를 사용하십시오.)

Water : 100 mg/mL

Ethanol : Insoluble

몰농도 계산기

질량	농도	부피	분자량
=	×	×

희석 계산기 분자량 계산기

In vivo 배치:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O Selleck 연구소에서 검증되었습니다. 이 제형에 대한 조정이 필요한 경우 맞춤 테스트를 위해 당사 영업팀에 문의하십시오.	2.500mg/ml (1.65mM)	Taking the 1 mL working solution as an example, add 50 μL of 50 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to make it clear; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

생체 내 제형 계산기 (투명한 용액)

1단계: 아래 정보 입력 (권장: 실험 중 손실을 고려하여 추가 동물 포함)

투여량: mg/kg 동물 평균 체중: g 동물당 투여량:μL 동물 수:

2단계: 생체 내 제형 입력 (이것은 계산기일 뿐 제형이 아닙니다. 용해도 섹션에 생체 내 제형이 없는 경우 먼저 당사에 문의하십시오.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

계산 결과:

작업 농도: mg/ml;

DMSO 원액 준비 방법: mg 약물 사전 용해 μL DMSO ( 원액 농도 mg/mL, 농도가 해당 약물 배치의 DMSO 용해도를 초과하는 경우 먼저 당사에 문의하십시오. )

생체 내 제형 준비 방법: 취하다 μL DMSO 원액, 다음 추가μL PEG300, 혼합하고 투명하게 한 다음 추가μL Tween 80, 혼합하고 투명하게 한 다음 추가 μL ddH₂O, 혼합하고 투명하게 합니다.

생체 내 제형 준비 방법: 취하다 μL DMSO 원액, 다음 추가 μL 옥수수 기름, 혼합하고 투명하게 합니다.

참고: 1. 다음 용매를 추가하기 전에 액체가 투명한지 확인하십시오.
2. 용매를 순서대로 추가해야 합니다. 다음 용매를 추가하기 전에 이전 추가에서 얻은 용액이 투명한 용액인지 확인해야 합니다. 와동, 초음파 또는 뜨거운 물 중탕과 같은 물리적 방법을 사용하여 용해를 도울 수 있습니다.

작용 메커니즘

시험관 내(In vitro)	UT-SCC-12A 및 UT-SCC-12B는 각각 14.2 nM 및 13 nM의 IC50으로 Bleomycin sulfate에 더 강한 내성을 보입니다. 0.01 μg/mL에서 1 μg/mL의 이 화합물과 18시간 동안 배양된 폐포 대식세포는 이 화학 물질 없이 배양된 대식세포보다 섬유아세포 성장 인자를 유의하게 더 많이 분비합니다. 이 화합물로 자극된 대식세포는 이 화학 물질을 제거하고 신선한 (Bleomycin sulfate가 없는) 배지로 교체한 후에도 상당한 양의 섬유아세포 성장 인자를 계속 생산합니다. 이 화합물로 자극된 폐포 대식세포에 의한 섬유아세포 성장 인자 분비는 사이클로헥시미드와 5-리폭시게나제 억제제 NDGA (노르디하이드로구아이아르산) 및 BW755c에 의해 억제되는데, 이는 단백질 합성뿐만 아니라 아라키돈산 대사의 5-리폭시게나제 경로의 대사 산물이 활동의 완전한 발현에 필요하다는 것을 나타냅니다. 이 화학 물질 (400 µg/mL)을 24시간 동안 배양하면 NTera-2 세포의 생존력이 감소하고, 카스파제-3, -8, -9 활성, Bax 및 세포질 cytochrome c 수준이 증가하며 Bcl-2 수준이 감소합니다. 불안정한 염색체 이상 측면에서, 이 화합물이 ADIPO-P2 세포에 미치는 염색체 손상 효과는 노출 후 최소 10일 동안 지속됩니다. 이 화학 물질 유도성 포유류 세포의 텔로미어 불안정성은 노출 후 여러 세대 동안 지속됩니다. 더욱이, 처리 후 10일째에 이 화합물에 노출된 세포에서 텔로미어 융합의 출현은 이 화학 물질이 지연된 텔로미어 불안정성을 유도할 수 있음을 시사합니다.
생체 내(In vivo)	Bleomycin sulfate 투여 후 7일째, NOX-/- BALf의 CD45+ 세포는 WT보다 1.7배 많으며, 이 중 57%는 Mf로, 21일째에는 WT에서 67%, NOX-/-에서 83% 감소합니다.
참조	[1] https://pubmed.ncbi.nlm.nih.gov/9288321/ [2] https://pubmed.ncbi.nlm.nih.gov/2464942/ [3] https://pubmed.ncbi.nlm.nih.gov/22469952/ [4] https://pubmed.ncbi.nlm.nih.gov/22564429/ [5] https://pubmed.ncbi.nlm.nih.gov/22643035/ [6] https://pubmed.ncbi.nlm.nih.gov/22640881/ [7] https://pubmed.ncbi.nlm.nih.gov/25356121/ [8] https://pubmed.ncbi.nlm.nih.gov/27330564/

적용 분야

방법	바이오마커	PMID
Western blot	LRP6 / Wnt5AB / Dvl2 / β-catenin phospho-eIF2α / eIF2α cytochrome c Bcl-xl Bcl-2	27649046
Immunofluorescence	LC3	23762310
ELISA	HMGB1	23762310

기술 지원

취급 설명서

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자주 묻는 질문

질문 1:
What is the ratio between bleomycin A2 and bleomycin B2 in it?

답변:
Its content of Bleomycin A2 and Bleomycin B2 is 62% and 29% respectively.

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):